{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:50:02Z","timestamp":1791510602919,"version":"4.3.4"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:00:00Z","timestamp":1754092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015335","name":"The Modern Agricultural Industry Technology System","doi-asserted-by":"publisher","award":["SDAIT-20-06"],"award-info":[{"award-number":["SDAIT-20-06"]}],"id":[{"id":"10.13039\/501100015335","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmaceutical Science Advances"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.pscia.2025.100087","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T22:17:30Z","timestamp":1754432250000},"page":"100087","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Nanoplatforms in sepsis storm: Multimodal synergy for precision immunomodulation and pathogen neutralizations"],"prefix":"10.1016","volume":"3","author":[{"given":"Xinxin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daquan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.pscia.2025.100087_bib1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nrneurol.2012.183","article-title":"Sepsis-associated encephalopathy","volume":"8","author":"Gofton","year":"2012","journal-title":"Nat. Rev. Neurol."},{"issue":"11","key":"10.1016\/j.pscia.2025.100087_bib2","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/s41581-021-00452-0","article-title":"Pathophysiology of COVID-19-associated acute kidney injury","volume":"17","author":"Legrand","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"issue":"23","key":"10.1016\/j.pscia.2025.100087_bib3","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1182\/blood.2020006000","article-title":"COVID-19 and its implications for thrombosis and anticoagulation","volume":"135","author":"Connors","year":"2020","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.pscia.2025.100087_bib4","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrd4368","article-title":"Strategies to improve drug development for sepsis","volume":"13","author":"Fink","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.pscia.2025.100087_bib5","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1038\/s41467-020-19706-9","article-title":"Immune suppression in the early stage of COVID-19 disease","volume":"11","author":"Tian","year":"2020","journal-title":"Nat. Commun."},{"issue":"22","key":"10.1016\/j.pscia.2025.100087_bib6","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V128.22.275.275","article-title":"Bacteremia, not coagulation proteases contribute to in vivo complement activation in sepsis","volume":"128","author":"Keshari","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.pscia.2025.100087_bib7","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.phrs.2016.07.019","article-title":"Immunotherapy: a promising approach to reverse sepsis-induced immunosuppression","volume":"111","author":"Patil","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"23","key":"10.1016\/j.pscia.2025.100087_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202206211","article-title":"Polysaccharide-based stimulus-responsive nanomedicines for combination cancer immunotherapy","volume":"19","author":"Li","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.pscia.2025.100087_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2023.102933","article-title":"The bioavailability, metabolism and microbial modulation of curcumin-loaded nanodelivery systems","volume":"318","author":"Chang","year":"2023","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.pscia.2025.100087_bib10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tifs.2019.06.001","article-title":"Analytical control of nanodelivery lipid-based systems for encapsulation of nutraceuticals: achievements and challenges","volume":"90","author":"Montes","year":"2019","journal-title":"Trends Food Sci. Technol."},{"issue":"1","key":"10.1016\/j.pscia.2025.100087_bib11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12929-020-00702-6","article-title":"Advances in sepsis diagnosis and management: a paradigm shift towards nanotechnology","volume":"28","author":"Pant","year":"2021","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.pscia.2025.100087_bib12","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.biomaterials.2015.04.025","article-title":"Inhibition of MAP kinase\/NF-kB mediated signaling and attenuation of lipopolysaccharide induced severe sepsis by cerium oxide nanoparticles","volume":"59","author":"Selvaraj","year":"2015","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.pscia.2025.100087_bib13","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1021\/acs.accounts.9b00079","article-title":"Bioinspired and biomimetic nanomedicines","volume":"52","author":"Chen","year":"2019","journal-title":"Acc. Chem. Res."