{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:18:48Z","timestamp":1779142728835,"version":"3.51.4"},"reference-count":78,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","theclinics.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychiatric Clinics of North America"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.psc.2025.01.012","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T12:17:39Z","timestamp":1741609059000},"page":"377-401","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genomics of Anxiety Disorders"],"prefix":"10.1016","volume":"48","author":[{"given":"Heike","family":"Weber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Hettema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Deckert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Erhardt-Lehmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.psc.2025.01.012_bib1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/mpr.1359","article-title":"Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States","volume":"21","author":"Kessler","year":"2012","journal-title":"Int J Methods Psychiatr Res"},{"issue":"24","key":"10.1016\/j.psc.2025.01.012_bib2","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1001\/jama.2022.22744","article-title":"Anxiety disorders","volume":"328","author":"Szuhany","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.psc.2025.01.012_bib3","series-title":"Diagnostic and statistical manual of mental disorders","year":"2013"},{"issue":"1","key":"10.1016\/j.psc.2025.01.012_bib4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41380-021-01161-7","article-title":"Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies","volume":"27","author":"Solmi","year":"2022","journal-title":"Mol Psychiatry"},{"issue":"9","key":"10.1016\/j.psc.2025.01.012_bib5","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S2215-0366(23)00193-1","article-title":"Age of onset and cumulative risk of mental disorders: a cross-national analysis of population surveys from 29 countries","volume":"10","author":"McGrath","year":"2023","journal-title":"Lancet Psychiatr"},{"issue":"3","key":"10.1016\/j.psc.2025.01.012_bib6","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.chc.2012.05.001","article-title":"Developmental epidemiology of anxiety disorders","volume":"21","author":"Beesdo-Baum","year":"2012","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"issue":"3","key":"10.1016\/j.psc.2025.01.012_bib7","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/mpr.1439","article-title":"Twelve-month prevalence, comorbidity and correlates of mental disorders in Germany: the mental health module of the German health interview and examination survey for adults (DEGS1-MH)","volume":"23","author":"Jacobi","year":"2014","journal-title":"Int J Methods Psychiatr Res"},{"issue":"10","key":"10.1016\/j.psc.2025.01.012_bib8","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1176\/appi.ajp.158.10.1568","article-title":"A review and meta-analysis of the genetic epidemiology of anxiety disorders","volume":"158","author":"Hettema","year":"2001","journal-title":"Am J Psychiatr"},{"issue":"2","key":"10.1016\/j.psc.2025.01.012_bib9","doi-asserted-by":"crossref","DOI":"10.1001\/archpsyc.62.2.182","article-title":"The structure of genetic and environmental risk factors for anxiety disorders in men and women","volume":"62","author":"Hettema","year":"2005","journal-title":"Arch Gen Psychiatry"},{"issue":"3","key":"10.1016\/j.psc.2025.01.012_bib10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s11920-019-1002-7","article-title":"Genetics of anxiety disorders","volume":"21","author":"Meier","year":"2019","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.psc.2025.01.012_bib11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/npp.2015.266","article-title":"The genetics of stress-related disorders: PTSD, depression, and anxiety disorders","volume":"41","author":"Smoller","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.psc.2025.01.012_bib12","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/ejhg.2012.47","article-title":"Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes","volume":"20","author":"Webb","year":"2012","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.psc.2025.01.012_bib13","doi-asserted-by":"crossref","DOI":"10.1111\/pcn.12291","article-title":"Genetics of anxiety disorders: genetic epidemiological and molecular studies in humans","author":"Shimada-Sugimoto","year":"2015","journal-title":"Psychiatry Clin Neurosci"},{"issue":"1","key":"10.1016\/j.psc.2025.01.012_bib14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/ejhg.2011.148","article-title":"A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene","volume":"20","author":"Gregersen","year":"2012","journal-title":"Eur J Hum