{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:52:25Z","timestamp":1791996745315,"version":"4.4.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2019JZZY020602"],"award-info":[{"award-number":["2019JZZY020602"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015335","name":"The Modern Agricultural Industry Technology System","doi-asserted-by":"publisher","award":["CARS-40-K09"],"award-info":[{"award-number":["CARS-40-K09"]}],"id":[{"id":"10.13039\/501100015335","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["3177261 9"],"award-info":[{"award-number":["3177261 9"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004306","name":"Shandong Agricultural University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2016YFD0500510"],"award-info":[{"award-number":["2016YFD0500510"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010203","name":"Agriculture Research System of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010203","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005580","name":"Vali-e-Asr University of Rafsanjan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005580","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.psj.2021.101669","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T10:43:27Z","timestamp":1640256207000},"page":"101669","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Central and peripheral effects of L-citrulline on thermal physiology and nitric oxide regeneration in broilers"],"prefix":"10.1016","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8903-8448","authenticated-orcid":false,"given":"Victoria Anthony","family":"Uyanga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingpeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchao","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2021.101669_bib0001","series-title":"Pages 3-17 in Brain Cytokines as Integrators of the Immune\u2013Neuroendocrine Network","author":"Besedovsky","year":"2008"},{"key":"10.1016\/j.psj.2021.101669_bib0002","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1017\/S0007114514002086","article-title":"In vitro anti-inflammatory effects of citrulline on peritoneal macrophages in Zucker diabetic fatty rats","volume":"113","author":"Breuillard","year":"2015","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.psj.2021.101669_bib0003","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1016\/j.psj.2019.11.062","article-title":"Effects of heat stress on pullet cloacal and body temperature","volume":"99","author":"Candido","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2021.101669_bib0004","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.3382\/ps.2007-00326","article-title":"Quantification of the spatial distribution of surface temperatures of broilers","volume":"87","author":"Cangar","year":"2008","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2021.101669_bib0005","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/ps\/85.2.312","article-title":"Evaluation of total plasma nitric oxide concentrations in broilers infused intravenously with sodium nitrite, lipopolysaccharide, aminoguanidine, and sodium nitroprusside","volume":"85","author":"Chapman","year":"2006","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2021.101669_bib0006","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0006-8993(94)91584-9","article-title":"Nitric oxide controls feeding behavior in the chicken","volume":"654","author":"Choi","year":"1994","journal-title":"Brain. Res."},{"key":"10.1016\/j.psj.2021.101669_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2141\/jpsa.0180024","article-title":"Heat stress biomarker amino acids and neuropeptide afford thermotolerance in chicks","volume":"56","author":"Chowdhury","year":"2019","journal-title":"J. Poult. Sci."},{"key":"10.1016\/j.psj.2021.101669_bib0008","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jtherbio.2017.07.007","article-title":"L-Citrulline acts as potential hypothermic agent to afford thermotolerance in chicks","volume":"69","author":"Chowdhury","year":"2017","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.psj.2021.101669_bib0009","first-page":"1","article-title":"L-citrulline and l-leucine-mediated thermoregulation affords thermotolerance","volume":"61","author":"Chowdhury","year":"2017","journal-title":"Proc. Jpn. Soc. Anim. Nutr. Metab."},{"key":"10.1016\/j.psj.2021.101669_bib0010","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2141\/jpsa.0150014","article-title":"Oral administration of L-citrulline, but not L-arginine or L-ornithine, acts as a hypothermic agent in chicks","volume":"52","author":"Chowdhury","year":"2015","journal-title":"J. Poult. Sci."