{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T20:29:46Z","timestamp":1793478586968,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.prp.2026.156671","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:28:37Z","timestamp":1788305317000},"page":"156671","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Identification of TRAF1 as a crucial regulator of inflammatory and oxidative injury in acute myocardial infarction"],"prefix":"10.1016","volume":"288","author":[{"given":"Fei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quancheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prp.2026.156671_bib1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.029971","article-title":"Acute Myocardial infarction: etiologies and mimickers in young patients","volume":"12","author":"Krittanawong","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.prp.2026.156671_bib2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00392-021-01937-5","article-title":"Pregnancy-related acute myocardial infarction: a review of the recent literature","volume":"111","author":"Merlo","year":"2022","journal-title":"Clin. Res. Cardiol."},{"key":"10.1016\/j.prp.2026.156671_bib3","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.tcm.2025.06.005","article-title":"Acute myocardial infarction in patients without standard modifiable risk factors -A state-of-the-art review","volume":"35","author":"Moysidis","year":"2025","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.prp.2026.156671_bib4","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1080\/13880209.2022.2055089","article-title":"C-Phycocyanin prevents acute myocardial infarction-induced oxidative stress, inflammation and cardiac damage","volume":"60","author":"Blas-Valdivia","year":"2022","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.prp.2026.156671_bib5","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1007\/s10557-024-07635-4","article-title":"Kirenol ameliorates myocardial ischemia-reperfusion injury by promoting mitochondrial function and inhibiting inflammasome activation","volume":"39","author":"Pan","year":"2025","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.prp.2026.156671_bib6","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.031415","article-title":"Percutaneous coronary intervention in acute myocardial infarction: community wealth matters","volume":"12","author":"Kamin Mukaz","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.prp.2026.156671_bib7","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/j.jacc.2023.09.840","article-title":"Management of severe mitral regurgitation in patients with acute myocardial infarction: JACC focus seminar 2\/5","volume":"83","author":"Est\u00e9vez-Loureiro","year":"2024","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.prp.2026.156671_bib8","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1016\/j.amjmed.2022.03.030","article-title":"Acute myocardial infarction following hospitalization for gastrointestinal bleeding: incidence, predictors, management, and outcomes","volume":"135","author":"Rubinfeld","year":"2022","journal-title":"Am. J. Med."},{"key":"10.1016\/j.prp.2026.156671_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102629","article-title":"Regulated cell death in acute myocardial infarction: Molecular mechanisms and therapeutic implications","volume":"104","author":"Zhu","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.prp.2026.156671_bib10","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.2174\/0115701808235958230923042422","article-title":"Kukoamine A activates Akt\/GSK-3\u03b2 pathway to repress oxidative stress and inflammation to alleviate myocardial ischemia-reperfusion injury","volume":"21","author":"Hong","year":"2024","journal-title":"Lett. Drug. Des. Discov."},{"key":"10.1016\/j.prp.2026.156671_bib11","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s10557-024-07566-0","article-title":"Aloperine alleviates myocardial injury induced by myocardial ischemia and reperfusion by activating the ERK1\/2\/\u03b2-catenin signaling pathway","volume":"39","author":"Wei","year":"2025","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.prp.2026.156671_bib12","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s10557-025-07726-w","article-title":"Macrophage migration inhibitory factor: the next adjunct to reperfusion therapy in acute myocardial infarction?","volume":"39","author":"Keefe","year":"2025","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.prp.2026.156671_bib13","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.2174\/1570180820666230217094512","article-title":"P-EKKE Alleviates Myocardial Infarction (MI) in MI Rats by Inhibiting Hedgehog Signaling Pathway-mediated Inflammation and Inhibiting \u03b1-actin Mediated Myocardial Fibrosis","volume":"21","author":"Guixian","year":"2024","journal-title":"Lett. Drug. Des. & Discov."