{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:53:34Z","timestamp":1781844814709,"version":"3.54.5"},"reference-count":55,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007917","name":"Agricultural Research Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["2021-67015-34530"],"award-info":[{"award-number":["2021-67015-34530"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.psj.2021.101671","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T03:17:33Z","timestamp":1640229453000},"page":"101671","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["A neurochemical biogeography of the broiler chicken intestinal tract"],"prefix":"10.1016","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1679-6854","authenticated-orcid":false,"given":"Joshua M.","family":"Lyte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6461-6443","authenticated-orcid":false,"given":"Diego A.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0700-1925","authenticated-orcid":false,"given":"Kelsy","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie M.","family":"Donoghue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karrie M.","family":"Daniels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8512-2581","authenticated-orcid":false,"given":"Mark","family":"Lyte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2021.101671_bib0001","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1172\/JCI118590","article-title":"Sympathetic discharge to mesenteric organs and the liver. Evidence for substantial mesenteric organ norepinephrine spillover","volume":"97","author":"Aneman","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.psj.2021.101671_bib0002","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/279075","article-title":"Effect of noradrenaline on the virulence properties of Campylobacter species","volume":"2014","author":"Aroori","year":"2014","journal-title":"Int. J. Microbiol."},{"key":"10.1016\/j.psj.2021.101671_bib0003","doi-asserted-by":"crossref","first-page":"G1288","DOI":"10.1152\/ajpgi.00341.2012","article-title":"Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice","volume":"303","author":"Asano","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.psj.2021.101671_bib0004","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0031-9384(99)00087-6","article-title":"In vivo adaptation of attenuated Salmonella typhimurium results in increased growth upon exposure to norepinephrine","volume":"67","author":"Bailey","year":"1999","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.psj.2021.101671_bib0005","doi-asserted-by":"crossref","first-page":"4597","DOI":"10.1128\/IAI.00630-07","article-title":"Differential effects of epinephrine, norepinephrine, and indole on Escherichia coli O157:H7 chemotaxis, colonization, and gene expression","volume":"75","author":"Bansal","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.psj.2021.101671_bib0006","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1476-5381.1962.tb01443.x","article-title":"Histamine and 5-hydroxytryptamine in the intestinal tract of germ-free animals, animals harbouring one microbial species and conventional animals","volume":"19","author":"Beaver","year":"1962","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"10.1016\/j.psj.2021.101671_bib0007","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2307\/1592597","article-title":"Effects of biogenic amines in broiler chickens","volume":"42","author":"Bermudez","year":"1998","journal-title":"Avian Dis."},{"key":"10.1016\/j.psj.2021.101671_bib0008","doi-asserted-by":"crossref","first-page":"819","DOI":"10.2174\/1381612822666151209150954","article-title":"Neuroimmune crosstalk in CNS disorders: the histamine connection","volume":"22","author":"Cacabelos","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.psj.2021.101671_bib0009","doi-asserted-by":"crossref","first-page":"20203","DOI":"10.1038\/s41598-019-56666-7","article-title":"Epinephrine affects motility, and increases adhesion, biofilm and virulence of Pseudomonas aeruginosa H103","volume":"9","author":"Cambronel","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2021.101671_bib0010","unstructured":"Cobb-Vantress 2013. Hatchery management guide.https:\/\/www.cobb-vantress.com\/assets\/Cobb-Files\/management-guides\/5fabb49dbf\/97447e70-bbd7-11e6-bd5d-55bb08833e29.pdf. Accessed May 2020."},{"key":"10.1016\/j.psj.2021.101671_bib0011","unstructured":"Cobb-Vantress. 2018. Cobb500 broiler performance & nutrition supplement."},{"key":"10.1016\/j.psj.2021.101671_bib0012","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1136\/gut.2006.114926","article-title":"Norepinephrine increases the pathogenic potential of Campylobacter jejuni","volume":"56","author":"Cogan","year":"2007","journal-title":"Gut"},{"issue":"Suppl","key":"10.1016\/j.psj.2021.101671_bib0013","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1016\/j.domaniend.2016.02.007","article-title":"Adrenergic and noradrenergic regulation of poultry behavior and production","volume":"56","author":"Dennis","year":"2016","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.psj.2021.101671_bib0014","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1574-6968.2006.00619.x","article-title":"Specificity of catecholamine-induced growth in Escherichia coli O157:H7, Salmonella enterica and Yersinia enterocolitica","volume":"269","author":"Freestone","year":"2007","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.psj.2021.101671_bib0015","doi-asserted-by":"crossref","first-page":"e00664","DOI":"10.1002\/mbo3.664","article-title":"The stress hormone norepinephrine increases the growth and virulence of Aeromonas hydrophila","volume":"8","author":"Gao","year":"2019","journal-title":"Microbiologyopen"},{"key":"10.1016\/j.psj.2021.101671_bib0016","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3181\/00379727-148-38729","article-title":"Concentration of serotonin in intestine and factors affecting its release","volume":"148","author":"Gross","year":"1975","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.psj.2021.101671_bib0017","doi-asserted-by":"crossref","first-page":"F260","DOI":"10.1152\/ajprenal.00471.2019","article-title":"Norepinephrine