{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:51:19Z","timestamp":1792497079862,"version":"4.5.0"},"reference-count":133,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychiatric Clinics of North America"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.psc.2023.02.008","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T07:34:16Z","timestamp":1679902456000},"page":"371-389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Treatment-Resistant Late-Life Depression"],"prefix":"10.1016","volume":"46","author":[{"given":"Subha","family":"Subramanian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanadi A.","family":"Oughli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Anne","family":"Gebara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben Julian A.","family":"Palanca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Lenze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psc.2023.02.008_bib1","author":"Organization"},{"issue":"Suppl 2","key":"10.1016\/j.psc.2023.02.008_bib2","doi-asserted-by":"crossref","first-page":"II57","DOI":"10.1007\/BF03035129","article-title":"Late-life depression","volume":"251","author":"Gottfries","year":"2001","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"2","key":"10.1016\/j.psc.2023.02.008_bib3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.maturitas.2014.05.026","article-title":"Late-life depression in the primary care setting: challenges, collaborative care, and prevention","volume":"79","author":"Hall","year":"2014","journal-title":"Maturitas"},{"issue":"2","key":"10.1016\/j.psc.2023.02.008_bib4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00019442-200105000-00004","article-title":"The association of late-life depression and anxiety with physical disability: a review of the literature and prospectus for future research","volume":"9","author":"Lenze","year":"2001","journal-title":"Am J Geriatr Psychiatry"},{"issue":"11","key":"10.1016\/j.psc.2023.02.008_bib5","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/JGP.0b013e318189806a","article-title":"The curiously strong relationship between cardiovascular disease and depression in the elderly","volume":"16","author":"Nemeroff","year":"2008","journal-title":"Am J Geriatr Psychiatry"},{"issue":"6","key":"10.1016\/j.psc.2023.02.008_bib6","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1370\/afm.143","article-title":"Depression and comorbid illness in elderly primary care patients: impact on multiple domains of health status and well-being","volume":"2","author":"Noel","year":"2004","journal-title":"Ann Fam Med"},{"issue":"8","key":"10.1016\/j.psc.2023.02.008_bib7","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1001\/jama.1991.03460080063033","article-title":"Depression and mortality in nursing homes","volume":"265","author":"Rovner","year":"1991","journal-title":"JAMA"},{"issue":"9","key":"10.1016\/j.psc.2023.02.008_bib8","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1001\/jama.291.9.1081","article-title":"Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: a randomized controlled trial","volume":"291","author":"Bruce","year":"2004","journal-title":"JAMA"},{"issue":"9","key":"10.1016\/j.psc.2023.02.008_bib9","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1176\/ps.50.9.1167","article-title":"Depression and aging: a look to the future","volume":"50","author":"Reynolds","year":"1999","journal-title":"Psychiatr Serv"},{"issue":"3","key":"10.1016\/j.psc.2023.02.008_bib10","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1001\/archpsyc.59.3.262","article-title":"National Depressive and Manic-Depressive Association consensus statement on the use of placebo in clinical trials of mood disorders","volume":"59","author":"Charney","year":"2002","journal-title":"Arch Gen Psychiatry"},{"issue":"12","key":"10.1016\/j.psc.2023.02.008_bib11","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/gps.1190","article-title":"Efficacy and tolerability of venlafaxine in geriatric outpatients with major depression: a double-blind, randomised 6-month comparative trial with citalopram","volume":"19","author":"Allard","year":"2004","journal-title":"Int J Geriatr Psychiatry"},{"issue":"6","key":"10.1016\/j.psc.2023.02.008_bib12","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1176\/ajp.2007.164.6.900","article-title":"Efficacy of duloxetine on cognition, depression, and pain in elderly patients with major depressive disorder: an 8-week, double-blind, placebo-controlled trial","volume":"164","author":"Raskin","year":"2007","journal-title":"Am J Psychiatry"},{"issue":"4","key":"10.1016\/j.psc.2023.02.008_bib13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/01.JGP.0000194645.70869.3b","article-title":"A\u00a0double-blind, placebo-controlled study of venlafaxine and fluoxetine in geriatric outpatients with major depression","volume":"14","author":"Schatzberg","year":"2006","journal-title":"Am J Geriatr Psychiatry"},{"issue":"7","key":"10.1016\/j.psc.2023.02.008_bib14","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/da.22772","article-title":"Predictors of recurrence in remitted late-life depression","volume":"35","author":"Deng","year":"2018","journal-title":"Depress Anxiety"},{"issue":"22","key":"10.1016\/j.psc.2023.02.008_bib15","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1056\/NEJMcp073754","article-title":"Clinical practice. Late-life depression","volume":"357","author":"Unutzer","year":"2007","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.psc.2023.02.008_bib16","article-title":"The