{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T02:30:16Z","timestamp":1786501816535,"version":"build-2736575974"},"reference-count":168,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004728","name":"Vellore Institute of Technology Deemed to be University","doi-asserted-by":"publisher","award":["SG20250049"],"award-info":[{"award-number":["SG20250049"]}],"id":[{"id":"10.13039\/501100004728","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.prp.2026.156611","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:19:54Z","timestamp":1783009194000},"page":"156611","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Extracellular vesicles as systems-level regulators of tumor progression: Integrating signaling networks, microenvironment reprogramming, and therapy resistance"],"prefix":"10.1016","volume":"286","author":[{"given":"Deepthi Maria","family":"Mathew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit Kumar","family":"Bharti S","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirban Goutam","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abilash Valsala","family":"Gopalakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babu","family":"Gajendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Nishu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2026.156611_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2025.155937","article-title":"Unraveling extracellular vesicle DNA: biogenesis, functions, and clinical implications","volume":"269","author":"Nouri","year":"2025","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.prp.2026.156611_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.100937","article-title":"Exosomal circular RNAs: a chief culprit in cancer chemotherapy resistance","volume":"67","author":"Guo","year":"2023","journal-title":"Drug. Resist. Updat."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.20517\/evcna.2025.161","article-title":"80 years of extracellular vesicles: from discovery to clinical translation","volume":"7","author":"Li","year":"2026","journal-title":"Extracell. Vesicles Circ. Nucl. Acids"},{"issue":"34","key":"10.1016\/j.prp.2026.156611_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202201609","article-title":"Extracellular Vesicles in Cancer Drug Resistance: Roles, Mechanisms, and Implications","volume":"9","author":"Yang","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.prp.2026.156611_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2026.156579","article-title":"Tumor-derived extracellular vesicles: From biogenesis and molecular composition to translational therapeutics","volume":"286","author":"Sheikh","year":"2026","journal-title":"Pathol. Res. Pract."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib6","article-title":"Biological properties of extracellular vesicles and their physiological functions","volume":"4","author":"M","year":"2015","journal-title":"J. Extracell. Vesicles"},{"issue":"5","key":"10.1016\/j.prp.2026.156611_bib7","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nrc.2017.6","article-title":"Pre-metastatic niches: organ-specific homes for metastases","volume":"17","author":"Peinado","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.prp.2026.156611_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1405267","article-title":"Emerging biomarkers for non-invasive diagnosis and treatment of cancer: a systematic review","volume":"14","author":"Zakari","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.prp.2026.156611_bib9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.canlet.2020.08.022","article-title":"Therapy-induced chemoexosomes: Sinister small extracellular vesicles that support tumor survival and progression","volume":"493","author":"Bandari","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.prp.2026.156611_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2022.100833","article-title":"The role of extracellular vesicles in the transfer of drug resistance competences to cancer cells","volume":"62","author":"Xavier","year":"2022","journal-title":"Drug. Resist. Updates"},{"issue":"3","key":"10.1016\/j.prp.2026.156611_bib11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.devcel.2019.04.011","article-title":"Exosome-Mediated Metastasis: Communication from a Distance","volume":"49","author":"Wortzel","year":"2019","journal-title":"Dev. Cell."},{"issue":"4","key":"10.1016\/j.prp.2026.156611_bib12","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.cell.2020.07.009","article-title":"Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers","volume":"182","author":"Hoshino","year":"2020","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib13","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v5.25355","article-title":"Extensive surface protein profiles of extracellular vesicles from cancer cells may provide diagnostic signatures from blood samples","volume":"5","author":"Belov","year":"2016","journal-title":"J. Extracell. Vesicles"},{"issue":"4","key":"10.1016\/j.prp.2026.156611_bib14","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14489","article-title":"A TGF -\u03b2 signaling-related lncRNA signature for prediction of glioma prognosis, immune microenvironment, and immunotherapy response","volume":"30","author":"Duan","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12935-026-04196-4","article-title":"Transforming growth factor-\u03b2 and integrins: key players in EMT and breast cancer progression","volume":"26","author":"Ramalingam","year":"2026","journal-title":"Cancer Cell. Int."},{"issue":"23","key":"10.1016\/j.prp.2026.156611_bib16","doi-asserted-by":"crossref","first-page":"15335","DOI":"10.3390\/ijms232315335","article-title":"Mechanism of Extracellular Vesicle Secretion Associated with TGF-\u03b2-Dependent Inflammatory Response in the Tumor Microenvironment","volume":"23","author":"Bonowicz","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"13","key":"10.1016\/j.prp.2026.156611_bib17","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.4161\/cc.8.13.8988","article-title":"Microvesicles: messengers and mediators of tumor progression","volume":"8","author":"Al-Nedawi","year":"2009","journal-title":"Cell. Cycle"},{"key":"10.1016\/j.prp.2026.156611_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1002742","article-title":"Extracellular vesicles: a new diagnostic biomarker and targeted drug in osteosarcoma","volume":"13","author":"Gao","year":"2022","journal-title":"Front. Immunol."