Genet"},{"issue":"10","key":"10.1016\/j.psc.2025.01.012_bib15","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/ejhg.2012.47","article-title":"Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes","volume":"20","author":"Webb","year":"2012","journal-title":"Eur J Hum Genet"},{"issue":"8","key":"10.1016\/j.psc.2025.01.012_bib16","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.biopsych.2008.06.002","article-title":"An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders","volume":"64","author":"Donner","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.psc.2025.01.012_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2019.100191","article-title":"Neurobiological links between stress and anxiety","volume":"11","author":"Daviu","year":"2019","journal-title":"Neurobiol Stress"},{"issue":"5","key":"10.1016\/j.psc.2025.01.012_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/mp.2015.138","article-title":"Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogenic pathways","volume":"21","author":"Howe","year":"2016","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.psc.2025.01.012_bib19","first-page":"1","article-title":"Genetic contributions to anxiety disorders : where we are and where we are heading","volume":"9","author":"Ask","year":"2021","journal-title":"Psychol Med"},{"issue":"6","key":"10.1016\/j.psc.2025.01.012_bib20","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/mp.2010.41","article-title":"TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies","volume":"16","author":"Erhardt","year":"2011","journal-title":"Mol Psychiatry"},{"issue":"9","key":"10.1016\/j.psc.2025.01.012_bib76","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1038\/tp.2012.85","article-title":"Replication and meta-analysis of TMEM132D gene variants in panic disorder","volume":"2","author":"Erhardt","year":"2012","journal-title":"Transl Psychiatry"},{"issue":"8","key":"10.1016\/j.psc.2025.01.012_bib77","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134865","article-title":"Generalised anxiety disorder--a twin study of genetic architecture, genome-wide association and differential gene expression","volume":"10","author":"Davies","year":"2015","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.psc.2025.01.012_bib30","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/mp.2015.197","article-title":"Meta-analysis of genome-wide association studies of anxiety disorders","volume":"21","author":"Otowa","year":"2016","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.psc.2025.01.012_bib23","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1038\/mp.2017.2","article-title":"GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder","volume":"22","author":"Deckert","year":"2017","journal-title":"Mol Psychiatry"},{"issue":"4","key":"10.1016\/j.psc.2025.01.012_bib31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/ajmg.b.32776","article-title":"Genome-wide association study of shared liability to anxiety disorders in Army STARRS","volume":"183","author":"Hettema","year":"2020","journal-title":"Am J Med Genet, Part B: Neuropsychiatric Genetics"},{"issue":"9","key":"10.1016\/j.psc.2025.01.012_bib32","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1001\/jamapsychiatry.2019.1119","article-title":"Genetic variants associated with anxiety and stress-related disorders","volume":"76","author":"Meier","year":"2019","journal-title":"JAMA Psychiatr"},{"issue":"7","key":"10.1016\/j.psc.2025.01.012_bib35","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/s41588-018-0151-7","article-title":"Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways","volume":"50","author":"Nagel","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.psc.2025.01.012_bib34","article-title":"A major role for common genetic variation in anxiety disorders","author":"Purves","year":"2019","journal-title":"Mol Psychiatry"},{"issue":"5","key":"10.1016\/j.psc.2025.01.012_bib80","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41588-018-0090-3","article-title":"Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression","volume":"50","author":"Wray","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.psc.2025.01.012_bib37","article-title":"Reproducible genetic risk loci for anxiety: results from \u223c200,000 participants in the million veteran Program","volume":"9","author":"Levey","year":"2020","journal-title":"Am J Psychiatr"},{"issue":"2","key":"10.1016\/j.psc.2025.01.012_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41562-023-01746-y","article-title":"Genome-wide meta-analysis, functional genomics and integrative analyses implicate new risk genes and therapeutic targets for anxiety disorders","volume":"8","author":"Li","year":"2023","journal-title":"Nat Hum Behav"},{"issue":"12","key":"10.1016\/j.psc.2025.01.012_bib81","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/pcn.13742","article-title":"Identification of novel genomic loci for