{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:40:52Z","timestamp":1792521652040,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Respiratory Reviews"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.prrv.2005.11.009","type":"journal-article","created":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T16:35:09Z","timestamp":1138379709000},"page":"2-8","source":"Crossref","is-referenced-by-count":89,"title":["The physiology of cough"],"prefix":"10.1016","volume":"7","author":[{"given":"Anne B.","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.prrv.2005.11.009_bib1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/thorax.58.4.339","article-title":"Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ)","volume":"58","author":"Birring","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2005.11.009_bib2","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1378\/chest.121.4.1123","article-title":"Evaluation of a cough-specific quality-of-life questionnaire","volume":"121","author":"French","year":"2002","journal-title":"Chest"},{"key":"10.1016\/j.prrv.2005.11.009_bib3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/fampra\/10.2.193","article-title":"Why do mothers consult when their children cough?","volume":"10","author":"Cornford","year":"1993","journal-title":"Fam Pract"},{"key":"10.1016\/j.prrv.2005.11.009_bib4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1136\/adc.79.5.465","article-title":"Cough, wheeze and sleep","volume":"79","author":"Davies","year":"1998","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.prrv.2005.11.009_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1136\/adc.82.4.327","article-title":"What do parents of wheezy children understand by \u201cwheeze\u201d?","volume":"82","author":"Cane","year":"2000","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.prrv.2005.11.009_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1465-9921-6-3","article-title":"Cough quality in children: a comparison of subjective vs. bronchoscopic findings","volume":"6","author":"Chang","year":"2005","journal-title":"Respir Res"},{"key":"10.1016\/j.prrv.2005.11.009_bib7","doi-asserted-by":"crossref","unstructured":"McCool FD. Global physiology and pathophysiology of cough. Chest 2006; in press.","DOI":"10.1378\/chest.129.1_suppl.48S"},{"key":"10.1016\/j.prrv.2005.11.009_bib8","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1152\/jappl.1994.77.4.1577","article-title":"Effect of enhanced supramaximal flows on cough clearance","volume":"77","author":"Bennett","year":"1994","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.prrv.2005.11.009_bib9","first-page":"739","article-title":"Effects of postural drainage, exercise and cough on mucus clearance in chronic bronchitis","volume":"120","author":"Oldenburg","year":"1979","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.prrv.2005.11.009_bib10","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1152\/jappl.1977.43.1.46","article-title":"Effects of exercise and eucapnic hyperventilation on bronchial clearance","volume":"43","author":"Wolff","year":"1977","journal-title":"J Appl Physiol"},{"issue":"Suppl 10","key":"10.1016\/j.prrv.2005.11.009_bib11","first-page":"47s","article-title":"The origin of cough sounds","volume":"23","author":"Korpas","year":"1987","journal-title":"Bull Eur Physiopathol Respir"},{"key":"10.1016\/j.prrv.2005.11.009_bib12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.1440-1843.2003.00432.x","article-title":"Influence of the rheological properties of airway mucus on cough sound generation","volume":"8","author":"Hashimoto","year":"2003","journal-title":"Respirology"},{"key":"10.1016\/j.prrv.2005.11.009_bib13","series-title":"Applied Respiratory Physiology","article-title":"Non-elastic resistance to gas flow","author":"Nunn","year":"1993"},{"key":"10.1016\/j.prrv.2005.11.009_bib14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0954-6111(05)80313-0","article-title":"Influence of simulated mucus on cough sounds in cats","volume":"87","author":"Korpas","year":"1993","journal-title":"Respir Med"},{"key":"10.1016\/j.prrv.2005.11.009_bib15","doi-asserted-by":"crossref","unstructured":"Canning BJ. Anatomy and neurophysiology of the cough reflex. Chest 2006; in press.","DOI":"10.1378\/chest.129.1_suppl.33S"},{"key":"10.1016\/j.prrv.2005.11.009_bib16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/pupt.2002.0362","article-title":"Physiology and plasticity of putative cough fibres in the Guinea pig","volume":"15","author":"Undem","year":"2002","journal-title":"Pulmon Pharmacol Ther"},{"key":"10.1016\/j.prrv.2005.11.009_bib17","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.pupt.2004.09.006","article-title":"Cough in chronic obstructive pulmonary disease","volume":"17","author":"Smith","year":"2004","journal-title":"Pulmon Pharmacol Ther"},{"key":"10.1016\/j.prrv.2005.11.009_bib18","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.pupt.2004.09.021","article-title":"Sensory regulation of the cough reflex","volume":"17","author":"Mazzone","year":"2004","journal-title":"Pulmon Pharmacol Ther"},{"key":"10.1016\/j.prrv.2005.11.009_bib19","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1113\/jphysiol.2003.057885","article-title":"Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs","volume":"557","author":"Canning","year":"2004","journal-title":"J Physiol"},{"key":"10.1016\/j.prrv.2005.11.009_bib20","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1164\/rccm.200310-1376OC","article-title":"Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests","volume":"169","author":"Smith","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.prrv.2005.11.009_bib21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.pupt.2004.09.025","article-title":"Ionotropic and metabotropic receptor mediated airway sensory nerve activation","volume":"17","author":"Lee","year":"2004","journal-title":"Pulmon Pharmacol