{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T10:32:13Z","timestamp":1767695533629,"version":"3.48.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["practicalradonc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Practical Radiation Oncology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.prro.2025.06.003","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T07:02:35Z","timestamp":1751007755000},"page":"40-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Staged I-125 Eye Plaque Brachytherapy for the Treatment of Large Uveal Melanoma: A Single Institution Experience"],"prefix":"10.1016","volume":"16","author":[{"given":"Kevin","family":"Tran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy C.","family":"Schefler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey N.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devin","family":"Olek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Chuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramiro","family":"Pino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward Brian","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin S.","family":"Teh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.prro.2025.06.003_bib0001","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41571-022-00714-1","article-title":"Advances in the clinical management of uveal melanoma","volume":"20","author":"Carvajal","year":"2023","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.prro.2025.06.003_bib0002","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2147\/OPTH.S89591","article-title":"Uveal melanoma: Epidemiology, etiology, and treatment of primary disease","volume":"11","author":"Krantz","year":"2017","journal-title":"Clin Ophthalmol"},{"year":"2023","series-title":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae)","key":"10.1016\/j.prro.2025.06.003_bib0003"},{"key":"10.1016\/j.prro.2025.06.003_bib0004","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0002-9394(98)00039-7","article-title":"The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma II: initial mortality findings. COMS report no. 10","volume":"125","year":"1998","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.prro.2025.06.003_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brachy.2013.11.008","article-title":"The American Brachytherapy Society consensus guidelines for plaque brachytherapy of uveal melanoma and retinoblastoma","volume":"13","year":"2014","journal-title":"Brachytherapy"},{"key":"10.1016\/j.prro.2025.06.003_bib0006","doi-asserted-by":"crossref","first-page":"303","DOI":"10.5114\/jcb.2020.98108","article-title":"Eye plaque brachytherapy versus enucleation for ocular melanoma: an analysis from the National Cancer Database","volume":"12","author":"Messer","year":"2020","journal-title":"J Contemp Brachytherapy"},{"key":"10.1016\/j.prro.2025.06.003_bib0007","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1159\/000495249","article-title":"Iodine-125 episcleral plaque brachytherapy for AJCC T4 posterior uveal melanoma: Clinical outcomes in 158 patients","volume":"5","author":"King","year":"2019","journal-title":"Ocul Oncol Pathol"},{"key":"10.1016\/j.prro.2025.06.003_bib0008","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/S0161-6420(03)00661-4","article-title":"Iodine brachytherapy as an alternative to enucleation for large uveal melanomas","volume":"110","author":"Puusaari","year":"2003","journal-title":"Ophthalmology"},{"key":"10.1016\/j.prro.2025.06.003_bib0009","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1001\/jamaophthalmol.2013.5677","article-title":"Palladium-103 plaque radiation therapy for American Joint Committee on Cancer T3- and T4-staged choroidal melanomas","volume":"132","author":"Semenova","year":"2014","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.prro.2025.06.003_bib0010","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.ijrobp.2006.01.020","article-title":"Proton beam radiotherapy for uveal melanoma: Results of Curie Institut-Orsay Proton Therapy Center (ICPO)","volume":"65","author":"Dendale","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2025.06.003_bib0011","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1001\/archopht.124.6.838","article-title":"Estimates of ocular and visual retention following treatment of extra-large uveal melanomas by proton beam radiotherapy","volume":"124","author":"Conway","year":"2006","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.prro.2025.06.003_bib0012","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ajo.2016.02.027","article-title":"Outcomes after proton beam therapy for large choroidal melanomas in 492 patients","volume":"165","author":"Bensoussan","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.prro.2025.06.003_bib0013","first-page":"1194","article-title":"Outcomes of treatment with stereotactic radiosurgery or proton beam therapy for choroidal melanoma","volume":"29","author":"Sikuade","year":"2015","journal-title":"Eye (Basingstoke)"},{"key":"10.1016\/j.prro.2025.06.003_bib0014","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.ijrobp.2005.01.016","article-title":"Proton beam radiotherapy of choroidal melanoma: The Liverpool-Clatterbridge experience","volume":"62","author":"Damato","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2025.06.003_bib0015","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0360-3016(02)04200-1","article-title":"Eye retention after proton beam radiotherapy for uveal melanoma","volume":"55","author":"Egger","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2025.06.003_bib0016","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1136\/bjophthalmol-2013-304031","article-title":"Local tumour control and eye preservation after gamma-knife radiosurgery of choroidal melanomas","volume":"98","author":"Wackernagel","year":"2014","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.prro.2025.06.003_bib0017","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/CMR.0000000000000689","article-title":"Clinical outcomes and secondary glaucoma after gamma-knife radiosurgery and Ruthenium-106 brachytherapy for uveal melanoma: a single institution experience","volume":"31","author":"Mazzini","year":"2021","journal-title":"Melanoma