{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:46:41Z","timestamp":1792856801953,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006462","name":"Anhui Agricultural University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006462","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006462","name":"Anhui Agricultural University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006462","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.psj.2021.01.012","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T10:28:36Z","timestamp":1610620116000},"page":"100989","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Epigallocatechin-3-gallate exhibits antiviral effects against the duck Tembusu virus via blocking virus entry and upregulating type I interferons"],"prefix":"10.1016","volume":"100","author":[{"given":"Yingqi","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangxue","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengjin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruichen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanwen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2021.01.012_bib1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.gene.2017.07.067","article-title":"Molecular cloning, characterization, and expression of duck 2'-5'-oligoadenylate synthetase-like gene","volume":"629","author":"Bi","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.psj.2021.01.012_bib2","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/hep.24803","article-title":"(-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry","volume":"55","author":"Calland","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.psj.2021.01.012_bib3","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.3201\/eid1710.101890","article-title":"Tembusu virus in ducks, China","volume":"17","author":"Cao","year":"2011","journal-title":"Emerg. Infect Dis."},{"key":"10.1016\/j.psj.2021.01.012_bib4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.virol.2016.06.012","article-title":"The green tea molecule EGCG inhibits Zika virus entry","volume":"496","author":"Carneiro","year":"2016","journal-title":"Virology"},{"key":"10.1016\/j.psj.2021.01.012_bib5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/bip.21371","article-title":"Identification of a heparin binding peptide from the Japanese encephalitis virus envelope protein","volume":"94","author":"Chen","year":"2010","journal-title":"Biopolymers"},{"key":"10.1016\/j.psj.2021.01.012_bib6","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13567-016-0358-5","article-title":"Avian Tembusu virus infection effectively triggers host innate immune response through MDA5 and TLR3-dependent signaling pathways","volume":"47","author":"Chen","year":"2016","journal-title":"Vet. Res."},{"key":"10.1016\/j.psj.2021.01.012_bib7","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s00705-013-1931-0","article-title":"Isolation and characterization of a Chinese strain of Tembusu virus from Hy-Line Brown layers with acute egg-drop syndrome in Fujian, China","volume":"159","author":"Chen","year":"2014","journal-title":"Arch. Virol."},{"key":"10.1016\/j.psj.2021.01.012_bib8","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.3389\/fimmu.2017.01006","article-title":"Goose Mx and OASL play vital roles in the antiviral effects of type I, II, and III interferon against newly emerging Avian flavivirus","volume":"8","author":"Chen","year":"2017","journal-title":"Front Immunol."},{"key":"10.1016\/j.psj.2021.01.012_bib9","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/nm0897-866","article-title":"Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate","volume":"3","author":"Chen","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.psj.2021.01.012_bib10","doi-asserted-by":"crossref","first-page":"7806","DOI":"10.1128\/JVI.00896-14","article-title":"A small molecule inhibits virion attachment to heparan sulfate- or sialic acid-containing glycans","volume":"88","author":"Colpitts","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.psj.2021.01.012_bib11","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.meegid.2015.03.004","article-title":"Evolutionary analysis of Tembusu virus: evidence for the emergence of a dominant genotype","volume":"32","author":"Dai","year":"2015","journal-title":"Infect Genet. Evol."},{"key":"10.1016\/j.psj.2021.01.012_bib12","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.antiviral.2018.07.012","article-title":"Multiple antiviral approaches of (-)-epigallocatechin-3-gallate (EGCG) against porcine reproductive and respiratory syndrome virus infection in\u00a0vitro","volume":"158","author":"Ge","year":"2018","journal-title":"Antivir. Res."},{"key":"10.1016\/j.psj.2021.01.012_bib13","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1080\/03079457.2014.973832","article-title":"Tembusu-like flavivirus (Perak virus) as the cause of neurological disease outbreaks in young Pekin ducks","volume":"43","author":"Homonnay","year":"2014","journal-title":"Avian Pathol."},{"key":"10.1016\/j.psj.2021.01.012_bib14","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1128\/AAC.00825-07","article-title":"Epigallocatechin gallate inactivates clinical isolates of herpes simplex virus","volume":"52","author":"Isaacs","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.psj.2021.01.012_bib15","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.antiviral.2013.08.002","article-title":"Inhibition of influenza virus internalization by (-)-epigallocatechin-3-gallate","volume":"100","author":"Kim","year":"2013","journal-title":"Antivir. Res."