},{"issue":"7659","key":"10.1016\/j.prp.2026.156611_bib19","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature22341","article-title":"Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer","volume":"546","author":"Kamerkar","year":"2017","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.prp.2026.156611_bib20","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1124\/pharmrev.123.000841","article-title":"Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications","volume":"75","author":"van de Wakker","year":"2023","journal-title":"Pharmacol. Rev."},{"issue":"4","key":"10.1016\/j.prp.2026.156611_bib21","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12943-019-0965-7","article-title":"Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance","volume":"18","author":"Maacha","year":"2019","journal-title":"Mol. Cancer"},{"issue":"2","key":"10.1016\/j.prp.2026.156611_bib23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/nrm732","article-title":"Secretory lysosomes","volume":"3","author":"Blott","year":"2002","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"7","key":"10.1016\/j.prp.2026.156611_bib24","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1111\/cas.15801","article-title":"Extracellular vesicles in tumor angiogenesis and resistance to anti-angiogenic therapy","volume":"114","author":"Ye","year":"2023","journal-title":"Cancer Sci."},{"issue":"6","key":"10.1016\/j.prp.2026.156611_bib25","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1242\/jcs.114454","article-title":"Membrane curvature at a glance","volume":"128","author":"McMahon","year":"2015","journal-title":"J. Cell. Sci."},{"issue":"11","key":"10.1016\/j.prp.2026.156611_bib26","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1073\/pnas.1200448109","article-title":"Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein","volume":"109","author":"Nabhan","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib27","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s12951-023-01969-1","article-title":"Apoptotic bodies: bioactive treasure left behind by the dying cells with robust diagnostic and therapeutic application potentials","volume":"21","author":"Yu","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib28","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"C","year":"2018","journal-title":"J. Extracell. Vesicles"},{"issue":"3","key":"10.1016\/j.prp.2026.156611_bib29","doi-asserted-by":"crossref","first-page":"461a","DOI":"10.1016\/j.bpj.2018.11.2488","article-title":"Reverse Topology Membrane Scission by the ESCRTs","volume":"116","author":"Hurley","year":"2019","journal-title":"Biophys. J."},{"issue":"7","key":"10.1016\/j.prp.2026.156611_bib30","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/j.1600-0854.2009.00920.x","article-title":"Multivesicular Endosome Biogenesis in the Absence of ESCRTs","volume":"10","author":"Stuffers","year":"2009","journal-title":"Traffic"},{"key":"10.1016\/j.prp.2026.156611_bib31","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.semcancer.2021.09.010","article-title":"Extracellular heat shock proteins in cancer: From early diagnosis to new therapeutic approach","volume":"86","author":"Caruso Bavisotto","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.devcel.2011.05.015","article-title":"The ESCRT Pathway","volume":"21","author":"Henne","year":"2011","journal-title":"Dev. Cell."},{"key":"10.1016\/j.prp.2026.156611_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2018.02.013","article-title":"Biogenesis and function of extracellular vesicles in cancer","volume":"188","author":"Bebelman","year":"2018","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib34","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Rev. Cell. Dev. Biol."},{"key":"10.1016\/j.prp.2026.156611_bib35","article-title":"Extracellular Vesicles in Tumors: A Potential Mediator of Bone Metastasis","volume":"9","author":"Li","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"issue":"1979","key":"10.1016\/j.prp.2026.156611_bib36","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1126\/science.1153124","article-title":"Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes","volume":"319","author":"Trajkovic","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.prp.2026.156611_bib37","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.semcancer.2021.01.007","article-title":"Landscape of extracellular vesicles in the tumour microenvironment: Interactions with stromal cells and with non-cell components, and impacts on metabolic reprogramming, horizontal transfer of neoplastic traits, and the emergence of therapeutic resistance","volume":"74","author":"Zhang","year":"2021","journal-title":"Semin. Cancer Biol."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12943-021-01440-5","article-title":"Exosomes in the hypoxic TME: from release, uptake and biofunctions to clinical applications","volume":"21","author":"He","year":"2022","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib39","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12943-025-02282-1","article-title":"Extracellular vesicles in cancer\u00b4s communication: messages we can read and how to answer","volume":"24","author":"Semeradtova","year":"2025","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib40","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12943-019-0963-9","article-title":"Mechanisms associated with biogenesis of exosomes in cancer","volume":"18","author":"McAndrews","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.prp.2026.156611_bib41","article-title":"Hypoxia Induced Changes of Exosome Cargo and Subsequent Biological Effects","volume":"13","author":"Jiang","year":"2022","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.prp.2026.156611_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12310","article-title":"Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF-1\u03b1","volume":"12","author":"Wang","year":"2023","journal-title":"J. Extracell. Vesicles"},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib43","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/s41598-022-05161-7","article-title":"Hypoxia-induced HIF1\u03b1 activation regulates small extracellular vesicle release in human embryonic kidney cells","volume":"12","author":"Mu\u00f1iz-Garc\u00eda","year":"2022","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib44","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s13046-018-0911-3","article-title":"Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1\/JAK2\/STAT3 signaling pathway","volume":"37","author":"Zhou","year":"2018","journal-title":"J. Exp. & Clin. Cancer Res."