},{"key":"10.1016\/j.prp.2026.156671_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.137431","article-title":"Identification of a lactylation-related gene signature as the novel biomarkers for early diagnosis of acute myocardial infarction","volume":"282","author":"Zhu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.prp.2026.156671_bib15","doi-asserted-by":"crossref","first-page":"10175","DOI":"10.1038\/s41598-024-60945-3","article-title":"Dynamic molecular signatures of acute myocardial infarction based on transcriptomics and metabolomics","volume":"14","author":"Wang","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.prp.2026.156671_bib16","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1007\/s10557-024-07590-0","article-title":"Heme Oxygenase-1, Cardiac Senescence, and Myocardial Infarction: A Critical Review of the Triptych","volume":"39","author":"Padda","year":"2025","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.prp.2026.156671_bib17","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s10557-024-07662-1","article-title":"Recombinant dsAAV9-mediated Endogenous Overexpression of Macrophage Migration Inhibitory Factor Alleviates Myocardial Ischemia-Reperfusion Injury via Activating AMPK and ERK1\/2 Signaling Pathways","volume":"39","author":"Chen","year":"2025","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.prp.2026.156671_bib18","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3390\/biom14050510","article-title":"TRAF1 from a Structural Perspective","volume":"14","author":"Jang","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.prp.2026.156671_bib19","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.3389\/fimmu.2018.02969","article-title":"TRAF1 Signaling in Human Health and Disease","volume":"9","author":"Edilova","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.prp.2026.156671_bib20","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/s41388-021-02095-8","article-title":"RNA demethylase ALKBH5 promotes tumorigenesis in multiple myeloma via TRAF1-mediated activation of NF-\u03baB and MAPK signaling pathways","volume":"41","author":"Qu","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.prp.2026.156671_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.107601","article-title":"Elabela inhibits TRAF1\/NF-\u03baB induced oxidative DNA damage to promote diabetic foot ulcer wound healing","volume":"26","author":"Hong","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.prp.2026.156671_bib22","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s10020-025-01349-5","article-title":"Helicobacter pylori VacA modulates TRAF1-mediated 4-1BB\/NF-kappaB axis to induce host apoptosis and chronic inflammatory damage","volume":"31","author":"Yuan","year":"2025","journal-title":"Mol. Med."},{"key":"10.1016\/j.prp.2026.156671_bib23","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1186\/s13287-021-02593-2","article-title":"SPION-MSCs enhance therapeutic efficacy in sepsis by regulating MSC-expressed TRAF1-dependent macrophage polarization","volume":"12","author":"Xu","year":"2021","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.prp.2026.156671_bib24","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012575","article-title":"TRAF1 Exacerbates Myocardial Ischemia Reperfusion Injury via ASK1-JNK\/p38 Signaling","volume":"8","author":"Xu","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.prp.2026.156671_bib25","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41418-020-00703-w","article-title":"The ubiquitin system: from cell signalling to disease biology and new therapeutic opportunities","volume":"28","author":"Damgaard","year":"2021","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.prp.2026.156671_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115572","article-title":"TRIM21 exacerbates hypoxia-induced cardiomyocyte Pyroptosis through GSDMD ubiquitination in post-myocardial infarction heart failure","volume":"166","author":"Lin","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.prp.2026.156671_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2025.108865","article-title":"USP1 inhibition: A journey from target discovery to clinical translation","volume":"271","author":"Torrado","year":"2025","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.prp.2026.156671_bib28","doi-asserted-by":"crossref","first-page":"6042","DOI":"10.1038\/s41467-020-19939-8","article-title":"UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression","volume":"11","author":"Song","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.prp.2026.156671_bib29","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.yjmcc.2023.11.007","article-title":"Targeting heat shock protein 47 alleviated doxorubicin-induced cardiotoxicity and remodeling in mice through suppression of the NLRP3 inflammasome","volume":"186","author":"Shi","year":"2024","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.prp.2026.156671_bib30","doi-asserted-by":"crossref","first-page":"5192","DOI":"10.1016\/j.ymthe.2025.07.008","article-title":"A BACH1 inhibitor ameliorates myocardial infarction and limb ischemia in mice","volume":"33","author":"Lin","year":"2025","journal-title":"Mol. Ther."