},{"key":"10.1016\/j.psj.2021.101669_bib0011","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.cbpa.2013.12.020","article-title":"Oxidative damage and brain concentrations of free amino acid in chicks exposed to high ambient temperature","volume":"169","author":"Chowdhury","year":"2014","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.psj.2021.101669_bib0012","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.cbpa.2009.06.005","article-title":"Role of brain nitric oxide in the thermoregulation of broiler chicks","volume":"154","author":"Coleone","year":"2009","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.psj.2021.101669_bib0013","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00726-005-0235-4","article-title":"Almost all about citrulline in mammals","volume":"29","author":"Curis","year":"2005","journal-title":"Amino Acids"},{"key":"10.1016\/j.psj.2021.101669_bib0014","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/sj.ki.5002058","article-title":"Molecular mechanisms involved in the reciprocal regulation of cyclooxygenase and nitric oxide synthase enzymes","volume":"71","author":"Cuzzocrea","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.psj.2021.101669_bib0015","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000341278","article-title":"Leucine and citrulline: two major regulators of protein turnover","volume":"105","author":"Cynober","year":"2013","journal-title":"World Rev. Nutr. Diet."},{"key":"10.1016\/j.psj.2021.101669_bib0016","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.clnu.2010.07.006","article-title":"The 2009 ESPEN Sir David Cuthbertson. Citrulline: a new major signaling molecule or just another player in the pharmaconutrition game?","volume":"29","author":"Cynober","year":"2010","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.psj.2021.101669_bib0017","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1297-9716-44-8","article-title":"Chickens treated with a nitric oxide inhibitor became more resistant to Plasmodium gallinaceum infection due to reduced anemia, thrombocytopenia and inflammation","volume":"44","author":"de Macchi","year":"2013","journal-title":"Vet. Res."},{"key":"10.1016\/j.psj.2021.101669_bib0018","doi-asserted-by":"crossref","first-page":"36","DOI":"10.36380\/jwpr.2020.5","article-title":"The potency of oral administration of l-citrulline as anti heat stress agent in KUB chickens","volume":"10","author":"Erwan","year":"2020","journal-title":"J. World Poult. Res."},{"key":"10.1016\/j.psj.2021.101669_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2021.109081","article-title":"Quantitative determination of neuronal size and density using flow cytometry","volume":"352","author":"Farrow","year":"2021","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.psj.2021.101669_bib0020","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S1734-1140(13)71527-5","article-title":"Cytokines, prostaglandins and nitric oxide in the regulation of stress-response systems","volume":"65","author":"G\u0105dek-Michalska","year":"2013","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.psj.2021.101669_bib0021","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.yfrne.2011.12.002","article-title":"Cytokines and brain excitability","volume":"33","author":"Galic","year":"2012","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.psj.2021.101669_bib0022","first-page":"22","article-title":"Histology of the central nervous system","volume":"39","author":"Garman","year":"2010","journal-title":"Toxicol"},{"key":"10.1016\/j.psj.2021.101669_bib0023","first-page":"30","article-title":"Nitric oxide and body temperature control","volume":"14","author":"Gerstberger","year":"1999","journal-title":"News Physiol. Sci."},{"key":"10.1016\/j.psj.2021.101669_bib0024","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141572","article-title":"L-Citrulline protects skeletal muscle cells from cachectic stimuli through an iNOS-dependent mechanism","volume":"10","author":"Ham","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.psj.2021.101669_bib0025","doi-asserted-by":"crossref","unstructured":"Kaore, S. N., and N. M. Kaore. 2014. Citrulline: Pharmacological perspectives and role as a biomarker in diseases and toxicities. Pages 883-905 in Biomarkers in Toxicology. R. Gupta ed. Academic Press; Cambridge, MA.","DOI":"10.1016\/B978-0-12-404630-6.00053-1"},{"key":"10.1016\/j.psj.2021.101669_bib0026","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1440-1789.2003.00483.x","article-title":"Immunohistochemical study of the expression of cytokines and nitric oxide synthases in brains of patients with dementia with Lewy bodies","volume":"23","author":"Katsuse","year":"2003","journal-title":"Neuropathology"},{"key":"10.1016\/j.psj.2021.101669_bib0027","doi-asserted-by":"crossref","first-page":"E915","DOI":"10.1152\/ajpendo.00339.2015","article-title":"Acute ingestion of citrulline stimulates nitric oxide synthesis but does not increase blood flow in healthy young and older adults with heart failure","volume":"309","author":"Kim","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.psj.2021.101669_bib0028","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.niox.2011.07.002","article-title":"The role of nitric oxide in prostaglandin biology: update","volume":"25","author":"Kim","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.psj.2021.101669_bib0029","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mgene.2015.07.008","article-title":"Association between pro-(IL-8) and anti-inflammatory (IL-10) cytokine variants and their serum levels and H. pylori-related gastric carcinogenesis in northern India","volume":"6","author":"Kumar","year":"2015","journal-title":"Meta