},{"issue":"10","key":"10.1016\/j.prp.2026.156611_bib45","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1161\/CIRCRESAHA.117.309681","article-title":"Extracellular Vesicles in Angiogenesis","volume":"120","author":"Todorova","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.prp.2026.156611_bib46","article-title":"miR-183-5p-enriched extracellular vesicles promote the crosstalk between hepatocellular carcinoma cell and endothelial cell via SIK1\/PI3K\/AKT and CCL20\/CCR6 signaling pathways","volume":"15","author":"Han","year":"2025","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib47","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s12943-025-02358-y","article-title":"Extracellular vesicles: the \u2018Trojan Horse\u2019 within breast cancer host microenvironments","volume":"24","author":"Kang","year":"2025","journal-title":"Mol. Cancer"},{"issue":"34","key":"10.1016\/j.prp.2026.156611_bib48","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.1038\/onc.2017.105","article-title":"Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1","volume":"36","author":"Hsu","year":"2017","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.prp.2026.156611_bib49","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm0603-677","article-title":"Regulation of angiogenesis by hypoxia: role of the HIF system","volume":"9","author":"Pugh","year":"2003","journal-title":"Nat. Med."},{"issue":"14","key":"10.1016\/j.prp.2026.156611_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12166","article-title":"Secretion of pro-angiogenic extracellular vesicles during hypoxia is dependent on the autophagy-related protein GABARAPL1","volume":"10","author":"Keulers","year":"2021","journal-title":"J. Extracell. Vesicles"},{"issue":"8","key":"10.1016\/j.prp.2026.156611_bib51","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nrc2664","article-title":"Targeting PI3K signalling in cancer: opportunities, challenges and limitations","volume":"9","author":"Engelman","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.prp.2026.156611_bib52","doi-asserted-by":"crossref","unstructured":"Y. Samuels and T. Waldman, \u201cOncogenic Mutations of PIK3CA in Human Cancers,\u201d 2010, pp. 21\u201341. doi: 10.1007\/82_2010_68.","DOI":"10.1007\/82_2010_68"},{"issue":"10","key":"10.1016\/j.prp.2026.156611_bib53","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1073\/pnas.0804543106","article-title":"Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR","volume":"106","author":"Al-Nedawi","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"11","key":"10.1016\/j.prp.2026.156611_bib54","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/onc.2016.304","article-title":"Wnt signaling in cancer","volume":"36","author":"Zhan","year":"2017","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib55","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","article-title":"Wnt\/\u03b2-catenin signalling: function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"9","key":"10.1016\/j.prp.2026.156611_bib56","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1111\/cas.15393","article-title":"DDX55 promotes hepatocellular carcinoma progression by interacting with BRD4 and participating in exosome-mediated cell-cell communication","volume":"113","author":"Yu","year":"2022","journal-title":"Cancer Sci."},{"issue":"10","key":"10.1016\/j.prp.2026.156611_bib57","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/ncb2574","article-title":"Active Wnt proteins are secreted on exosomes","volume":"14","author":"Gross","year":"2012","journal-title":"Nat. Cell. Biol."},{"issue":"6938","key":"10.1016\/j.prp.2026.156611_bib58","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature01611","article-title":"Wnt proteins are lipid-modified and can act as stem cell growth factors","volume":"423","author":"Willert","year":"2003","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.prp.2026.156611_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080777","article-title":"FZD10 Carried by Exosomes Sustains Cancer Cell Proliferation","volume":"8","author":"Scavo","year":"2019","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.prp.2026.156611_bib60","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.molonc.2014.03.011","article-title":"14-3-3 and \u03b2-catenin are secreted on extracellular vesicles to activate the oncogenic Wnt pathway","volume":"8","author":"Dovrat","year":"2014","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.prp.2026.156611_bib61","first-page":"5454","article-title":"Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines","volume":"103","author":"Pukrop","year":"2006"},{"key":"10.1016\/j.prp.2026.156611_bib62","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.omtn.2021.02.027","article-title":"miR-181a, delivered by hypoxic PTC-secreted exosomes, inhibits DACT2 by downregulating MLL3, leading to YAP-VEGF-mediated angiogenesis","volume":"24","author":"Wang","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"2","key":"10.1016\/j.prp.2026.156611_bib63","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/hmg\/ddv461","article-title":"New function of TSGA10 gene in angiogenesis and tumor metastasis: a response to a challengeable paradox","volume":"25","author":"Mansouri","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.prp.2026.156611_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119937","article-title":"Colorectal cancer cell-derived extracellular vesicles transfer miR-221-3p to promote endothelial cell angiogenesis via targeting suppressor of cytokine signaling 3","volume":"285","author":"Dokhanchi","year":"2021","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib65","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2019.1690217","article-title":"Extracellular vesicles containing oncogenic mutant \u03b2-catenin activate Wnt signalling pathway in the recipient cells","volume":"8","author":"Kalra","year":"2019","journal-title":"J. Extracell. Vesicles"},{"issue":"3\u20134","key":"10.1016\/j.prp.2026.156611_bib66","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s10555-012-9375-7","article-title":"TGF-\u03b2 signalling and its role in cancer progression and metastasis","volume":"31","author":"Drabsch","year":"2012","journal-title":"Cancer Metastas-.