{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:17:12Z","timestamp":1787887032315,"version":"build-2784847793"},"reference-count":48,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Research: Neuroimaging"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.pscychresns.2011.12.007","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T06:01:07Z","timestamp":1347429667000},"page":"201-206","source":"Crossref","is-referenced-by-count":40,"title":["Regional cerebral blood flow differences in patients with mild cognitive impairment between those who did and did not develop Alzheimer's disease"],"prefix":"10.1016","volume":"203","author":[{"given":"Kyung Won","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jin","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do-Young","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong C.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SangYun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pscychresns.2011.12.007_bb0005","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1001\/archneur.62.11.1728","article-title":"Heterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to Alzheimer disease","volume":"62","author":"Anchisi","year":"2005","journal-title":"Archives of Neurology"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0010","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1034\/j.1600-0404.107.s179.7.x","article-title":"Neuropsychological features of mild cognitive impairment and preclinical Alzheimer's disease","volume":"179","author":"Arnaiz","year":"2003","journal-title":"Acta Neurologica Scandinavica. Supplementum"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0015","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1001\/archneur.1983.04050110029003","article-title":"The fluorodeoxyglucose 18F scan in Alzheimer's disease and multi-infarct dementia","volume":"40","author":"Benson","year":"1983","journal-title":"Archives of Neurology"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0020","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neurobiolaging.2004.12.010","article-title":"Combined 99mTc-ECD SPECT and neuropsychological studies in MCI for the assessment of conversion to AD","volume":"27","author":"Borroni","year":"2006","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0025","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1093\/brain\/awf185","article-title":"Cerebral perfusion SPET correlated with Braak pathological stage in Alzheimer's disease","volume":"125","author":"Bradley","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0030","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1212\/01.wnl.0000249117.23318.e1","article-title":"Mild cognitive impairment: long-term course of four clinical subtypes","volume":"26","author":"Busse","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0035","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1179\/016164104225016155","article-title":"Relevance of functional neuroimaging in the progression of mild cognitive impairment","volume":"26","author":"Cabranes","year":"2004","journal-title":"Neurological Research"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0045","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1007\/s00415-007-0631-7","article-title":"Cerebral perfusion correlates of conversion to Alzheimer's disease in amnestic mild cognitive impairment","volume":"254","author":"Caroli","year":"2007","journal-title":"Journal of Neurology"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0050","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3109\/07853890008995904","article-title":"Age-related cognitive decline, mild cognitive impairment or preclinical Alzheimer's disease?","volume":"32","author":"Celsis","year":"2000","journal-title":"Annals of Medicine"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0055","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1109\/TNS.1978.4329385","article-title":"A method for attenuation correction in radionuclide computed tomography","volume":"25","author":"Chang","year":"1978","journal-title":"IEEE Transactions on Nuclear Science"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0060","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1503\/cmaj.070797","article-title":"Diagnosis and treatment of dementia: 3. Mild cognitive impairment and cognitive impairment without dementia","volume":"178","author":"Chertkow","year":"2008","journal-title":"Canadian Medical Association Journal"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0065","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1212\/01.WNL.0000055847.17752.E6","article-title":"Mild cognitive impairment: can FDG-PET predict who is to rapidly convert to Alzheimer's disease?","volume":"60","author":"Chetelat","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0070","doi-asserted-by":"crossref","first-page":"10966","DOI":"10.1073\/pnas.191044198","article-title":"Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-d-glucose\/positron-emission tomography (FDG\/PET)","volume":"98","author":"de Leon","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0075","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0197-4580(01)00230-5","article-title":"Hippocampal formation glucose metabolism and volume losses in MCI and AD","volume":"22","author":"De Santi","year":"2001","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0080","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1007\/s00259-003-1194-1","article-title":"Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study","volume":"30","author":"Drzezga","year":"2003","journal-title":"European Journal of Nuclear Medicine and Molecular Imaging"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0085","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1007\/s00259-003-1277-z","article-title":"Regional cerebral blood flow assessed with 99mTc-ECD SPET as a marker of progression of mild cognitive impairment to Alzheimer's disease","volume":"30","author":"Encinas","year":"2003","journal-title":"European Journal of Nuclear Medicine and Molecular Imaging"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0090","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/hbm.460020402","article-title":"Statistical parametric maps in functional imaging: a general linear approach","volume":"2","author":"Friston","year":"1994","journal-title":"Human Brain Mapping"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0095","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/hbm.460030303","article-title":"Spatial registration and normalization of images","volume":"3","author":"Friston","year":"1995","journal-title":"Human Brain Mapping"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0100","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1006\/nimg.1996.0074","article-title":"Detecting activations in PET and fMRI: levels of inference and power","volume":"4","author":"Friston","year":"1996","journal-title":"NeuroImage"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0105","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1073\/pnas.0308627101","article-title":"Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI","volume":"101","author":"Greicius","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0110","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00259-009-1285-8","article-title":"Brain perfusion SPECT correlates with CSF biomarkers in Alzheimer's disease","volume":"37","author":"Habert","year":"2010","journal-title":"European Journal of Nuclear Medicine and Molecular Imaging"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0115","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.neuroimage.2005.06.066","article-title":"The prediction of rapid conversion to Alzheimer's disease in mild cognitive impairment using regional cerebral blood flow SPECT","volume":"28","author":"Hirao","year":"2005","journal-title":"NeuroImage"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0120","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2377-2-9","article-title":"Cingulate cortex hypoperfusion predicts Alzheimer's disease in mild cognitive