{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T18:04:23Z","timestamp":1784397863807,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T00:00:00Z","timestamp":1587168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011809","name":"Anhui Agricultural University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.psj.2020.03.064","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T13:29:08Z","timestamp":1587734948000},"page":"3675-3687","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Role of LsrR in the regulation of antibiotic sensitivity in avian pathogenic Escherichia coli"],"prefix":"10.1016","volume":"99","author":[{"given":"Lumin","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtian","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5644-6613","authenticated-orcid":false,"given":"Ting","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2020.03.064_bib1","first-page":"303","article-title":"Antimicrobial resistance of Escherichia coli isolated from chickens with colibacillosis","volume":"4","author":"Aggad","year":"2010","journal-title":"Glob. Vet."},{"key":"10.1016\/j.psj.2020.03.064_bib2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/jac\/dkm124","article-title":"AI-2 quorum sensing affects antibiotic susceptibility in Streptococcus anginosus","volume":"60","author":"Ahmed","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.psj.2020.03.064_bib3","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S1369-5274(99)00025-9","article-title":"How bacteria talk to each other: regulation of gene expression by quorum sensing","volume":"2","author":"Bassler","year":"1999","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.psj.2020.03.064_bib4","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0092-8674(02)00749-3","article-title":"Small talk. Cell-to-cell communication in bacteria","volume":"109","author":"Bassler","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.psj.2020.03.064_bib5","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1128\/jb.179.12.4043-4045.1997","article-title":"Cross-species induction of luminescence in the quorum-sensing bacterium Vibrio harveyi","volume":"179","author":"Bassler","year":"1997","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.psj.2020.03.064_bib6","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1073\/pnas.120163297","article-title":"One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products","volume":"97","author":"Datsenko","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.psj.2020.03.064_bib7","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.3382\/ps.2013-03194","article-title":"Characterization and antimicrobial resistance analysis of avian pathogenic Escherichia coli isolated from Italian Turkey flocks","volume":"92","author":"Davide","year":"2013","journal-title":"Poult. Sci"},{"key":"10.1016\/j.psj.2020.03.064_bib8","first-page":"299","article-title":"Avian pathogenic Escherichia coli (APEC)","volume":"30","author":"Dho-Moulin","year":"1999","journal-title":"Vet. Res."},{"key":"10.1016\/j.psj.2020.03.064_bib9","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1128\/JB.00165-06","article-title":"A LuxS-dependent cell-to-cell language regulates social behavior and development in Bacillus subtilis","volume":"188","author":"Esteban","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.psj.2020.03.064_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.vetmic.2004.09.008","article-title":"Molecular epidemiology of avian pathogenic Escherichia coli (APEC) isolated from colisepticemia in poultry","volume":"104","author":"Ewers","year":"2004","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.psj.2020.03.064_bib11","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1128\/IAI.00412-06","article-title":"The BarA-UvrY two-component system regulates virulence in avian pathogenic Escherichia coli O78:K80:H9","volume":"74","author":"Herren","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.psj.2020.03.064_bib12","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/j.1365-2958.2004.04449.x","article-title":"Indole induces the expression of multidrug exporter genes in Escherichia coli","volume":"55","author":"Hirakawa","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.psj.2020.03.064_bib13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cimid.2011.12.004","article-title":"TonB is essential for virulence in avian pathogenic Escherichia coli","volume":"35","author":"Holden","year":"2012","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.psj.2020.03.064_bib14","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1128\/JB.01448-09","article-title":"Multidrug efflux pump MdtBC of Escherichia coli is active only as a B2C heterotrimer","volume":"192","author":"Hong-Suk","year":"2010","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.psj.2020.03.064_bib15","doi-asserted-by":"crossref","first-page":"5693","DOI":"10.1128\/JB.00217-06","article-title":"Growth phase-dependent expression of drug exporters in Escherichia coli and its contribution to drug tolerance","volume":"188","author":"Kobayashi","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.psj.2020.03.064_bib16","doi-asserted-by":"crossref","first-page":"204141","DOI":"10.1155\/2013\/204141","article-title":"Modulation of bacterial multidrug resistance efflux pumps of the major facilitator superfamily","volume":"2013","author":"Kumar","year":"2013","journal-title":"Int. J. Bacteriol."