{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:43:34Z","timestamp":1789753414936,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2024SF-GJHX-38"],"award-info":[{"award-number":["2024SF-GJHX-38"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2024JC-YBMS-667"],"award-info":[{"award-number":["2024JC-YBMS-667"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.prp.2026.156567","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T06:31:53Z","timestamp":1780122713000},"page":"156567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Ndufa4l2 drives the pathological activation of M\u00fcller cells in ischemic retinopathy via the PI3K\/AKT signaling pathway"],"prefix":"10.1016","volume":"286","author":[{"given":"Pengfei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianchun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8372-5784","authenticated-orcid":false,"given":"Jiaxing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.prp.2026.156567_bib1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1001\/jamaophthalmol.2023.6435","article-title":"Diabetic retinopathy and quality of life: a systematic review and meta-analysis","volume":"142","author":"Zayed","year":"2024","journal-title":"JAMA Ophthalmol."},{"issue":"1","key":"10.1016\/j.prp.2026.156567_bib2","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/s41467-025-55970-3","article-title":"Endothelial AGGF1 promotes retinal angiogenesis by coordinating TNFSF12\/FN14 signalling","volume":"16","author":"Cheng","year":"2025","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.prp.2026.156567_bib3","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1007\/s00125-024-06215-3","article-title":"Heterotypic macrophages\/microglia differentially contribute to retinal ischaemia and neovascularisation","volume":"67","author":"Yamaguchi","year":"2024","journal-title":"Diabetologia"},{"key":"10.1016\/j.prp.2026.156567_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2024.1513686","article-title":"M\u00fcller cells and retinal angiogenesis: critical regulators in health and disease","volume":"18","author":"Medina-Arellano","year":"2024","journal-title":"Front. Cell. Neurosci."},{"issue":"4","key":"10.1016\/j.prp.2026.156567_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167087","article-title":"TIMP3\/Wnt axis regulates gliosis of M\u00fcller glia","volume":"1870","author":"Hung","year":"2024","journal-title":"Biochim. Et. Biophys. Acta Mol. Basis Dis."},{"issue":"4","key":"10.1016\/j.prp.2026.156567_bib6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.preteyeres.2006.05.003","article-title":"M\u00fcller cells in the healthy and diseased retina","volume":"25","author":"Bringmann","year":"2006","journal-title":"Progress. Retin. Eye Res."},{"key":"10.1016\/j.prp.2026.156567_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101151","article-title":"Elucidating glial responses to products of diabetes-associated systemic dyshomeostasis","volume":"94","author":"Padovani-Claudio","year":"2023","journal-title":"Progress. Retin. Eye Res."},{"key":"10.1016\/j.prp.2026.156567_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2023.101169","article-title":"Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma","volume":"93","author":"Miao","year":"2023","journal-title":"Progress. Retin. Eye Res."},{"key":"10.1016\/j.prp.2026.156567_bib9","article-title":"Nitro-Oleic acid protects from neovascularization, oxidative stress, gliosis and neurodegeneration in oxygen-induced retinopathy","volume":"83","author":"Victoria","year":"2025","journal-title":"Redox Biol."},{"issue":"7975","key":"10.1016\/j.prp.2026.156567_bib10","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/s41586-023-06409-6","article-title":"Lactate limits CNS autoimmunity by stabilizing HIF-1\u03b1 in dendritic cells","volume":"620","author":"Sanmarco","year":"2023","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.prp.2026.156567_bib11","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.cmet.2011.10.008","article-title":"Induction of the mitochondrial NDUFA4L2 protein by HIF-1\u03b1 decreases oxygen consumption by inhibiting Complex I activity","volume":"14","author":"Tello","year":"2011","journal-title":"Cell. Metab."},{"issue":"11","key":"10.1016\/j.prp.2026.156567_bib12","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1158\/1078-0432.CCR-15-1511","article-title":"Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma","volume":"22","author":"Minton","year":"2016","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"issue":"2","key":"10.1016\/j.prp.2026.156567_bib13","first-page":"487","article-title":"Lenvatinib-activated NDUFA4L2\/IL33\/PADI4 pathway induces neutrophil extracellular traps that inhibit cuproptosis in hepatocellular carcinoma","volume":"48","author":"Yi","year":"2025","journal-title":"Cell. Oncol. (Dordr. Neth. )"},{"issue":"1","key":"10.1016\/j.prp.2026.156567_bib14","article-title":"NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma","volume":"24","author":"Kubala","year":"2023","journal-title":"J. ]. Cancer Biol. Ther."},{"issue":"5","key":"10.1016\/j.prp.2026.156567_bib15","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.7150\/thno.79538","article-title":"Repopulated retinal microglia promote M\u00fcller glia reprogramming and preserve visual function in retinal degenerative mice","volume":"13","author":"Cheng","year":"2023","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.prp.2026.156567_bib16","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12974-024-03175-8","article-title":"CD44 signaling in M\u00fcller cells impacts photoreceptor function and survival in healthy and diseased retinas","volume":"21","author":"Ayten","year":"2024","journal-title":"J. Neuroinflamm."},{"issue":"11","key":"10.1016\/j.prp.2026.156567_bib17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1167\/iovs.66.11.74","article-title":"Autophagy regulates M\u00fcller glial cell inflammatory activation","volume":"66","author":"Doggett","year":"2025","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.prp.2026.156567_bib18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.preteyeres.2009.07.001","article-title":"Cellular signaling and factors involved in M\u00fcller cell gliosis: neuroprotective and detrimental effects","volume":"28","author":"Bringmann","year":"2009","journal-title":"Progress. Retin. Eye Res."