{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:18:48Z","timestamp":1791260328515,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T00:00:00Z","timestamp":1587168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.psj.2020.04.012","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T07:27:28Z","timestamp":1587972448000},"page":"3617-3627","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Interactive effect of dietary calcium and phytase on broilers challenged with subclinical necrotic enteritis: 3. Serum calcium and phosphorus, and bone mineralization"],"prefix":"10.1016","volume":"99","author":[{"given":"H.K.","family":"Zanu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.K.","family":"Kheravii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.K.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.R.","family":"Bedford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.A.","family":"Swick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2020.04.012_bib1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/09712119.2016.1206903","article-title":"Effects of dietary oil sources, calcium and phosphorus levels on growth performance, carcass characteristics and bone quality of broiler chickens","volume":"45","author":"Abdulla","year":"2017","journal-title":"J. Appl. Anim. Res."},{"key":"10.1016\/j.psj.2020.04.012_bib2","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.3382\/ps\/pey446","article-title":"Interactive effects of calcium and top-dressed 25-hydroxy vitamin D3 on egg production, egg shell quality, and bones attributes in aged Lohmann LSL-lite layers","volume":"98","author":"Akbari Moghaddam Kakhki","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib3","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1556\/avet.50.2002.3.7","article-title":"Effects of microbial phytase and 1,25-dihydroxycholecalciferol on the absorption of minerals from broiler chicken diets containing different levels of calcium","volume":"50","author":"Aksakal","year":"2002","journal-title":"Acta Vet. Hung."},{"key":"10.1016\/j.psj.2020.04.012_bib4","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/japr\/11.4.471","article-title":"Phytic acid Chemistry: influence on Phytin-phosphorus availability and phytase efficacy","volume":"11","author":"Angel","year":"2002","journal-title":"J. Appl. Poult. Res."},{"key":"10.1016\/j.psj.2020.04.012_bib5","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/ps\/82.7.1140","article-title":"Effect of dietary calcium, 25-hydroxycholecalciferol, or bird strain on small intestinal phytase activity in broiler chickens","volume":"82","author":"Applegate","year":"2003","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib6","series-title":"Ross 308 Broiler: Performance Objectives","year":"2014"},{"key":"10.1016\/j.psj.2020.04.012_bib7","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.3382\/ps\/pex012","article-title":"Hydrolysis of phytate to its lower esters can influence the growth performance and nutrient utilization of broilers with regular or super doses of phytase","volume":"96","author":"Beeson","year":"2017","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib8","first-page":"1327","article-title":"The effects of microbial phytase on serum calcium and phosphorus levels and alkaline phosphatase activities in broilers fed diets containing different levels of phosphorus","volume":"43","author":"Bilal","year":"2015","journal-title":"Acta Sci. Vet."},{"key":"10.1016\/j.psj.2020.04.012_bib9","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/jn\/128.5.917","article-title":"Calcium absorption\u2014a Paradigm for mineral absorption","volume":"128","author":"Bronner","year":"1998","journal-title":"J. Nutr."},{"key":"10.1016\/j.psj.2020.04.012_bib10","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/japr\/16.1.126","article-title":"Metabolic challenges and early bone development","volume":"16","author":"Dibner","year":"2007","journal-title":"J. Appl. Poult. Res."},{"key":"10.1016\/j.psj.2020.04.012_bib11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3382\/japr.2013-00842","article-title":"Influence of phytate level on broiler performance and the efficacy of 2 microbial phytases from 0 to 21 days of age","volume":"23","author":"dos Santos","year":"2014","journal-title":"J. Appl. Poult. Res."},{"key":"10.1016\/j.psj.2020.04.012_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/03079459408418973","article-title":"Variations of clinical biochemical parameters of laying hens and broiler chickens fed aflatoxin-containing feed","volume":"23","author":"Fernandez","year":"1994","journal-title":"Avian Pathol."},{"key":"10.1016\/j.psj.2020.04.012_bib13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3382\/ps\/pex291","article-title":"Effects of a high level of phytase on broiler performance, bone ash, phosphorus utilization, and phytate dephosphorylation to inositol","volume":"97","author":"Gautier","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib14","doi-asserted-by":"crossref","first-page":"883","DOI":"10.3382\/ps\/pev056","article-title":"Genetic analysis of bone quality traits and growth in a random mating broiler population","volume":"94","author":"Gonz\u00e1lez-Cer\u00f3n","year":"2015","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib15","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3382\/ps.0730904","article-title":"The role of Environment and management on leg Abnormalities in meat-Type Fowl","volume":"73","author":"Hester","year":"1994","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib16","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1080\/09712119.2017.1352506","article-title":"Changes in serum calcium and phosphorus levels and their relationship to egg production in laying hens infected with velogenic Newcastle disease virus","volume":"46","author":"Igwe","year":"2018","journal-title":"J. Appl. Anim. Res."