released by intestinal Paneth cells exacerbates ischemic AKI","volume":"318","author":"Han","year":"2020","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.psj.2021.101671_bib0018","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/jpn.12238","article-title":"Gender-specific effects of a phytogenic feed additive on performance, intestinal physiology and morphology in broiler chickens","volume":"99","author":"Humer","year":"2015","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl)"},{"key":"10.1016\/j.psj.2021.101671_bib0019","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ebiom.2016.05.037","article-title":"Serotonin activates bacterial quorum sensing and enhances the virulence of Pseudomonas aeruginosa in the host","volume":"9","author":"Knecht","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.psj.2021.101671_bib0020","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1476-5381.1979.tb07827.x","article-title":"Evidence that adrenaline is released from adrenergic neurones in the rectum of the fowl","volume":"65","author":"Komori","year":"1979","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.psj.2021.101671_bib0021","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1476-5381.1979.tb07826.x","article-title":"The appearance of noradrenaline and adrenaline and the developmental changes in the their concentrations in the gut of the chick","volume":"65","author":"Konaka","year":"1979","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.psj.2021.101671_bib0022","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s12640-017-9818-6","article-title":"Salsolinol: an unintelligible and double-faced molecule-lessons learned from in vivo and in vitro experiments","volume":"33","author":"Kurnik-Lucka","year":"2018","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.psj.2021.101671_bib0023","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jcmgh.2019.01.004","article-title":"Modulation of gut microbiota composition by serotonin signaling influences intestinal immune response and susceptibility to colitis","volume":"7","author":"Kwon","year":"2019","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.psj.2021.101671_bib0024","article-title":"Informal Nutrition Symposium: leveraging the microbiome (and the metabolome) for poultry production","volume":"101","author":"Lee","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2021.101671_bib0025","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1093\/ps\/85.12.2149","article-title":"Effects of particle size and physical form of diets on mast cell numbers, histamine, and stem cell factor concentration in the small intestine of broiler chickens","volume":"85","author":"Liu","year":"2006","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2021.101671_bib0026","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1038\/s41396-018-0227-5","article-title":"Chemotaxis of Escherichia coli to major hormones and polyamines present in human gut","volume":"12","author":"Lopes","year":"2018","journal-title":"ISME J."},{"key":"10.1016\/j.psj.2021.101671_bib0027","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1677\/joe.0.1370343","article-title":"The role of microbial endocrinology in infectious disease","volume":"137","author":"Lyte","year":"1993","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.psj.2021.101671_bib0028","doi-asserted-by":"crossref","first-page":"381","DOI":"10.4161\/gmic.28682","article-title":"Microbial endocrinology: host-microbiota neuroendocrine interactions influencing brain and behavior","volume":"5","author":"Lyte","year":"2014","journal-title":"Gut Microbes"},{"key":"10.1016\/j.psj.2021.101671_bib0029","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.VMBF-0021-2015","article-title":"Microbial endocrinology in the pathogenesis of infectious disease","volume":"4","author":"Lyte","year":"2016","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.psj.2021.101671_bib0030","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0024-3205(92)90273-R","article-title":"Catecholamine induced growth of gram negative bacteria","volume":"50","author":"Lyte","year":"1992","journal-title":"Life Sci."},{"key":"10.1016\/j.psj.2021.101671_bib0031","series-title":"Microbial Endocrinology: Interkingdom Signaling in Infectious Disease and Health","author":"Lyte","year":"2010"},{"key":"10.1016\/j.psj.2021.101671_bib0032","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40168-020-00962-2","article-title":"Japanese quail (Coturnix japonica) as a novel model to study the relationship between the avian microbiome and microbial endocrinology-based host-microbe interactions","volume":"9","author":"Lyte","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.psj.2021.101671_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2020.12.041","article-title":"Serotonin modulates Campylobacter jejuni physiology and invitro interaction with the gut epithelium","volume":"100","author":"Lyte","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2021.101671_bib0034","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jneuroim.2004.08.008","article-title":"Intravenous catecholamine administration affects mouse intestinal lymphocyte number and apoptosis","volume":"158","author":"Marra","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.psj.2021.101671_bib0035","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1099\/00221287-137-3-621","article-title":"Catabolism of 3- and 4-hydroxyphenylacetic acid by Klebsiella pneumoniae","volume":"137","author":"Martin","year":"1991","journal-title":"J. Gen. Microbiol."