{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:16:36Z","timestamp":1792811796428,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T00:00:00Z","timestamp":1648857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010950","name":"Department of Science and Technology of Henan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.psj.2022.101905","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T02:08:21Z","timestamp":1649210901000},"page":"101905","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"title":["Polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota"],"prefix":"10.1016","volume":"101","author":[{"given":"Yingying","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changzhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongpeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyselov","family":"Oleksandr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2022.101905_bib0001","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.1016\/j.psj.2020.06.026","article-title":"Effects of Achyranthes bidentata polysaccharides on performance, immunity, antioxidant capacity, and meat quality in Pekin ducks","volume":"99","author":"Ao","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2022.101905_bib0002","first-page":"272","article-title":"Dietary fructans and their potential beneficial influence on health and performance parametrs in broiler chickens","volume":"13","author":"Boguslawska","year":"2012","journal-title":"J. Cent. Eur. Agric."},{"key":"10.1016\/j.psj.2022.101905_bib0003","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.3382\/ps.2007-00249","article-title":"History of the use of antibiotic as growth promoters in European poultry feeds","volume":"86","author":"Castanon","year":"2007","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2022.101905_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2019.103470","article-title":"Polysaccharides from the flowers of tea (Camellia sinensis L.) modulate gut health and ameliorate cyclophosphamide-induced immunosuppression","volume":"61","author":"Chen","year":"2019","journal-title":"J. Funct. Foods."},{"key":"10.1016\/j.psj.2022.101905_bib0005","doi-asserted-by":"crossref","first-page":"5382","DOI":"10.1038\/s41598-020-60135-x","article-title":"Microbiota and metabolome responses in the cecum and serum of broiler chickens fed with plant essential oils or virginiamycin","volume":"10","author":"Chen","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2022.101905_bib0006","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3389\/fimmu.2017.00666","article-title":"Immunomodulatory activities of a fungal protein extracted from Hericium erinaceus through regulating the gut microbiota","volume":"8","author":"Diling","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2022.101905_bib0007","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.bpg.2017.09.011","article-title":"Action and function of Faecalibacterium prausnitzii in health and disease","volume":"31","author":"Ferreira-Halder","year":"2017","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.psj.2022.101905_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104424","article-title":"Probiotic-fermented Chinese dwarf cherry [Cerasus humilis (Bge.) Sok.] juice modulates the intestinal mucosal barrier and increases the abundance of Akkermansia in the gut in association with polyphenols","volume":"80","author":"Guo","year":"2021","journal-title":"J. Funct. Foods."},{"key":"10.1016\/j.psj.2022.101905_bib0009","doi-asserted-by":"crossref","first-page":"37376","DOI":"10.1038\/srep37376","article-title":"Differential fecal microbiota are retained in broiler chicken lines divergently selected for fatness traits","volume":"6","author":"Hou","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2022.101905_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2020.612063","article-title":"Influence of Glycyrrhiza glabra extract on growth, gene expression of gut integrity, and Campylobacter jejuni colonization in broiler chickens","volume":"7","author":"Ibrahim","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.psj.2022.101905_bib0011","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12876-015-0330-2","article-title":"Comparison of the gut microbiota composition between obese and non-obese individuals in a Japanese population, as analyzed by terminal restriction fragment length polymorphism and next-generation sequencing","volume":"15","author":"Kasai","year":"2015","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.psj.2022.101905_bib0012","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.anifeedsci.2018.10.008","article-title":"The effect of microbiome modulation on the intestinal health of poultry","volume":"250","author":"Kogut","year":"2019","journal-title":"Anim. Feed Sci Tech."},{"key":"10.1016\/j.psj.2022.101905_bib0013","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.cmet.2015.10.001","article-title":"Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of Prevotella","volume":"22","author":"Kovatcheva","year":"2015","journal-title":"Cell. Metab."},{"key":"10.1016\/j.psj.2022.101905_bib0014","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.psj.2020.10.021","article-title":"Effects of Astragalus polysaccharides on intestinal morphology and intestinal immune cells of Muscovy ducklings infected with Muscovy duck reovirus","volume":"100","author":"Liao","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2022.101905_bib0015","doi-asserted-by":"crossref","first-page":"990","DOI":"10.3389\/fvets.2020.601336","article-title":"Algae-derived polysaccharides promote growth performance by improving antioxidant capacity and intestinal barrier function in broiler chickens","volume":"7","author":"Liu","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.psj.2022.101905_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101139","article-title":"Algae-derived polysaccharides supplementation ameliorates heat stress-induced impairment of bursa of Fabricius via modulating NF-\u03baB signaling pathway in broilers","volume":"100","author":"Liu","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2022.101905_bib0017","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.psj.2020.09.089","article-title":"Microbiota populations and short-chain fatty acids production in cecum of immunosuppressed broilers consuming diets containing \u03b3-irradiated Astragalus polysaccharides","volume":"100","author":"Liu","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2022.101905_bib0018","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.psj.2019.10.043","article-title":"Effects of dietary Lycium barbarum polysaccharides on growth performance, digestive enzyme activities, antioxidant status, and immunity of broiler chickens","volume":"99","author":"Long","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2022.101905_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101028","article-title":"Effects of polysaccharide-enriched Acanthopanax senticosus extract on growth performance, immune function, antioxidation, and ileal microbial populations in broiler chickens","volume":"100","author":"Long","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2022.101905_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aninu.2019.11.004","article-title":"Dietary fiber and chicken microbiome interaction: where will it lead to?","volume":"6","author":"Mahmood","year":"2020","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.psj.2022.101905_bib0021","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1111\/are.14544","article-title":"Zingiber officinale and Glycyrrhiza glabra, individually or in combination, reduce heavy metal accumulation and improve growth performance and immune status in Nile tilapia, Oreochromis niloticus","volume":"51","author":"Mohammed","year":"2020","journal-title":"Aquacult. Res."