{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T07:08:45Z","timestamp":1788764925874,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["NO.CSTB2023NSCQ-MSX0821"],"award-info":[{"award-number":["NO.CSTB2023NSCQ-MSX0821"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017501","name":"Science-Health Joint Medical Scientific Research Project of Chongqing","doi-asserted-by":"publisher","award":["NO.2026MSXM155"],"award-info":[{"award-number":["NO.2026MSXM155"]}],"id":[{"id":"10.13039\/100017501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.prp.2026.156657","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T06:12:15Z","timestamp":1786342335000},"page":"156657","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["MARCH1 promotes malignant progression in lung adenocarcinoma by regulating PLPP3 ubiquitination"],"prefix":"10.1016","volume":"287","author":[{"given":"Yi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingshuang","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyue","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2026.156657_bib1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12885-025-15387-z","article-title":"Identification and functional characterization of genes associated with lipopolysaccharide in lung adenocarcinoma","volume":"26","author":"Zhou","year":"2025","journal-title":"BMC Cancer"},{"key":"10.1016\/j.prp.2026.156657_bib2","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.freeradbiomed.2025.12.030","article-title":"HHLA3 transcriptionally promotes GPX2 to enhance anti-oxidative capacity by attenuating KEAP1-mediated NRF2 ubiquitination in lung adenocarcinoma","volume":"244","author":"Zhang","year":"2026","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.prp.2026.156657_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.lddd.2026.100333","article-title":"Development of a RiskScore model related to cancer-associated fibroblasts for assessing patient prognosis and drug sensitivity in lung adenocarcinoma","volume":"22","author":"Li","year":"2025","journal-title":"Lett. Drug. Des. Discov."},{"key":"10.1016\/j.prp.2026.156657_bib4","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1038\/s41388-024-03194-y","article-title":"MAZ promotes tumor proliferation and immune evasion in lung adenocarcinoma","volume":"43","author":"Chen","year":"2024","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2026.156657_bib5","doi-asserted-by":"crossref","first-page":"14009","DOI":"10.1074\/jbc.RA119.009002","article-title":"Regulation of PLPP3 gene expression by NF-\u03baB family transcription factors","volume":"294","author":"Mao","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.prp.2026.156657_bib6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.atherosclerosis.2018.02.025","article-title":"Lipid phosphate phosphatase 3 in vascular pathophysiology","volume":"271","author":"Busnelli","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.prp.2026.156657_bib7","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1161\/ATVBAHA.122.317830","article-title":"Myeloid-Specific Deletion of Lipid Plpp3 (Phosphate Phosphatase 3) Increases Cardiac Inflammation After Myocardial Infarction","volume":"43","author":"Tripathi","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.prp.2026.156657_bib8","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.3390\/biom10091263","article-title":"Lipid Phosphate Phosphatases and Cancer","volume":"10","author":"Tang","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.prp.2026.156657_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.697922","article-title":"Sphingosine-1-Phosphate Catabolizing Enzymes Predict Better Prognosis in Triple-Negative Breast Cancer Patients and Correlates With Tumor-Infiltrating Immune Cells","volume":"8","author":"Nema","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.prp.2026.156657_bib10","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1186\/s12935-020-01671-4","article-title":"CD44, a marker of cancer stem cells, is positively correlated with PD-L1 expression and immune cells infiltration in lung adenocarcinoma","volume":"20","author":"Zhang","year":"2020","journal-title":"Cancer Cell. Int."},{"key":"10.1016\/j.prp.2026.156657_bib11","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.coi.2019.03.001","article-title":"MARCH ligases in immunity","volume":"58","author":"Liu","year":"2019","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.prp.2026.156657_bib12","doi-asserted-by":"crossref","first-page":"41884","DOI":"10.1038\/s41598-025-25817-4","article-title":"Major histocompatibility class II in murine antigen presenting cells is modified with a branched K63 and K11-linked ubiquitin chain","volume":"15","author":"Liu","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2026.156657_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2022.101895","article-title":"MARCH1 promotes the growth and maintaining of stem cell-like characteristics of gastric cancer cells by activating the Wnt\/\u03b2-catenin signaling pathway","volume":"78","author":"Liang","year":"2022","journal-title":"Tissue Cell."},{"key":"10.1016\/j.prp.2026.156657_bib14","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1111\/jcmm.14235","article-title":"MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K-AKT-\u03b2-catenin pathways","volume":"23","author":"Xie","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.prp.2026.156657_bib15","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1038\/s41388-025-03464-3","article-title":"MARCH1, transcriptionally regulated by POU2F2, facilitates acute myeloid leukemia progression via inducing MYCT1 degradation","volume":"44","author":"Liu","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2026.156657_bib16","article-title":"MARCH1 as a novel immune-related prognostic biomarker that shapes an inflamed tumor microenvironment in lung adenocarcinoma","volume":"12","author":"Xu","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.prp.2026.156657_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/pore.2021.1609926","article-title":"Bone-Specific Metastasis Pattern of Advanced-Stage Lung Adenocarcinoma According to the Localization of the Primary Tumor","volume":"27","author":"Radeczky","year":"2021","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.prp.2026.156657_bib18","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3389\/fonc.2020.00349","article-title":"Intratumor Heterogeneity in Early Lung Adenocarcinoma","volume":"10","author":"Senosain","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.prp.2026.156657_bib19","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1111\/crj.12771","article-title":"Exploration of differentially expressed plasma proteins in patients with lung adenocarcinoma using iTRAQ-coupled 2D LC-MS\/MS","volume":"12","author":"Li","year":"2018","journal-title":"Clin. Respir. J."