},{"key":"10.1016\/j.psj.2021.101671_bib0036","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1002\/jcp.25518","article-title":"Neurotransmitters: the critical modulators regulating gut-brain axis","volume":"232","author":"Mittal","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.psj.2021.101671_bib54","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.microc.2018.09.010","article-title":"Determination of histamine in fish without derivatization by indirect reverse phase-HPLC method","volume":"144","author":"Nadeem","year":"2019","journal-title":"Microchemical Journal"},{"key":"10.1016\/j.psj.2021.101671_bib0037","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1086\/513275","article-title":"Modulation of pathogenicity with norepinephrine related to the type III secretion system of Vibrio parahaemolyticus","volume":"195","author":"Nakano","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.psj.2021.101671_bib55","series-title":"Nutrient Requirements of Poultry","year":"1994"},{"key":"10.1016\/j.psj.2021.101671_bib0038","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/1574-6968.12608","article-title":"The chicken gastrointestinal microbiome","volume":"360","author":"Oakley","year":"2014","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.psj.2021.101671_bib0039","first-page":"305","article-title":"[Effect of serotonin (5-hydroxytryptamine) on the growth and differentiation of microorganisms]","volume":"67","author":"Oleskin","year":"1998","journal-title":"Mikrobiologiia"},{"key":"10.1016\/j.psj.2021.101671_bib0040","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF01965031","article-title":"Histamine distribution in the gastrointestinal wall of germ free and conventional chicken: evidence of the role of the digestive microflora","volume":"25","author":"Perez-Ruiz","year":"1988","journal-title":"Agents Actions"},{"key":"10.1016\/j.psj.2021.101671_bib0041","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/192380a0","article-title":"Serotonin in the small intestine of conventional and germfree chicks","volume":"192","author":"Phillips","year":"1961","journal-title":"Nature"},{"key":"10.1016\/j.psj.2021.101671_bib0042","article-title":"A wide diversity of bacteria from the human gut produces and degrades biogenic amines","volume":"28","author":"Pugin","year":"2017","journal-title":"Microb. Ecol. Health Dis."},{"key":"10.1016\/j.psj.2021.101671_bib0043","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.3389\/fmicb.2019.03064","article-title":"Oral treatments with probiotics and live Salmonella vaccine induce unique changes in gut neurochemicals and microbiome in chickens","volume":"10","author":"Redweik","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.psj.2021.101671_bib0044","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1093\/jn\/101.12.1623","article-title":"Effect of zinc, certain related dietary factors and age on the histamine content of chick tissues","volume":"101","author":"Reimann","year":"1971","journal-title":"J. Nutr."},{"key":"10.1016\/j.psj.2021.101671_bib0045","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1021\/jm00187a027","article-title":"Actions of two dopamine derivatives at adreno- and cholinoceptors","volume":"22","author":"Rodger","year":"1979","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.psj.2021.101671_bib0046","article-title":"Histamine poisoning from ingestion of fish or scombroid syndrome","volume":"2014","author":"Tortorella","year":"2014","journal-title":"Case Rep. Emerg. Med"},{"key":"10.1016\/j.psj.2021.101671_bib0047","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3390\/pathogens9070555","article-title":"An investigation of the effect of catecholamines and glucocorticoids on the growth and pathogenicity of Campylobacter jejuni","volume":"9","author":"Truccollo","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.psj.2021.101671_bib0048","doi-asserted-by":"crossref","first-page":"C104","DOI":"10.1152\/ajpcell.1998.275.1.C104","article-title":"Uptake and intracellular fate of L-DOPA in a human intestinal epithelial cell line: Caco-2","volume":"275","author":"Vieira-Coelho","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.psj.2021.101671_bib0049","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.3389\/fmicb.2018.03092","article-title":"Production of the neurotoxin salsolinol by a gut-associated bacterium and its modulation by alcohol","volume":"9","author":"Villageliu","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.psj.2021.101671_bib0050","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.3382\/ps\/pex148","article-title":"Microbial endocrinology: why the intersection of microbiology and neurobiology matters to poultry health","volume":"96","author":"Villageliu","year":"2017","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2021.101671_bib0051","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0207038","article-title":"Dopamine production in Enterococcus faecium: a microbial endocrinology-based mechanism for the selection of probiotics based on neurochemical-producing potential","volume":"13","author":"Villageliu","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.psj.2021.101671_bib0052","doi-asserted-by":"crossref","DOI":"10.1093\/femsec\/fiy096","article-title":"A microbial endocrinology-based simulated small intestinal medium for the evaluation of neurochemical production by gut microbiota","volume":"94","author":"Villageliu","year":"2018","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.psj.2021.101671_bib0053","doi-asserted-by":"crossref","first-page":"452","DOI":"10.3389\/fmicb.2015.00452","article-title":"Transcriptomic analysis of Campylobacter jejuni NCTC 11168 in response to epinephrine and norepinephrine","volume":"6","author":"Xu","year":"2015","journal-title":"Front. Microbiol."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003257912100691X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003257912100691X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T22:42:05Z","timestamp":1758494525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003257912100691X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S003257912100691X"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2021.101671","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A neurochemical biogeography of the broiler chicken intestinal tract","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2021.101671","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"101671"}}