-. Rev."},{"issue":"23","key":"10.1016\/j.prp.2026.156611_bib67","doi-asserted-by":"crossref","first-page":"9621","DOI":"10.1158\/0008-5472.CAN-10-1722","article-title":"Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation","volume":"70","author":"Webber","year":"2010","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.prp.2026.156611_bib68","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1158\/1541-7786.MCR-17-0784","article-title":"Exosomes Induce Fibroblast Differentiation into Cancer-Associated Fibroblasts through TGF\u03b2 Signaling","volume":"16","author":"Ringuette Goulet","year":"2018","journal-title":"Mol. Cancer Res."},{"issue":"5","key":"10.1016\/j.prp.2026.156611_bib69","first-page":"2432","article-title":"Exosome-mediated transfer from the tumor microenvironment increases TGF\u03b2 signaling in squamous cell carcinoma","volume":"8","author":"Languino","year":"2016","journal-title":"Am. J. Transl. Res."},{"issue":"7","key":"10.1016\/j.prp.2026.156611_bib70","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.224","article-title":"Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts","volume":"7","author":"Baroni","year":"2016","journal-title":"Cell. Death Dis."},{"issue":"5","key":"10.1016\/j.prp.2026.156611_bib71","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative Activation of Macrophages: Mechanism and Functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.prp.2026.156611_bib72","doi-asserted-by":"crossref","first-page":"10415","DOI":"10.18632\/aging.202802","article-title":"Exosomal miR-222 from adriamycin-resistant MCF-7 breast cancer cells promote macrophages M2 polarization via PTEN\/Akt to induce tumor progression","volume":"13","author":"Chen","year":"2021","journal-title":"Aging"},{"key":"10.1016\/j.prp.2026.156611_bib73","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2026.1711686","article-title":"Macrophage-derived long non-coding RNAs in cancer: pioneering targets for immune modulation and personalized therapy","volume":"17","author":"Ramalingam","year":"2026","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.prp.2026.156611_bib74","article-title":"Thymosin \u03b11 reverses oncolytic adenovirus-induced M2 polarization of macrophages to improve antitumor immunity and therapeutic efficacy","volume":"5","author":"Liu","year":"2024","journal-title":"Cell. Rep. Med."},{"issue":"8","key":"10.1016\/j.prp.2026.156611_bib75","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.cell.2023.03.010","article-title":"The role of extracellular vesicles in cancer","volume":"186","author":"Kalluri","year":"2023","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.prp.2026.156611_bib76","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1152\/physrev.00008.2020","article-title":"Moving immune therapy forward targeting tme","volume":"101","author":"Goliwas","year":"2021","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib77","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.1038\/s41467-022-31250-2","article-title":"Breast cancer cell-derived extracellular vesicles promote CD8+\u2009T cell exhaustion via TGF-\u03b2 type II receptor signaling","volume":"13","author":"Xie","year":"2022","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib78","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2019.1599680","article-title":"Tumor-secreted extracellular vesicles promote the activation of cancer-associated fibroblasts via the transfer of microRNA-125b","volume":"8","author":"Vu","year":"2019","journal-title":"J. Extracell. Vesicles"},{"issue":"40","key":"10.1016\/j.prp.2026.156611_bib79","doi-asserted-by":"crossref","first-page":"6354","DOI":"10.1038\/s41388-020-01406-9","article-title":"miR-21a in exosomes from Lewis lung carcinoma cells accelerates tumor growth through targeting PDCD4 to enhance expansion of myeloid-derived suppressor cells","volume":"39","author":"Zhang","year":"2020","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.prp.2026.156611_bib80","first-page":"727","article-title":"PD-1\/PD-L1 pathway: current researches in cancer","volume":"10","author":"Han","year":"2020","journal-title":"Am. J. Cancer Res."},{"issue":"8","key":"10.1016\/j.prp.2026.156611_bib81","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/s41422-018-0060-4","article-title":"Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth","volume":"28","author":"Yang","year":"2018","journal-title":"Cell. Res."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib82","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12943-021-01448-x","article-title":"Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934\/SHP2 axis in NSCLC","volume":"20","author":"Chen","year":"2021","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib83","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12943-023-01898-5","article-title":"Extracellular vesicles remodel tumor environment for cancer immunotherapy","volume":"22","author":"Yue","year":"2023","journal-title":"Mol. Cancer"},{"issue":"4","key":"10.1016\/j.prp.2026.156611_bib84","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cell.2006.11.001","article-title":"Cancer Metastasis: Building a Framework","volume":"127","author":"Gupta","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.prp.2026.156611_bib85","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00870","article-title":"Macrophages Interaction and MicroRNA Interplay in the Modulation of Cancer Development and Metastasis","volume":"11","author":"Iurca","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib86","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41392-024-01937-7","article-title":"Pre-metastatic niche: formation, characteristics and therapeutic implication","volume":"9","author":"Wang","year":"2024","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"4","key":"10.1016\/j.prp.2026.156611_bib87","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ccr.2014.03.007","article-title":"Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis","volume":"25","author":"Zhou","year":"2014","journal-title":"Cancer Cell."