{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:20:11Z","timestamp":1783063211892,"version":"3.54.6"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2024SF-YBXM-521"],"award-info":[{"award-number":["2024SF-YBXM-521"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.prp.2026.156527","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:53:30Z","timestamp":1778547210000},"page":"156527","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Licochalcone A targets ADRB2 to enhance CD8+ T cell anti-leukemia activity via regulation involving the AKT2\/FOXO1\/GLUT2 axis"],"prefix":"10.1016","volume":"284","author":[{"given":"Pingping","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongzhi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2026.156527_bib1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/stmcls\/sxad095","article-title":"Aberrant lipid metabolic signatures in acute Myeloid Leukemia","volume":"42","author":"Singh","year":"2024","journal-title":"Stem Cells"},{"key":"10.1016\/j.prp.2026.156527_bib2","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1038\/s41401-024-01304-w","article-title":"Targeting metabolism to enhance immunotherapy within tumor microenvironment","volume":"45","author":"Liang","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.prp.2026.156527_bib3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ccell.2022.12.007","article-title":"MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors","volume":"41","author":"Kilian","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.prp.2026.156527_bib4","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/ijlh.14214","article-title":"Prognostic significance of the frequencies of bone marrow lymphocyte subsets in adult acute myeloid leukemia at diagnosis","volume":"46","author":"Sun","year":"2024","journal-title":"Int. J. Lab. Hematol."},{"key":"10.1016\/j.prp.2026.156527_bib5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00011-023-01839-4","article-title":"CD8\u2009+\u2009T cell-based molecular subtypes with heterogeneous immune landscapes and clinical significance in acute myeloid leukemia","volume":"73","author":"Zhong","year":"2024","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.prp.2026.156527_bib6","article-title":"CD8(+) T-cell immunity orchestrated by iNKT cells","volume":"13","author":"Qin","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.prp.2026.156527_bib7","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.immuni.2022.04.016","article-title":"Dendritic cells can prime anti-tumor CD8(+) T cell responses through major histocompatibility complex cross-dressing","volume":"55","author":"MacNabb","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.prp.2026.156527_bib8","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/s41556-022-00942-8","article-title":"Dapl1 controls NFATc2 activation to regulate CD8(+) T cell exhaustion and responses in chronic infection and cancer","volume":"24","author":"Zhu","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.prp.2026.156527_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150738","article-title":"Impaired mitochondrial oxidative phosphorylation induces CD8(+) T cell exhaustion","volume":"734","author":"Liu","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.prp.2026.156527_bib10","doi-asserted-by":"crossref","DOI":"10.1177\/15347354231210867","article-title":"Licochalcone A Induces Ferroptosis in Hepatocellular Carcinoma via Reactive Oxygen Species Activated by the SLC7A11\/GPX4 Pathway","volume":"22","author":"Zhang","year":"2023","journal-title":"Integr. Cancer Ther."},{"key":"10.1016\/j.prp.2026.156527_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5687832","article-title":"Licochalcone A Promotes the Ubiquitination of c-Met to Abrogate Gefitinib Resistance","volume":"2022","author":"Han","year":"2022","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.prp.2026.156527_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113989","article-title":"Licochalcone A inhibits proliferation and promotes apoptosis of colon cancer cell by targeting programmed cell death-ligand 1 via the NF-\u03baB and Ras\/Raf\/MEK pathways","volume":"273","author":"Liu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.prp.2026.156527_bib13","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1038\/s41401-024-01287-8","article-title":"GPC3-targeted CAR-T cells expressing GLUT1 or AGK exhibit enhanced antitumor activity against hepatocellular carcinoma","volume":"45","author":"Sun","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.prp.2026.156527_bib14","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nrrheum.2017.134","article-title":"Functional autoantibodies targeting G protein-coupled receptors in rheumatic diseases","volume":"13","author":"Cabral-Marques","year":"2017","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.prp.2026.156527_bib15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00262-018-2243-8","article-title":"\u03b2-Adrenergic signaling blocks murine CD8+ T-cell metabolic reprogramming during activation: a mechanism for immunosuppression by adrenergic stress","volume":"68","author":"Qiao","year":"2019","journal-title":"Cancer Immunol. Immun."},{"key":"10.1016\/j.prp.2026.156527_bib16","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1016\/j.ymthe.2024.08.028","article-title":"Intrinsic ADRB2 inhibition improves CAR-T cell therapy efficacy against prostate cancer","volume":"32","author":"Ajmal","year":"2024","journal-title":"Mol. Ther."