},{"issue":"4","key":"10.1016\/j.pscia.2025.100087_bib14","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41569-021-00629-x","article-title":"Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis","volume":"19","author":"Chen","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"issue":"43","key":"10.1016\/j.pscia.2025.100087_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201803618","article-title":"Bioresponsive nanoparticles targeted to infectious microenvironments for sepsis management","volume":"30","author":"Zhang","year":"2018","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.pscia.2025.100087_bib16","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1038\/s41467-017-02402-6","article-title":"The podoplanin-CLEC-2 axis inhibits inflammation in sepsis","volume":"8","author":"Rayes","year":"2017","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.pscia.2025.100087_bib17","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/BF01720718","article-title":"Retracted article: circulating adhesion molecules in the critically ill: a comparison between trauma and sepsis patients","volume":"22","author":"Boldt","year":"1996","journal-title":"Intensive Care Med."},{"issue":"11","key":"10.1016\/j.pscia.2025.100087_bib18","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1007\/s00134-018-5379-2","article-title":"Effectiveness of sodium bicarbonate infusion on mortality in septic patients with metabolic acidosis","volume":"44","author":"Zhang","year":"2018","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.pscia.2025.100087_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101215","article-title":"STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3","volume":"24","author":"Li","year":"2019","journal-title":"Redox Biol."},{"issue":"51","key":"10.1016\/j.pscia.2025.100087_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202209185","article-title":"Co-Delivery of an amyloid-disassembling polyphenol cross-linked in a micellar shell with core-loaded antibiotics for balanced biofilm dispersal and killing","volume":"32","author":"Tian","year":"2022","journal-title":"Adv. Funct. Mater."},{"issue":"22","key":"10.1016\/j.pscia.2025.100087_bib21","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1002\/adma.200703158","article-title":"Enzyme-responsive nanoparticle systems","volume":"20","author":"Ghadiali","year":"2008","journal-title":"Adv. Mater."},{"issue":"14","key":"10.1016\/j.pscia.2025.100087_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202207448","article-title":"Rapidly inhibiting the inflammatory cytokine storms and restoring cellular homeostasis to alleviate sepsis by blocking pyroptosis and mitochondrial apoptosis pathways","volume":"10","author":"Yan","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.pscia.2025.100087_bib23","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ijbiomac.2022.01.194","article-title":"Improvement of pneumonia by curcumin-loaded bionanosystems based on platycodon grandiflorum polysaccharides via calming cytokine storm","volume":"202","author":"Li","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.pscia.2025.100087_bib24","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/s41551-018-0234-x","article-title":"Micelles with ultralow critical micelle concentration as carriers for drug delivery","volume":"2","author":"Lu","year":"2018","journal-title":"Nat. Biomed. Eng."},{"issue":"45","key":"10.1016\/j.pscia.2025.100087_bib25","article-title":"Cation-free siRNA micelles as effective drug delivery platform and potent RNAi nanomedicines for glioblastoma therapy","volume":"33","author":"Jiang","year":"2021","journal-title":"Adv. Mater."