{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:19:55Z","timestamp":1783109995523,"version":"3.54.6"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["DST\/CSRI\/2018\/10"],"award-info":[{"award-number":["DST\/CSRI\/2018\/10"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Research: Neuroimaging"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.pscychresns.2026.112248","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:31:23Z","timestamp":1778859083000},"page":"112248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Brain white matter microstructural integrity differences between pre-post buprenorphine-naloxone treated individuals with opioid use disorder: Evidence from a DTI study"],"prefix":"10.1016","volume":"361","author":[{"given":"Simranjit","family":"Kaur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0988-7694","authenticated-orcid":false,"given":"Abhishek","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teddy","family":"Salan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirag","family":"Ahuja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paramjit","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Modi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Nehra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasish","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varan","family":"Govind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pscychresns.2026.112248_bib0002","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.nurt.2007.05.011","article-title":"Diffusion tensor imaging of the brain","volume":"4","author":"Alexander","year":"2007","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.pscychresns.2026.112248_bib0001","series-title":"Diagnostic and Statistical Manual of Mental Disorders: DSM-5-TR","author":"American Psychiatric Association","year":"2022"},{"key":"10.1016\/j.pscychresns.2026.112248_bib0003","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jpsychires.2008.12.002","article-title":"Diffusion abnormalities in adolescents and young adults with a history of heavy cannabis use","volume":"43","author":"Ashtari","year":"2009","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0004","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2217\/iim.13.49","article-title":"Diffusion tensor MRI as a biomarker in axonal and myelin damage","volume":"5","author":"Aung","year":"2013","journal-title":"Imaging Med."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0005","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3390\/brainsci15070699","article-title":"Cannabis use in opioid maintenance therapy: prevalence, clinical correlates and reasons for use","volume":"15","author":"Backmund","year":"2025","journal-title":"Brain Sci."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0006","first-page":"E181","article-title":"Longitudinal changes in white matter integrity among adolescent substance users","volume":"37","author":"Bava","year":"2013","journal-title":"Alcohol. ClinExp. Res."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0007","first-page":"159","article-title":"Assessing white matter integrity as a function of abstinence duration in former cocaine-dependent individuals","volume":"114","author":"Bell","year":"2011","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0008","doi-asserted-by":"crossref","first-page":"6990","DOI":"10.1038\/s41598-021-86505-7","article-title":"Free-water diffusion tensor imaging improves the accuracy and sensitivity of white matter analysis in Alzheimer\u2019s disease","volume":"11","author":"Bergamino","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0009","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1369-1600.2010.00266.x","article-title":"White matter microstructure in opiate addiction","volume":"17","author":"Bora","year":"2012","journal-title":"Addict. Biol."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0010","first-page":"804","article-title":"Not lesser but greater fractional anisotropy in adolescents with alcohol use disorders","volume":"2","author":"Cardenas","year":"2013","journal-title":"NeuroimageClin"},{"issue":"3","key":"10.1016\/j.pscychresns.2026.112248_bib0011","first-page":"263","article-title":"Glial modulators: a novel pharmacological approach to altering the behavioral effects of abused substances","volume":"25","author":"Cooper","year":"2016","journal-title":"Expert. Opin. Investig. Drugs"},{"key":"10.1016\/j.pscychresns.2026.112248_bib0012","doi-asserted-by":"crossref","first-page":"287","DOI":"10.15288\/jsad.2022.83.287","article-title":"Effects of nicotine and cannabis co-use during late adolescence on white matter fiber tract microstructure","volume":"83","author":"Courtney","year":"2022","journal-title":"J. Stud. Alcohol Drugs"},{"key":"10.1016\/j.pscychresns.2026.112248_bib0013","doi-asserted-by":"crossref","first-page":"16913","DOI":"10.1073\/pnas.1415297111","article-title":"Long-term effects of marijuana use on the brain","volume":"111","author":"Filbey","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0014","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fninf.2014.00008","article-title":"Dipy contributors. dipy, a library for the analysis of diffusion MRI data","volume":"8","author":"Garyfallidis","year":"2014","journal-title":"Front. Neuroinform."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0015","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/s41380-022-01833-y","article-title":"Whole-brain white matter abnormalities in human cocaine and heroin use disorders: association with craving, recency, and cumulative use","volume":"28","author":"Gaudreault","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.pscychresns.2026.112248_bib0016","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ajp.2019.02.009","article-title":"Risk, reversibility and resilience of brain circuitries linked to opioid dependence: a diffusion tensor imaging study","volume":"40","author":"Ghosh","year":"2019","journal-title":"Asian J. Psychiatr."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0017","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1093\/brain\/awr145","article-title":"Cigarette smoking is associated with reduced microstructural integrity of cerebral white matter","volume":"134","author":"Gons","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.pscychresns.2026.112248_bib0018","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1037\/a0023034","article-title":"White matter alterations associated with impulsivity in chronic marijuana smokers","volume":"19","author":"Gruber","year":"2011","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0019","first-page":"146","article-title":"Why so impulsive? White matter alterations are associated with impulsivity in chronic marijuana smokers","volume":"22","author":"Gruber","year":"2014","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0020","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.drugalcdep.2019.02.005","article-title":"Substance abuse and white matter: findings, limitations, and future of diffusion tensor imaging research","volume":"197","author":"Hampton","year":"2019","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0021","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","volume":"62","author":"Jenkinson","year":"2012","journal-title":"FSL. Neuroimage"},{"key":"10.1016\/j.pscychresns.2026.112248_bib0022","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1007\/s11739-022-02936-8","article-title":"Understanding and co-managing medication treatment options for opioid use disorder","volume":"17","author":"Kay","year":"2022","journal-title":"Intern. Emerg. Med."