Res"},{"key":"10.1016\/j.prro.2025.06.003_bib0018","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000501971","article-title":"Gamma knife radiosurgery for uveal melanoma: A retrospective review of clinical complications in a tertiary referral center","volume":"6","author":"Modorati","year":"2020","journal-title":"Ocul Oncol Pathol"},{"key":"10.1016\/j.prro.2025.06.003_bib0019","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/CMR.0000000000000023","article-title":"Quality of life in the follow-up of uveal melanoma patients after CyberKnife treatment","volume":"23","author":"Klingenstein","year":"2013","journal-title":"Melanoma Res"},{"key":"10.1016\/j.prro.2025.06.003_bib0020","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ijrobp.2010.04.035","article-title":"Local tumor control, visual acuity, and survival after hypofractionated stereotactic photon radiotherapy of choroidal melanoma in 212 patients treated between 1997 and 2007","volume":"81","author":"Dunavoelgyi","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2025.06.003_bib0021","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.ijrobp.2013.02.005","article-title":"Dosimetric and late radiation toxicity comparison between iodine-125 brachytherapy and stereotactic radiation therapy for juxtapapillary choroidal melanoma","volume":"86","author":"Krema","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2025.06.003_bib0022","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4274\/tjo.galenos.2019.78370","article-title":"Early results of stereotactic radiosurgery in uveal melanoma and risk factors for radiation retinopathy","volume":"50","author":"\u00d6zcan","year":"2020","journal-title":"Turk J Ophthalmol"},{"key":"10.1016\/j.prro.2025.06.003_bib0023","article-title":"Staged eye-plaque brachytherapy: A novel approach for large uveal melanoma","volume":"6","author":"Chevli","year":"2021","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.prro.2025.06.003_bib0024","doi-asserted-by":"crossref","first-page":"e671","DOI":"10.1016\/j.ijrobp.2023.06.2119","article-title":"Radiobiological insights of staged brachytherapy using eye plaque for large uveal melanoma","volume":"117","author":"He","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2025.06.003_bib0025","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1167\/iovs.04-0066","article-title":"Effect of radiation dose on ocular complications after iodine brachytherapy for large uveal melanoma: empirical data and simulation of collimating plaques","volume":"45","author":"Puusaari","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.prro.2025.06.003_bib0026","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/950975","article-title":"Outcomes and control rates for I-125 plaque brachytherapy for uveal melanoma: A community-based institutional experience","volume":"2014","author":"Wagner","year":"2014","journal-title":"ISRN Ophthalmol"},{"key":"10.1016\/j.prro.2025.06.003_bib0027","doi-asserted-by":"crossref","first-page":"123","DOI":"10.5114\/jcb.2018.75597","article-title":"Visual outcome after posterior uveal melanoma episcleral brachytherapy including radiobiological doses","volume":"10","author":"Miguel","year":"2018","journal-title":"J Contemp Brachytherapy"},{"key":"10.1016\/j.prro.2025.06.003_bib0028","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3390\/cancers15020333","article-title":"Ocular complications of radiotherapy in uveal melanoma","volume":"15","author":"Zemba","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.prro.2025.06.003_bib0029","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1097\/IAE.0000000000002144","article-title":"Large uveal melanoma (\u226510 mm thickness): Clinical features and millimeter-by-millimeter risk of metastasis in 1311 cases. The 2018 Albert E. Finley Lecture","volume":"38","author":"Shields","year":"2018","journal-title":"Retina"},{"key":"10.1016\/j.prro.2025.06.003_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101041","article-title":"Metastatic uveal melanoma: the final frontier","volume":"90","author":"Rantala","year":"2022","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.prro.2025.06.003_bib0031","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.ophtha.2012.02.017","article-title":"Collaborative ocular oncology group report number 1: prospective validation of a multi-gene prognostic assay in uveal melanoma","volume":"119","author":"Onken","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.prro.2025.06.003_bib0032","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2353\/jmoldx.2010.090220","article-title":"An accurate, clinically feasible multi-gene expression assay for predicting metastasis in uveal melanoma","volume":"12","author":"Onken","year":"2010","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.prro.2025.06.003_bib0033","unstructured":"Harbour JW, Chen R. The DecisionDx-UM gene expression profile test provides risk stratification and individualized patient care in uveal melanoma. PLoS Curr. 2013(Apr 2013);5:ecurrents.eogt.af8ba80fc776c8f1ce8f5dc485d4a618."},{"key":"10.1016\/j.prro.2025.06.003_bib0034","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1158\/1078-0432.CCR-15-2071","article-title":"PRAME as an independent biomarker for metastasis in uveal melanoma","volume":"22","author":"Field","year":"2016","journal-title":"Clin Cancer Res"}],"container-title":["Practical Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879850025001651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879850025001651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T10:30:50Z","timestamp":1767695450000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879850025001651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1879850025001651"],"URL":"https:\/\/doi.org\/10.1016\/j.prro.2025.06.003","relation":{},"ISSN":["1879-8500"],"issn-type":[{"type":"print","value":"1879-8500"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Staged I-125 Eye Plaque Brachytherapy for the Treatment of Large Uveal Melanoma: A Single Institution Experience","name":"articletitle","label":"Article Title"},{"value":"Practical Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prro.2025.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}]}}