{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T08:54:08Z","timestamp":1769072048937,"version":"3.49.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"am","delay-in-days":367,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["practicalradonc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Practical Radiation Oncology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.prro.2022.06.012","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T22:45:02Z","timestamp":1657752302000},"page":"e73-e79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Safety and Efficacy of Stereotactic Ablative Radiation Therapy for Renal Cell Cancer: 24-Month Results of the RSR1 Phase 1 Dose Escalation Study"],"prefix":"10.1016","volume":"13","author":[{"given":"Ariane","family":"Lapierre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lionel","family":"Badet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Rouviere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Crehange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Berthiller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Paparel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0347-8598","authenticated-orcid":false,"given":"Olivier","family":"Chapet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.prro.2022.06.012_bib0001","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1148\/radiology.170.3.2644658","article-title":"Renal cell carcinoma: Earlier discovery and increased detection","volume":"170","author":"Smith","year":"1989","journal-title":"Radiology"},{"key":"10.1016\/j.prro.2022.06.012_bib0002","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0090-4295(97)00506-2","article-title":"Increased incidence of serendipitously discovered renal cell carcinoma","volume":"51","author":"Jayson","year":"1998","journal-title":"Urology"},{"key":"10.1016\/j.prro.2022.06.012_bib0003","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1001\/jama.2019.1672","article-title":"Management of small kidney tumors in 2019","volume":"321","author":"Kang","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.prro.2022.06.012_bib0004","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.juro.2007.11.047","article-title":"Excise, ablate or observe: The small renal mass dilemma\u2014a meta-analysis and review","volume":"179","author":"Kunkle","year":"2008","journal-title":"J Urol"},{"key":"10.1016\/j.prro.2022.06.012_bib0005","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.juro.2007.09.077","article-title":"Radical nephrectomy for pT1a renal masses may be associated with decreased overall survival compared with partial nephrectomy","volume":"179","author":"Thompson","year":"2008","journal-title":"J Urol"},{"key":"10.1016\/j.prro.2022.06.012_bib0006","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.juro.2008.09.017","article-title":"Partial nephrectomy versus radical nephrectomy in patients with small renal tumors\u2014is there a difference in mortality and cardiovascular outcomes?","volume":"181","author":"Huang","year":"2009","journal-title":"J Urol"},{"key":"10.1016\/j.prro.2022.06.012_bib0007","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/cncr.24035","article-title":"Radical versus partial nephrectomy: Effect on overall and noncancer mortality","volume":"115","author":"Zini","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.prro.2022.06.012_bib0008","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0022-5347(01)62052-4","article-title":"Partial nephrectomy for unilateral renal carcinoma and a normal contralateral kidney: 10-Year followup","volume":"161","author":"Herr","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.prro.2022.06.012_bib0009","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0022-5347(05)67896-2","article-title":"Long-term results of nephron sparing surgery for localized renal cell carcinoma: 10-year followup","volume":"163","author":"Fergany","year":"2000","journal-title":"J Urol"},{"key":"10.1016\/j.prro.2022.06.012_bib0010","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1016\/S0022-5347(01)66032-4","article-title":"Disease outcome in patients with low stage renal cell carcinoma treated with nephron sparing or radical surgery","volume":"155","author":"Lerner","year":"1996","journal-title":"J Urol"},{"key":"10.1016\/j.prro.2022.06.012_bib0011","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0022-5347(05)67793-2","article-title":"Surgical management of renal tumors 4 cm or less in a contemporary cohort","volume":"163","author":"Lee","year":"2000","journal-title":"J Urol"},{"key":"10.1016\/j.prro.2022.06.012_bib0012","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.eururo.2019.02.011","article-title":"European Association of Urology guidelines on renal cell carcinoma: The 2019 update","volume":"75","author":"Ljungberg","year":"2019","journal-title":"Eur Urol"},{"key":"10.1016\/j.prro.2022.06.012_bib0013","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/S0090-4295(00)00752-4","article-title":"Laparoscopic renal cryoablation in 32 patients","volume":"56","author":"Gill","year":"2000","journal-title":"Urology"},{"key":"10.1016\/j.prro.2022.06.012_bib0014","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0090-4295(02)02004-6","article-title":"Retroperitoneal laparoscopic cryoablation of small renal tumors: Intermediate results","volume":"61","author":"Lee","year":"2003","journal-title":"Urology"},{"key":"10.1016\/j.prro.2022.06.012_bib0015","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0022-5347(05)66523-8","article-title":"Percutaneous renal tumor cryoablation with magnetic resonance