},{"key":"10.1016\/j.psj.2020.03.064_bib17","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.1128\/JB.00014-07","article-title":"Quorum sensing in Escherichia coli is signaled by AI-2\/LsrR: effects on small RNA and biofilm architecture","volume":"189","author":"Li","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.psj.2020.03.064_bib18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12917-016-0800-y","article-title":"Iron-regulated gene ireA in avian pathogenic Escherichia coli participates in adhesion and stress-resistance","volume":"12","author":"Li","year":"2016","journal-title":"Bmc Vet. Res."},{"key":"10.1016\/j.psj.2020.03.064_bib19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1046\/j.1365-2958.2001.02616.x","article-title":"Mutation of luxS affects growth and virulence factor expression in Streptococcus pyogenes","volume":"42","author":"Lyon","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.psj.2020.03.064_bib20","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1128\/IAI.71.1.494-503.2003","article-title":"Role of avian pathogenic Escherichia coli virulence factors in bacterial interaction with chicken heterophils and macrophages","volume":"71","author":"Melha","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.psj.2020.03.064_bib21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.micro.55.1.165","article-title":"Quorum sensing in bacteria","volume":"55","author":"Miller","year":"2001","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.psj.2020.03.064_bib22","doi-asserted-by":"crossref","first-page":"5853","DOI":"10.1128\/jb.178.20.5853-5859.1996","article-title":"Multidrug efflux pumps of gram-negative bacteria","volume":"178","author":"Nikaido","year":"1996","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.psj.2020.03.064_bib23","doi-asserted-by":"crossref","first-page":"5803","DOI":"10.1128\/JB.183.20.5803-5812.2001","article-title":"Analysis of a complete library of putative drug transporter genes in Escherichia coli","volume":"183","author":"Nishino","year":"2001","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.psj.2020.03.064_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40588-016-0027-5","article-title":"Epidemiology of extended-spectrum \u03b2-lactamase-producing Escherichia coli in the human-livestock environment","volume":"3","author":"N\u00fcesch-Inderbinen","year":"2016","journal-title":"Curr. Clin. Microbiol. Rep."},{"key":"10.1016\/j.psj.2020.03.064_bib25","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.1002\/j.1460-2075.1993.tb06089.x","article-title":"Molecular genetic analysis of a locus required for resistance to antimicrobial peptides in Salmonella typhimurium","volume":"12","author":"Parra-Lopez","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/j.psj.2020.03.064_bib26","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1128\/MMBR.64.4.672-693.2000","article-title":"Molecular properties of bacterial multidrug transporters","volume":"64","author":"Putman","year":"2000","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.psj.2020.03.064_bib27","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1128\/JB.185.1.274-284.2003","article-title":"LuxS-based signaling in Streptococcus gordonii: autoinducer 2 controls carbohydrate metabolism and biofilm formation with Porphyromonas gingivalis","volume":"185","author":"Roderick","year":"2003","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.psj.2020.03.064_bib28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1046\/j.1365-2958.2001.02532.x","article-title":"The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule","volume":"41","author":"Schauder","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.psj.2020.03.064_bib29","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbrc.2007.06.175","article-title":"Characterization of the multidrug efflux regulator AcrR from Escherichia coli","volume":"361","author":"Su","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.psj.2020.03.064_bib30","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1128\/AAC.45.4.1126-1136.2001","article-title":"Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes","volume":"45","author":"Sulavik","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.psj.2020.03.064_bib31","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1128\/JB.187.6.2066-2076.2005","article-title":"Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli","volume":"187","author":"Wang","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.psj.2020.03.064_bib32","doi-asserted-by":"crossref","first-page":"8350","DOI":"10.1128\/JB.187.24.8350-8360.2005","article-title":"luxS-dependent