{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:55:30Z","timestamp":1790682930835,"version":"4.1.0"},"reference-count":105,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01AG019724"],"award-info":[{"award-number":["P01AG019724"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AG023481"],"award-info":[{"award-number":["T32 AG023481"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AG062422"],"award-info":[{"award-number":["P30AG062422"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychiatric Clinics of North America"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.psc.2020.02.006","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T20:06:55Z","timestamp":1586376415000},"page":"331-344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Frontotemporal Dementia"],"prefix":"10.1016","volume":"43","author":[{"given":"Kyan","family":"Younes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psc.2020.02.006_bib1","series-title":"The behavioral neurology of dementia","author":"Miller","year":"2016"},{"issue":"2","key":"10.1016\/j.psc.2020.02.006_bib2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/neur.1995.0021","article-title":"Synapse loss and gliosis in the molecular layer of the cerebral cortex in Alzheimer\u2019s disease and in frontal lobe degeneration","volume":"4","author":"Brun","year":"1995","journal-title":"Neurodegeneration"},{"issue":"8","key":"10.1016\/j.psc.2020.02.006_bib3","article-title":"Mapping neurodegenerative disease onset and progression","volume":"9","author":"Seeley","year":"2017","journal-title":"ColdSpringHarb Perspect Biol"},{"issue":"Pt 9","key":"10.1016\/j.psc.2020.02.006_bib4","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"issue":"11","key":"10.1016\/j.psc.2020.02.006_bib5","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of primary progressive aphasia and its variants","volume":"76","author":"Gorno-Tempini","year":"2011","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.psc.2020.02.006_bib6","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","article-title":"Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria","volume":"51","author":"Neary","year":"1998","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.psc.2020.02.006_bib7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0167-4943(87)90021-5","article-title":"Frontal lobe degeneration of non-Alzheimer type. I. Neuropathology","volume":"6","author":"Brun","year":"1987","journal-title":"Arch Gerontol Geriatr"},{"issue":"3","key":"10.1016\/j.psc.2020.02.006_bib8","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s12031-011-9528-0","article-title":"Pathological staging of frontotemporal lobar degeneration","volume":"45","author":"Kril","year":"2011","journal-title":"J\u00a0Mol Neurosci"},{"issue":"5","key":"10.1016\/j.psc.2020.02.006_bib9","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1247\/csf.21.283","article-title":"Microtubule-associated proteins regulate microtubule function as the track for intracellular membrane organelle transports","volume":"21","author":"Sato-Harada","year":"1996","journal-title":"Cell Struct Funct"},{"issue":"7","key":"10.1016\/j.psc.2020.02.006_bib10","first-page":"a006247","article-title":"Biochemistry and cell biology of tau protein in neurofibrillary degeneration","volume":"2","author":"Mandelkow","year":"2012","journal-title":"ColdSpringHarb Perspect Med"},{"issue":"Suppl 5","key":"10.1016\/j.psc.2020.02.006_bib11","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1002\/ana.10571","article-title":"The neuropathology and biochemistry of frontotemporal dementia","volume":"54","author":"Munoz","year":"2003","journal-title":"Ann Neurol"},{"issue":"2","key":"10.1016\/j.psc.2020.02.006_bib12","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1074\/jbc.M507753200","article-title":"Inducible expression of tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs","volume":"281","author":"Khlistunova","year":"2006","journal-title":"J\u00a0Biol Chem"},{"issue":"1","key":"10.1016\/j.psc.2020.02.006_bib13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1001\/jamaneurol.2018.2505","article-title":"Mechanisms of cell-to-cell transmission of pathological tau: a review","volume":"76","author":"Gibbons","year":"2019","journal-title":"JAMA Neurol"},{"issue":"5","key":"10.1016\/j.psc.2020.02.006_bib14","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1097\/00001756-200104170-00014","article-title":"Intracellular processing of aggregated tau differs between corticobasal degeneration and progressive supranuclear palsy","volume":"12","author":"Arai","year":"2001","journal-title":"Neuroreport"},{"issue":"3","key":"10.1016\/j.psc.2020.02.006_bib15","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/ana.24885","article-title":"Typical