{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:59:21Z","timestamp":1791575961668,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.psj.2022.101791","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T20:16:00Z","timestamp":1645128960000},"page":"101791","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Poly (lactic-co-glycolic acid) nanoparticle-based vaccines delivery systems as a novel adjuvant for H9N2 antigen enhance immune responses"],"prefix":"10.1016","volume":"101","author":[{"given":"Adelijiang","family":"Wusiman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Telieke","family":"Ayihengbieke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xike","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuerhong","family":"Kudereti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saifuding","family":"Abula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2022.101791_bib0001","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1086\/508174","article-title":"Safety and immunogenicity of nonadjuvanted and MF59-adjuvanted influenza A\/H9N2 vaccine preparations","volume":"43","author":"Atmar","year":"2006","journal-title":"Clin. Infect Dis."},{"key":"10.1016\/j.psj.2022.101791_bib0002","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.carbpol.2018.10.057","article-title":"Mechanism of Lycium barbarum polysaccharides liposomes on activating murine dendritic cells","volume":"205","author":"Bo","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.psj.2022.101791_bib0003","doi-asserted-by":"crossref","first-page":"6289","DOI":"10.2147\/IJN.S136820","article-title":"Simple nanoliposomes encapsulating Lycium barbarum polysaccharides as adjuvants improve humoral and cellular immunity in mice","volume":"12","author":"Bo","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.psj.2022.101791_bib0004","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.virol.2018.02.016","article-title":"Characterization of H9N2 avian influenza viruses from the Middle East demonstrates heterogeneity at amino acid position 226 in the hemagglutinin and potential for transmission to mammals","volume":"518","author":"Chrzastek","year":"2018","journal-title":"Virology"},{"key":"10.1016\/j.psj.2022.101791_bib0005","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jconrel.2016.12.039","article-title":"Biodegradable nanoparticle delivery of inactivated swine influenza virus vaccine provides heterologous cell-mediated immune response in pigs","volume":"247","author":"Dhakal","year":"2017","journal-title":"J. Control. Release."},{"issue":"1","key":"10.1016\/j.psj.2022.101791_bib35","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1186\/s12917-018-1689-4","article-title":"Interaction between avian influenza subtype H9N2 and Newcastle disease virus vaccine strain (LaSota) in chickens","volume":"14","author":"Ellakany","year":"2018","journal-title":"BMC Vet Res."},{"key":"10.1016\/j.psj.2022.101791_bib36","first-page":"77","article-title":"Enhancing immunogenicity and protective efficacy of inactivated avian influenza H9N2vaccine with recombinant chicken IFN-\u03b1 in chicken, Veterinary Microbiology","volume":"234","author":"Gan","year":"2019","journal-title":"Volume."},{"key":"10.1016\/j.psj.2022.101791_bib0006","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.smim.2018.05.001","article-title":"Correlates of adjuvanticity: a review on adjuvants in licensed vaccines","volume":"39","author":"Giuseppe","year":"2018","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.psj.2022.101791_bib0007","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.micpath.2017.12.050","article-title":"Recombinant M2e-HA2 fusion protein inducedimmunityresponses against intranasally administered H9N2 influenza virus","volume":"115","author":"Golchin","year":"2017","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.psj.2022.101791_bib0008","doi-asserted-by":"crossref","first-page":"6971","DOI":"10.1016\/j.vaccine.2012.09.059","article-title":"Adjuvants and inactivated polio vaccine: a systematic","volume":"30","author":"Hawken","year":"2012","journal-title":"Rev. Vaccine."},{"key":"10.1016\/j.psj.2022.101791_bib0009","first-page":"1545","article-title":"Efficacy of commercial vaccines against the prevalent strains of Newcastle disease and avian influenza (h9n2) infections in broilers in Pakistan","volume":"32","author":"Irshad","year":"2018","journal-title":"J. Biol. Regul. Homeost. Agents."