imaging guidance","volume":"165","author":"Shingleton","year":"2001","journal-title":"J Urol"},{"key":"10.1016\/j.prro.2022.06.012_bib0016","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0022-5347(05)64032-3","article-title":"Laparoscopic application of radio frequency energy enables in situ renal tumor ablation and partial nephrectomy","volume":"169","author":"Jacomides","year":"2003","journal-title":"J Urol"},{"key":"10.1016\/j.prro.2022.06.012_bib0017","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S0090-4295(02)02096-4","article-title":"Percutaneous radiofrequency ablation of renal tumors: Technique, limitations, and morbidity","volume":"60","author":"Ogan","year":"2002","journal-title":"Urology"},{"key":"10.1016\/j.prro.2022.06.012_bib0018","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1148\/radiol.2262012062","article-title":"Renal cell carcinoma: Clinical experience and technical success with radio-frequency ablation of 42 tumors","volume":"226","author":"Gervais","year":"2003","journal-title":"Radiology"},{"key":"10.1016\/j.prro.2022.06.012_bib0019","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0022-5347(05)65371-2","article-title":"Percutaneous radio frequency ablation of small renal tumors: Initial results","volume":"167","author":"Pavlovich","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.prro.2022.06.012_bib0020","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.eururo.2012.02.039","article-title":"Systematic review of oncological outcomes following surgical management of localised renal cancer","volume":"61","author":"MacLennan","year":"2012","journal-title":"Eur Urol"},{"key":"10.1016\/j.prro.2022.06.012_bib0021","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ijrobp.2009.09.042","article-title":"American Society for Therapeutic Radiology and Oncology (ASTRO) and American College of Radiology (ACR) practice guideline for the performance of stereotactic body radiation therapy","volume":"76","author":"Potters","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2022.06.012_bib0022","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1200\/JCO.2006.09.7469","article-title":"Stereotactic body radiation therapy in multiple organ sites","volume":"25","author":"Timmerman","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.prro.2022.06.012_bib0023","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/neuonc\/now241","article-title":"Diagnosis and treatment of brain metastases from solid tumors: Guidelines from the European Association of Neuro-Oncology (EANO)","volume":"19","author":"Soffietti","year":"2017","journal-title":"Neuro-Oncol"},{"key":"10.1016\/j.prro.2022.06.012_bib0024","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/cncr.31196","article-title":"Surgery versus stereotactic body radiation therapy for stage I non-small cell lung cancer: A comprehensive review","volume":"124","author":"Tandberg","year":"2018","journal-title":"Cancer"},{"key":"10.1016\/j.prro.2022.06.012_bib0025","doi-asserted-by":"crossref","first-page":"e502","DOI":"10.1016\/j.wneu.2017.10.011","article-title":"Radiosurgery for treatment of renal cell metastases to spine: A systematic review of the literature","volume":"109","author":"Smith","year":"2018","journal-title":"World Neurosurg"},{"key":"10.1016\/j.prro.2022.06.012_bib0026","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.canrad.2017.07.040","article-title":"Radioth\u00e9rapie en conditions st\u00e9r\u00e9otaxiques des tumeurs h\u00e9patiques: \u00c9tat de l'art","volume":"21","author":"Riou","year":"2017","journal-title":"Cancer\/Radioth\u00e9rapie"},{"key":"10.1016\/j.prro.2022.06.012_bib0027","doi-asserted-by":"crossref","first-page":"e170","DOI":"10.1016\/S1470-2045(13)70569-2","article-title":"Radiotherapy for renal-cell carcinoma","volume":"15","author":"De Meerleer","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.prro.2022.06.012_bib0028","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/(SICI)1097-0142(19990101)85:1<251::AID-CNCR42>3.0.CO;2-Y","article-title":"Stereotactic radiosurgery for brain metastasis from renal cell carcinoma","volume":"85","author":"Nieder","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/j.prro.2022.06.012_bib0029","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0360-3016(00)00536-8","article-title":"The role of whole brain radiotherapy and stereotactic radiosurgery on brain metastases from renal cell carcinoma","volume":"47","author":"Goyal","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2022.06.012_bib0030","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.radonc.2005.03.022","article-title":"Extracranial stereotactic radiotherapy for primary and metastatic renal cell carcinoma","volume":"77","author":"Wers\u00e4ll","year":"2005","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"10.1016\/j.prro.2022.06.012_bib0031","doi-asserted-by":"crossref","first-page":"S349","DOI":"10.1016\/j.ijrobp.2006.07.656","article-title":"2249: Hypo-fractionated stereotactic extra-cranial radiosurgery(HFSR) for primary and metastatic renal cell carcinoma","volume":"66","author":"Gilson","year":"2006","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.prro.2022.06.012_bib0032","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1080\/02841860600954875","article-title":"A prospective phase II trial of using extracranial stereotactic radiotherapy in primary and metastatic renal cell carcinoma","volume":"45","author":"Svedman","year":"2006","journal-title":"Acta Oncol"},{"key":"10.1016\/j.prro.2022.06.012_bib0033","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1080\/02841860802123196","article-title":"Stereotactic