{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T07:08:57Z","timestamp":1788764937399,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.prp.2026.156663","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T23:25:32Z","timestamp":1787095532000},"page":"156663","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Golvatinib (E7050) restores chemosensitivity in multidrug-resistant cancer cells by inhibiting ABCG2 transporter"],"prefix":"10.1016","volume":"287","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2653-1726","authenticated-orcid":false,"given":"Xuan-Yu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5147-457X","authenticated-orcid":false,"given":"Lu-Qi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3416-8931","authenticated-orcid":false,"given":"Harsh","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7822-760X","authenticated-orcid":false,"given":"Abel B.","family":"Daartey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanning","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6919-0286","authenticated-orcid":false,"given":"Xinman","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo-Xun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9758-6746","authenticated-orcid":false,"given":"Saurabh","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2048-8598","authenticated-orcid":false,"given":"Sven Marcel","family":"Stefan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8289-097X","authenticated-orcid":false,"given":"Zhe-Sheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2026.156663_bib1","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/s41571-025-01059-1","article-title":"Understanding and overcoming multidrug resistance in cancer","volume":"22","author":"Ge","year":"2025","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.prp.2026.156663_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2022.100905","article-title":"ABC transporters affects tumor immune microenvironment to regulate cancer immunotherapy and multidrug resistance","volume":"66","author":"Fan","year":"2023","journal-title":"Drug. Resist. Updat."},{"key":"10.1016\/j.prp.2026.156663_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cancergen.2025.12.001","article-title":"Genetic modulation of ABCB1: Sunvozertinib reverses ABCB1-mediated multidrug resistance in cancer cells","volume":"300-301","author":"Cao","year":"2026","journal-title":"Cancer Genet."},{"key":"10.1016\/j.prp.2026.156663_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2025.101310","article-title":"Beyond the boundary: the emerging roles of ATP-binding cassette transporters in multidrug resistance (MDR) and therapeutic targeting in cancer","volume":"84","author":"Sun","year":"2026","journal-title":"Drug. Resist. Updat."},{"key":"10.1016\/j.prp.2026.156663_bib5","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/s41568-023-00612-3","article-title":"Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters","volume":"23","author":"Sajid","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.prp.2026.156663_bib6","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2174\/1574892817666220112100036","article-title":"Inhibiting the activity of ABCG2 by KU55933 in colorectal cancer","volume":"17","author":"Liu","year":"2022","journal-title":"Recent. Pat. Anticancer. Drug. Discov."},{"key":"10.1016\/j.prp.2026.156663_bib7","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1002\/1873-3468.13947","article-title":"The ABCG2\/BCRP transporter and its variants - from structure to pathology","volume":"594","author":"Sarkadi","year":"2020","journal-title":"FEBS Lett."},{"key":"10.1016\/j.prp.2026.156663_bib8","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1038\/s41467-021-24651-2","article-title":"Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism","volume":"12","author":"Yu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.prp.2026.156663_bib9","article-title":"A structure-based view on ABC-transporter linked to multidrug resistance","volume":"28","author":"Huang","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.prp.2026.156663_bib10","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/sj.bjc.6604213","article-title":"Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors","volume":"98","author":"Lemos","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.prp.2026.156663_bib11","doi-asserted-by":"crossref","first-page":"7896","DOI":"10.1158\/1078-0432.CCR-04-0795","article-title":"Breast cancer resistance protein and P-glycoprotein in 149 adult acute myeloid leukemias","volume":"10","author":"Benderra","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2026.156663_bib12","doi-asserted-by":"crossref","first-page":"7764","DOI":"10.1158\/1078-0432.CCR-04-1895","article-title":"MRP3, BCRP, and P-glycoprotein activities are prognostic factors in adult acute myeloid leukemia","volume":"11","author":"Benderra","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2026.156663_bib13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.leukres.2004.06.004","article-title":"BCRP mRNA expression v. clinical outcome in 40 adult AML patients","volume":"29","author":"Uggla","year":"2005","journal-title":"Leuk. Res."