{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T07:27:57Z","timestamp":1793604477815,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010203","name":"Agriculture Research System of China","doi-asserted-by":"publisher","award":["CARS-41-G11"],"award-info":[{"award-number":["CARS-41-G11"]}],"id":[{"id":"10.13039\/501100010203","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.psj.2021.101663","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T21:05:07Z","timestamp":1639602307000},"page":"101663","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Dietary soya saponin improves the lipid metabolism and intestinal health of laying hens"],"prefix":"10.1016","volume":"101","author":[{"given":"Peng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingkun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahuan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojia","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfa","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahir","family":"Mahmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengpeng","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2021.101663_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.animal.2020.100022","article-title":"Nanoencapsulation (in vitro and in vivo) as an efficient technology to boost the potential of garlic essential oil as alternatives for antibiotics in broiler nutrition","volume":"15","author":"Amiri","year":"2021","journal-title":"Animal"},{"key":"10.1016\/j.psj.2021.101663_bib0002","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1021\/jf053072o","article-title":"Complete quantification of group A and group B soyasaponins in soybeans","volume":"54","author":"Berhow","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.psj.2021.101663_bib0003","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1152\/ajpgi.00132.2007","article-title":"Anti-inflammatory properties of Lactobacillus gasseri expressing manganese superoxide dismutase using the interleukin 10-deficient mouse model of colitis","volume":"293","author":"Carroll","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.psj.2021.101663_bib0004","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1080\/01635581.2014.956245","article-title":"Soyasaponins prevent H(2)O(2)-induced inhibition of gap junctional intercellular communication by scavenging reactive oxygen species in rat liver cells","volume":"66","author":"Chen","year":"2014","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.psj.2021.101663_bib0005","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1021\/acs.jafc.7b06069","article-title":"Transcriptomics-related mechanisms of supplementing laying broiler breeder hens with dietary daidzein to improve the immune function and growth performance of offspring","volume":"66","author":"Fan","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.psj.2021.101663_bib0006","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jnutbio.2009.11.007","article-title":"Statistics and bioinformatics in nutritional sciences: analysis of complex data in the era of systems biology","volume":"21","author":"Fu","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.psj.2021.101663_bib0007","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1039\/C4FO01065E","article-title":"Impact of soyasaponin I on TLR2 and TLR4 induced inflammation in the MUTZ-3-cell model","volume":"6","author":"Fussbroich","year":"2015","journal-title":"Food Funct."},{"key":"10.1016\/j.psj.2021.101663_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2019.165541","article-title":"Type 1 diabetes induces cognitive dysfunction in rats associated with alterations of the gut microbiome and metabolomes in serum and hippocampus","volume":"1865","author":"Gao","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.psj.2021.101663_bib0009","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.3389\/fimmu.2019.02326","article-title":"Lactobacillus gasseri suppresses the production of proinflammatory cytokines in Helicobacter pylori-infected macrophages by inhibiting the expression of ADAM17","volume":"10","author":"Gebremariam","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2021.101663_bib0010","doi-asserted-by":"crossref","first-page":"8247","DOI":"10.1021\/jf503047a","article-title":"Biological functionality of soyasaponins and soyasapogenols","volume":"62","author":"Guang","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.psj.2021.101663_bib0011","doi-asserted-by":"crossref","first-page":"988","DOI":"10.3390\/nu10080988","article-title":"The potential of gut commensals in reinforcing intestinal barrier function and alleviating inflammation","volume":"10","author":"Hiippala","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.psj.2021.101663_bib0012","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nrd4280","article-title":"Liver X receptors in lipid metabolism: opportunities for drug discovery","volume":"13","author":"Hong","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.psj.2021.101663_bib0013","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1007\/s13197-018-3091-4","article-title":"Inhibitory effect of soy saponins on the activity of beta-lactamases, including New Delhi metallo-beta-lactamase 