{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:17:40Z","timestamp":1790439460971,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Research: Neuroimaging"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.pscychresns.2018.08.012","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T16:11:59Z","timestamp":1534954319000},"page":"56-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder"],"prefix":"10.1016","volume":"280","author":[{"given":"Jakub","family":"Kraus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2516-9075","authenticated-orcid":false,"given":"Andreas","family":"Frick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Howner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Fredrikson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Furmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6101","key":"10.1016\/j.pscychresns.2018.08.012_bib0001","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1126\/science.1223006","article-title":"Disruption of reconsolidation erases a fear memory trace in the human amygdala","volume":"337","author":"\u00c5gren","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.pscychresns.2018.08.012_bib0002","series-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"issue":"9","key":"10.1016\/j.pscychresns.2018.08.012_bib0003","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.biopsych.2005.01.044","article-title":"Increased activation of the anterior cingulate cortex during processing of disgust faces in individuals with social phobia","volume":"57","author":"Amir","year":"2005","journal-title":"Biol. Psychiatry"},{"issue":"8","key":"10.1016\/j.pscychresns.2018.08.012_bib0004","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1001\/archpsyc.64.8.903","article-title":"Incidence of social anxiety disorder and the consistent risk for secondary depression in the first three decades of life","volume":"64","author":"Beesdo","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"issue":"9","key":"10.1016\/j.pscychresns.2018.08.012_bib0005","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1176\/appi.ajp.2008.07071060","article-title":"Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders","volume":"165","author":"Blair","year":"2008","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.pscychresns.2018.08.012_bib0007","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.nicl.2016.09.023","article-title":"Specifically altered brain responses to threat in generalized anxiety disorder relative to social anxiety disorder and panic disorder","volume":"12","author":"Buff","year":"2016","journal-title":"NeuroImage Clin."},{"issue":"3","key":"10.1016\/j.pscychresns.2018.08.012_bib0008","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.neuroscience.2010.04.024","article-title":"Elevated response of human amygdala to neutral stimuli in mild post traumatic stress disorder: neural correlates of generalized emotional response","volume":"168","author":"Brunetti","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.pscychresns.2018.08.012_bib0009","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.neubiorev.2014.08.003","article-title":"Neuroimaging in social anxiety disorder\u2014a meta-analytic review resulting in a new neurofunctional model","volume":"47","author":"Br\u00fchl","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"9","key":"10.1016\/j.pscychresns.2018.08.012_bib0010","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.tics.2010.06.007","article-title":"Cognitive theory and therapy of anxiety and depression: convergence with neurobiological findings","volume":"14","author":"Clark","year":"2010","journal-title":"Trends Cognit. Sci."},{"key":"10.1016\/j.pscychresns.2018.08.012_bib0011","series-title":"Pictures of Facial Affect","author":"Ekman","year":"1976"},{"issue":"10","key":"10.1016\/j.pscychresns.2018.08.012_bib0012","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1176\/appi.ajp.2007.07030504","article-title":"Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia","volume":"164","author":"Etkin","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.pscychresns.2018.08.012_bib0014","series-title":"Structured Clinical Interview for DSM-IV Axis I Disorders - Non-Patient Edition. Biometrics Research","author":"First","year":"1997"},{"key":"10.1016\/j.pscychresns.2018.08.012_bib0016","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1159\/000351938","article-title":"Neuroimaging in anxiety disorders","volume":"29","author":"Fredrikson","year":"2013","journal-title":"J. Anxiety Disord."},{"key":"10.1016\/j.pscychresns.2018.08.012_bib0017","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.pnpbp.2010.02.028","article-title":"Neuroimaging in social anxiety disorder: a systematic review of the literature","volume":"34","author":"Freitas-Ferrari","year":"2010","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pscychresns.2018.08.012_bib0018","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1017\/S0033291701004056","article-title":"The Liebowitz social anxiety scale: a comparison of the psychometric properties of self-report and clinician-administered formats","volume":"31","author":"Fresco","year":"2001","journal-title":"Psychol. Med."