},{"issue":"1","key":"10.1016\/j.pscychresns.2026.112248_bib47","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/npp.2009.110","article-title":"Neurocircuitry of addiction","volume":"35","author":"Koob","year":"2010","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.pscychresns.2026.112248_bib0023","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1151\/spp021113","article-title":"The neurobiology of opioid dependence: implications for treatment","volume":"1","author":"Kosten","year":"2002","journal-title":"Sci. Pract. Perspect."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0024","first-page":"6","article-title":"Methadone-induced damage to white matter integrity in Methadone maintenance patients: a longitudinal self-control DTI study","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0025","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainres.2013.07.036","article-title":"White matter impairment in chronic heroin dependence: a quantitative DTI study","volume":"1531","author":"Li","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0027","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1369-1600.2010.00250.x","article-title":"Differences between smokers and non-smokers in regional gray matter volumes: a voxel-based morphometry study","volume":"17","author":"Liao","year":"2012","journal-title":"Addict. Biol."},{"issue":"4","key":"10.1016\/j.pscychresns.2026.112248_bib0028","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2174\/1570159043359477","article-title":"Buprenorphine: a unique drug with complex pharmacology","volume":"2","author":"Lutfy","year":"2004","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0029","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.drugalcdep.2016.12.016","article-title":"A preliminary longitudinal study of white matter alteration in cocaine use disorder subjects","volume":"173","author":"Ma","year":"2017","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0030","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1038\/s41380-019-0577-z","article-title":"Brain structural changes in cannabis dependence: association with MAGL","volume":"25","author":"Manza","year":"2020","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.pscychresns.2026.112248_bib0031","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.neuroimage.2009.01.002","article-title":"Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: application to normal elderly and Alzheimer\u2019s disease participants","volume":"46","author":"Oishi","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.pscychresns.2026.112248_bib0032","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.schres.2014.07.031","article-title":"The extent of diffusion MRI markers of neuroinflammation and white matter deterioration in chronic schizophrenia","volume":"161","author":"Pasternak","year":"2015","journal-title":"Schizophr. Res."},{"issue":"1","key":"10.1016\/j.pscychresns.2026.112248_bib0033","first-page":"79","article-title":"Transcallosal white matter degradation detected with quantitative fiber tracking in alcoholic men and women: selective relations to dissociable functions","volume":"39","author":"Pfefferbaum","year":"2015","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0034","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1360-0443.1987.tb01532.x","article-title":"The application of the SODQ to the measurement of the severity of opiate dependence in a British sample","volume":"82","author":"Phillips","year":"1987","journal-title":"Br. J. Addict."},{"issue":"Suppl. 1","key":"10.1016\/j.pscychresns.2026.112248_bib0035","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuropharm.2004.06.025","article-title":"Structural plasticity associated with exposure to drugs of abuse","volume":"47","author":"Robinson","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pscychresns.2026.112248_bib0036","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1017\/S0033291715002342","article-title":"Effect of high-potency cannabis on corpus callosum microstructure","volume":"46","author":"Rigucci","year":"2016","journal-title":"Psychol. Med."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2025.e00770","article-title":"Novel neurotherapeutic targets for substance use disorders: neuroplasticity, neuroinflammation, gasotransmitters and non-canonical organ systems","volume":"22","author":"Sharma","year":"2025","journal-title":"Neurotherapeutics"},{"issue":"4","key":"10.1016\/j.pscychresns.2026.112248_bib0038","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.pscychresns.2026.112248_bib0039","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12839","article-title":"A multimodal investigation of cerebellar integrity associated with high-risk cannabis use","volume":"25","author":"Sweigert","year":"2020","journal-title":"Addict. Biol."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.addbeh.2019.106152","article-title":"Recent tobacco use has widespread associations with adolescent white matter microstructure","volume":"101","author":"Thayer","year":"2020","journal-title":"Addict. Behav."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0041","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1002\/mrm.22924","article-title":"Diffusion tensor imaging and beyond","volume":"65","author":"Tournier","year":"2011","journal-title":"MagnReson Med."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0042","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neulet.2011.02.053","article-title":"White matter impairment in heroin addicts undergoing methadone maintenance treatment and prolonged abstinence: a preliminary DTI study","volume":"494","author":"Wang","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0043","series-title":"International Classification of Diseases 11th Revision (ICD-11)","author":"World Health Organization","year":"2019"},{"issue":"4","key":"10.1016\/j.pscychresns.2026.112248_bib0044","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s10067-014-2517-2","article-title":"Low-dose naltrexone for the treatment of chronic pain: a review of the literature","volume":"33","author":"Younger","year":"2014","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.pscychresns.2026.112248_bib0045","article-title":"Regional grey and white matter changes in heavy male smokers","volume":"6","author":"Yu","year":"2016","journal-title":"PLoS. One"},{"issue":"4","key":"10.1016\/j.pscychresns.2026.112248_bib0046","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nn.3045","article-title":"Plasticity in gray and white: neuroimaging changes in brain structure during learning","volume":"15","author":"Zatorre","year":"2012","journal-title":"Nat. Neurosci."}],"container-title":["Psychiatry Research: Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925492726001137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925492726001137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:34:59Z","timestamp":1783107299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925492726001137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":46,"alternative-id":["S0925492726001137"],"URL":"https:\/\/doi.org\/10.1016\/j.pscychresns.2026.112248","relation":{},"ISSN":["0925-4927"],"issn-type":[{"value":"0925-4927","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain white matter microstructural integrity differences between pre-post buprenorphine-naloxone treated individuals with opioid use disorder: Evidence from a DTI study","name":"articletitle","label":"Article Title"},{"value":"Psychiatry Research: Neuroimaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pscychresns.2026.112248","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112248"}}