Gene"},{"key":"10.1016\/j.psj.2021.101669_bib0030","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.jff.2017.09.054","article-title":"L-Citrulline improves cerebral blood flow in migraine model rats","volume":"38","author":"Kurauchi","year":"2017","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.psj.2021.101669_bib0059","doi-asserted-by":"crossref","first-page":"476","DOI":"10.2527\/jam2016-0995","article-title":"Effect of supplemental citrulline on thermal and production parameters during heat stress in growing pigs","volume":"94","author":"Kvidera","year":"2016","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.psj.2021.101669_bib0031","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.brainresbull.2005.06.002","article-title":"Nitric oxide pathway is an important modulator of heat loss in rats during exercise","volume":"67","author":"Lacerda","year":"2005","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.psj.2021.101669_bib0032","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.4049\/jimmunol.1801569","article-title":"L-Arginine synthesis from l-citrulline in myeloid cells drives host defense against mycobacteria in vivo","volume":"202","author":"Lange","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.psj.2021.101669_bib0033","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.3389\/fimmu.2018.02911","article-title":"L-Arginine and L-Citrulline supplementation have different programming effect on regulatory t-cells function of infantile rats","volume":"9","author":"Lee","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2021.101669_bib0060","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/jpn.13028","article-title":"Effects of L-citrulline supplementation on heat stress physiology, lactation performance and subsequent reproductive performance of sows in summer","volume":"103","author":"Liu","year":"2019","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl)."},{"key":"10.1016\/j.psj.2021.101669_bib0034","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1210\/en.2013-1632","article-title":"Glucocorticoids increase NPY gene expression via hypothalamic AMPK signaling in broiler chicks","volume":"155","author":"Liu","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.psj.2021.101669_bib0035","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.3382\/ps\/pev168","article-title":"Glucocorticoids inhibited hypothalamic target of rapamycin in high fat diet-fed chicks","volume":"94","author":"Liu","year":"2015","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2021.101669_bib0036","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0361-9230(95)02020-R","article-title":"Nitric oxide reduces body temperature and sympathetic input to brown adipose tissue during PGE -hyperthermia","volume":"38","author":"Monda","year":"1995","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.psj.2021.101669_bib0037","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbrc.2014.10.029","article-title":"Oral supplementation with a combination of l-citrulline and l-arginine rapidly increases plasma l-arginine concentration and enhances NO bioavailability","volume":"454","author":"Morita","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.psj.2021.101669_bib0038","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1590\/S1516-35982012000500033","article-title":"Bands of respiratory rate and cloacal temperature for different broiler chicken strains","volume":"41","author":"Nascimento","year":"2012","journal-title":"Rev. Bras. Zootec."},{"key":"10.1016\/j.psj.2021.101669_bib0039","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.lfs.2008.04.003","article-title":"Capsaicin pretreatment attenuates LPS-induced hypothermia through TRPV1-independent mechanisms in chicken","volume":"82","author":"Nikami","year":"2008","journal-title":"Life Sci"},{"key":"10.1016\/j.psj.2021.101669_bib0040","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/j.clnu.2017.10.009","article-title":"Citrulline in health and disease. Review on human studies","volume":"37","author":"Papadia","year":"2018","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.psj.2021.101669_bib0041","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0149-7634(05)80001-6","article-title":"Immunoregulators in the nervous system","volume":"15","author":"Plata-Salam\u00e1n","year":"1991","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.psj.2021.101669_bib0042","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/toxsci\/kfx277","article-title":"Brain vacuolation resulting from administration of the type ii ampakine CX717 is an artifact related to molecular structure and chemical reaction with tissue fixative agents","volume":"162","author":"Purcell","year":"2018","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.psj.2021.101669_bib0043","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.bbi.2009.02.009","article-title":"Re-exposure to endotoxin induces differential cytokine gene expression in the rat hypothalamus and spleen","volume":"23","author":"Rey","year":"2009","journal-title":"Brain, Behav. Immun."