anxiety symptoms and extensive genetic overlap with psychiatric disorders","volume":"78","author":"Tesfaye","year":"2024","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.1016\/j.psc.2025.01.012_bib40","article-title":"Gene discovery and biological insights into anxiety disorders from a multi-ancestry genome-wide association study of >1.2 million participants","author":"Friligkou","year":"2024","journal-title":"medRxiv"},{"key":"10.1016\/j.psc.2025.01.012_bib41","article-title":"Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling","author":"Strom","year":"2024","journal-title":"medRxiv"},{"issue":"11","key":"10.1016\/j.psc.2025.01.012_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112559","article-title":"Genome-wide and gene-based association studies of anxiety disorders in european and african american samples","volume":"9","author":"Otowa","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.psc.2025.01.012_bib22","doi-asserted-by":"crossref","DOI":"10.1186\/1755-8166-6-26","article-title":"Intragenic deletion of RBFOX1 associated with neurodevelopmental\/neuropsychiatric disorders and possibly other clinical presentations","volume":"6","author":"Zhao","year":"2013","journal-title":"Mol Cytogenet"},{"issue":"9","key":"10.1016\/j.psc.2025.01.012_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2017.186","article-title":"Modulation of defensive reactivity by GLRB allelic variation: converging evidence from an intermediate phenotype approach","volume":"7","author":"Lueken","year":"2017","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.psc.2025.01.012_bib25","article-title":"Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression","author":"Forstner","year":"2019","journal-title":"Mol Psychiatry"},{"issue":"4","key":"10.1016\/j.psc.2025.01.012_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058676","article-title":"First genome-wide association study on anxiety-related behaviours in childhood","volume":"8","author":"Trzaskowski","year":"2013","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.psc.2025.01.012_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080326","article-title":"Performance of polygenic scores for predicting phobic anxiety","volume":"8","author":"Walter","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.psc.2025.01.012_bib28","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/ajmg.b.32448","article-title":"Genome-wide association study of generalized anxiety symptoms in the hispanic community health study\/study of latinos","volume":"174","author":"Dunn","year":"2017","journal-title":"Am J Med Genet, Part B: Neuropsychiatric Genetics"},{"issue":"2","key":"10.1016\/j.psc.2025.01.012_bib29","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/ajmg.b.32520","article-title":"Genetic risk variants for social anxiety","volume":"174","author":"Stein","year":"2017","journal-title":"Am J Med Genet Part B: Neuropsychiatric Genetics"},{"issue":"7","key":"10.1016\/j.psc.2025.01.012_bib33","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1038\/sj.npp.1301537","article-title":"Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B)","volume":"33","author":"Zhang","year":"2008","journal-title":"Neuropsychopharmacology"},{"issue":"10","key":"10.1016\/j.psc.2025.01.012_bib36","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1038\/s41380-019-0639-2","article-title":"Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders","volume":"25","author":"Notaras","year":"2020","journal-title":"Mol Psychiatry"},{"issue":"1","key":"10.1016\/j.psc.2025.01.012_bib42","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12888-024-05624-3","article-title":"A causal relationship between panic disorder and risk of alzheimer disease: a two-sample mendelian randomization analysis","volume":"24","author":"Tian","year":"2024","journal-title":"BMC Psychiatr"},{"issue":"3","key":"10.1016\/j.psc.2025.01.012_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0298998","article-title":"The relationship between emotional disorders and heart rate variability: a Mendelian randomization study","volume":"19","author":"Luo","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.psc.2025.01.012_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/ehf2.14676","article-title":"Anxiety disorder and cardiovascular disease: a two-sample Mendelian randomization study","author":"Peng","year":"2024","journal-title":"ESC Heart Fail"},{"issue":"1","key":"10.1016\/j.psc.2025.01.012_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/s41525-019-0098-3","article-title":"A large data resource of genomic copy number variation across neurodevelopmental disorders","volume":"4","author":"Zarrei","year":"2019","journal-title":"NPJ Genom Med"},{"issue":"5","key":"10.1016\/j.psc.2025.01.012_bib46","first-page":"904","article-title":"A general framework for identifying oligogenic