},{"key":"10.1016\/j.psj.2020.04.012_bib17","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1093\/ps\/77.12.1773","article-title":"Rapid growth problems: ascites and skeletal deformities in broilers","volume":"77","author":"Julian","year":"1998","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib18","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3382\/ps\/pey346","article-title":"Relative bioavailability of phosphorus in high-protein sunflower meal for broiler chickens and effects of dietary phytase supplementation on bone traits, growth performance, and apparent ileal digestibility of nutrients","volume":"98","author":"Kim","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib19","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.3382\/ps\/pey304","article-title":"Effects of limestone particle size and dietary Ca concentration on apparent P and Ca digestibility in the presence or absence of phytase","volume":"97","author":"Kim","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib20","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s10517-010-0712-y","article-title":"Modulating effects of calcium on immune response of homoiothermal animal under thermoneutral conditions and during deep cooling","volume":"148","author":"Kozyreva","year":"2009","journal-title":"Bul. Exp. Biol. Med."},{"key":"10.1016\/j.psj.2020.04.012_bib21","doi-asserted-by":"crossref","first-page":"811","DOI":"10.3382\/ps\/pey389","article-title":"Evaluation of high dietary phytase supplementation on performance, bone mineralization, and apparent ileal digestible energy of growing broilers","volume":"98","author":"Leyva-Jimenez","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib22","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.3382\/ps\/pev273","article-title":"Age and adaptation to Ca and P deficiencies: 2. Impacts on amino acid digestibility and phytase efficacy in broilers","volume":"94","author":"Li","year":"2015","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib23","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3382\/ps\/pev354","article-title":"Impacts of dietary calcium, phytate, and nonphytate phosphorus concentrations in the presence or absence of phytase on inositol hexakisphosphate (IP6) degradation in different segments of broilers digestive tract","volume":"95","author":"Li","year":"2016","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib24","doi-asserted-by":"crossref","first-page":"552","DOI":"10.5713\/ajas.2011.11266","article-title":"The influence of dietary calcium and phosphorus imbalance on intestinal NaPi-IIb and Calbindin mRNA expression and tibia parameters of broilers","volume":"25","author":"Li","year":"2012","journal-title":"Asian-Australasian J. Anim. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib25","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.3382\/ps.2014-03978","article-title":"The interplay of dietary nutrient specification and varying calcium to total phosphorus ratio on efficacy of a bacterial phytase: 1. Growth performance and tibia mineralization","volume":"93","author":"Olukosi","year":"2014","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib26","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/ps\/82.11.1787","article-title":"Bone densitometry as an indicator of percentage tibia ash in broiler chicks fed varying dietary calcium and phosphorus levels","volume":"82","author":"Onyango","year":"2003","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib55","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.3382\/ps.2013-03298","article-title":"Influence of dietary calcium level, calcium source, and phytase on bird performance and mineral digestibility during a natural necrotic enteritis episode","volume":"92","author":"Paiva","year":"2013","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib27","first-page":"39","article-title":"Effect of phytase supplementation to a phytate-rich diet based on wheat, barley and soya on the bioavailability of dietary phosphorus, calcium, magnesium, zinc and protein in piglets","volume":"47","author":"Pallauf","year":"1994","journal-title":"Agribiol. Res."},{"key":"10.1016\/j.psj.2020.04.012_bib28","first-page":"240","article-title":"Effect of dietary calcium and dairy proteins on the adipose tissue gene expression profile in diet-induced obesity","volume":"1","author":"Pilvi","year":"2008","journal-title":"J. Nutrigenet. Nutrigenomics"},{"key":"10.1016\/j.psj.2020.04.012_bib29","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3382\/ps.2007-00231","article-title":"Interaction of calcium and phytate in broiler diets. 1. effects on apparent prececal digestibility and retention of phosphorus","volume":"87","author":"Plumstead","year":"2008","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib30","first-page":"264","article-title":"Effect of locomotor activity on leg disorder in fattening chicken","volume":"122","author":"Reiter","year":"2009","journal-title":"Berl.und Munch. Tierarztl. Wochenschr."},{"key":"10.1016\/j.psj.2020.04.012_bib31","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1637\/10774-011614-Reg.1","article-title":"A multifactorial analysis of the extent to which Eimeria and fishmeal predispose broiler chickens to necrotic enteritis","volume":"59","author":"Rodgers","year":"2015","journal-title":"Avian Dis."},{"key":"10.1016\/j.psj.2020.04.012_bib32","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.3382\/ps.2011-01702","article-title":"Effect of a novel phytase on growth performance, apparent metabolizable energy, and the availability of minerals and amino acids in a low-phosphorus corn-soybean meal diet for broilers","volume":"91","author":"Rutherfurd","year":"2012","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib33","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s12602-014-9170-6","article-title":"Bone mineralization of broiler chicks challenged with Salmonella enteritidis fed diet containing probiotic (Bacillus subtilis)","volume":"6","author":"Sadeghi","year":"2014","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"10.1016\/j.psj.2020.04.012_bib34","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.3382\/ps\/pev292","article-title":"Effect of various fiber types and choice feeding of fiber on performance, gut development, humoral immunity, and fiber preference in broiler chicks","volume":"94","author":"Sadeghi","year":"2015","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib35","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3923\/ijps.2012.666.672","article-title":"Does inclusion at low levels of organically complexed minerals versus inorganic forms create a weakness in performance or antioxidant defense system in broiler diets?","volume":"11","author":"Saripinar-Aksu","year":"2012","journal-title":"Int. J. Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib37","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3382\/ps.2008-00278","article-title":"The effect of calcium source and particle size on the production performance and bone quality of laying hens","volume":"88","author":"Saunders-Blades","year":"2009","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib38","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.3382\/ps.0751516","article-title":"Efficacy of supplemental microbial phytase at different dietary calcium levels on growth performance and mineral utilization of broiler chickens","volume":"75","author":"Sebastian","year":"1996","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib39","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.livsci.2009.01.006","article-title":"Consequences of calcium interactions with phytate and phytase for poultry and pigs","volume":"124","author":"Selle","year":"2009","journal-title":"Liv. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib40","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1079\/WPS19930002","article-title":"Calcium tolerance of growing chickens: effect of ratio of dietary calcium to available phosphorus","volume":"49","author":"Shafey","year":"1993","journal-title":"World's Poult. Sci. J."},{"key":"10.1016\/j.psj.2020.04.012_bib41","doi-asserted-by":"crossref","first-page":"e104739","DOI":"10.1371\/journal.pone.0104739","article-title":"Differential responses of cecal microbiota to fishmeal, Eimeria and Clostridium perfringens in a necrotic enteritis challenge model in chickens","volume":"9","author":"Stanley","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.psj.2020.04.012_bib42","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40729-018-0134-6","article-title":"Direct activation of platelets by addition of CaCl2 leads coagulation of platelet-rich plasma","volume":"4","author":"Toyoda","year":"2018","journal-title":"Int. J. Implant Dent."},{"key":"10.1016\/j.psj.2020.04.012_bib43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1134\/S1990747810010125","article-title":"The role of calcium in modulation of the kinetics of synchronous and asynchronous quantal release at the neuromuscular junction","volume":"4","author":"Vasin","year":"2010","journal-title":"Biochem. (Moscow) Suppl. Ser. A: Membr. Cell Biol."},{"key":"10.1016\/j.psj.2020.04.012_bib44","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/ps\/81.8.1172","article-title":"Effects of microbial phytase supplementation on mineral utilization and serum enzyme activities in broiler chicks fed different levels of phosphorus","volume":"81","author":"Viveros","year":"2002","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib45","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.3382\/ps.0702295","article-title":"Effect of dietary sodium zeolite A and graded levels of calcium on growth, plasma, and tibia characteristics of chicks","volume":"70","author":"Watkins","year":"1991","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib46","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1017\/S0043933911000699","article-title":"Exploiting calcium-specific appetite in poultry nutrition","volume":"67","author":"Wilkinson","year":"2011","journal-title":"World's Poult. Sci. J."},{"key":"10.1016\/j.psj.2020.04.012_bib47","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/03079450500112195","article-title":"Intercurrent coccidiosis and necrotic enteritis of chickens: rational, integrated disease management by maintenance of gut integrity","volume":"34","author":"Williams","year":"2005","journal-title":"Avian Pathol."},{"key":"10.1016\/j.psj.2020.04.012_bib48","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1093\/ps\/84.8.1232","article-title":"Evaluation of the broiler\u2019s ability to adapt to an early moderate deficiency of phosphorus and calcium","volume":"84","author":"Yan","year":"2005","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib49","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3382\/ps\/pew300","article-title":"Effect of carbohydrase and protease on growth performance and gut health of young broilers fed diets containing rye, wheat, and feather meal","volume":"96","author":"Yan","year":"2017","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib50","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3382\/ps.2008-00258","article-title":"Toxicological and gene expression analysis of the impact of aflatoxin B1 on hepatic function of male broiler chicks","volume":"88","author":"Yarru","year":"2009","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib51","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.3382\/ps.2013-03363","article-title":"Temporary modulation of responses to common vaccines and serum cation status in broilers during exposure to low doses of aflatoxin B1","volume":"92","author":"Yunus","year":"2013","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib52","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.psj.2019.11.021","article-title":"Interactive effect of two dietary calcium and phytase levels on broilers challenged with subclinical necrotic enteritis: 1. Broiler performance, gut lesions and pH, bacterial counts and apparent ileal digestibility","volume":"99","author":"Zanu","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib53","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.3382\/ps.2009-00608","article-title":"Comparison of hydrated sodium calcium aluminosilicate and yeast cell wall on counteracting aflatoxicosis in broiler chicks","volume":"89","author":"Zhao","year":"2010","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2020.04.012_bib54","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.3382\/ps\/pex401","article-title":"High calcium to phosphorus ratio impairs growth and bone mineralization in Pekin ducklings","volume":"97","author":"Zhu","year":"2018","journal-title":"Poult. Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579120302522?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579120302522?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T22:28:11Z","timestamp":1758493691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579120302522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S0032579120302522"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2020.04.012","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interactive effect of dietary calcium and phytase on broilers challenged with subclinical necrotic enteritis: 3. Serum calcium and phosphorus, and bone mineralization","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2020.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}]}}