},{"key":"10.1016\/j.prp.2026.156663_bib14","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1158\/1078-0432.CCR-0937-3","article-title":"Breast cancer resistance protein impacts clinical outcome in platinum-based chemotherapy for advanced non-small cell lung cancer","volume":"10","author":"Yoh","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2026.156663_bib15","doi-asserted-by":"crossref","first-page":"595","DOI":"10.2174\/138920111795163913","article-title":"The challenge of exploiting ABCG2 in the clinic","volume":"12","author":"Robey","year":"2011","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.prp.2026.156663_bib16","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bcp.2019.05.015","article-title":"Tepotinib reverses ABCB1-mediated multidrug resistance in cancer cells","volume":"166","author":"Wu","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.prp.2026.156663_bib17","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1016\/j.apsb.2021.12.018","article-title":"MET inhibitor tepotinib antagonizes multidrug resistance mediated by ABCG2 transporter: In vitro and in vivo study","volume":"12","author":"Wu","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.prp.2026.156663_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2025.104321","article-title":"Epigenetic code underlying EGFR-TKI resistance in non-small cell lung cancer: elucidation of mechanisms and perspectives on therapeutic strategies","volume":"30","author":"Yao","year":"2025","journal-title":"Drug. Discov. Today"},{"key":"10.1016\/j.prp.2026.156663_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.640957","article-title":"Cabozantinib reverses topotecan resistance in human non-small cell lung cancer NCI-H460\/TPT10 cell line and tumor Xenograft Model","volume":"9","author":"Lei","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.prp.2026.156663_bib20","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.1158\/1078-0432.CCR-14-0409","article-title":"A phase I, dose-escalation study of the multitargeted receptor tyrosine kinase inhibitor, golvatinib, in patients with advanced solid tumors","volume":"20","author":"Molife","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.prp.2026.156663_bib21","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/mco2.106","article-title":"Overcoming multidrug resistance by knockout of ABCB1 gene using CRISPR\/Cas9 system in SW620\/Ad300 colorectal cancer cells","volume":"2","author":"Lei","year":"2021","journal-title":"MedComm (2020)"},{"key":"10.1016\/j.prp.2026.156663_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.607275","article-title":"Establishment and characterization of a topotecan resistant non-small cell lung cancer NCI-H460\/TPT10 Cell Line","volume":"8","author":"Lei","year":"2020","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.prp.2026.156663_bib23","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1158\/0008-5472.CAN-13-2064","article-title":"MDR1 synonymous polymorphisms alter transporter specificity and protein stability in a stable epithelial monolayer","volume":"74","author":"Fung","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.prp.2026.156663_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2025.114851","article-title":"Overcoming multidrug resistance in cancer cells targeting ABC transporter ABCB1 with tyrosine kinase inhibitor: Olverembatinib","volume":"455","author":"Zhang","year":"2026","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/j.prp.2026.156663_bib25","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1358\/dot.2022.58.8.3432777","article-title":"Amivantamab: a monoclonal EGFR-MET bispecific antibody for EGFR exon 20 insertion in non-small cell lung cancer","volume":"58","author":"Xie","year":"2022","journal-title":"Drugs Today (Barc)"},{"key":"10.1016\/j.prp.2026.156663_bib26","article-title":"Reversal of ABCG2-mediated drug resistance by tinodasertib (ETC-206)","volume":"16","author":"Yang","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.prp.2026.156663_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12113249","article-title":"Poziotinib Inhibits the Efflux Activity of the ABCB1 and ABCG2 Transporters and the Expression of the ABCG2 Transporter Protein in Multidrug Resistant Colon Cancer Cells","volume":"12","author":"Zhang","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.prp.2026.156663_bib28","article-title":"Tivantinib, A c-Met inhibitor in clinical trials, is susceptible to ABCG2-mediated drug resistance","volume":"12","author":"Wu","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.prp.2026.156663_bib29","article-title":"Overexpression of ABCC1 confers drug resistance to betulin","volume":"11","author":"Chen","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.prp.2026.156663_bib30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.phrs.2017.01.024","article-title":"Modulating the function of ATP-binding cassette subfamily G member 2 (ABCG2) with inhibitor cabozantinib","volume":"119","author":"Zhang","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.prp.2026.156663_bib31","article-title":"Overexpression of ABCG2 Confers Resistance to MLN7243, a Ubiquitin-Activating Enzyme (UAE) Inhibitor","volume":"9","author":"Wu","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.prp.2026.156663_bib32","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.prp.2026.156663_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101065","article-title":"ABCB1-dependent collateral sensitivity of multidrug-resistant colorectal cancer cells to the survivin inhibitor MX106\u20134\u2009C","volume":"73","author":"Lei","year":"2024","journal-title":"Drug. Resist. Updat."