},{"key":"10.1016\/j.psj.2022.101791_bib0010","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3109\/21691401.2015.1129626","article-title":"Comparative assessment of humoral immune responses of aluminum hydroxide and oil-emulsion adjuvants in Influenza (H9N2) and Newcastle inactive vaccines to chickens","volume":"45","author":"Jafari","year":"2017","journal-title":"Artif. Cells. Nanomed. Biotechnol."},{"issue":"27","key":"10.1016\/j.psj.2022.101791_bib0040","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1016\/j.vaccine.2018.05.093","article-title":"Examination of the effects of virus inactivation methods on the induction of antibody- and cell-mediated immune responses against whole inactivated H9N2 avian influenza virus vaccines in chickens","volume":"36","author":"Jake","year":"2018","journal-title":"Vaccine."},{"key":"10.1016\/j.psj.2022.101791_bib0011","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1637\/11145-050815-Reg","article-title":"Comparative effectiveness of two oil adjuvant\u2013inactivated avian influenza H9N2 vaccines","volume":"60","author":"Kilany","year":"2016","journal-title":"Avian. Dis."},{"key":"10.1016\/j.psj.2022.101791_bib0012","doi-asserted-by":"crossref","first-page":"6569","DOI":"10.1016\/j.vaccine.2008.09.043","article-title":"Genetic characterization and protective. immunity of cold-adapted attenuated avian H9N2 influenza vaccine","volume":"26","author":"Lee","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.psj.2022.101791_bib0013","doi-asserted-by":"crossref","first-page":"5746","DOI":"10.1039\/C9NR08958F","article-title":"Nanoparticle formulated vaccine: opportunities and challenges","volume":"12","author":"Lung","year":"2020","journal-title":"Nanoscale"},{"key":"10.1016\/j.psj.2022.101791_bib0014","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.vaccine.2019.10.025","article-title":"The effect of maternal antibodies on the cellular immune response after infant vaccination: a review","volume":"38","author":"Marjolein","year":"2020","journal-title":"Vaccine"},{"key":"10.1016\/j.psj.2022.101791_bib0015","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.colsurfb.2017.07.038","article-title":"Recent applications of PLGA based nanostructures in drug delivery","volume":"159","author":"Mir","year":"2017","journal-title":"Colloids. Surf. B. Bionterfaces."},{"key":"10.1016\/j.psj.2022.101791_bib0016","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3382\/ps\/pew250","article-title":"Diatoms and diatomaceous earth as novel poultry vaccine adjuvants","volume":"96","author":"Nazmi","year":"2017","journal-title":"Poult. Sci"},{"key":"10.1016\/j.psj.2022.101791_bib0017","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.vaccine.2009.09.103","article-title":"Safety and immunogenicity of whole-virus, alum-adjuvanted whole-virus, virosomal, and whole-virus intradermal influenza A\/H9N2 vaccine formulations","volume":"28","author":"Nicholson","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.psj.2022.101791_bib0018","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.vetmic.2014.01.001","article-title":"Supplementation of oil-based inactivated H9N2 vaccine with M2e antigen enhances resistance against heterologous H9N2 avian influenza virus infection","volume":"169","author":"Park","year":"2014","journal-title":"Vet. Microbiol."},{"issue":"17","key":"10.1016\/j.psj.2022.101791_bib39","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1016\/j.vaccine.2006.01.065","article-title":"HIV-1 Tat-coated nanoparticles result in enhanced humoral immune responses and neutralizing antibodies compared to alum adjuvant","volume":"24","author":"Patel","year":"2006","journal-title":"Vaccine."},{"key":"10.1016\/j.psj.2022.101791_bib0041","doi-asserted-by":"crossref","unstructured":"Plotkin. and Stanley., History of vaccination. (2014). P Natl Acad Sci USA. 111:12283\u201312287.","DOI":"10.1073\/pnas.1400472111"},{"key":"10.1016\/j.psj.2022.101791_bib0019","first-page":"66","article-title":"Comparative efficacy of different adjuvant containing inactivated vaccines against low-pathogenicity avian influenza H9N2 virus","volume":"4","author":"Riaz","year":"2017","journal-title":"Int. J. Biometeor."},{"key":"10.1016\/j.psj.2022.101791_bib0020","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3390\/v10030121","article-title":"Challenge for one health: co-circulation of zoonotic H5N1 and H9N2 avian influenza viruses in Egypt","volume":"10","author":"Shin-Hee","year":"2018","journal-title":"Viruses. Basel."