combinations of rare variants in complex disorders","volume":"32","author":"Pounraja","year":"2022","journal-title":"Genome Res"},{"issue":"12","key":"10.1016\/j.psc.2025.01.012_bib47","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/jhg.2011.117","article-title":"A genome-wide CNV association study on panic disorder in a Japanese population","volume":"56","author":"Kawamura","year":"2011","journal-title":"J Hum Genet"},{"issue":"8","key":"10.1016\/j.psc.2025.01.012_bib48","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/ajmg.b.32464","article-title":"Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population","volume":"171","author":"Gregersen","year":"2016","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"1","key":"10.1016\/j.psc.2025.01.012_bib49","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-017-0088-0","article-title":"Whole-exome sequencing and gene-based rare variant association tests suggest that PLA2G4E might be a risk gene for panic disorder","volume":"8","author":"Morimoto","year":"2018","journal-title":"Transl Psychiatry"},{"issue":"7","key":"10.1016\/j.psc.2025.01.012_bib50","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1017\/S0033291721005201","article-title":"Psychopathology in adults with copy number variants","volume":"53","author":"Adams","year":"2023","journal-title":"Psychol Med"},{"issue":"7","key":"10.1016\/j.psc.2025.01.012_bib51","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.biopsych.2023.01.028","article-title":"Impact of copy number variants and polygenic risk scores on psychopathology in the UK biobank","volume":"94","author":"Mollon","year":"2023","journal-title":"Biol Psychiatry"},{"issue":"6","key":"10.1016\/j.psc.2025.01.012_bib52","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/da.23251","article-title":"Whole-exome DNA sequencing in childhood anxiety disorders identifies rare de novo damaging coding variants","volume":"39","author":"Olfson","year":"2022","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.psc.2025.01.012_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2023.110928","article-title":"Identification of novel rare variants for anxiety: an exome-wide association study in the UK Biobank","volume":"130","author":"Pan","year":"2024","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"11","key":"10.1016\/j.psc.2025.01.012_bib54","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1080\/17425255.2021.1991912","article-title":"The role of pharmacogenetics in the treatment of anxiety disorders and the future potential for targeted therapeutics","volume":"17","author":"Scherf-Clavel","year":"2021","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"10","key":"10.1016\/j.psc.2025.01.012_bib55","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1080\/14656566.2018.1491966","article-title":"Pharmacotherapy for generalized anxiety disorder in adult and pediatric patients: an evidence-based treatment review","volume":"19","author":"Strawn","year":"2018","journal-title":"Expert Opin Pharmacother"},{"issue":"1","key":"10.1016\/j.psc.2025.01.012_bib56","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/a-1288-1061","article-title":"Review and consensus on pharmacogenomic testing in psychiatry","volume":"54","author":"Bousman","year":"2021","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.psc.2025.01.012_bib57","first-page":"1","article-title":"Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs","author":"Roseberry","year":"2023","journal-title":"Mol Psychiatry"},{"issue":"4","key":"10.1016\/j.psc.2025.01.012_bib58","first-page":"123","article-title":"The therapygenetics of anxiety disorders","volume":"33","author":"Vashishtha","year":"2023","journal-title":"Psychiatr Genet"},{"key":"10.1016\/j.psc.2025.01.012_bib59","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.euroneuro.2021.01.004","article-title":"Therapygenetic effects of 5-HTTLPR on cognitive-behavioral therapy in anxiety disorders: a meta-analysis","volume":"44","author":"Schiele","year":"2021","journal-title":"Eur Neuropsychopharmacol"},{"issue":"12","key":"10.1016\/j.psc.2025.01.012_bib60","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/da.22430","article-title":"HPA axis related genes and response to psychological therapies: genetics and epigenetics","volume":"32","author":"Roberts","year":"2015","journal-title":"Depress Anxiety"},{"issue":"1","key":"10.1016\/j.psc.2025.01.012_bib61","first-page":"150","article-title":"A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders","volume":"9","author":"Rayner","year":"2019"},{"issue":"3","key":"10.1016\/j.psc.2025.01.012_bib62","doi-asserted-by":"crossref","DOI":"10.1111\/gbb.12423","article-title":"Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders","volume":"17","author":"Schiele","year":"2018","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.psc.2025.01.012_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpr.2020.101830","article-title":"The