{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:05:38Z","timestamp":1791212738748,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Research: Neuroimaging"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1016\/j.pscychresns.2006.01.005","type":"journal-article","created":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T07:21:46Z","timestamp":1141802506000},"page":"243-249","source":"Crossref","is-referenced-by-count":162,"title":["Diffusion tensor imaging in early Alzheimer's disease"],"prefix":"10.1016","volume":"146","author":[{"given":"Olivier","family":"Naggara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Oppenheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doroth\u00e9e","family":"Rieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Raoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Rodrigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Dalla Barba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Meder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pscychresns.2006.01.005_bib1","first-page":"1857","article-title":"Diffusion tensor imaging of the hippocampal formation in temporal lobe epilepsy","volume":"24","author":"Assaf","year":"2003","journal-title":"AJNR American Journal of Neuroradiology"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib2","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1212\/WNL.57.6.1135","article-title":"Quantification of tissue damage in AD using diffusion tensor and magnetization transfer MRI","volume":"57","author":"Bozzali","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib3","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1136\/jnnp.72.6.742","article-title":"White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging","volume":"72","author":"Bozzali","year":"2002","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib4","first-page":"1030","article-title":"Diffusion and perfusion MR imaging in cases of Alzheimer's disease: correlations with cortical atrophy and lesion load","volume":"22","author":"Bozzao","year":"2001","journal-title":"AJNR American Journal of Neuroradiology"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/ana.410190306","article-title":"A white matter disorder in dementia of the Alzheimer type: a pathoanatomical study","volume":"19","author":"Brun","year":"1986","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib6","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00415-002-0752-y","article-title":"Intra-voxel and inter-voxel coherence in patients with multiple sclerosis assessed using diffusion tensor MRI","volume":"249","author":"Cercignani","year":"2002","journal-title":"Journal of Neurology"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/0891988704271763","article-title":"Diffusion tensor imaging of frontal white matter microstructure in early Alzheimer's disease: a preliminary study","volume":"18","author":"Choi","year":"2005","journal-title":"Journal of Geriatric Psychiatry and Neurology"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nbd.2004.01.008","article-title":"Alzheimer pathology disorganizes cortico\u2013cortical circuitry: direct evidence from a transgenic animal model","volume":"16","author":"Delatour","year":"2004","journal-title":"Neurobiology of Disease"},{"issue":"Suppl 1","key":"10.1016\/j.pscychresns.2006.01.005_bib9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000051183","article-title":"Neuropathology of white matter changes in Alzheimer's disease and vascular dementia","volume":"9","author":"Englund","year":"1998","journal-title":"Dementia and Geriatrric Cognitive Disorders"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib10","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/brain\/124.3.617","article-title":"Diffusion tensor imaging in patients with epilepsy and malformations of cortical development","volume":"124","author":"Eriksson","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000077817","article-title":"Ultrastructural hippocampal and white matter alterations in mild cognitive impairment: a diffusion tensor imaging study","volume":"18","author":"Fellgiebel","year":"2004","journal-title":"Dementia and Geriatrric Cognitive Disorders"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0022-510X(99)00135-5","article-title":"Diffusion-weighted and magnetization transfer imaging of the corpus callosum in Alzheimer's disease","volume":"167","author":"Hanyu","year":"1999","journal-title":"Journal of Neurological Science"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib13","first-page":"1091","article-title":"MR determination of hippocampal volume: comparison of three methods","volume":"17","author":"Hasboun","year":"1996","journal-title":"AJNR American Journal of Neuroradiology"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib14","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/cercor\/bhh003","article-title":"Differential vulnerability of anterior white matter in nondemented aging with minimal acceleration in dementia of the Alzheimer type: evidence from diffusion tensor imaging","volume":"14","author":"Head","year":"2004","journal-title":"Cerebral Cortex"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib15","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1093\/cercor\/bhh174","article-title":"Frontal-hippocampal double dissociation between normal aging and Alzheimer's disease","volume":"15","author":"Head","year":"2005","journal-title":"Cerebral Cortex"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0006-3223(02)01311-2","article-title":"Frontal white matter microstructure, aggression, and impulsivity in men with schizophrenia: a preliminary study","volume":"52","author":"Hoptman","year":"2002","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1148\/radiology.219.1.r01ap14101","article-title":"Mild cognitive impairment and Alzheimer disease: regional diffusivity of water","volume":"219","author":"Kantarci","year":"2001","journal-title":"Radiology"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib18","unstructured":"Medina, D., Detoledo-Morrell, L., Urresta, F., Gabrieli, J.D., Moseley, M., Fleischman, D., Bennett, D.A., Leurgans, S., Turner, D.A., Stebbins, G.T., in press. White matter changes in mild cognitive impairment and AD: a diffusion tensor imaging study. Neurobiology of Aging."