},{"key":"10.1016\/j.prp.2026.156527_bib17","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1182\/blood.2023021680","article-title":"CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia","volume":"144","author":"Mazziotta","year":"2024","journal-title":"Blood"},{"key":"10.1016\/j.prp.2026.156527_bib18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1080\/1354750X.2024.2435867","article-title":"Peripheral blood CD8+ CD28+ T cells as predictive biomarkers for treatment response in metastatic colorectal cancer","volume":"30","author":"Fei","year":"2025","journal-title":"Biomarkers"},{"key":"10.1016\/j.prp.2026.156527_bib19","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.bbi.2024.10.012","article-title":"Social isolation promotes tumor immune evasion via \u03b22-adrenergic receptor","volume":"123","author":"Zhao","year":"2025","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.prp.2026.156527_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109883","article-title":"\u03b22-adrenergic receptor signaling regulates metabolic pathways critical to myeloid-derived suppressor cell function within the TME","volume":"37","author":"Mohammadpour","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.prp.2026.156527_bib21","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1002\/hep.28286","article-title":"Akt-mediated foxo1 inhibition is required for liver regeneration","volume":"63","author":"Pauta","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.prp.2026.156527_bib22","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s11239-020-02112-9","article-title":"AKT2 regulates endothelial-mediated coagulation homeostasis and promotes intrathrombotic recanalization and thrombus resolution in a mouse model of venous thrombosis","volume":"50","author":"Xie","year":"2020","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.prp.2026.156527_bib23","article-title":"Simiao Wan and its ingredients alleviate type 2 diabetes mellitus via IRS1\/AKT2\/FOXO1\/GLUT2 signaling","volume":"9","author":"Xia","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.prp.2026.156527_bib24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00210-015-1179-1","article-title":"High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the \u03b22-adrenergic receptor","volume":"389","author":"Werner","year":"2016","journal-title":"Naunyn Schmiede Arch. Pharm."},{"key":"10.1016\/j.prp.2026.156527_bib25","doi-asserted-by":"crossref","DOI":"10.20900\/immunometab20210007","article-title":"Diverse Roles of Akt in T cells","volume":"3","author":"Abdullah","year":"2021","journal-title":"Immunometabolism"},{"key":"10.1016\/j.prp.2026.156527_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108674","article-title":"FOXO1 constrains activation and regulates senescence in CD8 T cells","volume":"34","author":"Delpoux","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.prp.2026.156527_bib27","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1038\/s42255-023-00913-9","article-title":"The glucose transporter 2 regulates CD8(+) T cell function via environment sensing","volume":"5","author":"Fu","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.prp.2026.156527_bib28","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1038\/s42255-023-00913-9","article-title":"The glucose transporter 2 regulates CD8+ T cell function via environment sensing","volume":"5","author":"Fu","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.prp.2026.156527_bib29","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.cels.2024.11.010","article-title":"Metabolic immunoengineering approaches to enhance CD8+ T cell-based cancer immunotherapy","volume":"15","author":"Feng","year":"2024","journal-title":"Cell Syst."},{"key":"10.1016\/j.prp.2026.156527_bib30","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10456-017-9588-z","article-title":"Tip-cell behavior is regulated by transcription factor FoxO1 under hypoxic conditions in developing mouse retinas","volume":"21","author":"Fukumoto","year":"2018","journal-title":"Angiogenesis"},{"key":"10.1016\/j.prp.2026.156527_bib31","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.2147\/DDDT.S244059","article-title":"Resveratrol Exerts Anti-Osteoarthritic Effect by Inhibiting TLR4\/NF-\u03baB Signaling Pathway via the TLR4\/Akt\/FoxO1 Axis in IL-1\u03b2-Stimulated SW1353 Cells","volume":"14","author":"Xu","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.prp.2026.156527_bib32","doi-asserted-by":"crossref","first-page":"11278","DOI":"10.1073\/pnas.0502738102","article-title":"Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation","volume":"102","author":"Matsuzaki","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.prp.2026.156527_bib33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3389\/fphar.2018.00147","article-title":"Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity","volume":"9","author":"Lv","year":"2018","journal-title":"Front. Pharm."},{"key":"10.1016\/j.prp.2026.156527_bib34","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.3390\/ijms18081761","article-title":"Licochalcone A Inhibits the Proliferation of Human Lung Cancer Cell Lines A549 and H460 by Inducing G2\/M Cell Cycle Arrest and ER Stress","volume":"18","author":"Qiu","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.prp.2026.156527_bib35","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3390\/cells8030218","article-title":"Licochalcone A Inhibits Cellular Motility by Suppressing E-cadherin and MAPK Signaling in Breast Cancer","volume":"8","author":"Huang","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.prp.2026.156527_bib36","article-title":"Systemic Multifunctional Nanovaccines for Potent Personalized Immunotherapy of Acute Myeloid Leukemia","volume":"36","author":"Zhang","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.prp.2026.156527_bib37","doi-asserted-by":"crossref","first-page":"63","DOI":"10.21037\/atm-23-1824","article-title":"Remodeling of the bone marrow