},{"key":"10.1016\/j.prp.2026.156671_bib31","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.187072","article-title":"Klf9 promotes the repair of myocardial infarction by regulating macrophage recruitment and polarization","volume":"10","author":"Xu","year":"2025","journal-title":"JCI Insight"},{"key":"10.1016\/j.prp.2026.156671_bib32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.yexcr.2019.02.005","article-title":"TRAF6-p38\/JNK-ATF2 axis promotes microglial inflammatory activation","volume":"376","author":"Li","year":"2019","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/j.prp.2026.156671_bib33","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1161\/STROKEAHA.123.045781","article-title":"ATF2\/BAP1 Axis Mediates Neuronal Apoptosis After Subarachnoid Hemorrhage via P53 Pathway","volume":"55","author":"Tian","year":"2024","journal-title":"Stroke"},{"key":"10.1016\/j.prp.2026.156671_bib34","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jare.2025.03.031","article-title":"MG53 protects against septic cardiac dysfunction by ubiquitinating ATF2","volume":"79","author":"Tian","year":"2026","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.prp.2026.156671_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103400","article-title":"LGR6 protects against myocardial ischemia-reperfusion injury via suppressing necroptosis","volume":"78","author":"Zhao","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.prp.2026.156671_bib36","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.redox.2017.11.004","article-title":"DUSP1 alleviates cardiac ischemia\/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways","volume":"14","author":"Jin","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.prp.2026.156671_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.112202","article-title":"Sirt3-Bnip3 signaling axis alleviates myocardial ischemia\/reperfusion-induced cardiac injury via regulating GSDME","volume":"138","author":"Yin","year":"2026","journal-title":"Cell. Signal."},{"key":"10.1016\/j.prp.2026.156671_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.112144","article-title":"Fibroblast-secreted ADAMTSL2 promotes cardiac repair after myocardial infarction by activating LRP6\/\u03b2-catenin signaling","volume":"136","author":"Wang","year":"2025","journal-title":"Cell. Signal."},{"key":"10.1016\/j.prp.2026.156671_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104744","article-title":"Interleukin-34-NF-\u03baB signaling aggravates myocardial ischemic\/reperfusion injury by facilitating macrophage recruitment and polarization","volume":"95","author":"Zhuang","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.prp.2026.156671_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1252942","article-title":"Tanshinone IIA inhibits cardiomyocyte pyroptosis through TLR4\/NF-\u03baB p65 pathway after acute myocardial infarction","volume":"11","author":"Chai","year":"2023","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.prp.2026.156671_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2025.128142","article-title":"VacA promotes pyroptosis via TNFAIP3\/TRAF1 signaling to induce onset of atrophic gastritis","volume":"296","author":"Xiao","year":"2025","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.prp.2026.156671_bib42","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3390\/md23010047","article-title":"Methyl 3-Bromo-4,5-dihydroxybenzoate Attenuates Inflammatory Bowel Disease by Regulating TLR\/NF-\u03baB Pathways","volume":"23","author":"Huang","year":"2025","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.prp.2026.156671_bib43","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000662","article-title":"Dysferlin mediates the cytoprotective effects of TRAF2 following myocardial ischemia reperfusion injury","volume":"3","author":"Tzeng","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.prp.2026.156671_bib44","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1038\/s41467-025-60123-7","article-title":"Myocardial mitochondrial antiviral signaling protein promotes heart Ischemia-reperfusion injury via RIG-I signaling in mice","volume":"16","author":"Kang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.prp.2026.156671_bib45","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3892\/ijmm.2022.5200","article-title":"Role of GADD45A in myocardial ischemia\/reperfusion through mediation of the JNK\/p38 MAPK and STAT3\/VEGF pathways","volume":"50","author":"Wang","year":"2022","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.prp.2026.156671_bib46","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.7150\/thno.72826","article-title":"CRISPR\/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells","volume":"12","author":"Tyagi","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.prp.2026.156671_bib47","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1158\/1535-7163.MCT-22-0409","article-title":"Ubiquitinated PCNA drives USP1 synthetic lethality in cancer","volume":"22","author":"Simoneau","year":"2023","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.prp.2026.156671_bib48","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2504195122","article-title":"USP1-TRAF2 