applied implications of epigenetics in anxiety, affective and stress-related disorders - a review and synthesis on psychosocial stress, psychotherapy and prevention","volume":"77","author":"Schiele","year":"2020","journal-title":"Clin Psychol Rev"},{"issue":"9","key":"10.1016\/j.psc.2025.01.012_bib64","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1017\/S146114571200020X","article-title":"Monoamine oxidase A gene DNA hypomethylation - a risk factor for panic disorder?","volume":"15","author":"Domschke","year":"2012","journal-title":"Int J Neuropsychopharmacol"},{"issue":"4","key":"10.1016\/j.psc.2025.01.012_bib65","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.41","article-title":"MAOA gene hypomethylation in panic disorder-reversibility of an epigenetic risk pattern by psychotherapy","volume":"6","author":"Ziegler","year":"2016","journal-title":"Transl Psychiatry"},{"issue":"12","key":"10.1016\/j.psc.2025.01.012_bib66","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-017-0026-1","article-title":"DNA Methylation signatures in panic disorder","volume":"7","author":"Iurato","year":"2017","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.psc.2025.01.012_bib67","first-page":"1","article-title":"Effects of stressful life - events on DNA methylation in panic disorder and major depressive disorder","author":"Czamara","year":"2022","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.psc.2025.01.012_bib68","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13148-016-0307-1","article-title":"Epigenome-wide association study of DNA methylation in panic disorder","volume":"9","author":"Shimada-Sugimoto","year":"2017","journal-title":"Clin Epigenetics"},{"issue":"1","key":"10.1016\/j.psc.2025.01.012_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13148-020-00972-9","article-title":"Altered immune phenotype and DNA methylation in panic disorder","volume":"12","author":"Petersen","year":"2020","journal-title":"Clin Epigenetics"},{"issue":"1","key":"10.1016\/j.psc.2025.01.012_bib70","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-019-0648-6","article-title":"The DNA methylome in panic disorder: a case-control and longitudinal psychotherapy-epigenetic study","volume":"9","author":"Ziegler","year":"2019","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.psc.2025.01.012_bib71","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-022-01802-7","article-title":"DNA-methylation dynamics across short-term, exposure-containing CBT in patients with panic disorder","author":"Moser","year":"2022","journal-title":"Transl Psychiatry"},{"issue":"2","key":"10.1016\/j.psc.2025.01.012_bib72","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/npp.2017.102","article-title":"Anxiety associated increased CpG methylation in the promoter of Asb1: a translational approach evidenced by epidemiological and clinical studies and a murine model","volume":"43","author":"Emeny","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.psc.2025.01.012_bib73","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jpsychires.2018.03.008","article-title":"Changes in methylation within the STK32B promoter are associated with an increased risk for generalized anxiety disorder in adolescents","volume":"102","author":"Ciuculete","year":"2018","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.psc.2025.01.012_bib74","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41398-021-01225-w","article-title":"DNA methylation differences associated with social anxiety disorder and early life adversity","volume":"11","author":"Wiegand","year":"2021","journal-title":"Transl Psychiatry"},{"issue":"8","key":"10.1016\/j.psc.2025.01.012_bib75","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1038\/s41380-023-02205-w","article-title":"Methylome-wide association study of anxiety disorders","volume":"28","author":"Hettema","year":"2023","journal-title":"Mol Psychiatry"}],"container-title":["Psychiatric Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0193953X25000127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0193953X25000127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T04:23:57Z","timestamp":1746764637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0193953X25000127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":78,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S0193953X25000127"],"URL":"https:\/\/doi.org\/10.1016\/j.psc.2025.01.012","relation":{},"ISSN":["0193-953X"],"issn-type":[{"value":"0193-953X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomics of Anxiety Disorders","name":"articletitle","label":"Article Title"},{"value":"Psychiatric Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psc.2025.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}