Indirect Costs of Late-Life Depression in the United States: A Literature Review and Perspective","volume":"1","author":"Snow","year":"2016","journal-title":"Geriatrics (Basel)"},{"issue":"4","key":"10.1016\/j.psc.2023.02.008_bib17","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.psc.2013.08.008","article-title":"The economic, public health, and caregiver burden of late-life depression","volume":"36","author":"Zivin","year":"2013","journal-title":"Psychiatr Clin North Am"},{"issue":"3","key":"10.1016\/j.psc.2023.02.008_bib18","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jagp.2019.10.012","article-title":"An Evaluation of the Clinical and Economic Burden Among Older Adult Medicare-Covered Beneficiaries With Treatment-Resistant Depression","volume":"28","author":"Benson","year":"2020","journal-title":"Am J Geriatr Psychiatry"},{"issue":"3","key":"10.1016\/j.psc.2023.02.008_bib19","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.16m11371","article-title":"Executive Function Predicts Antidepressant Treatment Noncompletion in Late-Life Depression","volume":"79","author":"Cristancho","year":"2018","journal-title":"J\u00a0Clin Psychiatry"},{"issue":"4","key":"10.1016\/j.psc.2023.02.008_bib20","doi-asserted-by":"crossref","first-page":"419","DOI":"10.31887\/DCNS.2008.10.4\/jlenze","article-title":"Incomplete response in late-life depression: getting to remission","volume":"10","author":"Lenze","year":"2008","journal-title":"Dialogues Clin Neurosci"},{"issue":"4","key":"10.1016\/j.psc.2023.02.008_bib21","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1177\/089198879901100404","article-title":"Treatment-resistant depression in late-life","volume":"11","author":"Mulsant","year":"1998","journal-title":"J\u00a0Geriatr Psychiatry Neurol"},{"issue":"6","key":"10.1016\/j.psc.2023.02.008_bib22","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.18m12483","article-title":"Predicting Remission in Late-Life Major Depression: A Clinical Algorithm Based Upon Past Treatment History","volume":"80","author":"Buchalter","year":"2019","journal-title":"J\u00a0Clin Psychiatry"},{"issue":"4","key":"10.1016\/j.psc.2023.02.008_bib23","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1111\/jgs.17592","article-title":"What else can we do?\"-Provider perspectives on treatment-resistant depression in late-life","volume":"70","author":"Hamm","year":"2022","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.psc.2023.02.008_bib24","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1146\/annurev.clinpsy.032408.153621","article-title":"Depression in older adults","volume":"5","author":"Fiske","year":"2009","journal-title":"Annu Rev Clin Psychol"},{"issue":"6","key":"10.1016\/j.psc.2023.02.008_bib25","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1176\/appi.ps.003582012","article-title":"Research to reduce the suicide rate among older adults: methodology roadblocks and promising paradigms","volume":"64","author":"Szanto","year":"2013","journal-title":"Psychiatr Serv"},{"issue":"6","key":"10.1016\/j.psc.2023.02.008_bib26","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/WCO.0000000000000028","article-title":"Depression in the elderly: brain correlates, neuropsychological findings, and role of vascular lesion load","volume":"26","author":"Vu","year":"2013","journal-title":"Curr Opin Neurol"},{"issue":"2","key":"10.1016\/j.psc.2023.02.008_bib27","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/JGP.0b013e3181b0fa13","article-title":"Late-life depression, mild cognitive impairment, and dementia: possible continuum?","volume":"18","author":"Panza","year":"2010","journal-title":"Am J Geriatr Psychiatry"},{"issue":"3","key":"10.1016\/j.psc.2023.02.008_bib28","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jagp.2012.12.009","article-title":"Neuropsychological predictors of dementia in late-life major depressive disorder","volume":"21","author":"Potter","year":"2013","journal-title":"Am J Geriatr Psychiatry"},{"issue":"5","key":"10.1016\/j.psc.2023.02.008_bib29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1192\/bjp.bp.107.044974","article-title":"Severity of depression and risk for subsequent dementia: cohort studies in China and the UK","volume":"193","author":"Chen","year":"2008","journal-title":"Br J Psychiatry"},{"issue":"6","key":"10.1016\/j.psc.2023.02.008_bib30","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1097\/00019442-200211000-00007","article-title":"Frontostriatal and limbic dysfunction in late-life depression","volume":"10","author":"Alexopoulos","year":"2002","journal-title":"Am J Geriatr Psychiatry"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pscychresns.2011.01.003","article-title":"Reduction of dorsolateral prefrontal cortex gray matter in late-life depression","volume":"193","author":"Chang","year":"2011","journal-title":"Psychiatry Res"},{"issue":"4","key":"10.1016\/j.psc.2023.02.008_bib32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.biopsych.2011.01.029","article-title":"Depression, hypothalamic pituitary adrenal axis, and hippocampal and entorhinal cortex volumes--the SMART Medea study","volume":"70","author":"Gerritsen","year":"2011","journal-title":"Biol Psychiatry"},{"issue":"9","key":"10.1016\/j.psc.2023.02.008_bib33","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/JGP.0b013e318211069a","article-title":"Amygdala volume in late-life depression: