{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T23:29:30Z","timestamp":1789082970818,"version":"build-2803163510"},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Respiratory Reviews"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.prrv.2010.10.011","type":"journal-article","created":{"date-parts":[[2010,11,25]],"date-time":"2010-11-25T09:35:49Z","timestamp":1290677749000},"page":"104-110","source":"Crossref","is-referenced-by-count":56,"title":["Pathogenesis of bronchiectasis"],"prefix":"10.1016","volume":"12","author":[{"given":"Paul","family":"King","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 2","key":"10.1016\/j.prrv.2010.10.011_bib0005","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1136\/thx.54.2008.S19","article-title":"The pathogenic consequences of a single mutated CFTR gene","volume":"54","author":"Griesenbach","year":"1999","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2010.10.011_bib0010","doi-asserted-by":"crossref","unstructured":"Boucher RC. Bronchiectasis: a continuum of ion transport dysfunction or multiple hits? Am J Respir Crit Care Med 2010;181:1017\u20139.","DOI":"10.1164\/rccm.201002-0284ED"},{"key":"10.1016\/j.prrv.2010.10.011_bib0015","doi-asserted-by":"crossref","unstructured":"Bienvenu T, Sermet-Gaudelus I, Burgel PR, et al. Cystic fibrosis transmembrane conductance regulator channel dysfunction in non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med 2010;181:1078\u201384.","DOI":"10.1164\/rccm.200909-1434OC"},{"key":"10.1016\/j.prrv.2010.10.011_bib0020","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s004390100467","article-title":"CFTR gene mutations--including three novel nucleotide substitutions-- and haplotype background in patients with asthma, disseminated bronchiectasis and chronic obstructive pulmonary disease","volume":"108","author":"Tzetis","year":"2001","journal-title":"Hum Genet"},{"key":"10.1016\/j.prrv.2010.10.011_bib0025","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1136\/thx.2003.020263","article-title":"Role of CFTR mutations in adult bronchiectasis","volume":"59","author":"King","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2010.10.011_bib0030","first-page":"85","article-title":"CFTR mutations and polymorphisms in adults with disseminated bronchiectasis: a controversial issue","volume":"60","author":"Divac","year":"2005","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2010.10.011_bib0035","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.cpm.0000171422.98696.ed","article-title":"Prevalence and Economic Burden of Bronchiectasis","volume":"4","author":"Weycker","year":"2005","journal-title":"Clinical Pulm Medicine"},{"key":"10.1016\/j.prrv.2010.10.011_bib0040","doi-asserted-by":"crossref","first-page":"200","DOI":"10.5694\/j.1326-5377.2002.tb04733.x","article-title":"Bronchiectasis in indigenous children in remote Australian communities","volume":"177","author":"Chang","year":"2002","journal-title":"Med J Aust"},{"key":"10.1016\/j.prrv.2010.10.011_bib0045","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1136\/adc.2004.066472","article-title":"New Zealand national incidence of bronchiectasis \u201ctoo high\u201d for a developed country","volume":"90","author":"Twiss","year":"2005","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.prrv.2010.10.011_bib0050","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/(SICI)1099-0496(200003)29:3<182::AID-PPUL5>3.0.CO;2-T","article-title":"Bronchiectasis in Alaska Native children: causes and clinical courses","volume":"29","author":"Singleton","year":"2000","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.prrv.2010.10.011_bib0055","first-page":"691","article-title":"Bronchiectasis: not an orphan disease in the East","volume":"8","author":"Tsang","year":"2004","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.prrv.2010.10.011_bib0060","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1136\/thx.7.3.213","article-title":"A study of the pathology and pathogenesis of bronchiectasis","volume":"7","author":"Whitwell","year":"1952","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2010.10.011_bib0065","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/15412550902766934","article-title":"Phenotypes of bronchiectasis: onset of productive cough in childhood and adulthood","volume":"6","author":"King","year":"2009","journal-title":"COPD"},{"key":"10.1016\/j.prrv.2010.10.011_bib0070","first-page":"6","article-title":"Inflammation: a two-edged sword--the model of bronchiectasis","volume":"147","author":"Cole","year":"1986","journal-title":"Eur J Respir Dis Suppl"},{"key":"10.1016\/j.prrv.2010.10.011_bib0075","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1164\/ajrccm\/138.6_Pt_2.S49","article-title":"The effect of bacterial products on ciliary function","volume":"138","author":"Wilson","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.prrv.2010.10.011_bib0080","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1164\/ajrccm.164.11.2104093","article-title":"Nontypeable Haemophilus influenzae in the Lower Respiratory Tract of Patients with Chronic Bronchitis","volume":"164","author":"Bandi","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.prrv.2010.10.011_bib0085","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35101627","article-title":"Gene expression in Pseudomonas aeruginosa