},{"issue":"10","key":"10.1016\/j.pscychresns.2018.08.012_bib0019","doi-asserted-by":"crossref","first-page":"e312","DOI":"10.1038\/tp.2013.85","article-title":"Altered fusiform connectivity during processing of fearful faces in social anxiety disorder","volume":"3","author":"Frick","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.pscychresns.2018.08.012_bib0020","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s001270050163","article-title":"Social phobia in the general population: prevalence and sociodemographic profile","volume":"34","author":"Furmark","year":"1999","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"issue":"5","key":"10.1016\/j.pscychresns.2018.08.012_bib0021","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1001\/archpsyc.59.5.425","article-title":"Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy","volume":"59","author":"Furmark","year":"2002","journal-title":"Arch. Gen. Psychiatry"},{"issue":"2","key":"10.1016\/j.pscychresns.2018.08.012_bib0022","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.biopsych.2005.03.029","article-title":"Cerebral blood flow changes after treatment of social phobia with the neurokinin-1 antagonist GR205171, citalopram, or placebo","volume":"58","author":"Furmark","year":"2005","journal-title":"Biol. Psychiatry"},{"issue":"49","key":"10.1016\/j.pscychresns.2018.08.012_bib0023","doi-asserted-by":"crossref","first-page":"13066","DOI":"10.1523\/JNEUROSCI.2534-08.2008","article-title":"A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxiety","volume":"28","author":"Furmark","year":"2008","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.pscychresns.2018.08.012_bib0024","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1139\/jpn.0904","article-title":"Genotype over-diagnosis in amygdala responsiveness: affective processing in social anxiety disorder","volume":"34","author":"Furmark","year":"2009","journal-title":"J Psychiatry Neurosci"},{"issue":"4","key":"10.1016\/j.pscychresns.2018.08.012_bib0025","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1503\/jpn.130080","article-title":"Behavioural and neural correlates of self-focused emotion regulation in social anxiety disorder","volume":"39","author":"Gaebler","year":"2014","journal-title":"J Psychiatry Neurosci"},{"issue":"3","key":"10.1016\/j.pscychresns.2018.08.012_bib0026","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/1535370215603514","article-title":"Beyond emotions: a meta-analysis of neural response within face processing system in social anxiety","volume":"241","author":"Gentili","year":"2016","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.pscychresns.2018.08.012_bib0027","article-title":"Combining escitalopram and cognitive\u2013behavioural therapy for social anxiety disorder: randomised controlled fMRI trial","volume":"115","author":"Gingnell","year":"2016","journal-title":"Br. J. Psychiatry"},{"issue":"2","key":"10.1016\/j.pscychresns.2018.08.012_bib0028","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1001\/archgenpsychiatry.2008.525","article-title":"Neural bases of social anxiety disorder: emotional reactivity and cognitive regulation during social and physical threat","volume":"66","author":"Goldin","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"issue":"11","key":"10.1016\/j.pscychresns.2018.08.012_bib0029","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.4088\/JCP.v66n1102","article-title":"The epidemiology of social anxiety disorder in the United States: results from the national epidemiologic survey on alcohol and related conditions","volume":"66","author":"Grant","year":"2005","journal-title":"J. Clin. Psychiatry"},{"issue":"6","key":"10.1016\/j.pscychresns.2018.08.012_bib0030","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"issue":"2","key":"10.1016\/j.pscychresns.2018.08.012_bib0031","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.bbr.2011.04.025","article-title":"The structural and functional connectivity of the amygdala: from normal emotion to pathological anxiety","volume":"223","author":"Kim","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.pscychresns.2018.08.012_bib0032","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.pscychresns.2010.05.001","article-title":"Amygdala reactivity to faces at varying intensities of threat in generalized social phobia: an event-related functional MRI study","volume":"183","author":"Klumpp","year":"2010","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.pscychresns.2018.08.012_bib0033","unstructured":"Lang, P.J., Bradley, M.M., Cuthbert, B.N., 2008. International affective picture system (IAPS): Affective ratings of pictures and instruction manual. Technical Report A-8, University of Florida, Gainesville, FL."},{"issue":"4","key":"10.1016\/j.pscychresns.2018.08.012_bib0034","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.neuroimage.2012.03.068","article-title":"A generalized form of context-dependent psychophysiological interactions (gPPI): a comparison to standard approaches","volume":"61","author":"McLaren","year":"2012","journal-title":"NeuroImage"},{"issue":"3","key":"10.1016\/j.pscychresns.2018.08.012_bib0035","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S1053-8119(03)00169-1","article-title":"An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets","volume":"19","author":"Maldjian","year":"2003","journal-title":"NeuroImage"},{"issue":"9","key":"10.1016\/j.pscychresns.2018.08.012_bib0036","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/scan\/nsv002","article-title":"Brain dynamics of visual attention during anticipation and encoding of threat- and safe-cues in spider-phobic individuals","volume":"10","author":"Michalowski","year":"2015","journal-title":"Soc. Cogn. Affect. Neurosci."