relationship with age of onset","volume":"19","author":"Burke","year":"2011","journal-title":"Am J Geriatr Psychiatry"},{"issue":"6","key":"10.1016\/j.psc.2023.02.008_bib34","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1136\/jnnp.2006.098087","article-title":"Hippocampal volume and subcortical white matter lesions in late-life depression: comparison of early and late onset depression","volume":"78","author":"Janssen","year":"2007","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"issue":"6","key":"10.1016\/j.psc.2023.02.008_bib35","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1080\/13607863.2012.678478","article-title":"Depression, hippocampal volume changes, and cognitive decline in a clinical sample of older depressed outpatients and non-depressed controls","volume":"16","author":"Sawyer","year":"2012","journal-title":"Aging Ment Health"},{"issue":"11","key":"10.1016\/j.psc.2023.02.008_bib36","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1038\/sj.npp.1301655","article-title":"Gray matter changes in late-life depression--a structural MRI analysis","volume":"33","author":"Andreescu","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.psc.2023.02.008_bib37","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1192\/bjp.186.3.197","article-title":"Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression","volume":"186","author":"Hickie","year":"2005","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.psc.2023.02.008_bib38","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1192\/bjp.184.6.488","article-title":"Hippocampal volume change in depression: late- and early-onset illness compared","volume":"184","author":"Lloyd","year":"2004","journal-title":"Br J Psychiatry"},{"issue":"8","key":"10.1016\/j.psc.2023.02.008_bib39","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1097\/JGP.0b013e31823e2cc7","article-title":"Neural correlates associated with cognitive decline in late-life depression","volume":"20","author":"Wang","year":"2012","journal-title":"Am J Geriatr Psychiatry"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib40","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1037\/a0028727","article-title":"Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review","volume":"139","author":"Snyder","year":"2013","journal-title":"Psychol Bull"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib41","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41398-019-0514-6","article-title":"Mechanisms and treatment of late-life depression","volume":"9","author":"Alexopoulos","year":"2019","journal-title":"Transl Psychiatry"},{"issue":"Suppl 1","key":"10.1016\/j.psc.2023.02.008_bib42","first-page":"S17","article-title":"State of the Science of Neural Systems in Late-Life Depression: Impact on Clinical Presentation and Treatment Outcome","volume":"66","author":"Manning","year":"2018","journal-title":"J\u00a0Am Geriatr Soc"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib43","first-page":"98","article-title":"Clinical presentation of the \"depression-executive dysfunction syndrome\" of late-life","volume":"10","author":"Alexopoulos","year":"2002","journal-title":"Am J Geriatr Psychiatry"},{"issue":"5","key":"10.1016\/j.psc.2023.02.008_bib44","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.jagp.2014.06.005","article-title":"Apathy in late-life depression: common, persistent, and disabling","volume":"23","author":"Yuen","year":"2015","journal-title":"Am J Geriatr Psychiatry"},{"issue":"12","key":"10.1016\/j.psc.2023.02.008_bib45","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.biopsych.2006.03.052","article-title":"Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression","volume":"60","author":"Bae","year":"2006","journal-title":"Biol Psychiatry"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib46","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/JGP.0b013e31817b60af","article-title":"Altered functioning of the executive control circuit in late-life depression: episodic and persistent phenomena","volume":"17","author":"Aizenstein","year":"2009","journal-title":"Am J Geriatr Psychiatry"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib47","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jagp.2015.05.010","article-title":"A\u00a0Meta-Analysis of Executive Dysfunction and Antidepressant Treatment Response in Late-Life Depression","volume":"24","author":"Pimontel","year":"2016","journal-title":"Am J Geriatr Psychiatry"},{"issue":"1\u20133","key":"10.1016\/j.psc.2023.02.008_bib48","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jad.2012.11.023","article-title":"Functional connectivity in apathy of late-life depression: a preliminary study","volume":"149","author":"Alexopoulos","year":"2013","journal-title":"J\u00a0Affect Disord"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib49","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jagp.2014.02.001","article-title":"FMRI activation during executive function predicts response to cognitive behavioral therapy in older, depressed adults","volume":"23","author":"Thompson","year":"2015","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.psc.2023.02.008_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2022.103157","article-title":"MRI predictors of pharmacotherapy response in major depressive disorder","volume":"36","author":"Gerlach","year":"2022","journal-title":"Neuroimage