biofilms","volume":"413","author":"Whiteley","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.prrv.2010.10.011_bib0090","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1749-6632.1994.tb39816.x","article-title":"Cells and cytokines in chronic bronchial infection","volume":"725","author":"Eller","year":"1994","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.prrv.2010.10.011_bib0095","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/thx.2006.061358","article-title":"Innate immune activation in neutrophilic asthma and bronchiectasis","volume":"62","author":"Simpson","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2010.10.011_bib0100","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1165\/ajrcmb\/1.4.297","article-title":"Immunopathology of experimental bronchiectasis","volume":"1","author":"Lapa e Silva","year":"1989","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.prrv.2010.10.011_bib0105","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1136\/thx.5.3.233","article-title":"Reduction in bronchial subdivisions in bronchiectasis","volume":"5","author":"Reid","year":"1950","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2010.10.011_bib0110","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1378\/chest.109.2.360","article-title":"Thin-section CT detection of emphysema associated with bronchiectasis and correlation with pulmonary function tests","volume":"109","author":"Loubeyre","year":"1996","journal-title":"Chest"},{"key":"10.1016\/j.prrv.2010.10.011_bib0115","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1081\/COPD-200050685","article-title":"Outcome in Adult Bronchiectasis","volume":"2","author":"King","year":"2005","journal-title":"COPD: Journal of Chronic Obstructive Pulmonary Diseases"},{"key":"10.1016\/j.prrv.2010.10.011_bib0120","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1136\/thx.2005.047332","article-title":"Longitudinal pulmonary function of childhood bronchiectasis and comparison with cystic fibrosis","volume":"61","author":"Twiss","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2010.10.011_bib0125","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1378\/chest.07-0490","article-title":"Factors associated with lung function decline in adult patients with stable non-cystic fibrosis bronchiectasis","volume":"132","author":"Martinez-Garcia","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.prrv.2010.10.011_bib0130","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/thorax.55.3.198","article-title":"Airflow obstruction in bronchiectasis: correlation between computed tomography features and pulmonary function tests","volume":"55","author":"Roberts","year":"2000","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2010.10.011_bib0135","unstructured":"King P, Holdsworth S, Freezer N, et al. Lung diffusing capacity in adult bronchiectasis: a longitudinal study. Respiratory Care In press."},{"key":"10.1016\/j.prrv.2010.10.011_bib0140","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/j.rmed.2006.03.012","article-title":"Characterisation of the onset and presenting clinical features of adult bronchiectasis","volume":"100","author":"King","year":"2006","journal-title":"Respir Med"},{"key":"10.1016\/j.prrv.2010.10.011_bib0145","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1136\/thx.39.3.179","article-title":"Atopy, immunological changes, and respiratory function in bronchiectasis","volume":"39","author":"Murphy","year":"1984","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2010.10.011_bib0150","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1136\/thx.44.11.948","article-title":"Prevalence of asthma, atopy, and bronchial hyperreactivity in bronchiectasis: a controlled study","volume":"44","author":"Pang","year":"1989","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2010.10.011_bib0155","first-page":"375","article-title":"Pulmonary function tests and airway responsiveness to methacholine in chronic bronchiectasis of the adult","volume":"20","author":"Bahous","year":"1984","journal-title":"Bull Eur Physiopathol Respir"},{"key":"10.1016\/j.prrv.2010.10.011_bib0160","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/S0264-410X(00)00029-3","article-title":"Seroepidemiology of Bordetella pertussis infections in the Spanish population: a cross-sectional study","volume":"18","author":"Garcia-Corbeira","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.prrv.2010.10.011_bib0165","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1056\/NEJM199802263380904","article-title":"Effect of pneumonia and whooping cough in childhood on adult lung function","volume":"338","author":"Johnston","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.prrv.2010.10.011_bib0170","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1136\/jcp.24.1.72","article-title":"Bronchiolitis obliterans, bronchiectasis, and other sequelae of adenovirus type 21 infection in young children","volume":"24","author":"Becroft","year":"1971","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.prrv.2010.10.011_bib0175","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1183\/09031936.98.12040982","article-title":"Primary ciliary dyskinesia: diagnosis and standards of care","volume":"12","author":"Bush","year":"1998","journal-title":"Eur Respir J"},{"key":"10.1016\/j.prrv.2010.10.011_bib0180","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1165\/ajrcmb\/4.1.26","article-title":"Effects of human neutrophil elastase and Pseudomonas