},{"issue":"5","key":"10.1016\/j.pscychresns.2018.08.012_bib0037","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2006.10.011","article-title":"Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert","volume":"62","author":"Milad","year":"2007","journal-title":"Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.pscychresns.2018.08.012_bib0038","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.biopsych.2014.02.014","article-title":"Ventromedial prefrontal cortex is critical for the regulation of amygdala activity in hrauchshinshinumans","volume":"77","author":"Motzkin","year":"2015","journal-title":"Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.pscychresns.2018.08.012_bib0040","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.biopsych.2005.08.012","article-title":"Association between amygdala hyperactivity to harsh faces and severity of social anxiety in generalized social phobia","volume":"59","author":"Phan","year":"2006","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.pscychresns.2018.08.012_bib0041","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.biopsych.2012.10.003","article-title":"Corticolimbic brain reactivity to social signals of threat before and after sertraline treatment in generalized social phobia","volume":"73","author":"Phan","year":"2013","journal-title":"Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.pscychresns.2018.08.012_bib0042","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/da.22014","article-title":"Aberrant amygdala-frontal cortex connectivity during perception of fearful faces and at rest in generalized social anxiety disorder","volume":"30","author":"Prater","year":"2013","journal-title":"Depress. Anxiety"},{"issue":"1","key":"10.1016\/j.pscychresns.2018.08.012_bib0043","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1749-6632.2003.tb07096.x","article-title":"Neuroimaging studies of amygdala function in anxiety disorders","volume":"985","author":"Rauch","year":"2003","journal-title":"Ann. N.Y. Acad. Sci."},{"issue":"4","key":"10.1016\/j.pscychresns.2018.08.012_bib0044","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1139\/jpn.0939","article-title":"Amygdala and insula response to emotional images in patients with generalized social anxiety disorder","volume":"34","author":"Shah","year":"2009","journal-title":"J. Psychiatry Neurosci."},{"issue":"1","key":"10.1016\/j.pscychresns.2018.08.012_bib0045","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/npp.2009.83","article-title":"The neurocircuitry of fear, stress, and anxiety disorders","volume":"35","author":"Shin","year":"2010","journal-title":"Neuropsychopharmacol"},{"issue":"11","key":"10.1016\/j.pscychresns.2018.08.012_bib0046","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1001\/archpsyc.59.11.1027","article-title":"Increased amygdala activation to angry and contemptuous faces in generalized social phobia","volume":"59","author":"Stein","year":"2002","journal-title":"Arch. Gen. Psychiatry"},{"issue":"12","key":"10.1016\/j.pscychresns.2018.08.012_bib0047","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1097\/01.mlr.0000185750.18119.fd","article-title":"Functional impact and health utility of anxiety disorders in primary care outpatients","volume":"43","author":"Stein","year":"2005","journal-title":"Med. Care"},{"issue":"9618","key":"10.1016\/j.pscychresns.2018.08.012_bib0048","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0140-6736(08)60488-2","article-title":"Social anxiety disorder","volume":"371","author":"Stein","year":"2008","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.pscychresns.2018.08.012_bib0049","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1017\/S0033291715002998","article-title":"Common and differential alterations of general emotion processing in obsessive-compulsive and social anxiety disorder","volume":"46","author":"Weidt","year":"2016","journal-title":"Psychol. Med."},{"issue":"10","key":"10.1016\/j.pscychresns.2018.08.012_bib0050","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0006-3223(03)00548-1","article-title":"Amygdala and insular responses to emotionally valenced human faces in small animal specific phobia","volume":"54","author":"Wright","year":"2003","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.pscychresns.2018.08.012_bib0051","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.pscychresns.2006.05.004","article-title":"Amygdala reactivity to emotional faces at high and low intensity in generalized social phobia: a 4-Tesla functional MRI study","volume":"154","author":"Yoon","year":"2007","journal-title":"Psychiat. Res. Neuroim."}],"container-title":["Psychiatry Research: Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925492718300659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925492718300659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T05:31:55Z","timestamp":1760419915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925492718300659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":47,"alternative-id":["S0925492718300659"],"URL":"https:\/\/doi.org\/10.1016\/j.pscychresns.2018.08.012","relation":{},"ISSN":["0925-4927"],"issn-type":[{"value":"0925-4927","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder","name":"articletitle","label":"Article Title"},{"value":"Psychiatry Research: Neuroimaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pscychresns.2018.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}