},{"key":"10.1016\/j.prp.2026.156663_bib34","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41594-018-0049-1","article-title":"Structural basis of small-molecule inhibition of human multidrug transporter ABCG2","volume":"25","author":"Jackson","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.prp.2026.156663_bib35","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.prp.2026.156663_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2021.166980","article-title":"Structural basis of drug recognition by the multidrug transporter ABCG2","volume":"433","author":"Kowal","year":"2021","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.prp.2026.156663_bib37","article-title":"Research progress of small molecule VEGFR\/c-Met Inhibitors as Anticancer Agents (2016-Present)","volume":"25","author":"Zhang","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.prp.2026.156663_bib38","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1349-7006.2009.01343.x","article-title":"E7050: a dual c-Met and VEGFR-2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in mouse xenograft models","volume":"101","author":"Nakagawa","year":"2010","journal-title":"Cancer Sci."},{"key":"10.1016\/j.prp.2026.156663_bib39","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.ajpath.2012.05.023","article-title":"Dual inhibition of Met kinase and angiogenesis to overcome HGF-induced EGFR-TKI resistance in EGFR mutant lung cancer","volume":"181","author":"Takeuchi","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.prp.2026.156663_bib40","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/cas.12409","article-title":"Lenvatinib in combination with golvatinib overcomes hepatocyte growth factor pathway-induced resistance to vascular endothelial growth factor receptor inhibitor","volume":"105","author":"Nakagawa","year":"2014","journal-title":"Cancer Sci."},{"key":"10.1016\/j.prp.2026.156663_bib41","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1038\/sj.bjc.6601370","article-title":"Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity","volume":"89","author":"Robey","year":"2003","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.prp.2026.156663_bib42","doi-asserted-by":"crossref","first-page":"47980","DOI":"10.1074\/jbc.M207857200","article-title":"Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation","volume":"277","author":"Ozvegy","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.prp.2026.156663_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/cells8101215","article-title":"Cellular Processing of the ABCG2 transporter-potential effects on gout and drug metabolism","volume":"8","author":"Mozner","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.prp.2026.156663_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.615729","article-title":"Identification of xspecific trafficking defects of naturally occurring variants of the human ABCG2 Transporter","volume":"9","author":"Bartos","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.prp.2026.156663_bib45","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1038\/s41467-020-16155-2","article-title":"ABCG2 transports anticancer drugs via a closed-to-open switch","volume":"11","author":"Orlando","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.prp.2026.156663_bib46","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1208\/s12248-014-9668-6","article-title":"Role of the breast cancer resistance protein (BCRP\/ABCG2) in drug transport--an update","volume":"17","author":"Mao","year":"2015","journal-title":"AAPS J."},{"key":"10.1016\/j.prp.2026.156663_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.101011","article-title":"Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2","volume":"71","author":"Wu","year":"2023","journal-title":"Drug. Resist. Updat."},{"key":"10.1016\/j.prp.2026.156663_bib48","first-page":"417","article-title":"Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C","volume":"1","author":"Allen","year":"2002","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.prp.2026.156663_bib49","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s11095-008-9752-7","article-title":"Major SNP (Q141K) variant of human ABC transporter ABCG2 undergoes lysosomal and proteasomal degradations","volume":"26","author":"Furukawa","year":"2009","journal-title":"Pharm. Res."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S034403382600316X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S034403382600316X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T06:36:03Z","timestamp":1788762963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S034403382600316X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":49,"alternative-id":["S034403382600316X"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2026.156663","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Golvatinib (E7050) restores chemosensitivity in multidrug-resistant cancer cells by inhibiting ABCG2 transporter","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2026.156663","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"156663"}}