{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:13:24Z","timestamp":1780341204056,"version":"3.54.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corp","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["practicalradonc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Practical Radiation Oncology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.prro.2019.12.011","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T11:52:18Z","timestamp":1579607538000},"page":"186-194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Who Benefits From a Prostate Rectal Spacer? Secondary Analysis of a Phase III Trial"],"prefix":"10.1016","volume":"10","author":[{"given":"Thomas J.","family":"Quinn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6355-0710","authenticated-orcid":false,"given":"Stephanie","family":"Daignault-Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7015-7204","authenticated-orcid":false,"given":"Walter","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Mariados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Sylvester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhiren","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6487-6170","authenticated-orcid":false,"given":"Eric","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Hudes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Beyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Kurtzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Bogart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Alex","family":"Hsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Logsdon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Zimberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Forsythe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7595-0332","authenticated-orcid":false,"given":"Edward","family":"Soffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Francke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3107-6705","authenticated-orcid":false,"given":"Constantine","family":"Mantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"DeWeese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiram A.","family":"Gay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0563-3766","authenticated-orcid":false,"given":"Jeff","family":"Michalski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6291-3444","authenticated-orcid":false,"given":"Daniel A.","family":"Hamstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prro.2019.12.011_bib1","first-page":"7","article-title":"Cancer statistics, 2016","volume":"66","author":"Siegel","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.prro.2019.12.011_bib2","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1056\/NEJMoa1606220","article-title":"10-year outcomes after monitoring, surgery, or radiotherapy for localized prostate cancer","volume":"375","author":"Hamdy","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.prro.2019.12.011_bib3","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.ijrobp.2016.12.024","article-title":"Continued benefit to rectal separation for prostate RT: final results of a Phase III Trial","volume":"97","author":"Hamstra","year":"2017","journal-title":"Int J Radiat Onc Biol Phys"},{"key":"10.1016\/j.prro.2019.12.011_bib4","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.ijrobp.2015.04.030","article-title":"Hydrogel spacer prospective multicenter randomized controlled pivotal trial: dosimetric and clinical effects of perirectal spacer application in men undergoing prostate IG-IMRT","volume":"92","author":"Mariados","year":"2015","journal-title":"Int J Radiat Bio Oncol Phys"},{"key":"10.1016\/j.prro.2019.12.011_bib5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.urology.2017.11.016","article-title":"Absorbable hydrogel spacer use in prostate radiotherapy: A comprehensive review of phase 3 clinical trial published data","volume":"115","author":"Karsh","year":"2018","journal-title":"Urology"},{"key":"10.1016\/j.prro.2019.12.011_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.urology.2014.08.044","article-title":"Minimally important difference for the expanded prostate cancer index composite short form","volume":"85","author":"Skolarus","year":"2015","journal-title":"Urology"},{"issue":"3 Suppl","key":"10.1016\/j.prro.2019.12.011_bib18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ijrobp.2009.03.078","article-title":"Radiation dose-volume effects in radiation-induced rectal injury","volume":"76","author":"Michalski","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2019.12.011_bib7","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ejmp.2016.03.003","article-title":"Predicting toxicity in radiotherapy for prostate cancer","volume":"32","author":"Landoni","year":"2016","journal-title":"Physica Medica"},{"key":"10.1016\/j.prro.2019.12.011_bib8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.radonc.2009.08.004","article-title":"Dose-volume effects for normal tissues in external radiotherapy: Pelvis","volume":"93","author":"Fiorino","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.prro.2019.12.011_bib9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijrobp.2018.05.013","article-title":"Predicting late fecal incontinence risk after radiation therapy for prostate cancer: New insights from external independent validation","volume":"102","author":"Cicchetti","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2019.12.011_bib10","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00384-012-1593-5","article-title":"Impact of late anorectal dysfunction on quality of life after pelvic radiotherapy","volume":"28","author":"Krol","year":"2013","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.prro.2019.12.011_bib11","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/cncr.10248","article-title":"The association of treatment-related symptoms with quality-of-life outcomes for localized prostate carcinoma patients","volume":"94","author":"Bacon","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.prro.2019.12.011_bib12","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0360-3016(94)90563-0","article-title":"Neoadjuvant hormonal therapy improves the therapeutic ratio in patients with bulky prostatic cancer treated with three-dimensional conformal radiation therapy","volume":"29","author":"Zelefsky","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2019.12.011_bib13","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/0360-3016(95)02064-0","article-title":"The potential for normal tissue dose reduction with neoadjuvant hormonal therapy in conformal treatment planning for stage C prostate cancer","volume":"33","author":"Yang","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2019.12.011_bib14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1012348","article-title":"Radiotherapy and short-term androgen deprivation for localized prostate cancer","volume":"365","author":"Jones","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.prro.2019.12.011_bib15","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1200\/JCO.2007.13.9881","article-title":"Short-term neoadjuvant androgen deprivation therapy and external-beam radiotherapy for locally advanced prostate cancer: Long-term results of RTOG 8610","volume":"26","author":"Roach","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.prro.2019.12.011_bib16","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.ijrobp.2011.03.056","article-title":"The benefits of including clinical factors in rectal normal tissue complication probability modeling after radiotherapy for prostate cancer","volume":"82","author":"Defraene","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2019.12.011_bib17","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.radonc.2011.06.032","article-title":"Inclusion of clinical risk factors into NTCP modeling of late rectal toxicity after high dose radiotherapy for prostate cancer","volume":"100","author":"Rancati","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.prro.2019.12.011_bib19","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.radonc.2016.08.026","article-title":"Who will benefit most from hydrogel rectum spacer implantation in prostate cancer radiotherapy? A model-based approach for patient selection","volume":"121","author":"Vanneste","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.prro.2019.12.011_bib20","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.radonc.2014.01.007","article-title":"Dose to the inferior rectum is strongly associated with patient reported bowel quality of life after radiation therapy for prostate cancer","volume":"110","author":"Stenmark","year":"2014","journal-title":"Radiother Oncol"}],"container-title":["Practical Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879850020300047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879850020300047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T10:22:15Z","timestamp":1761819735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879850020300047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S1879850020300047"],"URL":"https:\/\/doi.org\/10.1016\/j.prro.2019.12.011","relation":{},"ISSN":["1879-8500"],"issn-type":[{"value":"1879-8500","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Who Benefits From a Prostate Rectal Spacer? Secondary Analysis of a Phase III Trial","name":"articletitle","label":"Article Title"},{"value":"Practical Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prro.2019.12.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}]}}