{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:44:31Z","timestamp":1791837871302,"version":"4.3.4"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH\/NIBIB K08EB026503"],"award-info":[{"award-number":["NIH\/NIBIB K08EB026503"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR000100"],"award-info":[{"award-number":["UL1TR000100"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000892","name":"Prostate Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001960","name":"American Society for Radiation Oncology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001960","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004064","name":"Prostate Cancer Research and Education Foundation","doi-asserted-by":"publisher","award":["ASTRO-PCF #PCF20YOUN01"],"award-info":[{"award-number":["ASTRO-PCF #PCF20YOUN01"]}],"id":[{"id":"10.13039\/100004064","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","practicalradonc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Practical Radiation Oncology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.prro.2026.07.014","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:29:02Z","timestamp":1790710142000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Androgen Deprivation Therapy and Radiation Therapy With Imaging Evaluation Longitudinally Trial: Protocol, Early Results, and Implications of Neoadjuvant Androgen Deprivation Therapy for Focal Radiation Therapy Boost in Prostate Cancer"],"prefix":"10.1016","author":[{"given":"Yuze","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1386-4636","authenticated-orcid":false,"given":"Mariluz","family":"Rojo Domingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Conlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Dhillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Son","family":"Do","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Dornisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan","family":"Karunamuni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Lung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana R.","family":"McKay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren K.","family":"Mell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno J.","family":"Mundt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund M.","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhea","family":"Rupareliya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadley","family":"Schaub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Schwartzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders M.","family":"Dale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4089-7399","authenticated-orcid":false,"given":"Tyler M.","family":"Seibert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Sandhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Urbanic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil J.","family":"Advani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prro.2026.07.014_bib0001","doi-asserted-by":"crossref","first-page":"469","DOI":"10.6004\/jnccn.2025.0052","article-title":"Prostate cancer, version 3.2026, NCCN clinical practice guidelines in oncology","volume":"23","author":"Spratt","year":"2025","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.prro.2026.07.014_bib0002","doi-asserted-by":"crossref","DOI":"10.1148\/rycan.210115","article-title":"A multicompartmental diffusion model for improved assessment of whole-body diffusion-weighted imaging data and evaluation of prostate cancer bone metastases","volume":"5","author":"Conlin","year":"2023","journal-title":"Radiol Imaging Cancer"},{"key":"10.1016\/j.prro.2026.07.014_bib0003","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.euros.2022.11.009","article-title":"Automated patient-level prostate cancer detection with quantitative diffusion magnetic resonance imaging","volume":"47","author":"Zhong","year":"2023","journal-title":"Eur Urol Open Sci."},{"key":"10.1016\/j.prro.2026.07.014_bib0004","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/jmri.27623","article-title":"Voxel-level classification of prostate cancer on magnetic resonance imaging: Improving accuracy using four-compartment restriction spectrum imaging","volume":"54","author":"Feng","year":"2021","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.prro.2026.07.014_bib0005","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/JU.0000000000004611","article-title":"Restriction spectrum imaging as a quantitative biomarker for prostate cancer with reliable positive predictive value","volume":"214","author":"Domingo","year":"2025","journal-title":"J Urol"},{"key":"10.1016\/j.prro.2026.07.014_bib0006","doi-asserted-by":"crossref","DOI":"10.1002\/acm2.14514","article-title":"Quantitative MRI biomarker for classification of clinically significant prostate cancer: Calibration for reproducibility across echo times","volume":"25","author":"Kallis","year":"2024","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.prro.2026.07.014_bib0007","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s40644-024-00723-6","article-title":"Comparison of synthesized and acquired high b-value diffusion-weighted MRI for detection of prostate cancer","volume":"24","author":"Kallis","year":"2024","journal-title":"Cancer Imaging"},{"key":"10.1016\/j.prro.2026.07.014_bib0008","first-page":"26","article-title":"Systematic effects of patient factors and scanner\/protocol factors on a Restriction Spectrum Imaging (RSI) quantitative MRI biomarker for prostate cancer","author":"Do","year":"2026","journal-title":"Cancer