{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T03:27:14Z","timestamp":1786505234321,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004921","name":"Shanghai Jiaotong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.prp.2026.156633","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:53:34Z","timestamp":1784876014000},"page":"156633","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["RRM2 promotes lung adenocarcinoma progression and is associated with ferroptosis-inducer sensitivity through the NRF2\/GPX4 signaling axis"],"prefix":"10.1016","volume":"286","author":[{"given":"Xiangyuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenfen","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangfen","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhe","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianyong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9389-7395","authenticated-orcid":false,"given":"Meiling","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2026.156633_bib1","first-page":"7","article-title":"Cancer statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.prp.2026.156633_bib2","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1158\/1055-9965.EPI-19-0221","article-title":"Cancer progress and priorities: lung cancer","volume":"28","author":"Schabath","year":"2019","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.prp.2026.156633_bib3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/CCO.0000000000000703","article-title":"Lung cancer in China: current and prospect","volume":"33","author":"Wu","year":"2021","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.prp.2026.156633_bib4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.path.2019.11.002","article-title":"Targeted therapy and checkpoint immunotherapy in lung cancer","volume":"13","author":"Ruiz-Cordero","year":"2020","journal-title":"Surg. Pathol. Clin."},{"key":"10.1016\/j.prp.2026.156633_bib5","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.soc.2016.02.011","article-title":"Targeted therapy and immunotherapy for lung cancer","volume":"25","author":"Naylor","year":"2016","journal-title":"Surg. Oncol. Clin. N. Am."},{"key":"10.1016\/j.prp.2026.156633_bib6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0140-6736(16)30958-8","article-title":"Lung cancer: current therapies and new targeted treatments","volume":"389","author":"Hirsch","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.prp.2026.156633_bib7","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1080\/15548627.2024.2410619","article-title":"USP13 facilitates a ferroptosis-to-autophagy switch by activation of the NFE2L2\/NRF2-SQSTM1\/p62-KEAP1 axis dependent on the KRAS signaling pathway","volume":"21","author":"Chen","year":"2025","journal-title":"Autophagy"},{"key":"10.1016\/j.prp.2026.156633_bib8","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.prp.2026.156633_bib9","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.prp.2026.156633_bib10","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.freeradbiomed.2018.09.043","article-title":"The development of the concept of ferroptosis","volume":"133","author":"Hirschhorn","year":"2019","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.prp.2026.156633_bib11","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1186\/s12964-025-02293-x","article-title":"The solute carrier family 11 transporters: a bridge between iron homeostasis and tumor biology","volume":"23","author":"Banerjee","year":"2025","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.prp.2026.156633_bib12","article-title":"KRAS\/ABHD17C\/ALOX15B Axis promotes pancreatic cancer progression via ferroptosis evasion","volume":"12","author":"Li","year":"2025","journal-title":"Adv. Sci. (Weinh. )"},{"key":"10.1016\/j.prp.2026.156633_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156789","article-title":"Mori Folium ethanol extracts induce ferroptosis and suppress gastric cancer progression by inhibiting the AKT\/GSK3\u03b2\/NRF2 axis","volume":"142","author":"Hu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.prp.2026.156633_bib14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s12967-025-06241-8","article-title":"JMJD6 K375 acetylation restrains lung cancer progression by enhancing METTL14\/m6A\/SLC3A2 axis mediated cell ferroptosis","volume":"23","author":"Chen","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.prp.2026.156633_bib15","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.prp.2026.156633_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110996","article-title":"Inhibiting RRM2 to enhance the anticancer activity of chemotherapy","volume":"133","author":"Zhan","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.prp.2026.156633_bib17","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/370533a0","article-title":"Structure of ribonucleotide reductase protein R1","volume":"370","author":"Uhlin","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.prp.2026.156633_bib18","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/35003506","article-title":"A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage","volume":"404","author":"Tanaka","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.prp.2026.156633_bib19","doi-asserted-by":"crossref","first-page":"13302","DOI":"10.1073\/pnas.1211289109","article-title":"Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells","volume":"109","author":"Pontarin","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.prp.2026.156633_bib20","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1038\/onc.2014.155","article-title":"Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies","volume":"34","author":"Aye","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2026.156633_bib21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s13578-023-01157-6","article-title":"The key cellular senescence related molecule RRM2 regulates prostate cancer progression and resistance to docetaxel treatment","volume":"13","author":"Cheng","year":"2023","journal-title":"Cell. Biosci."},{"key":"10.1016\/j.prp.2026.156633_bib22","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.7150\/ijbs.106925","article-title":"Cyclin Y interacts with Chk1 to activate RRM2\/STAT3 signaling and promotes radioresistance in non-small cell lung cancer","volume":"21","author":"Liu","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.prp.2026.156633_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155204","article-title":"Triacanthine enhances the sensitivity of colorectal cancer cells to 5-fluorouracil by regulating RRM2","volume":"126","author":"Liu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.prp.2026.156633_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2017.04.026","article-title":"Liposomal curcumin alters chemosensitivity of breast cancer cells to Adriamycin via regulating microRNA expression","volume":"622","author":"Zhou","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.prp.2026.156633_bib25","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","article-title":"Visualizing and interpreting cancer genomics data via the Xena platform","volume":"38","author":"Goldman","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.prp.2026.156633_bib26","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.prp.2026.156633_bib27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.prp.2026.156633_bib28","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1158\/0008-5472.CAN-17-0307","article-title":"TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells","volume":"77","author":"Li","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2026.156633_bib29","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.prp.2026.156633_bib30","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"key":"10.1016\/j.prp.2026.156633_bib31","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.prp.2026.156633_bib32","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.prp.2026.156633_bib33","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1158\/1078-0432.CCR-18-4046","article-title":"A novel mechanism driving poor-prognosis prostate cancer: overexpression of the DNA repair gene, ribonucleotide reductase small subunit M2 (RRM2)","volume":"25","author":"Mazzu","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2026.156633_bib34","first-page":"2151","article-title":"Overexpression of catalytic subunit M2 in patients with ovarian cancer","volume":"125","author":"Wang","year":"2012","journal-title":"Chin. Med. J. (Engl. )"},{"key":"10.1016\/j.prp.2026.156633_bib35","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.gendis.2022.11.022","article-title":"Ribonucleotide reductase M2 (RRM2): regulation, function and targeting strategy in human cancer","volume":"11","author":"Zuo","year":"2024","journal-title":"Genes. Dis."},{"key":"10.1016\/j.prp.2026.156633_bib36","doi-asserted-by":"crossref","first-page":"533","DOI":"10.7150\/ijbs.30114","article-title":"RRM2 is a potential prognostic biomarker with functional significance in glioma","volume":"15","author":"Sun","year":"2019","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.prp.2026.156633_bib37","first-page":"119","article-title":"Novel Isatin-based activator of p53 transcriptional functions in tumor cells","volume":"8","author":"Mirgayazova","year":"2019","journal-title":"Mol. Biol. Res. Commun."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033826002864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033826002864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T02:35:45Z","timestamp":1786502145000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033826002864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":37,"alternative-id":["S0344033826002864"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2026.156633","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RRM2 promotes lung adenocarcinoma progression and is associated with ferroptosis-inducer sensitivity through the NRF2\/GPX4 signaling axis","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2026.156633","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156633"}}