Clin"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib51","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0163-8343(01)00171-2","article-title":"Predictors of nonresponse to treatment in primary care patients with dysthymia","volume":"24","author":"Katon","year":"2002","journal-title":"Gen Hosp Psychiatry"},{"issue":"5","key":"10.1016\/j.psc.2023.02.008_bib52","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1046\/j.1532-5415.2002.50206.x","article-title":"Association between medical comorbidity and treatment outcomes in late-life depression","volume":"50","author":"Oslin","year":"2002","journal-title":"J\u00a0Am Geriatr Soc"},{"issue":"11","key":"10.1016\/j.psc.2023.02.008_bib53","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1056\/NEJMoa052619","article-title":"Maintenance treatment of major depression in old age","volume":"354","author":"Reynolds","year":"2006","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.psc.2023.02.008_bib54","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cpr.2009.01.005","article-title":"The importance of functional impairment to mental health outcomes: a case for reassessing our goals in depression treatment research","volume":"29","author":"McKnight","year":"2009","journal-title":"Clin Psychol Rev"},{"issue":"4","key":"10.1016\/j.psc.2023.02.008_bib55","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1037\/0882-7974.11.4.572","article-title":"Relationship of physical disease and functional impairment to depression in older people","volume":"11","author":"Zeiss","year":"1996","journal-title":"Psychol Aging"},{"issue":"21","key":"10.1016\/j.psc.2023.02.008_bib56","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1001\/jama.279.21.1720","article-title":"Depressive symptoms and physical decline in community-dwelling older persons","volume":"279","author":"Penninx","year":"1998","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.psc.2023.02.008_bib57","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1176\/appi.ajp.2008.08081239","article-title":"Treatment-resistant depression and mortality after acute coronary syndrome","volume":"166","author":"Carney","year":"2009","journal-title":"Am J Psychiatry"},{"issue":"2\u20133","key":"10.1016\/j.psc.2023.02.008_bib58","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0165-0327(03)00105-8","article-title":"Worsening of depressive symptoms 6\u00a0months after an acute coronary event in older adults is associated with impairment of cardiac autonomic function","volume":"80","author":"de Guevara","year":"2004","journal-title":"J\u00a0Affect Disord"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib59","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cger.2014.08.022","article-title":"Depression Among Older Adults with Diabetes Mellitus","volume":"31","author":"Park","year":"2015","journal-title":"Clin Geriatr Med"},{"issue":"3","key":"10.1016\/j.psc.2023.02.008_bib60","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/gps.1456","article-title":"Depressive symptom profile in Parkinson's disease: a comparison with depression in elderly patients without Parkinson's disease","volume":"21","author":"Ehrt","year":"2006","journal-title":"Int J Geriatr Psychiatry"},{"issue":"3","key":"10.1016\/j.psc.2023.02.008_bib61","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0006-3223(03)00530-4","article-title":"Prevalence, etiology, and treatment of depression in Parkinson's disease","volume":"54","author":"McDonald","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.psc.2023.02.008_bib62","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.ne.09.030186.002041","article-title":"Parallel organization of functionally segregated circuits linking basal ganglia and cortex","volume":"9","author":"Alexander","year":"1986","journal-title":"Annu Rev Neurosci"},{"issue":"12","key":"10.1016\/j.psc.2023.02.008_bib63","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/(SICI)1099-1166(199912)14:12<1044::AID-GPS55>3.0.CO;2-0","article-title":"Review: Somatization in the elderly","volume":"14","author":"Sheehan","year":"1999","journal-title":"Int J Geriatr Psychiatry"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib64","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1177\/0020764010387065","article-title":"Psychological and clinical correlates of functional somatic complaints in depression","volume":"58","author":"Chakraborty","year":"2012","journal-title":"Int J Soc Psychiatry"},{"issue":"3","key":"10.1016\/j.psc.2023.02.008_bib65","first-page":"221","article-title":"The association of chronic pain and suicide","volume":"4","author":"Fishbain","year":"1999","journal-title":"Semin Clin Neuropsychiatry"},{"issue":"5","key":"10.1016\/j.psc.2023.02.008_bib66","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.17r11772","article-title":"Meta-Analysis of the Prevalence of Major Depressive Disorder Among Older Adults With Dementia","volume":"79","author":"Asmer","year":"2018","journal-title":"J\u00a0Clin Psychiatry"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib67","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1001\/jamapsychiatry.2016.3162","article-title":"Prevalence of Depression in Patients With Mild Cognitive Impairment: A Systematic Review and Meta-analysis","volume":"74","author":"Ismail","year":"2017","journal-title":"JAMA Psychiatry"},{"issue":"6","key":"10.1016\/j.psc.2023.02.008_bib68","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/YCO.0b013e32834bb9d4","article-title":"Depression in dementia: epidemiology, mechanisms, and treatment","volume":"24","author":"Enache","year":"2011","journal-title":"Curr Opin Psychiatry"},{"key":"10.1016\/j.psc.2023.02.008_bib69","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3389\/fphar.2020.00279","article-title":"Pathways Connecting Late-Life Depression and Dementia","volume":"11","author":"Linnemann","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.psc.2023.02.008_bib70","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fphar.2020.00034","article-title":"Depressive Symptoms in the Elderly-An Early Symptom of Dementia? A Systematic Review","volume":"11","author":"Wiels","year":"2020","journal-title":"Front Pharmacol"},{"issue":"3","key":"10.1016\/j.psc.2023.02.008_bib71","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.psyneuen.2010.09.012","article-title":"Inflammation-associated depression: from serotonin to kynurenine","volume":"36","author":"Dantzer","year":"2011","journal-title":"Psychoneuroendocrinology"},{"issue":"9","key":"10.1016\/j.psc.2023.02.008_bib72","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.biopsych.2008.11.029","article-title":"Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression","volume":"65","author":"Miller","year":"2009","journal-title":"Biol Psychiatry"},{"issue":"3","key":"10.1016\/j.psc.2023.02.008_bib73","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000026433","article-title":"Cytokine effects on glutamate uptake by human astrocytes","volume":"7","author":"Hu","year":"2000","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.psc.2023.02.008_bib74","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3389\/fncel.2014.00430","article-title":"Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity","volume":"8","author":"Calabrese","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.psc.2023.02.008_bib75","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3389\/fneur.2019.00515","article-title":"The Role of BDNF in the Neuroimmune Axis Regulation of Mood Disorders","volume":"10","author":"Jin","year":"2019","journal-title":"Front Neurol"},{"issue":"4","key":"10.1016\/j.psc.2023.02.008_bib76","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1176\/appi.ajp.162.4.718","article-title":"Remission in depressed geriatric primary care patients: a report from the PROSPECT study","volume":"162","author":"Alexopoulos","year":"2005","journal-title":"Am J Psychiatry"},{"issue":"8","key":"10.1016\/j.psc.2023.02.008_bib77","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.4088\/JCP.v66n0813","article-title":"Predictors of remission after electroconvulsive therapy in unipolar major depression","volume":"66","author":"Dombrovski","year":"2005","journal-title":"J\u00a0Clin Psychiatry"},{"issue":"5","key":"10.1016\/j.psc.2023.02.008_bib78","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/00004714-199410000-00012","article-title":"A\u00a0prospective study of lithium augmentation in antidepressant-resistant geriatric depression","volume":"14","author":"Flint","year":"1994","journal-title":"J\u00a0Clin Psychopharmacol"},{"issue":"11","key":"10.1016\/j.psc.2023.02.008_bib79","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1002\/gps.1804","article-title":"Predicting 6-week treatment response to escitalopram pharmacotherapy in late-life major depressive disorder","volume":"22","author":"Saghafi","year":"2007","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.psc.2023.02.008_bib80","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1192\/bjp.bp.106.027169","article-title":"Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study","volume":"190","author":"Andreescu","year":"2007","journal-title":"Br J Psychiatry"},{"issue":"12","key":"10.1016\/j.psc.2023.02.008_bib81","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/da.22964","article-title":"Comorbid anxiety in late-life depression: Relationship with remission and suicidal ideation on venlafaxine treatment","volume":"36","author":"Saade","year":"2019","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.psc.2023.02.008_bib82","unstructured":"Association AP. Diagnostic and statistical Manual of mental disorders Fifth ed, 2013."},{"issue":"5","key":"10.1016\/j.psc.2023.02.008_bib83","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jpsychores.2004.02.010","article-title":"Sleep disturbances and chronic disease in older adults: results of the 2003 National Sleep Foundation Sleep in America Survey","volume":"56","author":"Foley","year":"2004","journal-title":"J\u00a0Psychosom Res"},{"issue":"1\u20133","key":"10.1016\/j.psc.2023.02.008_bib84","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jad.2011.01.011","article-title":"Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies","volume":"135","author":"Baglioni","year":"2011","journal-title":"J\u00a0Affect Disord"},{"issue":"12","key":"10.1016\/j.psc.2023.02.008_bib85","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1176\/appi.ajp.2008.07121882","article-title":"Sleep disturbance and depression recurrence in community-dwelling older adults: a prospective study","volume":"165","author":"Cho","year":"2008","journal-title":"Am J Psychiatry"},{"issue":"8","key":"10.1016\/j.psc.2023.02.008_bib86","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/da.22776","article-title":"Effect of insomnia treatments on depression: A systematic review and meta-analysis","volume":"35","author":"Gebara","year":"2018","journal-title":"Depress