},{"issue":"9","key":"10.1016\/j.prp.2026.156611_bib88","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12125","article-title":"Extracellular vesicles in the development of organ-specific metastasis","volume":"10","author":"Urabe","year":"2021","journal-title":"J. Extracell. Vesicles"},{"issue":"4","key":"10.1016\/j.prp.2026.156611_bib89","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.devcel.2019.01.014","article-title":"Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo","volume":"48","author":"Hyenne","year":"2019","journal-title":"Dev. Cell."},{"issue":"7069","key":"10.1016\/j.prp.2026.156611_bib90","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/nature04186","article-title":"VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche","volume":"438","author":"Kaplan","year":"2005","journal-title":"Nature"},{"issue":"7578","key":"10.1016\/j.prp.2026.156611_bib91","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature15756","article-title":"Tumour exosome integrins determine organotropic metastasis","volume":"527","author":"Hoshino","year":"2015","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib92","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12943-023-01744-8","article-title":"Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments","volume":"22","author":"Yuan","year":"2023","journal-title":"Mol. Cancer"},{"issue":"2","key":"10.1016\/j.prp.2026.156611_bib93","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/jcmm.12730","article-title":"Exosomes from hypoxic endothelial cells have increased collagen crosslinking activity through up-regulation of lysyl oxidase-like 2","volume":"20","author":"de Jong","year":"2016","journal-title":"J. Cell. Mol. Med."},{"issue":"14","key":"10.1016\/j.prp.2026.156611_bib94","doi-asserted-by":"crossref","first-page":"10093","DOI":"10.1074\/jbc.C112.444562","article-title":"Heparanase Regulates Secretion, Composition, and Function of Tumor Cell-derived Exosomes","volume":"288","author":"Thompson","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.prp.2026.156611_bib95","article-title":"Synergistic effect of VEGF and SDF-1\u03b1 in endothelial progenitor cells and vascular smooth muscle cells","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"11","key":"10.1016\/j.prp.2026.156611_bib96","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.31557\/APJCP.2023.24.11.3969","article-title":"Increased Expression of the ABCA1 and ABCA3 Transporter Genes is Associated with Cisplatin Resistance in Breast Cancer Cells","volume":"24","author":"Al-Shumary","year":"2023","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"37","key":"10.1016\/j.prp.2026.156611_bib97","doi-asserted-by":"crossref","first-page":"15336","DOI":"10.1073\/pnas.1102855108","article-title":"Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3","volume":"108","author":"Aung","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.prp.2026.156611_bib98","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/clpt.2011.14","article-title":"Multidrug Efflux Pumps and Cancer Stem Cells: Insights Into Multidrug Resistance and Therapeutic Development","volume":"89","author":"Moitra","year":"2011","journal-title":"Clin. Pharmacol. Ther."},{"issue":"7","key":"10.1016\/j.prp.2026.156611_bib99","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.3390\/ijms25074118","article-title":"Extracellular Vesicles as Surrogates for the Regulation of the Drug Transporters ABCC2 (MRP2) and ABCG2 (BCRP)","volume":"25","author":"Rigalli","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.prp.2026.156611_bib100","doi-asserted-by":"crossref","DOI":"10.3390\/cells10112886","article-title":"Different Ability of Multidrug-Resistant and -Sensitive Counterpart Cells to Release and Capture Extracellular Vesicles","volume":"10","author":"Sousa","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib101","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s40164-024-00518-2","article-title":"Analysis of CD20 and PD-L1 levels on small extracellular vesicles (sEV) produced by DLBCL cells and EBV-transformed B cells, and potential role in T cell inhibition","volume":"13","author":"Akil","year":"2024","journal-title":"Exp. Hematol. Oncol."},{"issue":"2","key":"10.1016\/j.prp.2026.156611_bib102","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.bcmd.2005.07.001","article-title":"Tumor exosomes expressing Fas ligand mediate CD8+ T-cell apoptosis","volume":"35","author":"Abusamra","year":"2005","journal-title":"Blood Cells Mol. Dis."},{"issue":"9","key":"10.1016\/j.prp.2026.156611_bib103","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1002\/eji.201242909","article-title":"CD73 expression on extracellular vesicles derived from CD4+ CD25+ Foxp3 + T cells contributes to their regulatory function","volume":"43","author":"Smyth","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.prp.2026.156611_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113392","article-title":"Unlocking the full potential of memory T cells in adoptive T cell therapy for hematologic malignancies","volume":"144","author":"Sun","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.prp.2026.156611_bib105","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2026.1751463","article-title":"Experimental study on synergistic pulses improving the tumor microenvironment and assisting immunotherapy","volume":"17","author":"Dong","year":"2026","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib106","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12003","article-title":"EGFR-rich extracellular vesicles derived from highly metastatic nasopharyngeal carcinoma cells accelerate tumour metastasis through PI3K\/AKT pathway-suppressed ROS","volume":"10","author":"Li","year":"2020","journal-title":"J. Extracell. Vesicles"},{"issue":"5","key":"10.1016\/j.prp.2026.156611_bib107","doi-asserted-by":"crossref","first-page":"831","DOI":"10.3390\/cancers17050831","article-title":"Mesenchymal Stem Cell-Derived Exosomes in Cancer Resistance Against Therapeutics","volume":"17","author":"Easwaran","year":"2025","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.prp.2026.156611_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcp.2024.101964","article-title":"Exosomes regulate doxorubicin resistance in breast cancer via miR-34a-5p\/NOTCH1","volume":"76","author":"Chen","year":"2024","journal-title":"Mol. Cell. Probes"},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib109","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1186\/s12967-025-06794-8","article-title":"Hypoxic cancer-associated fibroblast exosomal circSTAT3 drives triple negative breast cancer stemness via miR-671-5p\/NOTCH1 signaling","volume":"23","author":"Yang","year":"2025","journal-title":"J. Transl. Med."