},{"issue":"5","key":"10.1016\/j.pscia.2025.100087_bib26","doi-asserted-by":"crossref","first-page":"5862","DOI":"10.1021\/acsnano.0c01012","article-title":"Reactive oxygen species responsive Theranostic nanoplatform for two-photon aggregation-induced emission imaging and therapy of acute and chronic inflammation","volume":"14","author":"Ma","year":"2020","journal-title":"ACS Nano"},{"issue":"11","key":"10.1016\/j.pscia.2025.100087_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax7964","article-title":"Nanoparticle-induced neutrophil apoptosis increases survival in sepsis and alleviates neurological damage in stroke","volume":"5","author":"Zhang","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.pscia.2025.100087_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.115972","article-title":"Construction of an environmentally friendly octenylsuccinic anhydride modified pH-sensitive chitosan nanoparticle drug delivery system to alleviate inflammation and oxidative stress","volume":"236","author":"Yu","year":"2020","journal-title":"Carbohydr. Polym."},{"issue":"8","key":"10.1016\/j.pscia.2025.100087_bib29","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/s41565-022-01137-w","article-title":"NAD(H)-loaded nanoparticles for efficient sepsis therapy via modulating immune and vascular homeostasis","volume":"17","author":"Ye","year":"2022","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.pscia.2025.100087_bib30","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jconrel.2019.11.032","article-title":"Ginsenoside Rg3-loaded, reactive oxygen species-responsive polymeric nanoparticles for alleviating myocardial ischemia-reperfusion injury","volume":"317","author":"Li","year":"2020","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.pscia.2025.100087_bib31","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.biomaterials.2017.08.008","article-title":"Reactive oxygen species-responsive polymeric nanoparticles for alleviating sepsis-induced acute liver injury in mice","volume":"144","author":"Chen","year":"2017","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.pscia.2025.100087_bib32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12951-019-0537-4","article-title":"Targeted delivery of antibiotics to the infected pulmonary tissues using ROS-responsive nanoparticles","volume":"17","author":"Wang","year":"2019","journal-title":"J. Nanobiotechnol."},{"issue":"9","key":"10.1016\/j.pscia.2025.100087_bib33","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1021\/ja211279u","article-title":"Lipase-sensitive polymeric triple-layered nanogel for \u201cOn-Demand\u201d drug delivery","volume":"134","author":"Xiong","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.pscia.2025.100087_bib34","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jconrel.2019.09.012","article-title":"In-vitro and in-vivo characterization of a multi-stage enzyme-responsive nanoparticle-in-microgel pulmonary drug delivery system","volume":"316","author":"Mej\u00edas","year":"2019","journal-title":"J. Contr. Release"},{"issue":"19","key":"10.1016\/j.pscia.2025.100087_bib35","doi-asserted-by":"crossref","first-page":"7882","DOI":"10.1021\/acs.nanolett.2c02560","article-title":"Macrophage-membrane-camouflaged nonviral gene vectors for the treatment of multidrug-resistant bacterial sepsis","volume":"22","author":"Cao","year":"2022","journal-title":"Nano Lett."},{"issue":"6","key":"10.1016\/j.pscia.2025.100087_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202107791","article-title":"Erythrocyte membrane camouflaged metal\u2013organic framework nanodrugs for remodeled tumor microenvironment and enhanced tumor chemotherapy","volume":"32","author":"Qiao","year":"2022","journal-title":"Adv. Funct. Mater."},{"issue":"9","key":"10.1016\/j.pscia.2025.100087_bib37","doi-asserted-by":"crossref","first-page":"14022","DOI":"10.1021\/acsnano.1c05922","article-title":"Polyethylene glycol immunogenicity: theoretical, clinical, and practical aspects of anti-polyethylene glycol antibodies","volume":"15","author":"Chen","year":"2021","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.pscia.2025.100087_bib38","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41569-019-0312-0","article-title":"Pro-inflammatory atherogenic role of platelets","volume":"17","author":"Lim","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"issue":"23","key":"10.1016\/j.pscia.2025.100087_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202101628","article-title":"Microbubble functionalization with platelet membrane enables targeting and early detection of sepsis-induced acute kidney injury","volume":"10","author":"Yang","year":"2021","journal-title":"Adv. Healthcare Mater."