},{"key":"10.1016\/j.psj.2021.101669_bib0044","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1210\/en.2005-0951","article-title":"Interleukin-8 synthesis, regulation, and steroidogenic role in H295R human adrenocortical cells","volume":"147","author":"Romero","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.psj.2021.101669_bib0045","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3389\/fimmu.2013.00480","article-title":"L-Citrulline protects from kidney damage in type 1 diabetic mice","volume":"4","author":"Romero","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2021.101669_bib0046","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1365-2125.2007.02990.x","article-title":"Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism","volume":"65","author":"Schwedhelm","year":"2008","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.psj.2021.101669_bib0047","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0079-6123(08)62041-5","article-title":"Nitric oxide and carbon monoxide in the brain pathology of heat stress","volume":"115","author":"Sharma","year":"1998","journal-title":"Prog. Brain. Res."},{"key":"10.1016\/j.psj.2021.101669_bib0048","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0306-4565(01)00038-9","article-title":"Nitric oxide in the regulation of body temperature and fever","volume":"26","author":"Steiner","year":"2001","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.psj.2021.101669_bib0049","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1016\/j.celrep.2018.04.053","article-title":"Induction of nitric-oxide metabolism in enterocytes alleviates colitis and inflammation-associated colon cancer","volume":"23","author":"Stettner","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.psj.2021.101669_bib0050","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.prostaglandins.2017.03.005","article-title":"Effect of central and peripheral injection of prostaglandin E2 and F2alpha on feeding and the crop-emptying rate in chicks","volume":"130","author":"Tachibana","year":"2017","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.psj.2021.101669_bib0051","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2141\/jpsa.0180136","article-title":"Oral administration of a medium containing L-citrulline-producing live bacteria reduces body temperature in chicks","volume":"56","author":"Tran","year":"2019","journal-title":"J. Poult. Sci."},{"key":"10.1016\/j.psj.2021.101669_bib0052","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jchromb.2004.09.022","article-title":"Assessment of nitric oxide biosynthesis and peroxynitrite formation within the central nervous system by measuring L-citrulline in the cerebrospinal fluid?","volume":"813","author":"Tsikas","year":"2004","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.psj.2021.101669_bib0053","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00228-005-0020-z","article-title":"Circulating and excretory nitrite and nitrate as indicators of nitric oxide synthesis in humans: methods of analysis","volume":"62","author":"Tsikas","year":"2006","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.psj.2021.101669_bib0054","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s40104-020-00507-5","article-title":"Dietary L-citrulline supplementation modulates nitric oxide synthesis and anti-oxidant status of laying hens during summer season","volume":"11","author":"Uyanga","year":"2020","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.psj.2021.101669_bib0055","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.671691","article-title":"L-Citrulline influences the body temperature, heat shock response and nitric oxide regeneration of broilers under thermoneutral and heat stress condition","volume":"12","author":"Uyanga","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.psj.2021.101669_bib0056","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1007\/s11357-013-9518-y","article-title":"Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques","volume":"35","author":"Willette","year":"2013","journal-title":"Age (Dordr)"},{"key":"10.1016\/j.psj.2021.101669_bib0057","doi-asserted-by":"crossref","first-page":"1673S","DOI":"10.1093\/jn\/137.6.1673S","article-title":"Pharmacokinetics and safety of arginine supplementation in animals","volume":"137","author":"Wu","year":"2007","journal-title":"J. Nutr."},{"key":"10.1016\/j.psj.2021.101669_bib0058","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3389\/fncel.2015.00322","article-title":"Implications of glial nitric oxide in neurodegenerative diseases","volume":"9","author":"Yuste","year":"2015","journal-title":"Front. Cell. Neurosci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579121006891?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579121006891?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:44:45Z","timestamp":1777437885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579121006891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0032579121006891"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2021.101669","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Central and peripheral effects of L-citrulline on thermal physiology and nitric oxide regeneration in broilers","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2021.101669","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"101669"}}