{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:26:04Z","timestamp":1785407164699,"version":"3.56.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"am","delay-in-days":329,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Research: Neuroimaging"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.pscychresns.2025.111967","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T08:10:03Z","timestamp":1739952603000},"page":"111967","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Depressive symptoms are associated with hippocampal volume in the oldest-old: The LifeAfter90 study"],"prefix":"10.1016","volume":"348","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7317-0444","authenticated-orcid":false,"given":"Alexander Ivan B.","family":"Posis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Paloma","family":"Rojas-Saunero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen M.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Gilsanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Maillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M.","family":"Corrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A.","family":"Whitmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pscychresns.2025.111967_bib0001","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.neuroimage.2009.02.018","article-title":"Multi-atlas based segmentation of brain images: atlas selection and its effect on accuracy","volume":"46","author":"Aljabar","year":"2009","journal-title":"NeuroImage"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0002","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.athoracsur.2015.11.024","article-title":"Adjust for multiple comparisons?","volume":"101","author":"Althouse","year":"2016","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.pscychresns.2025.111967_bib0003","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer's disease","volume":"367","author":"Bateman","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pscychresns.2025.111967_bib0004","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0895-4356(00)00314-0","article-title":"Adjusting for multiple testing\u2014When and how?","volume":"54","author":"Bender","year":"2001","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.pscychresns.2025.111967_bib0005","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/npp.2013.271","article-title":"Association of depressive symptoms with hippocampal volume in 1936 adults","volume":"39","author":"Brown","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0006","article-title":"Psychosocial well-being differences between the young old, old-old, and oldest old: a global comparison","volume":"8982643241264587","author":"Burns","year":"2024","journal-title":"J. Aging Health"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0007","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1017\/S1355617708081162","article-title":"Composite scores for executive function items: demographic heterogeneity and relationships with quantitative magnetic resonance imaging","volume":"14","author":"Crane","year":"2008","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.pscychresns.2025.111967_bib0008","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/gps.773","article-title":"Accuracy of the 15-item geriatric depression scale (GDS-15) in a community sample of the oldest old","volume":"18","author":"de Craen","year":"2003","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0009","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"NeuroImage"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0010","first-page":"367","article-title":"Depressive symptoms and brain volumes in older adults: a longitudinal magnetic resonance imaging study","volume":"34","author":"Dotson","year":"2009","journal-title":"J. Psychiatry Neurosci. JPN"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0011","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.683426","article-title":"Convolutional neural net learning can achieve production-level brain segmentation in structural magnetic resonance imaging","volume":"15","author":"Fletcher","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.pscychresns.2025.111967_bib0012","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3758\/s13415-021-00973-y","article-title":"Anxiety and hippocampal neuronal activity: relationship and potential mechanisms","volume":"22","author":"Ghasemi","year":"2022","journal-title":"Cogn. Affect. Behav. Neurosci."},{"key":"10.1016\/j.pscychresns.2025.111967_bib0013","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jad.2011.01.020","article-title":"Depressive symptoms, brain volumes and subclinical cerebrovascular disease in postmenopausal women: the Women's Health Initiative MRI Study","volume":"132","author":"Goveas","year":"2011","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.pscychresns.2025.111967_bib0014","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1136\/jnnp.2007.124651","article-title":"White matter hyperintensities in late life depression: a systematic review","volume":"79","author":"Herrmann","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0015","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.neuroimage.2014.09.053","article-title":"Optimization of a free water elimination two-compartment model for diffusion tensor imaging","volume":"103","author":"Hoy","year":"2014","journal-title":"NeuroImage"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0016","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"FSL","volume":"62","author":"Jenkinson","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0017","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1001\/archgenpsychiatry.2011.60","article-title":"Structural Neuroimaging Studies in major depressive disorder: meta-analysis and comparison with bipolar disorder","volume":"68","author":"Kempton","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0018","doi-asserted-by":"crossref","DOI":"10.1002\/alz.14217","article-title":"Gender differences in the association between education and late-life cognitive function in the LifeAfter90 Study: a multiethnic cohort of the oldest-old","author":"Lam","year":"2024","journal-title":"Alzheimers Dement. J. Alzheimers Assoc."