},{"issue":"14","key":"10.1016\/j.pscia.2025.100087_bib40","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1001\/jama.2018.12179","article-title":"Antibiotics for sepsis\u2014finding the equilibrium","volume":"320","author":"Klompas","year":"2018","journal-title":"JAMA"},{"issue":"Supplement 1","key":"10.1016\/j.pscia.2025.100087_bib41","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1182\/blood-2020-136725","article-title":"Effect of ABCB1 multidrug resistance protein on efficacy of anti-myeloma drugs in carfilzomib-resistant myeloma model","volume":"136","author":"Byrgazov","year":"2020","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.pscia.2025.100087_bib42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41565-019-0600-1","article-title":"Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis","volume":"15","author":"Hou","year":"2020","journal-title":"Nat. Nanotechnol."},{"issue":"6","key":"10.1016\/j.pscia.2025.100087_bib43","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/s41564-018-0164-0","article-title":"Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides","volume":"3","author":"L\u00e1z\u00e1r","year":"2018","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.pscia.2025.100087_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.100954","article-title":"Antimicrobial peptides for combating drug-resistant bacterial infections","volume":"68","author":"Xuan","year":"2023","journal-title":"Drug Resist. Updates"},{"key":"10.1016\/j.pscia.2025.100087_bib45","article-title":"A Zinc- and calcium-rich lysosomal nanoreactor rescues monocyte\/macrophage dysfunction under sepsis","author":"Zhao","year":"2023","journal-title":"Adv. Sci."},{"issue":"5","key":"10.1016\/j.pscia.2025.100087_bib46","doi-asserted-by":"crossref","first-page":"7732","DOI":"10.1021\/acsnano.1c11613","article-title":"Boronic acid-decorated multivariate photosensitive metal\u2013organic frameworks for combating multi-drug-resistant bacteria","volume":"16","author":"Chen","year":"2022","journal-title":"ACS Nano"},{"issue":"19","key":"10.1016\/j.pscia.2025.100087_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202112902","article-title":"Antibacterial films based on MOF composites that release iodine passively or upon triggering by near-infrared light","volume":"32","author":"Han","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.pscia.2025.100087_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101574","article-title":"Blocking glutathione regeneration: inorganic NADPH oxidase nanozyme catalyst potentiates tumoral ferroptosis","volume":"46","author":"Wu","year":"2022","journal-title":"Nano Today"},{"key":"10.1016\/j.pscia.2025.100087_bib49","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.mattod.2021.10.032","article-title":"Defect engineering in nanozymes","volume":"52","author":"Wu","year":"2022","journal-title":"Mater. Today"},{"key":"10.1016\/j.pscia.2025.100087_bib50","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mattod.2020.08.020","article-title":"Structure and activity of nanozymes: inspirations for de novo design of nanozymes","volume":"41","author":"Wang","year":"2020","journal-title":"Mater. Today"},{"key":"10.1016\/j.pscia.2025.100087_bib51","doi-asserted-by":"crossref","DOI":"10.34133\/2022\/9767643","article-title":"Decoy nanozymes enable multitarget blockade of proinflammatory cascades for the treatment of multi-drug-resistant bacterial sepsis","volume":"2022","author":"Du","year":"2022","journal-title":"Research"},{"issue":"1","key":"10.1016\/j.pscia.2025.100087_bib52","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41467-021-20965-3","article-title":"Surface-bound reactive oxygen species generating nanozymes for selective antibacterial action","volume":"12","author":"Gao","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pscia.2025.100087_bib53","doi-asserted-by":"crossref","unstructured":"K. Ma, Y.H. Cheung, K.O. Kirlikovali, H. Xie, K.B. Idrees, X. Wang, T. Islamoglu, J.H. Xin, O.K. Farha, Fibrous Zr-MOF nanozyme aerogels with macro-nanoporous structure for enhanced catalytic hydrolysis of organophosphate toxins, Adv. Mater. n\/a(n\/a) 2300951, https:\/\/doi.org\/https:\/\/doi.org\/10.1002\/adma.202300951.","DOI":"10.1002\/adma.202300951"},{"key":"10.1016\/j.pscia.2025.100087_bib54","doi-asserted-by":"crossref","unstructured":"R. Chen, J. Yang, M. Wu, D. Zhao, Z. Yuan, L. Zeng, J. Hu, X. Zhang, T. Wang, J. Xu, J. Zhang, M2 macrophage hybrid membrane-camouflaged targeted biomimetic nanosomes to reprogram inflammatory microenvironment for enhanced enzyme-thermo-immunotherapy, Adv. Mater. n\/a(n\/a) 2304123, https:\/\/doi.org\/https:\/\/doi.org\/10.1002\/adma.202304123.","DOI":"10.1002\/adma.202304123"},{"issue":"3","key":"10.1016\/j.pscia.2025.100087_bib55","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41571-018-0142-8","article-title":"Cancer immunoediting and resistance to T cell-based immunotherapy","volume":"16","author":"O'Donnell","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"12","key":"10.1016\/j.pscia.2025.100087_bib56","doi-asserted-by":"crossref","first-page":"e422","DOI":"10.1016\/S1473-3099(19)30567-5","article-title":"Current gaps in sepsis immunology: new opportunities for translational research","volume":"19","author":"Rubio","year":"2019","journal-title":"Lancet Infect. Dis."