gene regulation in Escherichia coli K-12 revealed by genomic expression profiling","volume":"187","author":"Wang","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.psj.2020.03.064_bib33","doi-asserted-by":"crossref","first-page":"e0138826","DOI":"10.1371\/journal.pone.0138826","article-title":"Crystal structure and identification of two key amino acids involved in AI-2 production and biofilm formation in Streptococcus suis LuxS","volume":"10","author":"Wang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.psj.2020.03.064_bib34","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00284-013-0509-0","article-title":"Biofilm formation, host-cell adherence, and virulence genes regulation of Streptococcus suis in response to autoinducer-2 signaling","volume":"68","author":"Wang","year":"2014","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.psj.2020.03.064_bib35","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1177\/104063879300500423","article-title":"Minimum inhibitory concentrations of bacteria isolated from septicemia and airsacculitis in ducks","volume":"5","author":"Watts","year":"1993","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.psj.2020.03.064_bib36","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nature03960","article-title":"Interference with AI-2-mediated bacterial cell-cell communication","volume":"437","author":"Xavier","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.psj.2020.03.064_bib37","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1021\/cb600444h","article-title":"Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria","volume":"2","author":"Xavier","year":"2007","journal-title":"Acs Chem. Biol."},{"key":"10.1016\/j.psj.2020.03.064_bib38","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/cr.2009.91","article-title":"LsrR-binding site recognition and regulatory characteristics in Escherichia coli AI-2 quorum sensing","volume":"19","author":"Xue","year":"2009","journal-title":"Cell Res"},{"key":"10.1016\/j.psj.2020.03.064_bib39","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.3168\/jds.2015-10543","article-title":"Short communication: the role of autoinducer 2 (AI-2) on antibiotic resistance regulation in an Escherichia coli strain isolated from a dairy cow with mastitis","volume":"99","author":"Xue","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.psj.2020.03.064_bib40","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ijantimicag.2012.08.016","article-title":"LuxS\/AI-2 system is involved in antibiotic susceptibility and autolysis in Staphylococcus aureus NCTC 8325","volume":"41","author":"Xue","year":"2013","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.psj.2020.03.064_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/mbo3.582","article-title":"Autoinducer2 affects trimethoprim-sulfamethoxazole susceptibility in avian pathogenic Escherichia coli dependent on the folate synthesis-associate pathway","volume":"7","author":"Yu","year":"2018","journal-title":"Microbiologyopen"},{"key":"10.1016\/j.psj.2020.03.064_bib42","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.3168\/jds.2017-13761","article-title":"Imidazole decreases the ampicillin resistance of an Escherichia coli strain isolated from a cow with mastitis by inhibiting the function of autoinducer 2","volume":"101","author":"Yu","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.psj.2020.03.064_bib43","doi-asserted-by":"crossref","first-page":"e5711","DOI":"10.7717\/peerj.5711","article-title":"The anti-biofilm effect of silver-nanoparticle-decorated quercetin nanoparticles on a multi-drug resistant Escherichia coli strain isolated from a dairy cow with mastitis","volume":"6","author":"Yu","year":"2018","journal-title":"PeerJ"},{"key":"10.1016\/j.psj.2020.03.064_bib44","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bej.2018.02.009","article-title":"Native efflux pumps of Escherichia coli responsible for short and medium chain alcohol","volume":"133","author":"Zhang","year":"2018","journal-title":"Biochem. Eng. J."},{"key":"10.1016\/j.psj.2020.03.064_bib45","doi-asserted-by":"crossref","first-page":"26576","DOI":"10.1074\/jbc.M111.243261","article-title":"The multidrug efflux pump MdtEF protects against nitrosative damage during the anaerobic respiration in Escherichia coli","volume":"286","author":"Zhang","year":"2011","journal-title":"J. Biol. Chem."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579120302480?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579120302480?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T22:26:01Z","timestamp":1758493561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579120302480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S0032579120302480"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2020.03.064","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of LsrR in the regulation of antibiotic sensitivity in avian pathogenic Escherichia coli","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2020.03.064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}]}}