},{"issue":"28","key":"10.1016\/j.prp.2026.156611_bib110","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1038\/s41388-018-0189-0","article-title":"Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3\/Rab proteins","volume":"37","author":"Dorayappan","year":"2018","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.prp.2026.156611_bib111","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/s41419-021-03963-7","article-title":"Exosomal annexin A6 induces gemcitabine resistance by inhibiting ubiquitination and degradation of EGFR in triple-negative breast cancer","volume":"12","author":"Li","year":"2021","journal-title":"Cell. Death Dis."},{"issue":"25","key":"10.1016\/j.prp.2026.156611_bib112","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1182\/blood-2014-05-576116","article-title":"Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1","volume":"124","author":"Umezu","year":"2014","journal-title":"Blood"},{"issue":"14","key":"10.1016\/j.prp.2026.156611_bib113","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.18632\/oncotarget.2159","article-title":"Multiple myeloma cell-derived microvesicles are enriched in CD147 expression and enhance tumor cell proliferation","volume":"5","author":"Arendt","year":"2014","journal-title":"Oncotarget"},{"issue":"10","key":"10.1016\/j.prp.2026.156611_bib114","doi-asserted-by":"crossref","first-page":"804","DOI":"10.2174\/1389200220666190819151946","article-title":"Cisplatin-resistant MDA-MB-231 Cell-derived Exosomes Increase the Resistance of Recipient Cells in an Exosomal miR-423-5p-dependent Manner","volume":"20","author":"Wang","year":"2019","journal-title":"Curr. Drug. Metab."},{"key":"10.1016\/j.prp.2026.156611_bib115","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.canlet.2019.05.035","article-title":"Exosomal transfer of miR-501 confers doxorubicin resistance and tumorigenesis via targeting of BLID in gastric cancer","volume":"459","author":"Liu","year":"2019","journal-title":"Cancer Lett."},{"issue":"7","key":"10.1016\/j.prp.2026.156611_bib116","doi-asserted-by":"crossref","first-page":"11917","DOI":"10.18632\/oncotarget.14440","article-title":"Exosomes as mediators of platinum resistance in ovarian cancer","volume":"8","author":"Crow","year":"2017","journal-title":"Oncotarget"},{"issue":"9","key":"10.1016\/j.prp.2026.156611_bib117","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/cncy.21442","article-title":"Programmed cell death 4 and micro RNA 21 inverse expression is maintained in cells and exosomes from ovarian serous carcinoma effusions","volume":"122","author":"Cappellesso","year":"2014","journal-title":"Cancer Cytopathol."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib118","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13578-021-00556-x","article-title":"Long non-coding RNA NEAT1 transported by extracellular vesicles contributes to breast cancer development by sponging microRNA-141-3p and regulating KLF12","volume":"11","author":"Zhou","year":"2021","journal-title":"Cell. Biosci."},{"issue":"5","key":"10.1016\/j.prp.2026.156611_bib119","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1159\/000485780","article-title":"Exosomal MicroRNA MiR-1246 Promotes Cell Proliferation, Invasion and Drug Resistance by Targeting CCNG2 in Breast Cancer","volume":"44","author":"Li","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"issue":"5","key":"10.1016\/j.prp.2026.156611_bib120","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70448","article-title":"Role of Triple-Negative Breast Cancer-Derived Extracellular Vesicles in Metastasis: Implications for Therapeutics and Biomarker Development","volume":"29","author":"Wan","year":"2025","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib121","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40364-025-00724-y","article-title":"Extracellular vesicles-derived miR-21 as a biomarker for early diagnosis and tumor activity in breast cancer subtypes","volume":"13","author":"Omarini","year":"2025","journal-title":"Biomark. Res."},{"issue":"4","key":"10.1016\/j.prp.2026.156611_bib122","doi-asserted-by":"crossref","first-page":"894","DOI":"10.3390\/cancers12040894","article-title":"An Updated Perspective on Current Prognostic and Predictive Biomarkers in Chronic Lymphocytic Leukemia in the Context of Chemoimmunotherapy and Novel Targeted Therapy","volume":"12","author":"Cohen","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"21","key":"10.1016\/j.prp.2026.156611_bib123","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1182\/bloodadvances.2021004621","article-title":"Rational biomarker development for the early and minimally invasive monitoring of AML","volume":"5","author":"Abdelhamed","year":"2021","journal-title":"Blood Adv."},{"key":"10.1016\/j.prp.2026.156611_bib124","article-title":"Circulating miRNAs can serve as potential diagnostic biomarkers in chronic myelogenous leukemia patients","volume":"16","author":"Keramati","year":"2021","journal-title":"Leuk. Res. Rep."},{"key":"10.1016\/j.prp.2026.156611_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2024.149186","article-title":"Comparative analysis of extracellular vesicles miRNAs (EV-miRNAs) and cell-free microRNAs (cf-miRNAs) reveals that EV-miRNAs are more promising as diagnostic and prognostic biomarkers for prostate cancer","volume":"939","author":"Nobrega","year":"2025","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib126","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"C","year":"2018","journal-title":"J. Extracell. Vesicles"},{"issue":"17","key":"10.1016\/j.prp.2026.156611_bib127","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.3390\/ijms21176097","article-title":"Extracellular Vesicles in the Development of Cancer Therapeutics","volume":"21","author":"Sun","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.prp.2026.156611_bib128","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/j.biomaterials.2013.11.083","article-title":"A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy","volume":"35","author":"Tian","year":"2014","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.prp.2026.156611_bib129","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3390\/pharmaceutics16060739","article-title":"Hybrid Nanosystem Formed by DOX-Loaded Liposomes and Extracellular Vesicles from MDA-MB-231 Is Effective against Breast Cancer Cells with Different Molecular Profiles","volume":"16","author":"Paschoal Barbosa","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.prp.2026.156611_bib130","article-title":"Preservation of extracellular vesicles for drug delivery: A comparative evaluation of storage buffers","volume":"107","author":"Geng","year":"2025","journal-title":"J. Drug. Deliv. Sci. Technol."