Anxiety"},{"issue":"3","key":"10.1016\/j.psc.2023.02.008_bib87","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s41105-019-00211-6","article-title":"Brief behavioral treatment for insomnia in older adults with late-life treatment-resistant depression and insomnia: a pilot study","volume":"17","author":"Gebara","year":"2019","journal-title":"Sleep Biol Rhythms"},{"key":"10.1016\/j.psc.2023.02.008_bib88","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jpsychires.2019.06.015","article-title":"Prevalence of obstructive sleep apnea in suicidal patients with major depressive disorder","volume":"116","author":"McCall","year":"2019","journal-title":"J\u00a0Psychiatr Res"},{"issue":"12","key":"10.1016\/j.psc.2023.02.008_bib89","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/da.22555","article-title":"Self-reported obstructive sleep apnea is associated with nonresponse to antidepressant pharmacotherapy in late-life depression","volume":"33","author":"Waterman","year":"2016","journal-title":"Depress Anxiety"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib90","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jaclp.2021.05.008","article-title":"Increased Suicidality and Worse Outcomes in MDD Patients With OSA: A Nationwide Inpatient Analysis of 11 Years From 2006 to 2017","volume":"63","author":"Reddy","year":"2022","journal-title":"J\u00a0Acad Consult Liaison Psychiatry"},{"issue":"12","key":"10.1016\/j.psc.2023.02.008_bib91","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143697","article-title":"Validation of the STOP-Bang Questionnaire as a Screening Tool for Obstructive Sleep Apnea among Different Populations: A Systematic Review and Meta-Analysis","volume":"10","author":"Nagappa","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.psc.2023.02.008_bib92","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0006-3223(88)90270-3","article-title":"Leukoencephalopathy in elderly depressed patients referred for ECT","volume":"24","author":"Coffey","year":"1988","journal-title":"Biol Psychiatry"},{"issue":"5","key":"10.1016\/j.psc.2023.02.008_bib93","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0006-3223(88)90025-X","article-title":"Leukoencephalopathy in patients diagnosed as major depressive","volume":"23","author":"Krishnan","year":"1988","journal-title":"Biol Psychiatry"},{"issue":"10","key":"10.1016\/j.psc.2023.02.008_bib94","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1161\/01.STR.30.10.2159","article-title":"Cerebrovascular disease and depression symptoms in the cardiovascular health study","volume":"30","author":"Steffens","year":"1999","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pscychresns.2004.08.004","article-title":"Greater MRI lesion volumes in elderly depressed subjects than in control subjects","volume":"139","author":"Taylor","year":"2005","journal-title":"Psychiatry Res"},{"issue":"1\u20133","key":"10.1016\/j.psc.2023.02.008_bib96","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jad.2011.06.052","article-title":"MRI signal hyperintensities and failure to remit following antidepressant treatment","volume":"135","author":"Sneed","year":"2011","journal-title":"J\u00a0Affect Disord"},{"issue":"3","key":"10.1016\/j.psc.2023.02.008_bib97","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jad.2010.04.004","article-title":"MRI signal hyperintensities and treatment remission of geriatric depression","volume":"126","author":"Gunning-Dixon","year":"2010","journal-title":"J\u00a0Affect Disord"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib98","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00019442-200201000-00013","article-title":"The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients","volume":"10","author":"Salloway","year":"2002","journal-title":"Am J Geriatr Psychiatry"},{"issue":"3","key":"10.1016\/j.psc.2023.02.008_bib99","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1001\/archgenpsychiatry.2009.204","article-title":"Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial","volume":"67","author":"Sheline","year":"2010","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"10.1016\/j.psc.2023.02.008_bib100","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1176\/appi.ajp.2007.07050744","article-title":"Microstructural white matter abnormalities and remission of geriatric depression","volume":"165","author":"Alexopoulos","year":"2008","journal-title":"Am J Psychiatry"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib101","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.pscychresns.2010.06.008","article-title":"Depression severity is correlated to the integrity of white matter fiber tracts in late-onset major depression","volume":"184","author":"Dalby","year":"2010","journal-title":"Psychiat Res-Neuroim"},{"issue":"3","key":"10.1016\/j.psc.2023.02.008_bib102","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1017\/S1041610205002796","article-title":"White matter and subcortical gray matter lesion volume changes and late-life depression outcome: a 4-year magnetic resonance imaging study","volume":"18","author":"Chen","year":"2006","journal-title":"Int Psychogeriatr"},{"issue":"11","key":"10.1016\/j.psc.2023.02.008_bib103","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1001\/archpsyc.60.11.1090","article-title":"White matter hyperintensity progression and late-life depression outcomes","volume":"60","author":"Taylor","year":"2003","journal-title":"Arch Gen