1","volume":"55","author":"Horie","year":"2018","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.psj.2021.101663_bib0014","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1093\/jn\/134.8.1867","article-title":"Soyasaponin I and sapongenol B have limited absorption by Caco-2 intestinal cells and limited bioavailability in women","volume":"134","author":"Hu","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.psj.2021.101663_bib0015","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0163-7827(01)00017-0","article-title":"The role Acyl-CoA thioesterases play in mediating intracellular lipid metabolism","volume":"41","author":"Hunt","year":"2002","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.psj.2021.101663_bib0016","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.bbadis.2012.03.009","article-title":"The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism","volume":"1822","author":"Hunt","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.psj.2021.101663_bib0017","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.nut.2013.10.017","article-title":"Comparison of bioavailability (I) between soyasaponins and soyasapogenols, and (II) between group A and B soyasaponins","volume":"30","author":"Kamo","year":"2014","journal-title":"Nutrition"},{"key":"10.1016\/j.psj.2021.101663_bib0018","doi-asserted-by":"crossref","first-page":"526","DOI":"10.4014\/jmb.1108.08047","article-title":"Effect of a probiotic strain, Enterococcus faecium, on the immune responses of olive flounder (Paralichthys olivaceus)","volume":"22","author":"Kim","year":"2012","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.psj.2021.101663_bib0019","doi-asserted-by":"crossref","first-page":"10929","DOI":"10.1021\/jf102296y","article-title":"Soyasaponin I attenuates TNBS-Induced colitis in mice by inhibiting NF-kappaB pathway","volume":"58","author":"Lee","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.psj.2021.101663_bib0020","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1177\/153537020523000705","article-title":"Soyasaponins lowered plasma cholesterol and increased fecal bile acids in female golden Syrian hamsters","volume":"230","author":"Lee","year":"2005","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.psj.2021.101663_bib0021","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s40104-021-00647-2","article-title":"Soy saponin improves egg-laying performance and immune function of laying hens","volume":"12","author":"Li","year":"2021","journal-title":"J. Anim. Sci. Biotechno"},{"key":"10.1016\/j.psj.2021.101663_bib0022","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.intimp.2015.12.001","article-title":"Soyasaponin Ab inhibits lipopolysaccharide-induced acute lung injury in mice","volume":"30","author":"Lin","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.psj.2021.101663_bib0023","article-title":"Disruption in the cecal microbiota of chickens challenged with Clostridium perfringens and other factors was alleviated by Bacillus licheniformis supplementation","volume":"12","author":"Lin","year":"2017","journal-title":"PLos One"},{"key":"10.1016\/j.psj.2021.101663_bib0024","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/1471-2180-13-298","article-title":"Differential modulation of innate immunity in vitro by probiotic strains of Lactobacillus gasseri","volume":"13","author":"Luongo","year":"2013","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.psj.2021.101663_bib0025","doi-asserted-by":"crossref","first-page":"13974","DOI":"10.1038\/s41598-018-32413-2","article-title":"Mucosal microbiota of intestinal polyps reveals putative biomarkers of colorectal cancer","volume":"8","author":"Mangifesta","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2021.101663_bib0026","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3390\/nu12020555","article-title":"Secretome analysis of mouse dendritic cells interacting with a probiotic strain of Lactobacillus gasseri","volume":"12","author":"Mazzeo","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.psj.2021.101663_bib0027","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/cei.13212","article-title":"Dietary soyasaponin attenuates 2,4-dinitrofluorobenzene-induced contact hypersensitivity via gut microbiota in mice","volume":"195","author":"Nagano","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.psj.2021.101663_bib0028","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/exd.13205","article-title":"Inhibitory effects of dietary soyasaponin on 2,4-dinitrofluorobenzene-induced contact hypersensitivity in mice","volume":"26","author":"Nagano","year":"2017","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.psj.2021.101663_bib0029","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/j.psj.2019.11.050","article-title":"Enhancement in humoral response against inactivated Newcastle disease vaccine in broiler chickens administered orally with plant-derived soyasaponin","volume":"99","author":"Naveed","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2021.101663_bib0030","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3390\/foods9040422","article-title":"Sapogenol is a major microbial metabolite in human plasma associated with high protein soy-based diets: the relevance for functional food formulations","volume":"9","author":"Neacsu","year":"2020","journal-title":"Foods"},{"key":"10.1016\/j.psj.2021.101663_bib0031","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nri2097","article-title":"T(H)1 