and atypical pathology in primary progressive aphasia variants","volume":"81","author":"Spinelli","year":"2017","journal-title":"Ann Neurol"},{"issue":"12","key":"10.1016\/j.psc.2020.02.006_bib16","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1093\/brain\/awx254","article-title":"Clinicopathological correlations in behavioural variant frontotemporal dementia","volume":"140","author":"Perry","year":"2017","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.psc.2020.02.006_bib17","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1136\/jnnp.56.6.605","article-title":"Dementia of frontal lobe type: neuropathology and immunohistochemistry","volume":"56","author":"Mann","year":"1993","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"issue":"2","key":"10.1016\/j.psc.2020.02.006_bib18","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1212\/WNL.58.2.198","article-title":"Patterns of brain atrophy in frontotemporal dementia and semantic dementia","volume":"58","author":"Rosen","year":"2002","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.psc.2020.02.006_bib19","first-page":"6","article-title":"Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration","volume":"246","author":"Dickson","year":"1999","journal-title":"J\u00a0Neurol"},{"issue":"4","key":"10.1016\/j.psc.2020.02.006_bib20","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/00005072-199904000-00006","article-title":"Progressive supranuclear palsy with dementia: cortical pathology","volume":"58","author":"Bigio","year":"1999","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"issue":"4","key":"10.1016\/j.psc.2020.02.006_bib21","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00401-013-1171-0","article-title":"Globular glial tauopathies (GGT): Consensus recommendations","volume":"126","author":"Ahmed","year":"2013","journal-title":"Acta Neuropathol"},{"issue":"3","key":"10.1016\/j.psc.2020.02.006_bib22","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.3233\/JAD-171115","article-title":"Argyrophilic Grain pathology in frontotemporal lobar degeneration: demographic, clinical, neuropathological, and genetic features","volume":"63","author":"Gil","year":"2018","journal-title":"J\u00a0Alzheimers Dis"},{"issue":"2","key":"10.1016\/j.psc.2020.02.006_bib23","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.molmed.2013.11.003","article-title":"TDP-43-mediated neurodegeneration: Towards a loss-of-function hypothesis?","volume":"20","author":"Vanden Broeck","year":"2014","journal-title":"Trends Mol Med"},{"issue":"1","key":"10.1016\/j.psc.2020.02.006_bib24","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00401-011-0845-8","article-title":"A\u00a0harmonized classification system for FTLD-TDP pathology","volume":"122","author":"Mackenzie","year":"2011","journal-title":"Acta Neuropathol"},{"issue":"24","key":"10.1016\/j.psc.2020.02.006_bib25","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1212\/WNL.0b013e318202038c","article-title":"TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia","volume":"75","author":"Rohrer","year":"2010","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.psc.2020.02.006_bib26","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s12031-011-9533-3","article-title":"Imaging signatures of molecular pathology in behavioral variant frontotemporal dementia","volume":"45","author":"Whitwell","year":"2011","journal-title":"J\u00a0Mol Neurosci"},{"issue":"1","key":"10.1016\/j.psc.2020.02.006_bib27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00401-010-0698-6","article-title":"FUS pathology defines the majority of tau-and TDP-43-negative frontotemporal lobar degeneration","volume":"120","author":"Urwin","year":"2010","journal-title":"Acta Neuropathol"},{"issue":"7","key":"10.1016\/j.psc.2020.02.006_bib28","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/j.1468-1331.2010.02975.x","article-title":"Caudate atrophy on MRI is a characteristic feature of FTLD-FUS","volume":"17","author":"Josephs","year":"2010","journal-title":"Eur J Neurol"},{"issue":"6","key":"10.1016\/j.psc.2020.02.006_bib29","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/WCO.0b013e32834cd442","article-title":"Phenotypic signatures of genetic frontotemporal dementia","volume":"24","author":"Rohrer","year":"2011","journal-title":"Curr Opin Neurol"},{"issue":"5","key":"10.1016\/j.psc.2020.02.006_bib30","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/jnnp.2010.212225","article-title":"Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review","volume":"82","author":"Seelaar","year":"2011","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"issue":"3","key":"10.1016\/j.psc.2020.02.006_bib31","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/brain\/awm331","article-title":"Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: Comparison with patients with MAPT and no known mutations","volume":"131","author":"Pickering-Brown","year":"2008","journal-title":"Brain"},{"issue":"11","key":"10.1016\/j.psc.2020.02.006_bib32","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1212\/01.wnl.0000187068.92184.63","article-title":"Comparison of family histories in FTLD subtypes and related tauopathies","volume":"65","author":"Goldman","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.psc.2020.02.006_bib33","volume":"vol. 148","author":"Deleon","year":"2018"},{"issue":"3","key":"10.1016\/j.psc.2020.02.006_bib34","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.psym.2011.04.005","article-title":"Schizophrenia or neurodegenerative disease prodrome? outcome of a first psychotic episode in a 35-year-old woman","volume":"53","author":"Khan","year":"1970","journal-title":"Psychosomatics"},{"issue":"6","key":"10.1016\/j.psc.2020.02.006_bib35","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.parkreldis.2010.04.004","article-title":"In\u00a0vivo detection of neuropathologic changes in presymptomatic MAPT mutation carriers: A PET and MRI study","volume":"16","author":"Miyoshi","year":"2010","journal-title":"Parkinsonism Relat Disord"},{"issue":"2","key":"10.1016\/j.psc.2020.02.006_bib36","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1212\/WNL.0000000000000583","article-title":"Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia","volume":"83","author":"Dopper","year":"2014","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.psc.2020.02.006_bib37","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/nan.12213","article-title":"Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: A chameleon for neuropathology and neuroimaging","volume":"41","author":"Ghetti","year":"2015","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"12","key":"10.1016\/j.psc.2020.02.006_bib38","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1093\/brain\/awx198","article-title":"Progranulin: A new avenue towards the understanding and treatment of neurodegenerative disease","volume":"140","author":"Chitramuthu","year":"2017","journal-title":"Brain"},{"issue":"10","key":"10.1016\/j.psc.2020.02.006_bib39","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s00109-003-0474-3","article-title":"Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis","volume":"81","author":"He","year":"2003","journal-title":"J\u00a0Mol Med"},{"issue":"2","key":"10.1016\/j.psc.2020.02.006_bib40","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/nen.0b013e31803020cf","article-title":"Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations","volume":"66","author":"Josephs","year":"2007","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"issue":"14","key":"10.1016\/j.psc.2020.02.006_bib41","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.2174\/156802612802652411","article-title":"Cysteine-rich mini-proteins in human biology","volume":"12","author":"Lavergne","year":"2012","journal-title":"Curr Top Med Chem"},{"issue":"7105","key":"10.1016\/j.psc.2020.02.006_bib42","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05016","article-title":"Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17","volume":"442","author":"Baker","year":"2006","journal-title":"Nature"},{"issue":"20","key":"10.1016\/j.psc.2020.02.006_bib43","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1093\/hmg\/ddl241","article-title":"Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration","volume":"15","author":"Gass","year":"2006","journal-title":"Hum Mol Genet"},{"issue":"6","key":"10.1016\/j.psc.2020.02.006_bib44","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.ajhg.2012.04.021","article-title":"Strikingly different clinicopathological phenotypes determined by progranulin-mutation dosage","volume":"90","author":"Smith","year":"2012","journal-title":"Am J Hum Genet"},{"issue":"5","key":"10.1016\/j.psc.2020.02.006_bib45","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.neurobiolaging.2007.08.022","article-title":"Prominent phenotypic variability associated with mutations in Progranulin","volume":"30","author":"Kelley","year":"2009","journal-title":"Neurobiol Aging"},{"issue":"3","key":"10.1016\/j.psc.2020.02.006_bib46","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1093\/brain\/awn012","article-title":"Phenotype variability in progranulin mutation carriers: A clinical, neuropsychological, imaging and genetic study","volume":"131","author":"Le Ber","year":"2008","journal-title":"Brain"},{"issue":"7\u20138","key":"10.1016\/j.psc.2020.02.006_bib47","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3109\/21678421.2015.1074700","article-title":"Distinct clinical and pathological phenotypes in