},{"issue":"14","key":"10.1016\/j.prp.2026.156611_bib131","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1039\/D4BM00558A","article-title":"A comprehensive review of engineered exosomes from the preparation strategy to therapeutic applications","volume":"12","author":"Fan","year":"2024","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.prp.2026.156611_bib132","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2023.102040","article-title":"CRISPR-Cas9 delivery strategies with engineered extracellular vesicles","volume":"34","author":"Lu","year":"2023","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib133","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/15384047.2021.2024040","article-title":"Loading of \u201dcocktail siRNAs\u201d into extracellular vesicles via TAT-DRBD peptide for the treatment of castration-resistant prostate cancer","volume":"23","author":"Diao","year":"2022","journal-title":"Cancer Biol. Ther."},{"issue":"49","key":"10.1016\/j.prp.2026.156611_bib134","doi-asserted-by":"crossref","first-page":"45455","DOI":"10.1021\/acsami.9b16637","article-title":"Aptamer-Based Erythrocyte-Derived Mimic Vesicles Loaded with siRNA and Doxorubicin for the Targeted Treatment of Multidrug-Resistant Tumors","volume":"11","author":"Wang","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"8","key":"10.1016\/j.prp.2026.156611_bib135","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1002\/ijc.35055","article-title":"Enhancing precision targeting of ovarian cancer tumor cells in vivo through extracellular vesicle engineering","volume":"155","author":"Alharbi","year":"2024","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.prp.2026.156611_bib136","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jcis.2024.09.224","article-title":"Engineering small extracellular vesicles with multivalent DNA probes for precise tumor targeting and enhanced synergistic therapy","volume":"679","author":"Zhang","year":"2025","journal-title":"J. Colloid Interface Sci."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib137","doi-asserted-by":"crossref","first-page":"40","DOI":"10.14744\/ejmo.2024.64067","article-title":"Immunomodulatory Effects of MDA-MB-231-derived Exosome Mimetic Nanovesicles on CD4+ T Cell Line","volume":"8","author":"Oztatlici","year":"2024","journal-title":"Eurasia J. Med. Oncol."},{"key":"10.1016\/j.prp.2026.156611_bib138","doi-asserted-by":"crossref","DOI":"10.34133\/research.0421","article-title":"Strategies for Small Extracellular Vesicle-Based Cancer Immunotherapy","volume":"7","author":"Chen","year":"2024","journal-title":"Research"},{"key":"10.1016\/j.prp.2026.156611_bib139","doi-asserted-by":"crossref","DOI":"10.34133\/research.0644","article-title":"Youthful Brain-Derived Extracellular Vesicle-Loaded GelMA Hydrogel Promotes Scarless Wound Healing in Aged Skin by Modulating Senescence and Mitochondrial Function","volume":"8","author":"Wu","year":"2025","journal-title":"Research"},{"key":"10.1016\/j.prp.2026.156611_bib140","article-title":"Perilla frutescens Leaf-Derived Extracellular Vesicle-Like Particles Carry Pab-miR-396a-5p to Alleviate Psoriasis by Modulating IL-17 Signaling","volume":"8","author":"Liu","year":"2025","journal-title":"Research"},{"issue":"19","key":"10.1016\/j.prp.2026.156611_bib141","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.1158\/0008-5472.CAN-12-0925","article-title":"Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression","volume":"72","author":"Bobrie","year":"2012","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib142","doi-asserted-by":"crossref","first-page":"13588","DOI":"10.1038\/ncomms13588","article-title":"ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins","volume":"7","author":"Villarroya-Beltri","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.prp.2026.156611_bib143","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.canlet.2017.08.020","article-title":"Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras\/Raf\/ERK1\/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells","volume":"408","author":"Datta","year":"2017","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib144","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10238-025-01763-3","article-title":"Microvesicle inhibition enhances the therapeutic effects of ATRA in acute promyelocytic leukemia cells via changes in miRNAs: the promising antileukemic potential of imipramine","volume":"25","author":"Kariminejad-Farsangi","year":"2025","journal-title":"Clin. Exp. Med."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib145","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1038\/s41467-021-25990-w","article-title":"A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib146","doi-asserted-by":"crossref","first-page":"10200","DOI":"10.1038\/s41598-021-89655-w","article-title":"Repurposing ketoconazole as an exosome directed adjunct to sunitinib in treating renal cell carcinoma","volume":"11","author":"Greenberg","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2026.156611_bib147","article-title":"Docosahexaenoic acid (DHA) inhibits pro-angiogenic effects of breast cancer cells via down-regulating cellular and exosomal expression of angiogenic genes and microRNAs","volume":"378","author":"Aslan","year":"2020","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.prp.2026.156611_bib148","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.tranon.2018.12.004","article-title":"Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells","volume":"12","author":"Kosgodage","year":"2019","journal-title":"Transl. Oncol."