},{"key":"10.1016\/j.prp.2026.156657_bib20","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s12032-025-02887-y","article-title":"Deciphering the transcriptional regulatory network driving lung adenocarcinoma progression","volume":"42","author":"Wang","year":"2025","journal-title":"Med. Oncol."},{"key":"10.1016\/j.prp.2026.156657_bib21","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1080\/1061186X.2025.2571547","article-title":"Development of an effective drug carrier for targeted therapy in lung adenocarcinoma using ROS-responsive micelles","volume":"34","author":"Liu","year":"2026","journal-title":"J. Drug. Target."},{"key":"10.1016\/j.prp.2026.156657_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2020.104141","article-title":"Prognostic role of lipid phosphate phosphatases in non-smoker, lung adenocarcinoma patients","volume":"129","author":"Nema","year":"2021","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.prp.2026.156657_bib23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1476-4598-10-51","article-title":"Lipid phosphate phosphatase-3 regulates tumor growth via \u03b2-catenin and CYCLIN-D1 signaling","volume":"10","author":"Chatterjee","year":"2011","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.prp.2026.156657_bib24","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1158\/0008-5472.CAN-17-3797","article-title":"The Autotaxin-Lysophosphatidic Acid Axis Promotes Lung Carcinogenesis","volume":"78","author":"Magkrioti","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2026.156657_bib25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.nbt.2016.12.002","article-title":"Overview of the membrane-associated RING-CH (MARCH) E3 ligase family","volume":"38","author":"Bauer","year":"2017","journal-title":"N. Biotechnol."},{"key":"10.1016\/j.prp.2026.156657_bib26","doi-asserted-by":"crossref","first-page":"6500","DOI":"10.4049\/jimmunol.0901521","article-title":"Discrete domains of MARCH1 mediate its localization, functional interactions, and posttranscriptional control of expression","volume":"183","author":"Jabbour","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.prp.2026.156657_bib27","doi-asserted-by":"crossref","first-page":"5875","DOI":"10.4049\/jimmunol.1301693","article-title":"Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10\/MARCH1-dependent mechanism","volume":"191","author":"Chattopadhyay","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.prp.2026.156657_bib28","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/cbin.11493","article-title":"5-FU inhibits migration and invasion of CRC cells through PI3K\/AKT pathway regulated by MARCH1","volume":"45","author":"Wang","year":"2021","journal-title":"Cell. Biol. Int."},{"key":"10.1016\/j.prp.2026.156657_bib29","doi-asserted-by":"crossref","first-page":"11717","DOI":"10.18632\/aging.103338","article-title":"Resveratrol inhibits the malignant progression of hepatocellular carcinoma via MARCH1-induced regulation of PTEN\/AKT signaling","volume":"12","author":"Dai","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.prp.2026.156657_bib30","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/cbin.12255","article-title":"MARCHF1 promotes breast cancer through accelerating REST ubiquitylation and following TFAM transcription","volume":"49","author":"Li","year":"2025","journal-title":"Cell. Biol. Int."},{"key":"10.1016\/j.prp.2026.156657_bib31","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s12094-021-02769-5","article-title":"MARCH1 silencing suppresses growth of oral squamous cell carcinoma through regulation of PHLPP2","volume":"24","author":"Liu","year":"2022","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.prp.2026.156657_bib32","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.3892\/or.2016.5076","article-title":"Silencing MARCH1 suppresses proliferation, migration and invasion of ovarian cancer SKOV3 cells via downregulation of NF-\u03baB and Wnt\/\u03b2-catenin pathways","volume":"36","author":"Meng","year":"2016","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.prp.2026.156657_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2024.106280","article-title":"An in-depth analysis of the effects of excessive acetochlor exposure on chicken liver health","volume":"208","author":"Zhang","year":"2025","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.prp.2026.156657_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121847","article-title":"Fluoride induces neutrophil extracellular traps and aggravates brain inflammation by disrupting neutrophil calcium homeostasis and causing ferroptosis","volume":"331","author":"Wang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.prp.2026.156657_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.140112","article-title":"NCOA4-dependent ferritinophagy drives perfluorooctanoic acid-triggered renal ferroptosis in chicken embryos","volume":"499","author":"Yang","year":"2025","journal-title":"J. Hazard. Mater."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033826003109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033826003109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T06:33:50Z","timestamp":1788762830000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033826003109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":35,"alternative-id":["S0344033826003109"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2026.156657","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MARCH1 promotes malignant progression in lung adenocarcinoma by regulating PLPP3 ubiquitination","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2026.156657","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156657"}}