{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:01:06Z","timestamp":1769922066552,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Adaptive Biotechnologies"}],"content-domain":{"domain":["practicalradonc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Practical Radiation Oncology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.prro.2018.11.009","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T14:03:28Z","timestamp":1544450608000},"page":"89-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Analysis of Local Control and Pain Control After Spine Stereotactic Radiosurgery Reveals Inferior Outcomes for Hepatocellular Carcinoma Compared With Other Radioresistant Histologies"],"prefix":"10.1016","volume":"9","author":[{"given":"Heather M.","family":"McGee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd J.","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umut","family":"Ozbek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine A.","family":"Kirkwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-Chi","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth","family":"Blacksburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle M.","family":"Germano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheryl","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Buckstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.prro.2018.11.009_bib1","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int J Cancer"},{"key":"10.1016\/j.prro.2018.11.009_bib2","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1200\/JCO.2015.64.7412","article-title":"Future of hepatocellular carcinoma incidence in the United States forecast through 2030","volume":"34","author":"Petrick","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.prro.2018.11.009_bib3","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1097\/00042737-200109000-00015","article-title":"Increased incidence of bone metastases in hepatocellular carcinoma","volume":"13","author":"Fukutomi","year":"2001","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.prro.2018.11.009_bib4","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.1002\/cncr.25960","article-title":"Hepatocellular carcinoma with extrahepatic metastasis","volume":"117","author":"Uchino","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.prro.2018.11.009_bib5","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1148\/radiology.216.3.r00se24698","article-title":"Extrahepatic metastases of hepatocellular carcinoma","volume":"216","author":"Katyal","year":"2000","journal-title":"Radiology"},{"key":"10.1016\/j.prro.2018.11.009_bib6","doi-asserted-by":"crossref","first-page":"e105268","DOI":"10.1371\/journal.pone.0105268","article-title":"Natural history of malignant bone disease in hepatocellular carcinoma: Final results of a multicenter bone metastasis survey","volume":"9","author":"Santini","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.prro.2018.11.009_bib7","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1056\/NEJMoa0708857","article-title":"Sorafenib in advanced hepatocellular carcinoma","volume":"359","author":"Llovet","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.prro.2018.11.009_bib8","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1478-3231.2005.01094.x","article-title":"Radiotherapy for painful bone metastases from hepatocellular carcinoma","volume":"25","author":"Seong","year":"2005","journal-title":"Liver Int"},{"key":"10.1016\/j.prro.2018.11.009_bib9","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1002\/cncr.24300","article-title":"Clinical features and prognostic factors in patients with bone metastases from hepatocellular carcinoma receiving external beam radiotherapy","volume":"115","author":"He","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.prro.2018.11.009_bib10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/jjco\/hyl128","article-title":"A retrospective study of radiotherapy for spinal bone metastases from hepatocellular carcinoma (HCC)","volume":"37","author":"Nakamura","year":"2007","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.prro.2018.11.009_bib11","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s10147-014-0717-z","article-title":"Radiobiological basis of SBRT and SRS","volume":"19","author":"Song","year":"2014","journal-title":"Int J Clin Oncol"},{"key":"10.1016\/j.prro.2018.11.009_bib12","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.ijrobp.2011.02.040","article-title":"Tumor control outcomes after hypofractionated and single-dose stereotactic image-guided intensity-modulated radiotherapy for extracranial metastases from renal cell carcinoma","volume":"82","author":"Zelefsky","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2018.11.009_bib13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11060-014-1455-9","article-title":"Stereotactic radiosurgery compared with external radiation therapy as a primary treatment in spine metastasis from renal cell carcinoma: A multicenter, matched-pair study","volume":"119","author":"Sohn","year":"2014","journal-title":"J Neurooncol"},{"key":"10.1016\/j.prro.2018.11.009_bib14","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s13014-014-0226-2","article-title":"Safety and efficacy of stereotactic body radiotherapy as primary treatment for vertebral metastases: A multi-institutional analysis","volume":"9","author":"Guckenberger","year":"2014","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.prro.2018.11.009_bib15","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s11060-011-0777-0","article-title":"Stereotactic radiosurgery for primary and metastatic sarcomas involving the spine","volume":"107","author":"Chang","year":"2012","journal-title":"J Neurooncol"},{"key":"10.1016\/j.prro.2018.11.009_bib16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3857\/roj.2015.33.3.217","article-title":"Clinical outcomes of stereotactic body radiotherapy for spinal metastases from hepatocellular carcinoma","volume":"33","author":"Lee","year":"2015","journal-title":"Radiat Oncol J"},{"key":"10.1016\/j.prro.2018.11.009_bib17","doi-asserted-by":"crossref","first-page":"72860","DOI":"10.18632\/oncotarget.20529","article-title":"Stereotactic ablative body radiotherapy for spinal metastasis from hepatocellular carcinoma: Its oncologic outcomes and risk of vertebral compression fracture","volume":"8","author":"Yoo","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.prro.2018.11.009_bib18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11060-014-1463-9","article-title":"Clinical