aeruginosa proteinases on human respiratory epithelium","volume":"4","author":"Amitani","year":"1991","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.prrv.2010.10.011_bib0185","first-page":"L893","article-title":"Pseudomonas pyocyanine alters calcium signaling in human airway epithelial cells","volume":"274","author":"Denning","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.prrv.2010.10.011_bib0190","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00408-004-2520-5","article-title":"Clinical value of ciliary assessment in bronchiectasis","volume":"183","author":"Tsang","year":"2005","journal-title":"Lung"},{"key":"10.1016\/j.prrv.2010.10.011_bib0195","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1164\/ajrccm.151.5.7735615","article-title":"Ciliary defects in healthy subjects, bronchiectasis, and primary ciliary dyskinesia","volume":"151","author":"de Iongh","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.prrv.2010.10.011_bib0200","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.rmed.2004.08.005","article-title":"Ciliary central microtubular orientation is of no clinical significance in bronchiectasis","volume":"99","author":"Tsang","year":"2005","journal-title":"Respir Med"},{"key":"10.1016\/j.prrv.2010.10.011_bib0205","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1164\/ajrccm.162.4.9906120","article-title":"An investigation into causative factors in patients with bronchiectasis","volume":"162","author":"Pasteur","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.prrv.2010.10.011_bib0210","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1148\/radiol.2253011575","article-title":"High-resolution CT quantification of bronchiectasis: clinical and functional correlation","volume":"225","author":"Ooi","year":"2002","journal-title":"Radiology"},{"key":"10.1016\/j.prrv.2010.10.011_bib0215","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1136\/thx.53.6.463","article-title":"IgG subclasses in the serum and sputum from patients with bronchiectasis","volume":"53","author":"Hill","year":"1998","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2010.10.011_bib0220","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1136\/thorax.57.1.15","article-title":"Bacterial colonisation in patients with bronchiectasis: microbiological pattern and risk factors","volume":"57","author":"Angrill","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2010.10.011_bib0225","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1164\/ajrccm.152.3.7663786","article-title":"Dynamics of respiratory tract colonization by Branhamella catarrhalis in bronchiectasis","volume":"152","author":"Klingman","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.prrv.2010.10.011_bib0230","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.rmed.2007.03.009","article-title":"Microbiologic follow-up study in adult bronchiectasis","volume":"101","author":"King","year":"2007","journal-title":"Respir Med"},{"key":"10.1016\/j.prrv.2010.10.011_bib0235","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/S0140-6736(80)91295-7","article-title":"Use of selective media in bacteriological investigation of patients with chronic suppurative respiratory infection","volume":"1","author":"Roberts","year":"1980","journal-title":"Lancet"},{"key":"10.1016\/j.prrv.2010.10.011_bib0240","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1164\/ajrccm.161.3.9812047","article-title":"Influenza virus inhibits lysozyme secretion by sputum neutrophils in subjects with chronic bronchial sepsis","volume":"161","author":"Pang","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.prrv.2010.10.011_bib0245","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1542\/peds.4.1.21","article-title":"Bronchiectasis in childhood","volume":"4","author":"Field","year":"1949","journal-title":"Pediatrics"},{"key":"10.1016\/j.prrv.2010.10.011_bib0250","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1136\/adc.36.190.587","article-title":"Bronchiectasis: a long-term follow-up of medicial and surgical cases from childhood","volume":"36","author":"Field","year":"1961","journal-title":"Archives of Disease of Childhood"},{"key":"10.1016\/j.prrv.2010.10.011_bib0255","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1136\/thorax.57.11.935","article-title":"Bronchoscopic findings in children with non-cystic fibrosis chronic suppurative lung disease","volume":"57","author":"Chang","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.prrv.2010.10.011_bib0260","doi-asserted-by":"crossref","first-page":"386","DOI":"10.5694\/j.1326-5377.2008.tb02085.x","article-title":"Management of bronchiectasis and chronic suppurative lung disease in indigenous children and adults from rural and remote Australian communities","volume":"189","author":"Chang","year":"2008","journal-title":"Med J Aust"}],"container-title":["Paediatric Respiratory Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526054210001053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526054210001053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T08:35:02Z","timestamp":1685867702000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526054210001053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S1526054210001053"],"URL":"https:\/\/doi.org\/10.1016\/j.prrv.2010.10.011","relation":{},"ISSN":["1526-0542"],"issn-type":[{"value":"1526-0542","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}