},{"key":"10.1016\/j.psj.2022.101791_bib0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13568-020-01036-0","article-title":"Effect of the selection pressure of vaccine antibodies on evolution of H9N2 avian influenza virus in chickens","volume":"10","author":"Su","year":"2020","journal-title":"AMB. Express"},{"key":"10.1016\/j.psj.2022.101791_bib0022","first-page":"562","article-title":"A systematic review and meta-analysis of the seroprevalence of influenza A(H9N2) infection among humans","volume":"4","author":"Uddin","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.psj.2022.101791_bib0023","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.3382\/ps\/pew069","article-title":"Synergistic effects of thymoquinone and curcumin on immune response and anti-viral activity against avian influenza virus (H9N2) in turkeys","volume":"95","author":"Umar","year":"2016","journal-title":"Poult. Sci"},{"key":"10.1016\/j.psj.2022.101791_bib0024","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.actbio.2018.11.023","article-title":"Alum-functionalized graphene oxide nanocomplexes for effective anticancer vaccination","volume":"83","author":"Wang","year":"2019","journal-title":"Acta. Biomater."},{"key":"10.1016\/j.psj.2022.101791_bib0025","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ijpharm.2016.09.082","article-title":"Improving adjuvanticity of quaternized chitosan\u2013based microgels for H5N1 split vaccine by tailoring the particle properties to achieve antigen dose sparing effect","volume":"515","author":"Wang","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.psj.2022.101791_bib0027","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.2147\/IJN.S203072","article-title":"Cationic polymer. modified PLGA nanoparticles encapsulating Alhagi honey polysaccharides as a vaccine delivery system for ovalbumin to improve immune responses","volume":"14","author":"Wusiman","year":"2019","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.psj.2022.101791_bib0028","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.ijbiomac.2019.05.038","article-title":"Macrophage immunomodulatory activity of the cationic polymer modified PLGA nanoparticles encapsulating Alhagi honey polysaccharide-ScienceDirect","volume":"134","author":"Wusiman","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.psj.2022.101791_bib0029","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.carbpol.2019.01.102","article-title":"Immunomodulatory effects of Alhagi honey polysaccharides encapsulated into PLGA nanoparticles","volume":"211","author":"Wusiman","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.psj.2022.101791_bib0030","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nmat5057","article-title":"Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination","volume":"17","author":"Xia","year":"2018","journal-title":"Nat. Mater."},{"key":"10.1016\/j.psj.2022.101791_bib0031","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.3382\/ps.2012-02431","article-title":"Pinon shell. polysaccharide enhances immunity against H9N2 avian influenza virus in chickens","volume":"91","author":"Xie","year":"2012","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2022.101791_bib0032","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1016\/j.vaccine.2019.09.046","article-title":"Commensal. gut microbiota can modulate adaptive immune responses in chickens vaccinated with whole inactivated avian influenza virus subtype H9N2","volume":"37","author":"Yitbarek","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.psj.2022.101791_bib0033","doi-asserted-by":"crossref","first-page":"5927","DOI":"10.1016\/j.vaccine.2015.07.100","article-title":"Polymeric micro\/nanoparticles: particle design and. potential. vaccine delivery applications","volume":"33","author":"Yue","year":"2015","journal-title":"Vaccine"},{"issue":"8","key":"10.1016\/j.psj.2022.101791_bib0037","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2174\/0929866525666180806110928","article-title":"Adjuvant Activity of Bursal Pentapeptide-(III-V) in Mice Immunized with the H9N2 Avian Influenza Vaccine","volume":"25","author":"Zhou","year":"2018","journal-title":"Protein Pept Lett."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579122000992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579122000992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T22:44:45Z","timestamp":1758494685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579122000992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S0032579122000992"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2022.101791","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Poly (lactic-co-glycolic acid) nanoparticle-based vaccines delivery systems as a novel adjuvant for H9N2 antigen enhance immune responses","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2022.101791","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"101791"}}