Psychiatry"},{"issue":"4","key":"10.1016\/j.psc.2023.02.008_bib104","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.biopsych.2012.01.019","article-title":"Cerebral hemodynamics and incident depression: the Rotterdam Study","volume":"72","author":"Direk","year":"2012","journal-title":"Biol Psychiatry"},{"issue":"8","key":"10.1016\/j.psc.2023.02.008_bib105","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/gps.1980","article-title":"Changes in regional cerebral blood flow following antidepressant treatment in late-life depression","volume":"23","author":"Ishizaki","year":"2008","journal-title":"Int J Geriatr Psychiatry"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib106","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1600-0447.1998.tb10042.x","article-title":"Changes in regional brain activity in major depression after successful treatment with antidepressant drugs","volume":"98","author":"Ogura","year":"1998","journal-title":"Acta Psychiatr Scand"},{"issue":"6","key":"10.1016\/j.psc.2023.02.008_bib107","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.18m12106","article-title":"Trajectories in Cerebral Blood Flow Following Antidepressant Treatment in Late-Life Depression: Support for the Vascular Depression Hypothesis","volume":"79","author":"Wei","year":"2018","journal-title":"J\u00a0Clin Psychiatry"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib108","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1001\/jamapsychiatry.2016.2586","article-title":"Toward an Evidence-Based, Operational Definition of Treatment-Resistant Depression: When Enough Is Enough","volume":"74","author":"Conway","year":"2017","journal-title":"JAMA Psychiatry"},{"issue":"10011","key":"10.1016\/j.psc.2023.02.008_bib109","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1016\/S0140-6736(15)00308-6","article-title":"Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late-life: a randomised, double-blind, placebo-controlled trial","volume":"386","author":"Lenze","year":"2015","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.psc.2023.02.008_bib110","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.17m11764","article-title":"Clinical Predictors of Extrapyramidal Symptoms Associated With Aripiprazole Augmentation for the Treatment of Late-Life Depression in a Randomized Controlled Trial","volume":"79","author":"Hsu","year":"2018","journal-title":"J\u00a0Clin Psychiatry"},{"key":"10.1016\/j.psc.2023.02.008_bib111","doi-asserted-by":"crossref","unstructured":"Lenze E.J., Mulsant B.H., Roose S.P., et al., Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression [published online ahead of print, 2023 Mar 3]. N Engl J Med. 2023;10.1056\/NEJMoa2204462. doi:10.1056\/NEJMoa2204462.","DOI":"10.1056\/NEJMoa2204462"},{"issue":"8","key":"10.1016\/j.psc.2023.02.008_bib112","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.4088\/JCP.v68n0803","article-title":"Lithium augmentation compared with phenelzine in treatment-resistant depression in the elderly: an open, randomized, controlled trial","volume":"68","author":"Kok","year":"2007","journal-title":"J\u00a0Clin Psychiatry"},{"issue":"11","key":"10.1016\/j.psc.2023.02.008_bib113","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1176\/appi.ajp.2016.15081101","article-title":"Right Unilateral Ultrabrief Pulse ECT in Geriatric Depression: Phase 1 of the PRIDE Study","volume":"173","author":"Kellner","year":"2016","journal-title":"Am J Psychiatry"},{"issue":"3","key":"10.1016\/j.psc.2023.02.008_bib114","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jagp.2014.05.002","article-title":"Older age is associated with rapid remission of depression after electroconvulsive therapy: a latent class growth analysis","volume":"23","author":"Rhebergen","year":"2015","journal-title":"Am J Geriatr Psychiatry"},{"issue":"2","key":"10.1016\/j.psc.2023.02.008_bib115","first-page":"93","article-title":"Effect of Age on Psychiatric Rehospitalization Rates After Electroconvulsive Therapy for Patients With Depression","volume":"32","author":"Rosen","year":"2016","journal-title":"J\u00a0ECT"},{"issue":"4","key":"10.1016\/j.psc.2023.02.008_bib116","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.psc.2013.08.007","article-title":"The role of electroconvulsive and neuromodulation therapies in the treatment of geriatric depression","volume":"36","author":"Riva-Posse","year":"2013","journal-title":"Psychiatr Clin North Am"},{"issue":"3","key":"10.1016\/j.psc.2023.02.008_bib117","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.psc.2016.04.004","article-title":"Adverse Effects of Electroconvulsive Therapy","volume":"39","author":"Andrade","year":"2016","journal-title":"Psychiatr Clin North Am"},{"issue":"4","key":"10.1016\/j.psc.2023.02.008_bib118","first-page":"326","article-title":"Post-ECT Delirium","volume":"9","author":"Fink","year":"1993","journal-title":"Convuls Ther"},{"issue":"10","key":"10.1016\/j.psc.2023.02.008_bib119","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1176\/ajp.140.10.1367","article-title":"Postictal excitement following bilateral and right-unilateral ECT","volume":"140","author":"Sackeim","year":"1983","journal-title":"Am J Psychiatry"},{"issue":"4","key":"10.1016\/j.psc.2023.02.008_bib120","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/00019442-200504000-00002","article-title":"Electroconvulsive therapy: a selected review","volume":"13","author":"Greenberg","year":"2005","journal-title":"Am J Geriatr