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib149","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/s41467-019-09387-4","article-title":"Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A","volume":"10","author":"Im","year":"2019","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.prp.2026.156611_bib150","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11060-013-1235-y","article-title":"Heparin blocks transfer of extracellular vesicles between donor and recipient cells","volume":"115","author":"Atai","year":"2013","journal-title":"J. Neurooncol"},{"issue":"6","key":"10.1016\/j.prp.2026.156611_bib151","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.devcel.2006.04.002","article-title":"Dynasore, a Cell-Permeable Inhibitor of Dynamin","volume":"10","author":"Macia","year":"2006","journal-title":"Dev. Cell."},{"issue":"5","key":"10.1016\/j.prp.2026.156611_bib152","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.7150\/thno.47996","article-title":"Endocytic pathway inhibition attenuates extracellular vesicle-induced reduction of chemosensitivity to bortezomib in multiple myeloma cells","volume":"11","author":"Tu","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.prp.2026.156611_bib153","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jconrel.2017.09.019","article-title":"Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis","volume":"266","author":"Costa Verdera","year":"2017","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.prp.2026.156611_bib154","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1242\/jcs.074088","article-title":"Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis","volume":"124","author":"Fitzner","year":"2011","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.prp.2026.156611_bib155","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00221","article-title":"Engineered Tumor-Derived Extracellular Vesicles: Potentials in Cancer Immunotherapy","volume":"11","author":"Taghikhani","year":"2020","journal-title":"Front. Immunol."},{"issue":"25","key":"10.1016\/j.prp.2026.156611_bib156","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202308662","article-title":"Novel Personalized Cancer Vaccine Using Tumor Extracellular Vesicles with Attenuated Tumorigenicity and Enhanced Immunogenicity","volume":"11","author":"Han","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.prp.2026.156611_bib157","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123333","article-title":"P-Pev: micelle-like complexes transformed from tumor extracellular vesicles by PEG-PE for personalized therapeutic tumor vaccine","volume":"321","author":"Tian","year":"2025","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib158","doi-asserted-by":"crossref","first-page":"8047","DOI":"10.1038\/s41467-023-43914-8","article-title":"Metabolic tagging of extracellular vesicles and development of enhanced extracellular vesicle based cancer vaccines","volume":"14","author":"Bhatta","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib159","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer: New Dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"issue":"3","key":"10.1016\/j.prp.2026.156611_bib160","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.devcel.2019.04.011","article-title":"Exosome-Mediated Metastasis: Communication from a Distance","volume":"49","author":"Wortzel","year":"2019","journal-title":"Dev. Cell."},{"issue":"3","key":"10.1016\/j.prp.2026.156611_bib161","doi-asserted-by":"crossref","first-page":"555","DOI":"10.20517\/evcna.2024.12","article-title":"Metabolic features of tumor-derived extracellular vesicles: challenges and opportunities","volume":"5","author":"Espiau-Romera","year":"2024","journal-title":"Extracell. Vesicles Circ. Nucl. Acids"},{"issue":"6","key":"10.1016\/j.prp.2026.156611_bib162","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nm.2753","article-title":"Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET","volume":"18","author":"Peinado","year":"2012","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.prp.2026.156611_bib163","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.devcel.2019.04.011","article-title":"Exosome-Mediated Metastasis: Communication from a Distance","volume":"49","author":"Wortzel","year":"2019","journal-title":"Dev. Cell."},{"key":"10.1016\/j.prp.2026.156611_bib164","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.737449","article-title":"Tumor-Derived Extracellular Vesicles: Modulation of Cellular Functional Dynamics in Tumor Microenvironment and Its Clinical Implications","volume":"9","author":"Santos","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"issue":"10","key":"10.1016\/j.prp.2026.156611_bib165","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/s41587-021-00895-7","article-title":"Computational principles and challenges in single-cell data integration","volume":"39","author":"Argelaguet","year":"2021","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.prp.2026.156611_bib166","doi-asserted-by":"crossref","first-page":"14357","DOI":"10.1038\/ncomms14357","article-title":"Connecting genetic risk to disease end points through the human blood plasma proteome","volume":"8","author":"Suhre","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.prp.2026.156611_bib167","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2025.1714972","article-title":"Small extracellular vesicle-associated surface protein biomarkers: emerging roles, opportunities, and challenges in diagnostics","volume":"13","author":"Pham","year":"2025","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"2","key":"10.1016\/j.prp.2026.156611_bib168","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3390\/bioengineering13020247","article-title":"Global Research Trends in Extracellular Vesicle\u2013Based Therapy for Regenerative Medicine: A Bibliometric Analysis (2014\u20132024)","volume":"13","author":"Rajendran","year":"2026","journal-title":"Bioengineering"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033826002645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033826002645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T02:24:30Z","timestamp":1786501470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033826002645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":168,"alternative-id":["S0344033826002645"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2026.156611","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extracellular vesicles as systems-level regulators of tumor progression: Integrating signaling networks, microenvironment reprogramming, and therapy resistance","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2026.156611","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156611"}}