frontotemporal dementia associated with MAPT, PGRN and C9orf72 mutations","volume":"16","author":"Snowden","year":"2015","journal-title":"Amyotroph Lateral Scler FrontotemporalDegener"},{"issue":"12","key":"10.1016\/j.psc.2020.02.006_bib48","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1001\/jamaneurol.2014.1316","article-title":"Extensive white matter involvement in patients with frontotemporal lobar degeneration: think progranulin","volume":"71","author":"Caroppo","year":"2014","journal-title":"JAMA Neurol"},{"issue":"15","key":"10.1016\/j.psc.2020.02.006_bib49","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1212\/WNL.0b013e3182a8237e","article-title":"Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers","volume":"81","author":"Jacova","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.psc.2020.02.006_bib50","doi-asserted-by":"crossref","first-page":"101751","DOI":"10.1016\/j.nicl.2019.101751","article-title":"Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers","volume":"22","author":"Lee","year":"2019","journal-title":"Neuroimage Clin"},{"issue":"6","key":"10.1016\/j.psc.2020.02.006_bib51","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S1474-4422(18)30126-1","article-title":"Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study","volume":"17","author":"Pottier","year":"2018","journal-title":"Lancet Neurol"},{"issue":"2","key":"10.1016\/j.psc.2020.02.006_bib52","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.psc.2020.02.006_bib53","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1212\/WNL.0b013e31827f08ea","article-title":"C9ORF72 hexanucleotide expansions of 20-22 repeats are associated with frontotemporal deterioration","volume":"80","author":"Gomez-Tortosa","year":"2013","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.psc.2020.02.006_bib54","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1212\/WNL.0b013e3182684634","article-title":"C9ORF72 repeat expansion in clinical and neuropathologic frontotemporal dementia cohorts","volume":"79","author":"Dobson-Stone","year":"2012","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.psc.2020.02.006_bib55","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/brain\/awr355","article-title":"Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations","volume":"135","author":"Snowden","year":"2012","journal-title":"Brain"},{"issue":"10","key":"10.1016\/j.psc.2020.02.006_bib56","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1212\/WNL.0b013e318268452e","article-title":"Frontotemporal dementia due to C9ORF72 mutations","volume":"79","author":"Sha","year":"2012","journal-title":"Neurology"},{"issue":"Pt 11","key":"10.1016\/j.psc.2020.02.006_bib57","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1093\/brain\/awu248","article-title":"Altered network connectivity in frontotemporal dementia with C9orf72 hexanucleotide repeat expansion","volume":"137","author":"Lee","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.psc.2020.02.006_bib58","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.nicl.2016.12.006","article-title":"Network degeneration and dysfunction in presymptomatic C9ORF72 expansion carriers","volume":"14","author":"Lee","year":"2017","journal-title":"Neuroimage Clin"},{"issue":"9","key":"10.1016\/j.psc.2020.02.006_bib59","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1136\/jnnp.2006.107326","article-title":"CSF neurofilament proteins in the differential diagnosis of dementia","volume":"78","author":"de Jong","year":"2007","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"issue":"21","key":"10.1016\/j.psc.2020.02.006_bib60","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1212\/WNL.0000000000001015","article-title":"CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival","volume":"83","author":"Skillback","year":"2014","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.psc.2020.02.006_bib61","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1002\/acn3.643","article-title":"Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory","volume":"5","author":"Ljubenkov","year":"2018","journal-title":"Ann Clin Transl Neurol"},{"issue":"2","key":"10.1016\/j.psc.2020.02.006_bib62","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3233\/JAD-160386","article-title":"Tau rather than TDP-43 proteins are potential cerebrospinal fluid biomarkers for frontotemporal lobar degeneration subtypes: a pilot study","volume":"55","author":"Kuiperij","year":"2017","journal-title":"J\u00a0Alzheimers Dis"},{"issue":"6","key":"10.1016\/j.psc.2020.02.006_bib63","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1136\/jnnp-2013-305972","article-title":"Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation","volume":"85","author":"Su\u00e1rez-Calvet","year":"2014","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"issue":"21","key":"10.1016\/j.psc.2020.02.006_bib64","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1212\/WNL.0000000000000445","article-title":"Progranulin