},{"key":"10.1016\/j.pscychresns.2025.111967_bib0019","first-page":"70","article-title":"Amyloid-\u03b2 imaging with Pittsburgh compound B and florbetapir: comparing radiotracers and quantification methods","volume":"54","author":"Landau","year":"2013","journal-title":"J. Nucl. Med. Off. Publ. Soc. Nucl. Med."},{"key":"10.1016\/j.pscychresns.2025.111967_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission","author":"Livingston","year":"2024","journal-title":"Lancet Lond. Engl"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0021","doi-asserted-by":"crossref","first-page":"e12261","DOI":"10.1002\/dad2.12261","article-title":"Instrumental validation of free water, peak-width of skeletonized mean diffusivity, and white matter hyperintensities: MarkVCID neuroimaging kits","volume":"14","author":"Maillard","year":"2022","journal-title":"Alzheimers Dement. Amst. Neth."},{"key":"10.1016\/j.pscychresns.2025.111967_bib0022","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s11682-023-00772-8","article-title":"Brain-based Sex Differences in depression: a Systematic Review of Neuroimaging Studies","volume":"17","author":"Mohammadi","year":"2023","journal-title":"Brain Imaging Behav"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0023","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1037\/1040-3590.16.4.347","article-title":"Spanish and English neuropsychological assessment scales (SENAS): further development and psychometric characteristics","volume":"16","author":"Mungas","year":"2004","journal-title":"Psychol. Assess."},{"key":"10.1016\/j.pscychresns.2025.111967_bib0024","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1007\/s11606-013-2755-z","article-title":"Six persistent research misconceptions","volume":"29","author":"Rothman","year":"2014","journal-title":"J. Gen. Intern. Med."},{"key":"10.1016\/j.pscychresns.2025.111967_bib0025","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1210\/edrv-7-3-284","article-title":"The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis","volume":"7","author":"Sapolsky","year":"1986","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.pscychresns.2025.111967_bib0026","series-title":"Clinical Gerontology : A Guide to Assessment and Intervention","first-page":"165","article-title":"Geriatric Depression scale (GDS) recent evidence and development of a shorter version","author":"Sheikh","year":"1986"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0027","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2337\/dc20-2031","article-title":"Specific dimensions of depression have different associations with cognitive decline in older adults with type 2 diabetes","volume":"44","author":"Soleimani","year":"2021","journal-title":"Diabetes Care"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0028","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1378\/chest.11-0523","article-title":"Correction for multiple testing: is there a resolution?","volume":"140","author":"Streiner","year":"2011","journal-title":"Chest"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0029","first-page":"82","article-title":"Neuroimaging in dementia","volume":"8","author":"Tartaglia","year":"2011","journal-title":"Neurother. J. Am. Soc. Exp. Neurother."},{"key":"10.1016\/j.pscychresns.2025.111967_bib0030","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/mp.2013.20","article-title":"The vascular depression hypothesis: mechanisms linking vascular disease with depression","volume":"18","author":"Taylor","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0031","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.1038\/s41380-022-01772-8","article-title":"Depressive symptoms in cognitively unimpaired older adults are associated with lower structural and functional integrity in a frontolimbic network","volume":"27","author":"Touron","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0032","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neuroimage.2014.05.044","article-title":"Large-scale evaluation of ANTs and FreeSurfer cortical thickness measurements","volume":"99","author":"Tustison","year":"2014","journal-title":"NeuroImage"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-024-02739-9","article-title":"Association of amyloid-beta with depression or depressive symptoms in older adults without dementia: a systematic review and meta-analysis","volume":"14","author":"Twait","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.pscychresns.2025.111967_bib0034","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1080\/13803390600678038","article-title":"Neuropsychological data in nondemented oldest old: the 90+ study","volume":"29","author":"Whittle","year":"2007","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.pscychresns.2025.111967_bib0035","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ynstr.2018.03.002","article-title":"Sex differences in chronic stress responses and Alzheimer's disease","volume":"8","author":"Yan","year":"2018","journal-title":"Neurobiol. Stress"}],"container-title":["Psychiatry Research: Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925492725000228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925492725000228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:23:14Z","timestamp":1741710194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925492725000228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":35,"alternative-id":["S0925492725000228"],"URL":"https:\/\/doi.org\/10.1016\/j.pscychresns.2025.111967","relation":{},"ISSN":["0925-4927"],"issn-type":[{"value":"0925-4927","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Depressive symptoms are associated with hippocampal volume in the oldest-old: The LifeAfter90 study","name":"articletitle","label":"Article Title"},{"value":"Psychiatry Research: Neuroimaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pscychresns.2025.111967","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111967"}}