Ther"},{"key":"10.1016\/j.prrv.2005.11.009_bib22","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.pupt.2004.09.022","article-title":"Production of reflex cough by brainstem respiratory networks","volume":"17","author":"Shannon","year":"2004","journal-title":"Pulmon Pharmacol Ther"},{"key":"10.1016\/j.prrv.2005.11.009_bib23","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1152\/jappl.1988.65.3.1007","article-title":"Afferent neural pathways in cough and reflex bronchoconstriction","volume":"65","author":"Karlsson","year":"1988","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.prrv.2005.11.009_bib24","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1164\/ajrccm\/145.5.1191","article-title":"Regional sensitivity of human airways to capsaicin-induced cough","volume":"145","author":"Hansson","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.prrv.2005.11.009_bib25","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1183\/09031936.95.08071193","article-title":"Neurophysiology of the cough reflex","volume":"8","author":"Widdicombe","year":"1995","journal-title":"Eur Respir J"},{"key":"10.1016\/j.prrv.2005.11.009_bib26","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1164\/ajrccm.164.5.16451","article-title":"The race to explore the pathway to cough: who won the silver medal?","volume":"164","author":"Widdicombe","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.prrv.2005.11.009_bib27","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1177\/000348947608500315","article-title":"Ear-cough (Arnold's) reflex","volume":"85","author":"Bloustine","year":"1976","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.prrv.2005.11.009_bib28","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.pupt.2004.09.008","article-title":"Plasticity of central mechanisms for cough","volume":"17","author":"Bonham","year":"2004","journal-title":"Pulmon Pharmacol Ther"},{"key":"10.1016\/j.prrv.2005.11.009_bib29","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1152\/jappl.1985.59.2.515","article-title":"Flow limitation, cough, and patterns of aerosol deposition in humans","volume":"59","author":"Smaldone","year":"1985","journal-title":"J Appl Physiol"},{"issue":"Suppl 10","key":"10.1016\/j.prrv.2005.11.009_bib30","first-page":"11s","article-title":"Glottic closure and high flows are not essential for productive cough","volume":"23","author":"Young","year":"1987","journal-title":"Bull Eur Physiopathol Respir"},{"key":"10.1016\/j.prrv.2005.11.009_bib31","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1164\/ajrccm.160.5.9901093","article-title":"Coughing in laryngectomized patients","volume":"160","author":"Fontana","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.prrv.2005.11.009_bib32","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1152\/jappl.1990.69.5.1670","article-title":"Cough-enhanced mucus clearance in the normal lung","volume":"69","author":"Bennett","year":"1990","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.prrv.2005.11.009_bib33","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1136\/bmj.328.7447.1062","article-title":"Acute cough in children","volume":"328","author":"Hay","year":"2004","journal-title":"BMJ"},{"issue":"Suppl 8A","key":"10.1016\/j.prrv.2005.11.009_bib34","doi-asserted-by":"crossref","first-page":"69S","DOI":"10.1016\/S0002-9343(01)00860-9","article-title":"Maturation and transformation of reflexes that protect the laryngeal airway from liquid aspiration from fetal to adult life","volume":"111","author":"Thach","year":"2001","journal-title":"Am J Med"},{"key":"10.1016\/j.prrv.2005.11.009_bib35","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/icb.1995.62","article-title":"Modifiers of the human mucosal immune system","volume":"73","author":"Gleeson","year":"1995","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.prrv.2005.11.009_bib36","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1046\/j.1365-2222.2003.01583.x","article-title":"T cell responses to allergens in childhood","volume":"33","author":"Smart","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.prrv.2005.11.009_bib37","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00247-002-0671-1","article-title":"Estimating cancer risks from pediatric CT: going from the qualitative to the quantitative","volume":"32","author":"Brenner","year":"2002","journal-title":"Pediatr Radiol"},{"key":"10.1016\/j.prrv.2005.11.009_bib38","series-title":"Applied Respiratory Physiology","author":"Nunn","year":"1993"},{"key":"10.1016\/j.prrv.2005.11.009_bib39","first-page":"625","article-title":"The functional development of the respiratory system from the period of gestation to adulthood","volume":"120","author":"Polgar","year":"1979","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.prrv.2005.11.009_bib40","series-title":"Basic Mechanisms of Pediatric Respiratory Disease","author":"Haddad","year":"2002"},{"key":"10.1016\/j.prrv.2005.11.009_bib41","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/(SICI)1099-0496(199907)28:1<59::AID-PPUL10>3.0.CO;2-Y","article-title":"State of the art: cough, cough receptors, and asthma in children","volume":"28","author":"Chang","year":"1999","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.prrv.2005.11.009_bib42","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1378\/chest.109.5.1262","article-title":"Habitual coughing and its associations with asthma, anxiety, and gastroesophageal reflux","volume":"109","author":"Ludviksdottir","year":"1996","journal-title":"Chest"},{"key":"10.1016\/j.prrv.2005.11.009_bib43","first-page":"1","article-title":"Cough: are children really different to adults?","author":"Chang","year":"2005","journal-title":"Cough"},{"key":"10.1016\/j.prrv.2005.11.009_bib44","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.pupt.2004.09.014","article-title":"Pathophysiology of airway viral infections","volume":"17","author":"Jacoby","year":"2004","journal-title":"Pulmon Pharmacol