Imag"},{"key":"10.1016\/j.prro.2026.07.014_bib0009","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1200\/JCO.20.02873","article-title":"Focal boost to the intraprostatic tumor in external beam radiotherapy for patients with localized prostate cancer: Results from the FLAME randomized phase III trial","volume":"39","author":"Kerkmeijer","year":"2021","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.prro.2026.07.014_bib0010","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s13014-023-02375-5","article-title":"Use of focal radiotherapy boost for prostate cancer: Radiation oncologists\u2019 perspectives and perceived barriers to implementation","volume":"18","author":"Zhong","year":"2023","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.prro.2026.07.014_bib0011","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s00345-023-04745-w","article-title":"Focal radiotherapy boost to MR-visible tumor for prostate cancer: A systematic review","volume":"42","author":"Dornisch","year":"2024","journal-title":"World J Urol"},{"key":"10.1016\/j.prro.2026.07.014_bib0012","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-82742-8","article-title":"Utility of quantitative measurement of T2 using restriction spectrum imaging for detection of clinically significant prostate cancer","volume":"14","author":"Rojo Domingo","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.prro.2026.07.014_bib0013","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.ijrobp.2011.07.009","article-title":"PSA nadir of <0.5 ng\/mL following brachytherapy for early-stage prostate adenocarcinoma is associated with freedom from prostate-specific antigen failure","volume":"83","author":"Ko","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2026.07.014_bib0014","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijrobp.2025.03.024","article-title":"Multidisciplinary consensus prostate contours on magnetic resonance imaging: Educational Atlas and reference standard for artificial intelligence benchmarking","volume":"123","author":"Song","year":"2025","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2026.07.014_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2025.111333","article-title":"PURE-MRI: An international study assessing physician accuracy in delineating the prostate and urethra on prostate MRI","volume":"216","author":"Nguyen","year":"2026","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.prro.2026.07.014_bib0016","first-page":"e608","article-title":"Prostate auto-segmentation model for MRI with or without Hydrogel Spacer","volume":"123","author":"Song","year":"2025","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2026.07.014_bib0017","first-page":"2062","article-title":"PI-RADS v2.1: What has changed and how to report","volume":"25","author":"Scott","year":"2021","journal-title":"SA J Radiol"},{"key":"10.1016\/j.prro.2026.07.014_bib0018","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/mrm.23062","article-title":"DCE and DW MRI in monitoring response to androgen deprivation therapy in patients with prostate cancer: A feasibility study","volume":"67","author":"Barrett","year":"2012","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.prro.2026.07.014_bib0019","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0167-8140(03)00031-8","article-title":"Neoadjuvant androgen deprivation and prostate gland shrinkage during conformal radiotherapy","volume":"66","author":"Sanguineti","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.prro.2026.07.014_bib0020","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1007\/s00330-015-3688-1","article-title":"Prostate cancer: Assessing the effects of androgen-deprivation therapy using quantitative multi-parametric MRI","volume":"25","author":"H\u00f6tker","year":"2015","journal-title":"Eur Radiol"},{"key":"10.1016\/j.prro.2026.07.014_bib0021","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ijrobp.2009.02.019","article-title":"Radiographic and anatomic basis for prostate contouring errors and methods to improve prostate contouring accuracy","volume":"76","author":"McLaughlin","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.prro.2026.07.014_bib0022","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1200\/JCO.20.02438","article-title":"Prostate radiotherapy with adjuvant androgen deprivation therapy (ADT) improves metastasis-free survival compared to neoadjuvant ADT: An individual patient meta-analysis","volume":"39","author":"Spratt","year":"2021","journal-title":"J Clin Oncol"}],"container-title":["Practical Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879850026002717?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879850026002717?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:45:30Z","timestamp":1791834330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879850026002717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":22,"alternative-id":["S1879850026002717"],"URL":"https:\/\/doi.org\/10.1016\/j.prro.2026.07.014","relation":{},"ISSN":["1879-8500"],"issn-type":[{"value":"1879-8500","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Androgen Deprivation Therapy and Radiation Therapy With Imaging Evaluation Longitudinally Trial: Protocol, Early Results, and Implications of Neoadjuvant Androgen Deprivation Therapy for Focal Radiation Therapy Boost in Prostate Cancer","name":"articletitle","label":"Article Title"},{"value":"Practical Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.prro.2026.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}]}}