},{"issue":"35","key":"10.1016\/j.pscia.2025.100087_bib57","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201902530","article-title":"Sono-immunotherapeutic nanocapturer to combat multidrug-resistant bacterial infections","volume":"31","author":"Pang","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.pscia.2025.100087_bib58","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.jconrel.2022.11.013","article-title":"Stimuli-responsive and biomimetic delivery systems for sepsis and related complications","volume":"352","author":"Ismail","year":"2022","journal-title":"J. Contr. Release"},{"issue":"11","key":"10.1016\/j.pscia.2025.100087_bib59","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V110.11.3803.3803","article-title":"HMGB1 expression in sickle cell disease: a pro-inflammatory cytokine and potential therapeutic target","volume":"110","author":"Barginear","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.pscia.2025.100087_bib60","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jconrel.2020.02.030","article-title":"Inflammation-targeting polymeric nanoparticles deliver sparfloxacin and tacrolimus for combating acute lung sepsis","volume":"321","author":"Yang","year":"2020","journal-title":"J. Contr. Release"},{"issue":"7","key":"10.1016\/j.pscia.2025.100087_bib61","doi-asserted-by":"crossref","first-page":"6178","DOI":"10.1021\/acsnano.2c05800","article-title":"Translatable drug-loaded iron oxide nanophore sensitizes Murine melanoma tumors to monoclonal antibody immunotherapy","volume":"17","author":"Stater","year":"2023","journal-title":"ACS Nano"},{"issue":"8","key":"10.1016\/j.pscia.2025.100087_bib62","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/ni.3790","article-title":"A guiding map for inflammation","volume":"18","author":"Netea","year":"2017","journal-title":"Nat. Immunol."},{"issue":"7147","key":"10.1016\/j.pscia.2025.100087_bib63","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/nature05836","article-title":"Gene-specific control of inflammation by TLR-induced chromatin modifications","volume":"447","author":"Foster","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.pscia.2025.100087_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120845","article-title":"Macrophage-preferable delivery of the leucine-rich repeat domain of NLRX1 ameliorates lethal sepsis by regulating NF-\u03baB and inflammasome signaling activation","volume":"274","author":"Koo","year":"2021","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.pscia.2025.100087_bib65","doi-asserted-by":"crossref","first-page":"7775","DOI":"10.1021\/acsnano.5b01696","article-title":"Nanoparticle-stabilized capsules for the treatment of bacterial biofilms","volume":"9","author":"Duncan","year":"2015","journal-title":"ACS Nano"},{"issue":"23","key":"10.1016\/j.pscia.2025.100087_bib66","doi-asserted-by":"crossref","first-page":"6574","DOI":"10.1021\/acs.jafc.9b02028","article-title":"Plant-based nanoparticles prepared from proteins and phospholipids consisting of a Core\u2013multilayer-shell structure: fabrication, stability, and foamability","volume":"67","author":"Chen","year":"2019","journal-title":"J. Agric. Food Chem."},{"issue":"43","key":"10.1016\/j.pscia.2025.100087_bib67","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202204587","article-title":"Suppression of lipopolysaccharide-induced sepsis by tetrahedral framework nucleic acid loaded with Quercetin","volume":"32","author":"Liu","year":"2022","journal-title":"Adv. Funct. Mater."},{"issue":"7","key":"10.1016\/j.pscia.2025.100087_bib68","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1166\/jbn.2017.2400","article-title":"New epigallocatechin gallate (EGCG) nanocomplexes Co-Assembled with 3-Mercapto-1-Hexanol and \u03b2-Lactoglobulin for improvement of antitumor activity","volume":"13","author":"Yang","year":"2017","journal-title":"J. Biomed. Nanotechnol."