},{"key":"10.1016\/j.psj.2022.101905_bib0022","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ijbiomac.2019.11.245","article-title":"Structural characterization and antioxidant activities of a water soluble polysaccharide isolated from Glycyrrhiza glabra","volume":"144","author":"Mutaillifu","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.psj.2022.101905_bib0023","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1023\/A:1005565708038","article-title":"Experimental ulcerative colitis impairs antioxidant defense system in rat intestine","volume":"45","author":"Nieto","year":"2000","journal-title":"Digest. Dis. Sci."},{"key":"10.1016\/j.psj.2022.101905_bib0024","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.1007\/s13277-015-3135-6","article-title":"A polysaccharide from Glycyrrhiza inflata Licorice inhibits proliferation of human oral cancer cells by inducing apoptosis via mitochondrial pathway","volume":"36","author":"Shen","year":"2015","journal-title":"Tumor Biol"},{"key":"10.1016\/j.psj.2022.101905_bib0025","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1080\/1040841X.2017.1373062","article-title":"Alternatives to antibiotics in poultry feed: molecular perspectives","volume":"44","author":"Suresh","year":"2018","journal-title":"Crit. Rev. Microbiol"},{"key":"10.1016\/j.psj.2022.101905_bib0026","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal mucosal barrier function in health and disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.psj.2022.101905_bib0027","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/jpn.13244","article-title":"Effects of Astragalus and Ginseng polysaccharides on growth performance, immune function and intestinal barrier in weaned piglets challenged with lipopolysaccharide","volume":"104","author":"Wang","year":"2020","journal-title":"J. Anim. Physiol Anim. Nutr"},{"key":"10.1016\/j.psj.2022.101905_bib0028","article-title":"The combined impact of xylo-oligosaccharides and gamma-irradiated Astragalus polysaccharides on growth performance and intestinal mucosal barrier function of broilers","volume":"100","author":"Wang","year":"2021","journal-title":"Poult. Sci"},{"key":"10.1016\/j.psj.2022.101905_bib0029","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ijbiomac.2013.07.013","article-title":"Astragalus polysaccharide reduces inflammatory response by decreasing permeability of LPS-infected Caco2 cells","volume":"61","author":"Wang","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.psj.2022.101905_bib0030","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ijbiomac.2014.05.004","article-title":"Sulfated Astragalus polysaccharide regulates the inflammatory reaction in LPS-infected broiler chicks","volume":"69","author":"Wang","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.psj.2022.101905_bib0031","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0924-8579(00)00301-0","article-title":"Selective pressure by antibiotic use in livestock","volume":"16","author":"Witte","year":"2000","journal-title":"Int. J. Antimicrob Ag."},{"key":"10.1016\/j.psj.2022.101905_bib0032","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.3382\/ps\/pey220","article-title":"Effect of dietary Astragalus membranaceus polysaccharide on the growth performance and immunity of juvenile broilers","volume":"97","author":"Wu","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2022.101905_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101549","article-title":"Glycyrrhiza polysaccharides can improve and prolong the response of chickens to the Newcastle disease vaccine","volume":"101","author":"Wu","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2022.101905_bib0034","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3389\/fphys.2019.00418","article-title":"Astragalus and Ginseng polysaccharides improve developmental, intestinal morphological, and immune functional characters of weaned piglets","volume":"10","author":"Yang","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.psj.2022.101905_bib0036","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00726-008-0142-6","article-title":"Dietary supplementation with Astragalus polysaccharide enhances ileal digestibilities and serum concentrations of amino acids in early weaned piglets","volume":"37","author":"Yin","year":"2009","journal-title":"Amino Acids"},{"key":"10.1016\/j.psj.2022.101905_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101168","article-title":"Effects of Glycyrrhiza polysaccharide in diet on growth performance, serum antioxidant capacity, and biochemistry of broilers","volume":"100","author":"Zhang","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2022.101905_bib0038","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700466","article-title":"Intestinal microbiota are involved in the immunomodulatory activities of Longan polysaccharide","volume":"61","author":"Zhang","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.psj.2022.101905_bib0039","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700554","article-title":"Dietary factors modulate colonic tumorigenesis through the interaction of gut microbiota and host chloride channels","volume":"62","author":"Zhang","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.psj.2022.101905_bib0040","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ijbiomac.2020.03.198","article-title":"Effects of polysaccharides from Yingshan Yunwu tea on meat quality, immune status and intestinal microflora in chickens","volume":"155","author":"Zhao","year":"2020","journal-title":"Int. J. Biol. Macromol"},{"key":"10.1016\/j.psj.2022.101905_bib0041","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3389\/fphar.2020.00349","article-title":"A review of the pharmacological action of Astragalus polysaccharide","volume":"11","author":"Zheng","year":"2020","journal-title":"Front. Pharmacol."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579122002024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579122002024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T22:42:43Z","timestamp":1758494563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579122002024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S0032579122002024"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2022.101905","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2022.101905","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"101905"}}