},{"key":"10.1016\/j.psj.2021.01.012_bib16","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0042-6822(02)00097-1","article-title":"Role of heparan sulfate for attachment and entry of tick-borne encephalitis virus","volume":"308","author":"Kroschewski","year":"2003","journal-title":"Virology."},{"key":"10.1016\/j.psj.2021.01.012_bib17","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s12906-018-2316-4","article-title":"Epigallocatechin gallate inhibits hepatitis B virus infection in human liver chimeric mice","volume":"18","author":"Lai","year":"2018","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.psj.2021.01.012_bib18","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3389\/fmicb.2015.00425","article-title":"Immune responses of ducks infected with duck Tembusu virus","volume":"6","author":"Li","year":"2015","journal-title":"Front Microbiol."},{"key":"10.1016\/j.psj.2021.01.012_bib19","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.virusres.2012.10.019","article-title":"An infectious full-length cDNA clone of duck Tembusu virus, a newly emerging flavivirus causing duck egg drop syndrome in China","volume":"171","author":"Li","year":"2013","journal-title":"Virus Res."},{"key":"10.1016\/j.psj.2021.01.012_bib20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.vetmic.2016.07.017","article-title":"The effect of Tembusu virus infection in different week-old Cherry Valley breeding ducks","volume":"192","author":"Lu","year":"2016","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.psj.2021.01.012_bib21","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jaci.2008.12.024","article-title":"Preclinical development of the green tea catechin, epigallocatechin gallate, as an HIV-1 therapy","volume":"123","author":"Nance","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.psj.2021.01.012_bib22","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s00705-018-3769-y","article-title":"Inhibitory effect of the green tea molecule EGCG against dengue virus infection","volume":"163","author":"Raekiansyah","year":"2018","journal-title":"Arch. Virol."},{"key":"10.1016\/j.psj.2021.01.012_bib23","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.antiviral.2005.06.010","article-title":"Antiviral effect of catechins in green tea on influenza virus","volume":"68","author":"Song","year":"2005","journal-title":"Antivir. Res."},{"key":"10.1016\/j.psj.2021.01.012_bib24","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1865-1682.2012.01328.x","article-title":"Characterization of a Tembusu virus isolated from naturally infected house sparrows (Passer domesticus) in Northern China","volume":"60","author":"Tang","year":"2013","journal-title":"Transbound Emerg. Dis."},{"key":"10.1016\/j.psj.2021.01.012_bib25","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.3201\/eid2112.150600","article-title":"Tembusu-related flavivirus in ducks, Thailand","volume":"21","author":"Thontiravong","year":"2015","journal-title":"Emerg. Infect Dis."},{"key":"10.1016\/j.psj.2021.01.012_bib26","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.vetmic.2015.10.001","article-title":"Effect of age and inoculation route on the infection of duck Tembusu virus in Goslings","volume":"181","author":"Ti","year":"2015","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.psj.2021.01.012_bib27","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.virusres.2018.06.009","article-title":"Epigallocatechin-3-gallate inhibits the early stages of Japanese encephalitis virus infection","volume":"253","author":"Wang","year":"2018","journal-title":"Virus Res."},{"key":"10.1016\/j.psj.2021.01.012_bib28","article-title":"(-)-Epigallocatechin-3-Gallate enhances hepatitis C virus Double-stranded RNA Intermediates-Triggered innate immune responses in hepatocytes","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2021.01.012_bib29","first-page":"2678","article-title":"Antiviral effect of epigallocatechin gallate (EGCG) on influenza A virus","volume":"33","author":"Xiao","year":"2008","journal-title":"Zhongguo Zhong Yao Za Zhi."},{"key":"10.1016\/j.psj.2021.01.012_bib30","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.3390\/ijms19082328","article-title":"Comparative Transcriptomic analysis of immune-Related gene expression in duck Embryo Fibroblasts following duck Tembusu virus infection","volume":"19","author":"Yu","year":"2018","journal-title":"Int. J. Mol. Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579121000237?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579121000237?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T22:31:15Z","timestamp":1758493875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579121000237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S0032579121000237"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2021.01.012","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigallocatechin-3-gallate exhibits antiviral effects against the duck Tembusu virus via blocking virus entry and upregulating type I interferons","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2021.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"100989"}}