},{"issue":"2","key":"10.1016\/j.pscia.2025.100087_bib69","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1021\/acsnano.1c08913","article-title":"Intrinsic radical species scavenging activities of tea polyphenols nanoparticles block pyroptosis in endotoxin-induced sepsis","volume":"16","author":"Chen","year":"2022","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.pscia.2025.100087_bib70","doi-asserted-by":"crossref","first-page":"FDD7","DOI":"10.4155\/fdd-2019-0001","article-title":"Polyphenol and self-assembly: metal polyphenol nanonetwork for drug delivery and pharmaceutical applications","volume":"1","author":"Zhang","year":"2019","journal-title":"Future Drug Discov."},{"issue":"1","key":"10.1016\/j.pscia.2025.100087_bib71","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1186\/s12951-022-01524-4","article-title":"Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer's disease via NLRP3-inhibition","volume":"20","author":"Ruan","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.pscia.2025.100087_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123677","article-title":"Achyranthes polysaccharide based dual-responsive nano-delivery system for treatment of rheumatoid arthritis","volume":"234","author":"Guo","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"7","key":"10.1016\/j.pscia.2025.100087_bib73","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2017.36","article-title":"The immunopathology of sepsis and potential therapeutic targets","volume":"17","author":"van der Poll","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.pscia.2025.100087_bib74","doi-asserted-by":"crossref","first-page":"10324","DOI":"10.1021\/acsnano.0c03807","article-title":"Sustainable nanosheet antioxidants for sepsis therapy via scavenging intracellular reactive oxygen and nitrogen species","volume":"14","author":"Yim","year":"2020","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.pscia.2025.100087_bib75","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1021\/acsnano.7b00696","article-title":"Direct single-enzyme biomineralization of catalytically active Ceria and Ceria\u2013Zirconia nanocrystals","volume":"11","author":"Curran","year":"2017","journal-title":"ACS Nano"},{"issue":"23","key":"10.1016\/j.pscia.2025.100087_bib76","article-title":"Bioinspired DNase-I-Coated melanin-like nanospheres for modulation of infection-associated NETosis dysregulation","volume":"7","author":"Park","year":"2020","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.pscia.2025.100087_bib77","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s43586-020-00009-8","article-title":"DNA origami","volume":"1","author":"Dey","year":"2021","journal-title":"Nat. Rev. Methods Prim."},{"issue":"3","key":"10.1016\/j.pscia.2025.100087_bib78","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1039\/D0CS00255K","article-title":"DNA origami-based protein networks: from basic construction to emerging applications","volume":"50","author":"Kong","year":"2021","journal-title":"Chem. Soc. Rev."},{"issue":"2","key":"10.1016\/j.pscia.2025.100087_bib79","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41578-022-00517-x","article-title":"Functionalizing DNA origami to investigate and interact with biological systems","volume":"8","author":"Knappe","year":"2023","journal-title":"Nat. Rev. Mater."},{"issue":"45","key":"10.1016\/j.pscia.2025.100087_bib80","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201804785","article-title":"Rationally designed DNA-origami nanomaterials for drug delivery in vivo","volume":"31","author":"Jiang","year":"2019","journal-title":"Adv. Mater."},{"issue":"31","key":"10.1016\/j.pscia.2025.100087_bib81","doi-asserted-by":"crossref","first-page":"12698","DOI":"10.1002\/anie.202002740","article-title":"DNA nanostructures for targeted antimicrobial delivery","volume":"59","author":"Mela","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"issue":"8","key":"10.1016\/j.pscia.2025.100087_bib82","doi-asserted-by":"crossref","first-page":"12520","DOI":"10.1021\/acsnano.2c03991","article-title":"DNA origami as a nanomedicine for targeted rheumatoid arthritis therapy through reactive oxygen species and nitric oxide scavenging","volume":"16","author":"Ma","year":"2022","journal-title":"ACS Nano"},{"issue":"48","key":"10.1016\/j.pscia.2025.100087_bib83","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abi9265","article-title":"Orally deliverable strategy based on microalgal biomass for intestinal disease