microenvironment during acute myeloid leukemia progression","volume":"12","author":"Urs","year":"2024","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.prp.2026.156527_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41375-021-01350-x","article-title":"Catch me if you can: how AML and its niche escape immunotherapy","volume":"36","author":"Tettamanti","year":"2022","journal-title":"Leukemia"},{"key":"10.1016\/j.prp.2026.156527_bib39","doi-asserted-by":"crossref","first-page":"28851","DOI":"10.18632\/oncotarget.4767","article-title":"Licochalcone A induces autophagy through PI3K\/Akt\/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells","volume":"6","author":"Tsai","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.prp.2026.156527_bib40","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/cpt.1894","article-title":"Propranolol suppresses the growth of colorectal cancer through simultaneously activating autologous CD8+ T cells and inhibiting tumor AKT\/MAPK pathway","volume":"108","author":"Liao","year":"2020","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.prp.2026.156527_bib41","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00210-015-1179-1","article-title":"High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the \u03b22-adrenergic receptor","volume":"389","author":"Werner","year":"2016","journal-title":"Naunyn Schmiede Arch. Pharm."},{"key":"10.1016\/j.prp.2026.156527_bib42","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/s41423-024-01148-8","article-title":"Cellular metabolism regulates the differentiation and function of T-cell subsets","volume":"21","author":"Ma","year":"2024","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.prp.2026.156527_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1347492","article-title":"Metabolic instruction of the graft-versus-leukemia immunity","volume":"15","author":"Burk","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.prp.2026.156527_bib44","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1016\/S1262-3636(14)72690-4","article-title":"Familial renal glycosuria and modifications of glucose renal excretion","volume":"40","author":"Pri\u00e9","year":"2014","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.prp.2026.156527_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.arcmed.2024.103179","article-title":"A. Le\u00f3n-Del-R\u00edo. NHERF2 Regulatory Function in Signal Transduction Pathways and Control of Gene Expression: Implications for Cellular Homeostasis and Breast Cancer","volume":"56","author":"Paredes-Villa","year":"2025","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.prp.2026.156527_bib46","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1016\/j.ymthe.2024.08.028","article-title":"Intrinsic ADRB2 inhibition improves CAR-T cell therapy efficacy against prostate cancer","volume":"32","author":"Ajmal","year":"2024","journal-title":"Mol. Ther."},{"key":"10.1016\/j.prp.2026.156527_bib47","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1016\/j.ymthe.2024.05.006","article-title":"GLUT1 overexpression enhances CAR T cell metabolic fitness and anti-tumor efficacy","volume":"32","author":"Shi","year":"2024","journal-title":"Mol. Ther."},{"key":"10.1016\/j.prp.2026.156527_bib48","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1016\/j.celrep.2016.07.060","article-title":"IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation","volume":"16","author":"Hedl","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.prp.2026.156527_bib49","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1808320115","article-title":"Lack of Sprouty 1 and 2 enhances survival of effector CD8(+) T cells and yields more protective memory cells","volume":"115","author":"Shehata","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.prp.2026.156527_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1325050","article-title":"Repurposing beta-blockers for combinatory cancer treatment: effects on conventional and immune therapies","volume":"14","author":"Massalee","year":"2024","journal-title":"Front. Pharm."},{"key":"10.1016\/j.prp.2026.156527_bib51","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1186\/s12964-024-01747-y","article-title":"Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress","volume":"22","author":"Lu","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.prp.2026.156527_bib52","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev-immunol-090222-110914","article-title":"T Cell Exhaustion","volume":"42","author":"Baessler","year":"2024","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.prp.2026.156527_bib53","article-title":"Role of Licochalcone A in Potential Pharmacological Therapy: a review","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharm."},{"key":"10.1016\/j.prp.2026.156527_bib54","article-title":"Repurposing beta-blockers for combinatory cancer treatment: effects on conventional and immune therapies","volume":"14","author":"Massalee","year":"2023","journal-title":"Front. Pharm."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033826001809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033826001809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T06:57:55Z","timestamp":1783061875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033826001809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":54,"alternative-id":["S0344033826001809"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2026.156527","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Licochalcone A targets ADRB2 to enhance CD8+ T cell anti-leukemia activity via regulation involving the AKT2\/FOXO1\/GLUT2 axis","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2026.156527","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156527"}}