protein levels are differently regulated in plasma and CSF","volume":"82","author":"Nicholson","year":"2014","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.psc.2020.02.006_bib65","doi-asserted-by":"crossref","first-page":"859","DOI":"10.15252\/emmm.201607486","article-title":"Poly-GP in cerebrospinal fluid links C9orf72-associated dipeptide repeat expression to the asymptomatic phase of ALS\/FTD","volume":"9","author":"Lehmer","year":"2017","journal-title":"EMBO Mol Med"},{"issue":"1","key":"10.1016\/j.psc.2020.02.006_bib66","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13195-018-0361-3","article-title":"Cerebrospinal fluid in the differential diagnosis of Alzheimer\u2019s disease: clinical utility of an extended panel of biomarkers in a specialist cognitive clinic","volume":"10","author":"Paterson","year":"2018","journal-title":"Alzheimers Res Ther"},{"issue":"3\u20134","key":"10.1016\/j.psc.2020.02.006_bib67","first-page":"204","article-title":"Progressive right frontotemporal degeneration: clinical, neuropsychological and SPECT characteristics","volume":"4","author":"Miller","year":"1993","journal-title":"Dementia"},{"issue":"2","key":"10.1016\/j.psc.2020.02.006_bib68","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/09540261.2013.778822","article-title":"Neuroimaging in frontotemporal dementia","volume":"25","author":"Rohrer","year":"2013","journal-title":"Int Rev Psychiatry"},{"issue":"4","key":"10.1016\/j.psc.2020.02.006_bib69","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1159\/000095128","article-title":"Patterns of frontal lobe atrophy in frontotemporal dementia: a volumetric MRI study","volume":"22","author":"Perry","year":"2006","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"7","key":"10.1016\/j.psc.2020.02.006_bib70","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.biopsych.2014.01.020","article-title":"Network dysfunction in Alzheimer\u2019s disease and frontotemporal dementia: Implications for psychiatry","volume":"75","author":"Zhou","year":"2014","journal-title":"Biol Psychiatry"},{"issue":"12","key":"10.1016\/j.psc.2020.02.006_bib71","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.tics.2013.09.017","article-title":"The evolution of distributed association networks in the human brain","volume":"17","author":"Buckner","year":"2013","journal-title":"Trends Cogn Sci"},{"issue":"1","key":"10.1016\/j.psc.2020.02.006_bib72","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0135058100","article-title":"Functional connectivity in the resting brain: a network analysis of the default mode hypothesis","volume":"100","author":"Greicius","year":"2003","journal-title":"Proc Natl Acad Sci US A"},{"issue":"9","key":"10.1016\/j.psc.2020.02.006_bib73","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1001\/jamaneurol.2016.2016","article-title":"Distinct subtypes of behavioral variant frontotemporal dementia based on patterns of network degeneration","volume":"73","author":"Ranasinghe","year":"2016","journal-title":"JAMA Neurol"},{"issue":"4","key":"10.1016\/j.psc.2020.02.006_bib74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/brb3.675","article-title":"Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration","volume":"7","author":"Binney","year":"2017","journal-title":"Brain Behav"},{"issue":"2","key":"10.1016\/j.psc.2020.02.006_bib75","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/brain\/awy319","article-title":"Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials","volume":"142","author":"Staffaroni","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.psc.2020.02.006_bib76","first-page":"1","article-title":"Patient-tailored, connectivity-based forecasts of spreading brain atrophy","author":"Brown","year":"2019","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.psc.2020.02.006_bib77","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.neuron.2013.07.037","article-title":"Article imaging of tau pathology in a tauopathy mouse model and in alzheimer patients compared to normal controls","volume":"79","author":"Maruyama","year":"2013","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.psc.2020.02.006_bib78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-019-0470-7","article-title":"18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes","volume":"11","author":"Tsai","year":"2019","journal-title":"Alzheimers Res Ther"},{"issue":"10","key":"10.1016\/j.psc.2020.02.006_bib79","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/ene.12212","article-title":"Midbrain atrophy is not a biomarker of progressive