body radiotherapy of primary and metastatic renal lesions for patients with only one functioning kidney","volume":"47","author":"Svedman","year":"2008","journal-title":"Acta Oncol"},{"key":"10.1016\/j.prro.2022.06.012_bib0034","first-page":"e6","article-title":"The treatment of primary and metastatic renal cell carcinoma (RCC) with image-guided stereotactic body radiation therapy (SBRT)","volume":"3","author":"Teh","year":"2007","journal-title":"Biomed Imaging Interv J"},{"key":"10.1016\/j.prro.2022.06.012_bib0035","doi-asserted-by":"crossref","first-page":"S283","DOI":"10.1016\/S0360-3016(03)01136-2","article-title":"Stereotactic extra-cranial radiosurgery for renal cell carcinoma","volume":"57","author":"Qian","year":"2003","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.prro.2022.06.012_bib0036","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1016\/j.ijrobp.2013.06.218","article-title":"A phase 1 dose-escalation study of robotic radiosurgery in inoperable primary renal cell carcinoma","volume":"87","author":"McBride","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2022.06.012_bib0037","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3892\/ol.2014.2129","article-title":"Novel application of stereotactic ablative radiotherapy using CyberKnife\u00ae for early-stage renal cell carcinoma in patients with pre-existing chronic kidney disease: Initial clinical experiences","volume":"8","author":"Lo","year":"2014","journal-title":"Oncol Lett"},{"key":"10.1016\/j.prro.2022.06.012_bib0038","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.radonc.2015.08.030","article-title":"Phase I dose-escalation study of stereotactic body radiotherapy (SBRT) for poor surgical candidates with localized renal cell carcinoma","volume":"117","author":"Ponsky","year":"2015","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"10.1016\/j.prro.2022.06.012_bib0039","first-page":"6944","article-title":"CyberKnife for inoperable renal tumors: Canadian pioneering experience","volume":"20","author":"Nair","year":"2013","journal-title":"Can J Urol"},{"key":"10.1016\/j.prro.2022.06.012_bib0040","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.ijrobp.2014.07.043","article-title":"Stereotactic ablative body radiation therapy for primary kidney cancer: A 3-dimensional conformal technique associated with low rates of early toxicity","volume":"90","author":"Pham","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2022.06.012_bib0041","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.juro.2014.08.044","article-title":"Single fraction radiosurgery for the treatment of renal tumors","volume":"193","author":"Staehler","year":"2015","journal-title":"J Urol"},{"key":"10.1016\/j.prro.2022.06.012_bib0042","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/bju.13811","article-title":"Stereotactic ablative body radiotherapy for inoperable primary kidney cancer: A prospective clinical trial","volume":"120","author":"Siva","year":"2017","journal-title":"BJU Int"},{"key":"10.1016\/j.prro.2022.06.012_bib0043","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1016\/j.clon.2016.04.002","article-title":"Stereotactic ablative body radiotherapy for primary renal cell carcinoma in non-surgical candidates: Initial clinical experience","volume":"28","author":"Chang","year":"2016","journal-title":"Clin Oncol R Coll Radiol G B"},{"key":"10.1016\/j.prro.2022.06.012_bib0044","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12894-019-0531-z","article-title":"Robotic stereotactic ablative radiotherapy for renal cell carcinoma in patients with impaired renal function","volume":"19","author":"Senger","year":"2019","journal-title":"BMC Urol"},{"key":"10.1016\/j.prro.2022.06.012_bib0045","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/cncr.31156","article-title":"Pooled analysis of stereotactic ablative radiotherapy for primary renal cell carcinoma: A report from the International Radiosurgery Oncology Consortium for Kidney (IROCK)","volume":"124","author":"Siva","year":"2018","journal-title":"Cancer"},{"key":"10.1016\/j.prro.2022.06.012_bib0046","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.2215\/CJN.11941116","article-title":"Renal functional outcomes after surgery, ablation, and active surveillance of localized renal tumors: A systematic review and meta-analysis","volume":"12","author":"Patel","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.prro.2022.06.012_bib0047","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3109\/02656736.2012.728017","article-title":"Thermal ablation in renal cell carcinoma: What affects renal function?","volume":"28","author":"Park","year":"2012","journal-title":"Int J Hyperthermia"}],"container-title":["Practical Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879850022002077?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879850022002077?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T10:25:23Z","timestamp":1761819923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879850022002077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S1879850022002077"],"URL":"https:\/\/doi.org\/10.1016\/j.prro.2022.06.012","relation":{},"ISSN":["1879-8500"],"issn-type":[{"value":"1879-8500","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and Efficacy of Stereotactic Ablative Radiation Therapy for Renal Cell Cancer: 24-Month Results of the RSR1 Phase 1 Dose Escalation Study","name":"articletitle","label":"Article Title"},{"value":"Practical Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prro.2022.06.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}