Psychiatry"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib121","first-page":"3","article-title":"Pharmacological strategies in the prevention of relapse after electroconvulsive therapy","volume":"29","author":"Prudic","year":"2013","journal-title":"J\u00a0ECT"},{"issue":"10","key":"10.1016\/j.psc.2023.02.008_bib122","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1001\/jama.285.10.1299","article-title":"Continuation pharmacotherapy in the prevention of relapse following electroconvulsive therapy: a randomized controlled trial","volume":"285","author":"Sackeim","year":"2001","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.psc.2023.02.008_bib123","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1001\/archpsyc.63.12.1337","article-title":"Continuation electroconvulsive therapy vs pharmacotherapy for relapse prevention in major depression: a multisite study from the Consortium for Research in Electroconvulsive Therapy (CORE)","volume":"63","author":"Kellner","year":"2006","journal-title":"Arch Gen Psychiatry"},{"issue":"3","key":"10.1016\/j.psc.2023.02.008_bib124","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jagp.2019.10.003","article-title":"Neurocognitive Effects of Combined Electroconvulsive Therapy (ECT) and Venlafaxine in Geriatric Depression: Phase 1 of the PRIDE Study","volume":"28","author":"Lisanby","year":"2020","journal-title":"Am J Geriatr Psychiatry"},{"issue":"1","key":"10.1016\/j.psc.2023.02.008_bib125","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s11920-018-0866-2","article-title":"Transcranial Magnetic Stimulation (TMS) in the Elderly","volume":"20","author":"Iriarte","year":"2018","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.psc.2023.02.008_bib126","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jad.2017.03.063","article-title":"Transcranial magnetic stimulation for treatment-resistant depression: Naturalistic treatment outcomes for younger versus older patients","volume":"217","author":"Conelea","year":"2017","journal-title":"J\u00a0Affect Disord"},{"key":"10.1016\/j.psc.2023.02.008_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101531","article-title":"Transcranial magnetic stimulation (TMS) for geriatric depression","volume":"74","author":"Cappon","year":"2022","journal-title":"Ageing Res Rev"},{"issue":"5","key":"10.1016\/j.psc.2023.02.008_bib128","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jagp.2021.09.014","article-title":"Comparison of Long-Term Efficacy and Safety of Esketamine Nasal Spray Plus Oral Antidepressant in Younger Versus Older Patients With Treatment-Resistant Depression: Post-Hoc Analysis of SUSTAIN-2, a Long-Term Open-Label Phase 3 Safety and Efficacy Study","volume":"30","author":"Ochs-Ross","year":"2022","journal-title":"Am J Geriatr Psychiatry"},{"issue":"2","key":"10.1016\/j.psc.2023.02.008_bib129","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jagp.2019.10.008","article-title":"Efficacy and Safety of Esketamine Nasal Spray Plus an Oral Antidepressant in Elderly Patients With Treatment-Resistant Depression-TRANSFORM-3","volume":"28","author":"Ochs-Ross","year":"2020","journal-title":"Am J Geriatr Psychiatry"},{"issue":"9","key":"10.1016\/j.psc.2023.02.008_bib130","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.jagp.2020.12.032","article-title":"Safety, Tolerability, and Real-World Effectiveness of Intravenous Ketamine in Older Adults With Treatment-Resistant Depression: A Case Series","volume":"29","author":"Lipsitz","year":"2021","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.psc.2023.02.008_bib131","article-title":"Intravenous Ketamine for Late-Life Treatment-Resistant Depression: A Pilot Study of Tolerability, Safety, Clinical Benefits, and Effect on Cognition [published online ahead of print, 2022 Dec 5]","author":"Oughli","year":"2022","journal-title":"Am J Geriatr Psychiatry"},{"issue":"5","key":"10.1016\/j.psc.2023.02.008_bib132","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.biopsych.2005.07.028","article-title":"A\u00a0one-year comparison of vagus nerve stimulation with treatment as usual for treatment-resistant depression","volume":"58","author":"George","year":"2005","journal-title":"Biol Psychiatry"},{"issue":"7","key":"10.1016\/j.psc.2023.02.008_bib133","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1176\/appi.ajp.2017.16010034","article-title":"A\u00a05-Year Observational Study of Patients With Treatment-Resistant Depression Treated With Vagus Nerve Stimulation or Treatment as Usual: Comparison of Response, Remission, and Suicidality","volume":"174","author":"Aaronson","year":"2017","journal-title":"Am J Psychiatry"}],"container-title":["Psychiatric Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0193953X23000205?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0193953X23000205?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T01:43:16Z","timestamp":1759282996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0193953X23000205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":133,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S0193953X23000205"],"URL":"https:\/\/doi.org\/10.1016\/j.psc.2023.02.008","relation":{},"ISSN":["0193-953X"],"issn-type":[{"value":"0193-953X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment-Resistant Late-Life Depression","name":"articletitle","label":"Article Title"},{"value":"Psychiatric Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psc.2023.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}