{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:23:34Z","timestamp":1792614214309,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G074609"],"award-info":[{"award-number":["G074609"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0C0319N"],"award-info":[{"award-number":["G0C0319N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001631","name":"University College Dublin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001631","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010648","name":"UZ Leuven","doi-asserted-by":"publisher","award":["R94859"],"award-info":[{"award-number":["R94859"]}],"id":[{"id":"10.13039\/501100010648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C24\/18\/095"],"award-info":[{"award-number":["C24\/18\/095"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012126","name":"Alzheimer&apos;s Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012126","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Research: Neuroimaging"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.pscychresns.2022.111443","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T11:58:42Z","timestamp":1642766322000},"page":"111443","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["An optimized MRI and PET based clinical protocol for improving the differential diagnosis of geriatric depression and Alzheimer's disease"],"prefix":"10.1016","volume":"320","author":[{"given":"Louise","family":"Emsell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heleen","family":"Vanhaute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristof","family":"Vansteelandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois-Laurent","family":"De Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Christiaens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Van den Stock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik","family":"Vandenberghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Van Laere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Sunaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Bouckaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Vandenbulcke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pscychresns.2022.111443_bib0001","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s00259-015-3156-9","article-title":"Amyloid imaging in cognitively normal older adults: comparison between (18)F-flutemetamol and (11)C-Pittsburgh compound B","volume":"43","author":"Adamczuk","year":"2016","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.pscychresns.2022.111443_bib0002","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0003","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1176\/appi.ajp.159.8.1424","article-title":"Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness duration","volume":"159","author":"Bell-McGinty","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.pscychresns.2022.111443_bib0004","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jalz.2014.02.009","article-title":"Delphi definition of the EADC-ADNI harmonized protocol for hippocampal segmentation on magnetic resonance","volume":"11","author":"Boccardi","year":"2015","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0005","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3233\/JAD-142955","article-title":"Neuroanatomy of Alzheimer's disease and late-life depression: a coordinate-based meta-analysis of MRI studies","volume":"46","author":"Boccia","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0006","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1017\/S1041610217001855","article-title":"Case series of mild behavioral impairment: toward an understanding of the early stages of neurodegenerative diseases affecting behavior and cognition","volume":"30","author":"Cieslak","year":"2018","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0007","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1176\/appi.ajp.2016.16030319","article-title":"No association of lower hippocampal volume with Alzheimer's disease pathology in late-life depression","volume":"174","author":"De Winter","year":"2017","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.pscychresns.2022.111443_bib0008","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s11920-013-0365-4","article-title":"Geriatric psychiatry review: differential diagnosis and treatment of the 3 D's - delirium, dementia, and depression","volume":"15","author":"Downing","year":"2013","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0009","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S1474-4422(07)70178-3","article-title":"Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria","volume":"6","author":"Dubois","year":"2007","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0010","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.encep.2017.03.002","article-title":"Late life depression or prodromal Alzheimer's disease: which tools for the differential diagnosis?","volume":"44","author":"Gasser","year":"2018","journal-title":"Encephale"},{"key":"10.1016\/j.pscychresns.2022.111443_bib0011","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.biopsych.2016.12.032","article-title":"Late-life depression, hippocampal volumes, and hypothalamic-pituitary-adrenal axis regulation: a systematic review and meta-analysis","volume":"82","author":"Geerlings","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pscychresns.2022.111443_bib0012","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.biopsych.2011.01.029","article-title":"Depression, hypothalamic pituitary adrenal axis, and hippocampal and entorhinal cortex volumes\u2013the SMART Medea study","volume":"70","author":"Gerritsen","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pscychresns.2022.111443_bib0013","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jalz.2015.05.017","article-title":"Neuropsychiatric symptoms as early manifestations of emergent dementia: provisional diagnostic criteria for mild behavioral impairment","volume":"12","author":"Ismail","year":"2016","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0014","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jalz.2011.03.004","article-title":"Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Jack","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0015","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1148\/radiology.172.2.2748838","article-title":"Anterior temporal lobes and hippocampal formations: normative volumetric measurements from MR images in young adults","volume":"172","author":"Jack","year":"1989","journal-title":"Radiology"},{"key":"10.1016\/j.pscychresns.2022.111443_bib0016","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.nicl.2015.05.003","article-title":"Automatic segmentation and volumetry of multiple sclerosis brain lesions from MR images","volume":"8","author":"Jain","year":"2015","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0017","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1001\/jama.2015.4668","article-title":"Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis","volume":"313","author":"Jansen","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.pscychresns.2022.111443_bib0018","first-page":"e106","article-title":"Update on appropriate use criteria