impairment","volume":"2","author":"Huang","year":"2002","journal-title":"BMC Neurology"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0125","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1600-0404.2006.00661.x","article-title":"Preclinical evidence of Alzheimer changes in progressive mild cognitive impairment: a qualitative and quantitative SPECT study","volume":"114","author":"Ishiwata","year":"2006","journal-title":"Acta Neurologica Scandinavica"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0130","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1212\/WNL.52.7.1397","article-title":"Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment","volume":"52","author":"Jack","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0135","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade","volume":"9","author":"Jack","year":"2010","journal-title":"Lancet Neurology"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0145","series-title":"Seoul Neuropsychological Screening Battery","author":"Kang","year":"2003"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0140","first-page":"300","article-title":"A validity study on the Korean Mini-Mental State Examination (K-MMSE) in dementia patients","volume":"15","author":"Kang","year":"1997","journal-title":"Journal of the Korean Neurological Association"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0150","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000278422","article-title":"Comparison of neuropsychological and FDG\u2013PET findings between early- versus late-onset mild cognitive impairment: a five-year longitudinal study","volume":"29","author":"Kim","year":"2010","journal-title":"Dementia and Geriatric Cognitive Disorders"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0160","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.2967\/jnumed.106.037218","article-title":"Role of neuroimaging in Alzheimer's disease, with emphasis on brain perfusion SPECT","volume":"48","author":"Matsuda","year":"2007","journal-title":"Journal of Nuclear Medicine"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0155","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1007\/s00259-002-0930-2","article-title":"Brain SPET abnormalities in Alzheimer's disease before and after atrophy correction","volume":"29","author":"Matsuda","year":"2002","journal-title":"European Journal of Nuclear Medicine and Molecular Imaging"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0165","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/ana.410420114","article-title":"Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease","volume":"42","author":"Minoshima","year":"1997","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0170","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2174\/156720506776383103","article-title":"Predictors of conversion to dementia of probable Alzheimer type in patients with mild cognitive impairment","volume":"3","author":"Modrego","year":"2006","journal-title":"Current Alzheimer Research"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0175","first-page":"89","article-title":"The need of appropriate brain SPECT templates for SPM comparisons","volume":"52","author":"Morbelli","year":"2008","journal-title":"The Quarterly Journal of Nuclear Medicine and Molecular Imaging"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0180","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0185","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1212\/WNL.59.6.867","article-title":"Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease","volume":"59","author":"Mungas","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0190","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1176\/appi.ajp.159.3.474","article-title":"Combined analysis of CSF tau levels and [123I]iodoamphetamine SPECT in mild cognitive impairment: implications for a novel predictor of Alzheimer's disease","volume":"159","author":"Okamura","year":"2002","journal-title":"The American Journal of Psychiatry"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0195","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1176\/appi.ajp.160.2.379","article-title":"Parahippocampal volume deficits in subjects with aging-associated cognitive decline","volume":"160","author":"Pantel","year":"2003","journal-title":"The American Journal of Psychiatry"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0200","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archneur.56.3.303","article-title":"Mild cognitive impairment: clinical characterization and outcome","volume":"56","author":"Petersen","year":"1999","journal-title":"Archives of Neurology"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0205","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1001\/archneur.58.12.1985","article-title":"Current concepts in mild cognitive impairment","volume":"58","author":"Petersen","year":"2001","journal-title":"Archives of Neurology"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0210","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1001\/archneur.59.11.1729","article-title":"Cerebrospinal fluid tau and beta-amyloid 42 proteins identify Alzheimer disease in subjects with mild cognitive impairment","volume":"59","author":"Riemenschneider","year":"2002","journal-title":"Archives of Neurology"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0215","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nn0405-404","article-title":"Alzheimer disease, in living color","volume":"8","author":"Small","year":"2005","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0220","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1001\/archneur.57.6.839","article-title":"The course of cognitive impairment in preclinical Alzheimer disease: three- and 6-year follow-up of a population-based sample","volume":"57","author":"Small","year":"2000","journal-title":"Archives of Neurology"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0225","series-title":"Co-Planar Stereotaxic Atlas of the Human Brain","author":"Talairach","year":"1988"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0040","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1212\/WNL.55.1.66","article-title":"The incidence of dementia in Canada","volume":"55","author":"The Canadian Study of Health and Aging Working Group","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0230","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.pscychresns.2008.05.002","article-title":"Accelerated hippocampal atrophy rates in stable and progressive amnestic mild cognitive impairment","volume":"171","author":"Wang","year":"2009","journal-title":"Psychiatry Research: Neuroimaging"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0240","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1365-2796.2004.01380.x","article-title":"Mild cognitive impairment\u2013beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment","volume":"256","author":"Winblad","year":"2004","journal-title":"Journal of Internal Medicine"},{"key":"10.1016\/j.pscychresns.2011.12.007_bb0235","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3174\/ajnr.A1357","article-title":"Fluorodeoxyglucose-positron-emission tomography, single-photon emission tomography, and structural MR imaging for prediction of rapid conversion to Alzheimer disease in patients with mild cognitive impairment: a meta-analysis","volume":"30","author":"Yuan","year":"2009","journal-title":"American Journal of Neuroradiology"}],"container-title":["Psychiatry Research: Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925492711003921?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925492711003921?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T21:59:18Z","timestamp":1542751158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925492711003921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":48,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0925492711003921"],"URL":"https:\/\/doi.org\/10.1016\/j.pscychresns.2011.12.007","relation":{},"ISSN":["0925-4927"],"issn-type":[{"value":"0925-4927","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}