},{"key":"10.1016\/j.pscychresns.2006.01.005_bib19","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0925-4927(99)00018-9","article-title":"Topography of callosal atrophy reflects distribution of regional cerebral volume reduction in Alzheimer's disease","volume":"90","author":"Pantel","year":"1999","journal-title":"Psychiatry Research. Neuroimaging"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib20","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1073\/pnas.82.13.4531","article-title":"Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease","volume":"82","author":"Pearson","year":"1985","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib21","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.neuroimage.2005.02.034","article-title":"Frontal circuitry degradation marks healthy adult aging: evidence from diffusion tensor imaging","volume":"26","author":"Pfefferbaum","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib22","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/jmri.20020","article-title":"Analytical error propagation in diffusion anisotropy calculations","volume":"19","author":"Poonawalla","year":"2004","journal-title":"Journal of Magnetic Resonance Imaging"},{"issue":"Suppl 3","key":"10.1016\/j.pscychresns.2006.01.005_bib23","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/PL00014170","article-title":"Retrogenesis: clinical, physiologic, and pathologic mechanisms in brain aging, Alzheimer's and other dementing processes","volume":"249","author":"Reisberg","year":"1999","journal-title":"European Archives of Psychiatry and Clinical Neuroscience"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1017\/S1041610299005554","article-title":"Towards a science of Alzheimer's disease management: a model based upon current knowledge of retrogenesis","volume":"11","author":"Reisberg","year":"1999","journal-title":"International Psychogeriatrics"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib25","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1177\/153331750201700411","article-title":"Evidence and mechanisms of retrogenesis in Alzheimer's and other dementias: management and treatment import","volume":"17","author":"Reisberg","year":"2002","journal-title":"American Journal of Alzheimer's Disease and Other Dementias"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib26","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1136\/jnnp.69.4.528","article-title":"Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging","volume":"69","author":"Rose","year":"2000","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib27","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000017099","article-title":"Diffusion-weighted magnetic resonance imaging in Alzheimer's disease","volume":"10","author":"Sandson","year":"1999","journal-title":"Dementia and Geriatric Cognitive Disorders"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib28","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1073\/pnas.052587399","article-title":"Mapping the evolution of regional atrophy in Alzheimer's disease: unbiased analysis of fluid-registered serial MRI","volume":"99","author":"Scahill","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib29","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0248-8663(05)81459-6","article-title":"Contribution of morphological imaging in the diagnosis of dementia. I. Alzheimer disease","volume":"15","author":"Scheltens","year":"1994","journal-title":"La Revue de Medecine Interne"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib30","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/BF00236024","article-title":"Posterior parietal projections to the intraparietal sulcus of the rhesus monkey","volume":"62","author":"Seltzer","year":"1986","journal-title":"Experimental Brain Research"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib31","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.nbd.2003.12.003","article-title":"Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition","volume":"15","author":"Song","year":"2004","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib32","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00330-003-2121-3","article-title":"Reproducibility of brain ADC histograms","volume":"14","author":"Steens","year":"2004","journal-title":"European Radiology"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0304-3940(02)00914-X","article-title":"Selective reduction of diffusion anisotropy in white matter of Alzheimer disease brains measured by 3.0 Tesla magnetic resonance imaging","volume":"332","author":"Takahashi","year":"2002","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib34","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0197-4580(97)00155-3","article-title":"Age-induced white matter changes in the human brain: a stereological investigation","volume":"18","author":"Tang","year":"1997","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib35","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF00868519","article-title":"White matter magnetic resonance imaging hyperintensity in Alzheimer's disease: correlations with corpus callosum atrophy","volume":"243","author":"Vermersch","year":"1996","journal-title":"Journal of Neurology"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib36","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000117014","article-title":"Evidence for atrophy of the corpus callosum in Alzheimer's disease","volume":"34","author":"Vermersch","year":"1994","journal-title":"European Neurology"},{"key":"10.1016\/j.pscychresns.2006.01.005_bib37","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1053-8119(03)00342-2","article-title":"High b value diffusion-weighted imaging is more sensitive to white matter degeneration in Alzheimer's disease","volume":"20","author":"Yoshiura","year":"2003","journal-title":"Neuroimage"}],"container-title":["Psychiatry Research: Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092549270600014X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092549270600014X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T19:50:36Z","timestamp":1547754636000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092549270600014X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S092549270600014X"],"URL":"https:\/\/doi.org\/10.1016\/j.pscychresns.2006.01.005","relation":{},"ISSN":["0925-4927"],"issn-type":[{"value":"0925-4927","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}