for amyloid PET imaging: dementia experts, mild cognitive impairment, and education. Amyloid imaging task force of the Alzheimer's Association and Society for nuclear medicine and molecular imaging","volume":"9","author":"Johnson","year":"2013","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0019","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/psyg.12176","article-title":"Patterns of hippocampal atrophy differ among Alzheimer's disease, amnestic mild cognitive impairment, and late-life depression","volume":"16","author":"Joko","year":"2016","journal-title":"Psychogeriatrics"},{"key":"10.1016\/j.pscychresns.2022.111443_bib0020","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1046\/j.1440-1614.2001.00967.x","article-title":"History of depression as a risk factor for dementia: an updated review","volume":"35","author":"Jorm","year":"2001","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.pscychresns.2022.111443_bib0021","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0006-3223(02)01348-3","article-title":"Depression in Alzheimer's disease: overview and treatment","volume":"52","author":"Lyketsos","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pscychresns.2022.111443_bib0022","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1159\/000345234","article-title":"Structural neuroimaging of concomitant depressive symptoms in amnestic mild cognitive impairment: a pilot study","volume":"2","author":"Morin","year":"2012","journal-title":"Dement. Geriatr. Cogn. Dis. Extra"},{"key":"10.1016\/j.pscychresns.2022.111443_bib0023","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1017\/S0033291797005606","article-title":"Temporal lobe magnetic resonance imaging can differentiate Alzheimer's disease from normal ageing, depression, vascular dementia and other causes of cognitive impairment","volume":"27","author":"O'Brien","year":"1997","journal-title":"Psychol. Med."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0024","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1001\/archpsyc.63.5.530","article-title":"Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis","volume":"63","author":"Ownby","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.pscychresns.2022.111443_bib0025","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3233\/JAD-2010-1352","article-title":"Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer's disease: the role of depression and apathy","volume":"20","author":"Palmer","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0026","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/JGP.0b013e3181b0fa13","article-title":"Late-life depression, mild cognitive impairment, and dementia: possible continuum?","volume":"18","author":"Panza","year":"2010","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.pscychresns.2022.111443_bib0027","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejrad.2017.07.014","article-title":"The diagnostic value of FDG and amyloid PET in Alzheimer's disease-A systematic review","volume":"94","author":"Rice","year":"2017","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0028","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/oxfordjournals.bmb.a011572","article-title":"Neuropsychology\u2013dementia and affective disorders","volume":"52","author":"Robbins","year":"1996","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0029","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000477759","article-title":"Distinguishing depressive pseudodementia from Alzheimer disease: a comparative study of hippocampal volumetry and cognitive tests","volume":"7","author":"Sahin","year":"2017","journal-title":"Dement Geriatr Cogn Dis Extra"},{"key":"10.1016\/j.pscychresns.2022.111443_bib0030","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1073\/pnas.93.9.3908","article-title":"Hippocampal atrophy in recurrent major depression","volume":"93","author":"Sheline","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0031","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1001\/jamapsychiatry.2017.0660","article-title":"Trajectories of depressive symptoms before diagnosis of dementia: a 28-year follow-up study","volume":"74","author":"Singh-Manoux","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.pscychresns.2022.111443_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2020.102243","article-title":"Automated MRI volumetry as a diagnostic tool for Alzheimer's disease: validation of icobrain dm","volume":"26","author":"Struyfs","year":"2020","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0033","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1016\/j.jagp.2013.11.004","article-title":"Hippocampus atrophy and the longitudinal course of late-life depression","volume":"22","author":"Taylor","year":"2014","journal-title":"Am. J. Geriatr. Psychiatry"},{"issue":"10","key":"10.1016\/j.pscychresns.2022.111443_bib0034","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.2967\/jnumed.114.142109","article-title":"Automated quantification of 18F-flutemetamol PET activity for categorizing scans as negative or positive for brain amyloid: concordance with visual image reads","volume":"55","author":"Thurfjell","year":"2014","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0035","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/ana.22068","article-title":"18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial","volume":"68","author":"Vandenberghe","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0036","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1532-5415.2000.tb04992.x","article-title":"Distinction between preclinical Alzheimer's disease and depression","volume":"48","author":"Visser","year":"2000","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0037","first-page":"23S","article-title":"Differential diagnosis between depression and dementia","volume":"94","author":"Yesavage","year":"1993","journal-title":"Am. J. Med."},{"key":"10.1016\/j.pscychresns.2022.111443_bib0038","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1176\/appi.ajp.160.5.857","article-title":"A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer's disease","volume":"160","author":"Zubenko","year":"2003","journal-title":"Am. J. Psychiatry"}],"container-title":["Psychiatry Research: Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092549272200004X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092549272200004X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T02:42:00Z","timestamp":1778380920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092549272200004X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":38,"alternative-id":["S092549272200004X"],"URL":"https:\/\/doi.org\/10.1016\/j.pscychresns.2022.111443","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.02.08.21251205","asserted-by":"object"}]},"ISSN":["0925-4927"],"issn-type":[{"value":"0925-4927","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An optimized MRI and PET based clinical protocol for improving the differential diagnosis of geriatric depression and Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Psychiatry Research: Neuroimaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pscychresns.2022.111443","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111443"}}