cells control themselves by producing interleukin-10","volume":"7","author":"O'Garra","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.psj.2021.101663_bib0032","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jhep.2013.04.018","article-title":"High prevalence of IgA class anti-neutrophil cytoplasmic antibodies (ANCA) is associated with increased risk of bacterial infection in patients with cirrhosis","volume":"59","author":"Papp","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.psj.2021.101663_bib0033","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1038\/s41467-019-11460-x","article-title":"Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome","volume":"10","author":"Russell","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.psj.2021.101663_bib0034","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2217\/imt.10.76","article-title":"Monitoring cytokine profiles during immunotherapy","volume":"2","author":"Siebert","year":"2010","journal-title":"Immunotherapy-UK"},{"key":"10.1016\/j.psj.2021.101663_bib0035","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cytogfr.2008.11.006","article-title":"Cytokine and cytokine receptor gene polymorphisms and their functionality","volume":"20","author":"Smith","year":"2009","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.psj.2021.101663_bib0036","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1128\/CVI.05277-11","article-title":"Assessment of Lactobacillus gasseri as a candidate oral vaccine vector","volume":"18","author":"Stoeker","year":"2011","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.psj.2021.101663_bib0037","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1099\/00207713-44-2-223","article-title":"Identification of lactobacilli from sourdough and description of Lactobacillus pontis sp. nov","volume":"44","author":"Vogel","year":"1994","journal-title":"Int. J. Syst. Bacteriol."},{"key":"10.1016\/j.psj.2021.101663_bib0038","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0165-2427(99)00041-0","article-title":"Evaluation of canine lymphocyte proliferation: comparison of three different colorimetric methods with the 3H-thymidine incorporation assay","volume":"70","author":"Wagner","year":"1999","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.psj.2021.101663_bib0039","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.7150\/thno.40128","article-title":"Soyasaponin II protects against acute liver failure through diminishing YB-1 phosphorylation and Nlrp3-inflammasome priming in mice","volume":"10","author":"Wang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.psj.2021.101663_bib0040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.psj.2021.101663_bib0041","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1101\/gad.9.9.1033","article-title":"LXR, a nuclear receptor that defines a distinct retinoid response pathway","volume":"9","author":"Willy","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.psj.2021.101663_bib0042","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201800205","article-title":"Soyasaponins reduce inflammation and improve serum lipid profiles and glucose homeostasis in high fat diet-induced obese mice","volume":"62","author":"Xie","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.psj.2021.101663_bib0043","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3109\/09637486.2015.1064865","article-title":"Lactobacillus pentosus var. plantarum C29 increases the protective effect of soybean against scopolamine-induced memory impairment in mice","volume":"66","author":"Yoo","year":"2015","journal-title":"Int. J. Food Sci. Nutr."},{"key":"10.1016\/j.psj.2021.101663_bib0044","doi-asserted-by":"crossref","first-page":"13424","DOI":"10.1038\/s41598-019-49462-w","article-title":"Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities","volume":"9","author":"Zeng","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2021.101663_bib0045","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.3389\/fmicb.2018.01716","article-title":"Dietary l-arginine supplementation alleviates the intestinal injury and modulates the gut microbiota in broiler chickens challenged by Clostridium perfringens","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.psj.2021.101663_bib0046","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.3390\/ijms18122535","article-title":"Dietary supplementation with Lactobacillus casei alleviates lipopolysaccharide-induced liver injury in a porcine model","volume":"18","author":"Zhao","year":"2017","journal-title":"Int. J. Mol. Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579121006787?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579121006787?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T22:40:48Z","timestamp":1758494448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579121006787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S0032579121006787"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2021.101663","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary soya saponin improves the lipid metabolism and intestinal health of laying hens","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2021.101663","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"101663"}}