supranuclear palsy pathology","volume":"20","author":"Whitwell","year":"2013","journal-title":"Eur J Neurol"},{"issue":"2","key":"10.1016\/j.psc.2020.02.006_bib80","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/ana.22424","article-title":"Clinicopathological correlations in corticobasal degeneration","volume":"70","author":"Lee","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.psc.2020.02.006_bib81","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.nicl.2017.09.008","article-title":"Advancing functional dysconnectivity and atrophy in progressive supranuclear palsy","volume":"16","author":"Brown","year":"2017","journal-title":"Neuroimage Clin"},{"issue":"7","key":"10.1016\/j.psc.2020.02.006_bib82","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1093\/brain\/awz122","article-title":"Neuropathological correlates of structural and functional imaging biomarkers in 4-repeat tauopathies","volume":"142","author":"Spina","year":"2019","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.psc.2020.02.006_bib83","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1097\/WAD.0b013e31815bf774","article-title":"A\u00a0model for management of behavioral symptoms in frontotemporal lobar degeneration","volume":"21","author":"Merrilees","year":"2007","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"1","key":"10.1016\/j.psc.2020.02.006_bib84","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jagp.2013.01.060","article-title":"Mental and physical activities delay cognitive decline in older persons with dementia","volume":"22","author":"Cheng","year":"2014","journal-title":"Am J Geriatr Psychiatry"},{"issue":"4","key":"10.1016\/j.psc.2020.02.006_bib85","first-page":"213","article-title":"Communication Bridge: A pilot feasibility study of Internet-based speech-language therapy for individuals with progressive aphasia","volume":"2","author":"Rogalski","year":"2016","journal-title":"AlzheimersDement(N Y)"},{"issue":"1","key":"10.1016\/j.psc.2020.02.006_bib86","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1212\/01.wnl.0000191304.55196.4d","article-title":"A\u00a0systematic review of neurotransmitter deficits and treatments in frontotemporal dementia","volume":"66","author":"Huey","year":"2006","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.psc.2020.02.006_bib87","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4088\/JCP.v58n0506","article-title":"Frontotemporal dementia: treatment response to serotonin selective reuptake inhibitors","volume":"58","author":"Swartz","year":"1997","journal-title":"J\u00a0Clin Psychiatry"},{"issue":"1","key":"10.1016\/j.psc.2020.02.006_bib88","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000067021","article-title":"Frontotemporal dementia: paroxetine as a possible treatment of behavior symptoms. A randomized, controlled, open 14-month study","volume":"49","author":"Moretti","year":"2003","journal-title":"Eur Neurol"},{"issue":"12","key":"10.1016\/j.psc.2020.02.006_bib89","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1136\/jnnp.2009.173260","article-title":"Behavioural abnormalities associated with rapid deterioration of language functions in semantic dementia respond to sertraline","volume":"80","author":"Prodan","year":"2009","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"issue":"9","key":"10.1016\/j.psc.2020.02.006_bib90","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/JGP.0b013e31823033f3","article-title":"Serotonergic function and treatment of behavioral and psychological symptoms of frontotemporal dementia","volume":"20","author":"Herrmann","year":"2012","journal-title":"Am J Geriatr Psychiatry"},{"issue":"4","key":"10.1016\/j.psc.2020.02.006_bib91","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1159\/000077171","article-title":"Frontotemporal dementia: a randomised, controlled trial with trazodone","volume":"17","author":"Lebert","year":"2004","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"4","key":"10.1016\/j.psc.2020.02.006_bib92","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/YIC.0000000000000023","article-title":"A\u00a0comparative review of escitalopram, paroxetine, and sertraline: are they all alike?","volume":"29","author":"Sanchez","year":"2014","journal-title":"Int Clin Psychopharmacol"},{"issue":"3","key":"10.1016\/j.psc.2020.02.006_bib93","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/sj.npp.1300886","article-title":"Methylphenidate ('Ritalin\u2019) can ameliorate abnormal risk-taking behavior in the frontal variant of frontotemporal dementia","volume":"31","author":"Rahman","year":"2006","journal-title":"Neuropsychopharmacology"},{"issue":"12","key":"10.1016\/j.psc.2020.02.006_bib94","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.4088\/JCP.v69n1219a","article-title":"Stimulant