},{"issue":"2","key":"10.1016\/j.prp.2026.156567_bib19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/glia.23243","article-title":"Microglial-induced M\u00fcller cell gliosis is attenuated by progesterone in a mouse model of retinitis pigmentosa","volume":"66","author":"Roche","year":"2018","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.prp.2026.156567_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.108111","article-title":"PRDX4 mitigates diabetic retinopathy by inhibiting reactive gliosis, apoptosis, ER stress, oxidative stress, and mitochondrial dysfunction in M\u00fcller cells","volume":"301","author":"Huang","year":"2025","journal-title":"J. Biol. Chem."},{"issue":"38","key":"10.1016\/j.prp.2026.156567_bib21","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1038\/s41388-024-03129-7","article-title":"MiR-183-5p inhibits lung squamous cell carcinoma survival through disrupting hypoxia adaptation mediated by HIF-1\u03b1\/NDUFA4L2 axis","volume":"43","author":"Han","year":"2024","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.prp.2026.156567_bib22","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1158\/1078-0432.CCR-15-1987","article-title":"NDUFA4L2 fine-tunes oxidative stress in hepatocellular carcinoma","volume":"22","author":"Lai","year":"2016","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"issue":"1","key":"10.1016\/j.prp.2026.156567_bib23","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41698-026-01358-5","article-title":"NDUFA4L2 regulates the progression and chemotherapy sensitivity of HNSCC by inhibiting PANoptosis","volume":"10","author":"Cui","year":"2026","journal-title":"NPJ Precis. Oncol."},{"issue":"1","key":"10.1016\/j.prp.2026.156567_bib24","article-title":"A multidimensional pan-cancer analysis of NDUFA4L2 and verification of the oncogenic value in colon cancer","volume":"39","author":"Yi","year":"2025","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"issue":"4","key":"10.1016\/j.prp.2026.156567_bib25","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41419-021-03646-3","article-title":"NDUFA4L2 promotes glioblastoma progression, is associated with poor survival, and can be effectively targeted by apatinib","volume":"12","author":"Chen","year":"2021","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.prp.2026.156567_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.515051","article-title":"NDUFA4L2 regulated by HIF-1\u03b1 promotes metastasis and epithelial-mesenchymal transition of osteosarcoma cells through inhibiting ROS production","volume":"8","author":"Xu","year":"2020","journal-title":"Front. Cell. Dev. Biol."},{"issue":"11","key":"10.1016\/j.prp.2026.156567_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0331-2","article-title":"Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy","volume":"51","author":"Xu","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.prp.2026.156567_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1393057","article-title":"The mechanics of the retina: M\u00fcller glia role on retinal extracellular matrix and modelling","volume":"11","author":"Prieto-L\u00f3pez","year":"2024","journal-title":"Front. Med."},{"issue":"1","key":"10.1016\/j.prp.2026.156567_bib29","first-page":"115","article-title":"Immunological landscape of retinal ischemia-reperfusion injury: insights into resident and peripheral immune cell responses","volume":"16","author":"He","year":"2024","journal-title":"Aging Dis."},{"issue":"8","key":"10.1016\/j.prp.2026.156567_bib30","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.7150\/ijbs.89942","article-title":"The PI3K\/Akt pathway and glucose metabolism: a dangerous liaison in cancer","volume":"20","author":"Fontana","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.prp.2026.156567_bib31","doi-asserted-by":"crossref","first-page":"6069","DOI":"10.1038\/s41467-023-41739-z","article-title":"NLRP6 potentiates PI3K\/AKT signalling by promoting autophagic degradation of p85\u03b1 to drive tumorigenesis","volume":"14","author":"Zhi","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.prp.2026.156567_bib32","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41392-021-00828-5","article-title":"Targeting PI3K\/Akt signal transduction for cancer therapy","volume":"6","author":"He","year":"2021","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"2","key":"10.1016\/j.prp.2026.156567_bib33","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41568-019-0216-7","article-title":"The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism","volume":"20","author":"Hoxhaj","year":"2020","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.prp.2026.156567_bib34","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.apsb.2021.07.023","article-title":"Targeting PI3K\/AKT signaling for treatment of idiopathic pulmonary fibrosis","volume":"12","author":"Wang","year":"2022","journal-title":"Acta Pharm. Sin. B."},{"key":"10.1016\/j.prp.2026.156567_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.632040","article-title":"Mingmu xiaomeng tablets restore autophagy and alleviate diabetic retinopathy by inhibiting PI3K\/Akt\/mTOR signaling","volume":"12","author":"Fang","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.prp.2026.156567_bib36","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10616-023-00590-2","article-title":"Hypoxia-induced the upregulation of NDUFA4L2 promoted colon adenocarcinoma progression through ROS-mediated PI3K\/AKT pathway","volume":"75","author":"Ye","year":"2023","journal-title":"Cytotechnology"},{"issue":"1","key":"10.1016\/j.prp.2026.156567_bib37","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1186\/s12964-025-02450-2","article-title":"Lactate shuttle between cytotrophoblast and syncytiotrophoblast in the placenta enhances ferroptosis resistance and maintains placental homeostasis: implications for early pregnancy loss","volume":"23","author":"Zhu","year":"2025","journal-title":"Cell communication signaling CCS"},{"issue":"1","key":"10.1016\/j.prp.2026.156567_bib38","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s10142-025-01779-8","article-title":"PCK1 attenuates intrahepatic cholangiocarcinoma progression by suppressing lactate accumulation and PI3K-AKT signaling","volume":"26","author":"Pei","year":"2025","journal-title":"Funct. Integr. Genom."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033826002207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033826002207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T02:27:40Z","timestamp":1786501660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033826002207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":38,"alternative-id":["S0344033826002207"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2026.156567","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ndufa4l2 drives the pathological activation of M\u00fcller cells in ischemic retinopathy via the PI3K\/AKT signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2026.156567","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"156567"}}