treatment","volume":"7","author":"Zhong","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.pscia.2025.100087_bib84","doi-asserted-by":"crossref","unstructured":"F. Zhang, Z. Li, C. Chen, H. Luan, R.H. Fang, L. Zhang, J. Wang, Biohybrid microalgae robots: design, fabrication, materials and applications, Adv. Mater. n\/a(n\/a) 2303714, https:\/\/doi.org\/https:\/\/doi.org\/10.1002\/adma.202303714.","DOI":"10.1002\/adma.202303714"},{"issue":"50","key":"10.1016\/j.pscia.2025.100087_bib85","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202201800","article-title":"Volbots: Volvox microalgae-based robots for multimode precision imaging and therapy","volume":"32","author":"Wang","year":"2022","journal-title":"Adv. Funct. Mater."},{"issue":"1","key":"10.1016\/j.pscia.2025.100087_bib86","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202204617","article-title":"Microalgae-based biohybrid microrobot for accelerated diabetic wound healing","volume":"19","author":"Choi","year":"2023","journal-title":"Small"},{"issue":"21","key":"10.1016\/j.pscia.2025.100087_bib87","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba5996","article-title":"Engineered algae: a novel oxygen-generating system for effective treatment of hypoxic cancer","volume":"6","author":"Qiao","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.pscia.2025.100087_bib88","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mattod.2022.06.024","article-title":"Surface-engineered chlorella alleviated hypoxic tumor microenvironment for enhanced chemotherapy and immunotherapy of first-line drugs","volume":"58","author":"Gao","year":"2022","journal-title":"Mater. Today"},{"issue":"11","key":"10.1016\/j.pscia.2025.100087_bib89","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/ni.2987","article-title":"Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens","volume":"15","author":"Branzk","year":"2014","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.pscia.2025.100087_bib90","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1021\/acsnano.2c11280","article-title":"Nanoparticulate cationic poly(amino acid)s block cancer metastases by destructing neutrophil extracellular traps","volume":"17","author":"Liang","year":"2023","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.pscia.2025.100087_bib91","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202001378","article-title":"Nanotools for sepsis diagnosis and treatment","volume":"10","author":"Papafilippou","year":"2021","journal-title":"Adv. Healthcare Mater."},{"issue":"4","key":"10.1016\/j.pscia.2025.100087_bib92","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1164\/rccm.202105-1197TR","article-title":"The many roles of cholesterol in sepsis: a review","volume":"205","author":"Hofmaenner","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"46","key":"10.1016\/j.pscia.2025.100087_bib93","doi-asserted-by":"crossref","first-page":"19352","DOI":"10.1039\/D1NR06195J","article-title":"Artificial intelligence-powered microfluidics for nanomedicine and materials synthesis","volume":"13","author":"Liu","year":"2021","journal-title":"Nanoscale"},{"issue":"1","key":"10.1016\/j.pscia.2025.100087_bib94","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/s41467-023-36017-x","article-title":"Smartphone-based platforms implementing microfluidic detection with image-based artificial intelligence","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."}],"updated-by":[{"DOI":"10.1016\/j.pscia.2026.100151","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000}}],"container-title":["Pharmaceutical Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S277321692500025X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S277321692500025X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:14:21Z","timestamp":1764173661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S277321692500025X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":94,"alternative-id":["S277321692500025X"],"URL":"https:\/\/doi.org\/10.1016\/j.pscia.2025.100087","relation":{},"ISSN":["2773-2169"],"issn-type":[{"value":"2773-2169","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanoplatforms in sepsis storm: Multimodal synergy for precision immunomodulation and pathogen neutralizations","name":"articletitle","label":"Article Title"},{"value":"Pharmaceutical Science Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pscia.2025.100087","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Shandong University.","name":"copyright","label":"Copyright"}],"article-number":"100087"}}