treatment of frontotemporal dementia in 8 patients","volume":"69","author":"Huey","year":"2008","journal-title":"J\u00a0Clin Psychiatry"},{"issue":"5","key":"10.1016\/j.psc.2020.02.006_bib95","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/ana.20301","article-title":"A\u00a0clinical trial of bromocriptine for treatment of primary progressive aphasia","volume":"56","author":"Reed","year":"2004","journal-title":"Ann Neurol"},{"key":"10.1016\/j.psc.2020.02.006_bib96","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1468-1331.2007.02032.x","article-title":"Parkinsonism and tardive antecollis in frontotemporal dementia \u2013 increased sensitivity to newer antipsychotics\u202f?","volume":"507","author":"Czarnecki","year":"2008","journal-title":"Eur J Neurol"},{"issue":"3","key":"10.1016\/j.psc.2020.02.006_bib97","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/00004714-200006000-00018","article-title":"Case of pick\u2019s central lobar atrophy with apparent stabilization of cognitive decline after treatment with risperidone","volume":"20","author":"Curtis","year":"2000","journal-title":"J\u00a0Clin Psychopharmacol"},{"issue":"4","key":"10.1016\/j.psc.2020.02.006_bib98","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1177\/153331750301800410","article-title":"Olanzapine as a treatment of neuropsychiatric disorders of Alzheimer\u2019s disease and other dementias: a 24-month follow-up of 68 patients","volume":"18","author":"Moretti","year":"2003","journal-title":"Am J Alzheimers Dis Other Demen"},{"issue":"5","key":"10.1016\/j.psc.2020.02.006_bib99","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1177\/153331750201700504","article-title":"Goals in symptomatic pharmacologic management of frontotemporal lobar degeneration","volume":"17","author":"Chow","year":"2002","journal-title":"Am J Alzheimers Dis Other Demen"},{"issue":"2","key":"10.1016\/j.psc.2020.02.006_bib100","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1176\/appi.neuropsych.11030077","article-title":"Tetrabenazine treatment for stereotypies and tics associated with dementia","volume":"24","author":"Ondo","year":"2012","journal-title":"J\u00a0Neuropsychiatry Clin Neurosci"},{"issue":"2","key":"10.1016\/j.psc.2020.02.006_bib101","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1447-0594.2012.00956.x","article-title":"Pilot study of pharmacological treatment for frontotemporal dementia: risk of donepezil treatment for behavioral and psychological symptoms","volume":"13","author":"Kimura","year":"2013","journal-title":"Geriatr Gerontol Int"},{"issue":"4","key":"10.1016\/j.psc.2020.02.006_bib102","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3233\/JAD-2010-101632","article-title":"Memantine in behavioral variant frontotemporal dementia: negative results","volume":"23","author":"Vercelletto","year":"2011","journal-title":"J\u00a0Alzheimers Dis"},{"issue":"2","key":"10.1016\/j.psc.2020.02.006_bib103","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1474-4422(12)70320-4","article-title":"Memantine in patients with frontotemporal lobar degeneration: a multicentre, randomised, double-blind, placebo-controlled trial","volume":"12","author":"Boxer","year":"2013","journal-title":"Lancet Neurol"},{"issue":"1","key":"10.1016\/j.psc.2020.02.006_bib104","doi-asserted-by":"crossref","first-page":"492","DOI":"10.3892\/etm.2016.3284","article-title":"Efficacy of memantine on neuropsychiatric symptoms associated with the severity of behavioral variant frontotemporal dementia: A six-month, open-label, self-controlled clinical trial","volume":"12","author":"Li","year":"2016","journal-title":"Exp Ther Med"},{"issue":"2","key":"10.1016\/j.psc.2020.02.006_bib105","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jalz.2012.03.003","article-title":"The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier)","volume":"9","author":"Boxer","year":"2013","journal-title":"Alzheimers Dement"}],"container-title":["Psychiatric Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0193953X2030006X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0193953X2030006X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T01:38:51Z","timestamp":1759282731000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0193953X2030006X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":105,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0193953X2030006X"],"URL":"https:\/\/doi.org\/10.1016\/j.psc.2020.02.006","relation":{},"ISSN":["0193-953X"],"issn-type":[{"value":"0193-953X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Frontotemporal Dementia","name":"articletitle","label":"Article Title"},{"value":"Psychiatric Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psc.2020.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}