axis-regulated mortalin stability mediates chemoresistance by disrupting calcium transport in peripheral T-cell lymphoma","volume":"122","author":"Gui","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.prp.2026.156671_bib49","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00774-022-01350-6","article-title":"CD40\/TRAF1 decreases synovial cell apoptosis in patients with rheumatoid arthritis through JNK\/NF-\u03baB pathway","volume":"40","author":"Cheng","year":"2022","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.prp.2026.156671_bib50","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bbrc.2019.01.041","article-title":"TRAF1 meditates lipopolysaccharide-induced acute lung injury by up regulating JNK activation","volume":"511","author":"Bin","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.prp.2026.156671_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102564","article-title":"Increased ATF2 expression predicts poor prognosis and inhibits sorafenib-induced ferroptosis in gastric cancer","volume":"59","author":"Xu","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.prp.2026.156671_bib52","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.expneurol.2015.10.010","article-title":"JNK-mediated activation of ATF2 contributes to dopaminergic neurodegeneration in the MPTP mouse model of Parkinson's disease","volume":"277","author":"Huang","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.prp.2026.156671_bib53","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1007\/s10787-022-01075-y","article-title":"Nuciferine attenuates lipopolysaccharide-stimulated inflammatory responses by inhibiting p38 MAPK\/ATF2 signaling pathways","volume":"30","author":"Kim","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.prp.2026.156671_bib54","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/s42003-021-02391-9","article-title":"Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis","volume":"4","author":"Al-Yacoub","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.prp.2026.156671_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108913","article-title":"Parthenolide ameliorates neurological deficits and neuroinflammation in mice with traumatic brain injury by suppressing STAT3\/NF-\u03baB and inflammasome activation","volume":"108","author":"Ding","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.prp.2026.156671_bib56","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1038\/s41374-022-00834-3","article-title":"Parthenolide alleviates peritoneal fibrosis by inhibiting inflammation via the NF-\u03baB\/ TGF-\u03b2\/Smad signaling axis","volume":"102","author":"Zhang","year":"2022","journal-title":"Lab. Invest."},{"key":"10.1016\/j.prp.2026.156671_bib57","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6245798","article-title":"Assessing the effects of parthenolide on inflammation, bone loss, and glial cells within a collagen antibody-induced arthritis mouse model","volume":"2020","author":"Williams","year":"2020","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.prp.2026.156671_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.135209","article-title":"Pivotal role of JNK protein in the therapeutic efficacy of parthenolide against breast cancer: Novel and comprehensive evidences from network pharmacology, single-cell RNA sequencing and metabolomics","volume":"279","author":"Shi","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.prp.2026.156671_bib59","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00024382-200202000-00008","article-title":"Sesquiterpene lactone parthenolide, an inhibitor of IkappaB kinase complex and nuclear factor-kappaB, exerts beneficial effects in myocardial reperfusion injury","volume":"17","author":"Zingarelli","year":"2002","journal-title":"Shock"},{"key":"10.1016\/j.prp.2026.156671_bib60","first-page":"33","article-title":"parthenolide-induced cytotoxicity in H9c2 cardiomyoblasts involves oxidative stress","volume":"31","author":"Tsai","year":"2015","journal-title":"Acta Cardiol. Sin."},{"key":"10.1016\/j.prp.2026.156671_bib61","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.freeradbiomed.2006.11.012","article-title":"Parthenolide induces a distinct pattern of oxidative stress in cardiac myocytes","volume":"42","author":"Kurdi","year":"2007","journal-title":"Free. Radic. Biol. Med."}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033826003249?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033826003249?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:39:28Z","timestamp":1793475568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033826003249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":61,"alternative-id":["S0344033826003249"],"URL":"https:\/\/doi.org\/10.1016\/j.prp.2026.156671","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of TRAF1 as a crucial regulator of inflammatory and oxidative injury in acute myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"Pathology - Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prp.2026.156671","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156671"}}