result of stereotactic radiosurgery for spinal metastasis from hepatocellular carcinoma: Comparison with conventional radiation therapy","volume":"119","author":"Chang","year":"2014","journal-title":"J Neurooncol"},{"key":"10.1016\/j.prro.2018.11.009_bib19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.prro.2013.05.001","article-title":"RTOG 0631 phase 2\/3 study of image guided stereotactic radiosurgery for localized (1-3) spine metastases: Phase 2 results","volume":"4","author":"Ryu","year":"2014","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.prro.2018.11.009_bib20","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3171\/2010.3.SPINE09459","article-title":"Reliability analysis of the epidural spinal cord compression scale","volume":"13","author":"Bilsky","year":"2010","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.prro.2018.11.009_bib21","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3748\/wjg.v13.i3.414","article-title":"Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma","volume":"13","author":"Uka","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.prro.2018.11.009_bib22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1748-717X-3-11","article-title":"Conventionally-fractionated image-guided intensity modulated radiotherapy (IG-IMRT): A safe and effective treatment for cancer spinal metastasis","volume":"3","author":"Gong","year":"2008","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.prro.2018.11.009_bib23","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1470-2045(11)70384-9","article-title":"Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: A phase 1-2 trial","volume":"13","author":"Wang","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.prro.2018.11.009_bib24","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1097\/BRS.0b013e3181b8b6f5","article-title":"Radiotherapy and radiosurgery for metastatic spine disease","volume":"34","author":"Gerszten","year":"2009","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.prro.2018.11.009_bib25","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1200\/JCO.2012.44.1659","article-title":"Sequential phase I and II trials of stereotactic body radiotherapy for locally advanced hepatocellular carcinoma","volume":"31","author":"Bujold","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.prro.2018.11.009_bib26","doi-asserted-by":"crossref","first-page":"78","DOI":"10.14791\/btrt.2013.1.2.78","article-title":"Treatment options of metastatic brain tumors from hepatocellular carcinoma: Surgical resection vs. Gamma knife radiosurgery vs. whole brain radiation therapy","volume":"1","author":"Park","year":"2013","journal-title":"Brain Tumor Res Treat"},{"key":"10.1016\/j.prro.2018.11.009_bib27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3340\/jkns.2016.59.1.37","article-title":"Radiosurgery compared with external radiation therapy as a primary treatment in spine metastasis from hepatocellular carcinoma: A\u00a0multicenter, matched-pair study","volume":"59","author":"Sohn","year":"2015","journal-title":"J Korean Neurosurg Soc"},{"key":"10.1016\/j.prro.2018.11.009_bib28","doi-asserted-by":"crossref","first-page":"534","DOI":"10.3171\/2014.10.SPINE14444","article-title":"Tumor pseudoprogression of spinal metastasis after radiosurgery: A novel concept and case reports","volume":"22","author":"Taylor","year":"2015","journal-title":"J\u00a0Neurosurg Spine"},{"key":"10.1016\/j.prro.2018.11.009_bib29","doi-asserted-by":"crossref","first-page":"e55313","DOI":"10.1371\/journal.pone.0055313","article-title":"Silencing of APE1 enhances sensitivity of human hepatocellular carcinoma cells to radiotherapy in\u00a0vitro and in a xenograft model","volume":"8","author":"Cun","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.prro.2018.11.009_bib30","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.ijrobp.2011.01.003","article-title":"Sonic hedgehog signaling protects human hepatocellular carcinoma cells against ionizing radiation in an autocrine manner","volume":"80","author":"Chen","year":"2011","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.prro.2018.11.009_bib31","first-page":"7571","article-title":"Mucin 1 promotes radioresistance in hepatocellular carcinoma cells through activation of JAK2\/STAT3 signaling","volume":"14","author":"Yi","year":"2017","journal-title":"Oncol Lett"},{"key":"10.1016\/j.prro.2018.11.009_bib32","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.canlet.2011.10.012","article-title":"CD133+ liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma","volume":"315","author":"Piao","year":"2012","journal-title":"Cancer Lett"},{"key":"10.1016\/j.prro.2018.11.009_bib33","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1158\/1535-7163.MCT-14-0618","article-title":"HAb18G\/CD147 promotes radioresistance in hepatocellular carcinoma cells: A potential role for integrin 1 signaling","volume":"14","author":"Wu","year":"2015","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.prro.2018.11.009_bib34","doi-asserted-by":"crossref","first-page":"e292","DOI":"10.1038\/oncsis.2016.91","article-title":"Egr-1 regulates irradiation-induced autophagy through Atg4B to promote radioresistance in hepatocellular carcinoma cells","volume":"6","author":"Peng","year":"2017","journal-title":"Oncogenesis"},{"key":"10.1016\/j.prro.2018.11.009_bib35","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.ijrobp.2016.07.034","article-title":"A study of pseudoprogression after spine stereotactic body radiation therapy","volume":"96","author":"Bahig","year":"2016","journal-title":"Int J Radiat Oncol"}],"container-title":["Practical Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879850018303461?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879850018303461?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T10:21:24Z","timestamp":1761819684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879850018303461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S1879850018303461"],"URL":"https:\/\/doi.org\/10.1016\/j.prro.2018.11.009","relation":{},"ISSN":["1879-8500"],"issn-type":[{"value":"1879-8500","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of Local Control and Pain Control After Spine Stereotactic Radiosurgery Reveals Inferior Outcomes for Hepatocellular Carcinoma Compared With Other Radioresistant Histologies","name":"articletitle","label":"Article Title"},{"value":"Practical Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prro.2018.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}