Ther"},{"key":"10.1016\/j.prrv.2005.11.009_bib45","doi-asserted-by":"crossref","first-page":"L494","DOI":"10.1152\/ajplung.00414.2001","article-title":"Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus-infected lungs","volume":"283","author":"Hu","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.prrv.2005.11.009_bib46","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1164\/ajrccm.157.3.9707158","article-title":"Hypercapnia enhances the development of coughing during continuous infusion of water into the pharynx","volume":"157","author":"Nishino","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.prrv.2005.11.009_bib47","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1164\/rccm.200402-174OC","article-title":"Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough","volume":"170","author":"Groneberg","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.prrv.2005.11.009_bib48","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.pupt.2004.09.020","article-title":"Plasticity of vagal afferent fibres mediating cough","volume":"17","author":"Carr","year":"2004","journal-title":"Pulmon Pharmacol Ther"},{"key":"10.1016\/j.prrv.2005.11.009_bib49","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1136\/thorax.56.6.438","article-title":"Effect of manually assisted cough and mechanical insufflation on cough flow of normal subjects, patients with chronic obstructive pulmonary disease (COPD), and patients with respiratory muscle weakness","volume":"56","author":"Sivasothy","year":"2001","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2005.11.009_bib50","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1136\/thorax.58.8.680","article-title":"Resolution of bronchial inflammation is related to bacterial eradication following treatment of exacerbations of chronic bronchitis","volume":"58","author":"White","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2005.11.009_bib51","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1136\/thorax.58.6.528","article-title":"Comparison of airway immunopathology of eosinophilic bronchitis and asthma","volume":"58","author":"Brightling","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2005.11.009_bib52","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1152\/jappl.1997.82.3.738","article-title":"Esophageal stimulation by hydrochloric acid causes neurogenic inflammation in the airways in guinea pigs","volume":"82","author":"Hamamoto","year":"1997","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.prrv.2005.11.009_bib53","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1136\/thorax.58.12.1066","article-title":"Idiopathic chronic cough: association with organ specific autoimmune disease and bronchoalveolar lymphocytosis","volume":"58","author":"Birring","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2005.11.009_bib54","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1183\/09031936.97.10010071","article-title":"Effect of influenza A virus infection on acid-induced cough response in children with asthma","volume":"10","author":"Shimizu","year":"1997","journal-title":"Eur Respir J"},{"key":"10.1016\/j.prrv.2005.11.009_bib55","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1136\/thx.52.9.770","article-title":"Cough receptor sensitivity in children with acute and non-acute asthma","volume":"52","author":"Chang","year":"1997","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2005.11.009_bib56","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1136\/adc.77.4.331","article-title":"Cough sensitivity in children with asthma, recurrent cough, and cystic fibrosis","volume":"77","author":"Chang","year":"1997","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.prrv.2005.11.009_bib57","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1159\/000194868","article-title":"Changes induced by severe hypoxia in respiratory defence reflexes in anaesthetized cats","volume":"49","author":"Tatar","year":"1986","journal-title":"Respiration"},{"key":"10.1016\/j.prrv.2005.11.009_bib58","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/sj.bjp.0705056","article-title":"RSD931, a novel anti-tussive agent acting on airway sensory nerves","volume":"138","author":"Adcock","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.prrv.2005.11.009_bib59","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1183\/09031936.93.03050579","article-title":"Separation of cough and reflex bronchoconstriction by inhaled local anaesthetics","volume":"3","author":"Choudry","year":"1990","journal-title":"Eur Respir J"},{"key":"10.1016\/j.prrv.2005.11.009_bib60","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/00000542-200501000-00007","article-title":"Laryngeal reflex before and after placement of airway interventions: endotracheal tube and laryngeal mask airway","volume":"102","author":"Tanaka","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.prrv.2005.11.009_bib61","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1164\/ajrccm.158.2.9705094","article-title":"Defective motor control of coughing in Parkinson's disease","volume":"158","author":"Fontana","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.prrv.2005.11.009_bib62","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1006\/pupt.2002.0350","article-title":"Delta-opioid receptor antagonists as a new concept for central acting antitussive drugs","volume":"15","author":"Kamei","year":"2002","journal-title":"Pulmon Pharmacol Ther"}],"container-title":["Paediatric Respiratory Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526054205001107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526054205001107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T10:00:24Z","timestamp":1683367224000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526054205001107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S1526054205001107"],"URL":"https:\/\/doi.org\/10.1016\/j.prrv.2005.11.009","relation":{},"ISSN":["1526-0542"],"issn-type":[{"value":"1526-0542","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}