{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T17:27:14Z","timestamp":1771954034828,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["D18007"],"award-info":[{"award-number":["D18007"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.psj.2023.102482","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T11:11:42Z","timestamp":1673003502000},"page":"102482","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sodium dehydroacetate-induced disorder of coagulation function in broiler chickens and the protective effect afforded by vitamin K"],"prefix":"10.1016","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4675-3537","authenticated-orcid":false,"given":"Jinge","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuxing","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cunkai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0380-0241","authenticated-orcid":false,"given":"Yumei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2023.102482_bib0001","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.708946","article-title":"Vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) inhibition induces a proliferative and pro-inflammatory vascular smooth muscle cell phenotype","volume":"8","author":"Aksoy","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.psj.2023.102482_bib0002","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/jat.4156","article-title":"Integrated approaches to testing and assessment as a tool for the hazard assessment and risk characterization of cosmetic preservatives","volume":"41","author":"Canavez","year":"2021","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.psj.2023.102482_bib0003","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.thromres.2015.01.025","article-title":"Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse: VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain","volume":"135","author":"Caspers","year":"2015","journal-title":"Thromb. Res."},{"key":"10.1016\/j.psj.2023.102482_bib0005","article-title":"Sex metabolic differences and effects on blood coagulation among rats exposed to sodium dehydroacetate","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.psj.2023.102482_bib0004","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.rvsc.2019.05.002","article-title":"Sodium dehydroacetate induces coagulation dysfunction by inhibiting liver vitamin K epoxide reductase complex subunit 1 in Wistar rats","volume":"124","author":"Chen","year":"2019","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.psj.2023.102482_bib0006","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/oby.22206","article-title":"The vitamin K epoxide reductase vkorc1l1 promotes preadipocyte differentiation in mice","volume":"26","author":"Ding","year":"2018","journal-title":"Obesity (Silver Spring)."},{"key":"10.1016\/j.psj.2023.102482_bib0007","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1101\/sqb.2009.74.001","article-title":"Step-by-step evolution of vertebrate blood coagulation","volume":"74","author":"Doolittle","year":"2009","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.psj.2023.102482_bib0008","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/DER.0b013e31826f5b86","article-title":"Sodium dehydroacetate: an emerging allergen","volume":"23","author":"Foti","year":"2012","journal-title":"Dermatitis"},{"key":"10.1016\/j.psj.2023.102482_bib0009","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/cod.12575","article-title":"Allergic contact dermatitis caused by resorcinol and sodium dehydroacetate in a patient with leg ulcers","volume":"74","author":"Foti","year":"2016","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.psj.2023.102482_bib0010","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0092-8674(88)90567-3","article-title":"The molecular basis of blood coagulation","volume":"53","author":"Furie","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.psj.2023.102482_bib0011","doi-asserted-by":"crossref","first-page":"28733","DOI":"10.1074\/jbc.M113.457119","article-title":"VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy","volume":"288","author":"Hammed","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.psj.2023.102482_bib0012","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1080\/19440049.2019.1615644","article-title":"Determination of nine preservatives in processed foods using a modified QuEChERS extraction and quantified by HPLC-PDA","volume":"36","author":"Iwakoshi","year":"2019","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo Risk Assess."},{"key":"10.1016\/j.psj.2023.102482_bib0013","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1248\/cpb.c17-00938","article-title":"Photoreactivities of the antiseptics dehydroacetic acid and sodium dehydroacetate used in cosmetics","volume":"66","author":"Izawa","year":"2018","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.psj.2023.102482_bib0015","doi-asserted-by":"crossref","first-page":"970","DOI":"10.3390\/nu10080970","article-title":"VKORC1L1, an enzyme mediating the effect of vitamin K in liver and extrahepatic tissues","volume":"10","author":"Lacombe","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.psj.2023.102482_bib0016","doi-asserted-by":"crossref","first-page":"e96501","DOI":"10.1172\/jci.insight.96501","article-title":"VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo","volume":"3","author":"Lacombe","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.psj.2023.102482_bib0014","first-page":"41","article-title":"Studied on antibacterial properties of sodium dehydroacetate","volume":"2","author":"Li","year":"2004","journal-title":"China Food Addit."},{"key":"10.1016\/j.psj.2023.102482_bib0018","first-page":"144","article-title":"The preservative effect of sodium dehydroacetate on mink fresh compound feed","volume":"56","author":"Li","year":"2020","journal-title":"Chin. J Anim."},{"key":"10.1016\/j.psj.2023.102482_bib0017","first-page":"32","article-title":"A study on effect of antimildew agent dehydrogenated sodium acetate","volume":"7","author":"Li","year":"2008","journal-title":"Cereal Feed Ind."},{"key":"10.1016\/j.psj.2023.102482_bib0019","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1600-0536.2011.01958.x","article-title":"Allergic contact dermatitis caused by sodium dehydroacetate, not hyaluronic acid, in Ialuset(R) cream","volume":"65","author":"Milpied","year":"2011","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.psj.2023.102482_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2019.108635","article-title":"Avian interspecific differences in VKOR activity and inhibition: insights from amino acid sequence and mRNA expression ratio of VKORC1 and VKORC1L1","volume":"228","author":"Nakayama","year":"2020","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.psj.2023.102482_bib0022","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0083-6729(07)00003-9","article-title":"The vitamin K cycle","volume":"78","author":"Oldenburg","year":"2008","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.psj.2023.102482_bib0021","doi-asserted-by":"crossref","first-page":"6250","DOI":"10.3390\/nu7085280","article-title":"VKORC1 and VKORC1L1: why do vertebrates have two vitamin K 2, 3-epoxide reductases?","volume":"7","author":"Oldenburg","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.psj.2023.102482_bib0023","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10068-017-0238-4","article-title":"Simultaneous and rapid analysis of chemical preservatives in processed animal products by ultra-performance liquid chromatography","volume":"27","author":"Park","year":"2017","journal-title":"Food Sci. Biotechnol."},{"key":"10.1016\/j.psj.2023.102482_bib0024","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00239-012-9509-0","article-title":"Evolution of thrombin and other hemostatic proteases by survey of protochordate, hemichordate, and echinoderm genomes","volume":"74","author":"Ponczek","year":"2012","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.psj.2023.102482_bib0025","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/jat.1304","article-title":"Anticoagulant effect of sodium dehydroacetate (DHA-S) in rats","volume":"28","author":"Sakaguchi","year":"2008","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.psj.2023.102482_bib0026","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/19393210.2017.1412360","article-title":"Dehydroacetic acid in cheese and cheese coating, results of official control in Italy","volume":"11","author":"Scordino","year":"2018","journal-title":"Food Addit. Contam. Part B Surveill."},{"key":"10.1016\/j.psj.2023.102482_bib0029","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0022-3565(25)04227-2","article-title":"Dehydroacetic acid (DHA). Acute and chronic toxicity","volume":"99","author":"Spencer","year":"1950","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.psj.2023.102482_bib0028","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0300-483X(97)03637-8","article-title":"Cytotoxicity of food preservatives in cultured rat hepatocytes loaded with linolenic acid","volume":"120","author":"Sugihara","year":"1997","journal-title":"Toxicology"},{"key":"10.1016\/j.psj.2023.102482_bib0027","doi-asserted-by":"crossref","first-page":"369","DOI":"10.14219\/jada.archive.1958.0049","article-title":"Use of a sodium dehydroacetate-sodium oxalate dentifrice in the control of dental caries","volume":"56","author":"Sulser","year":"1958","journal-title":"J. Am. Dent. Assoc."},{"key":"10.1016\/j.psj.2023.102482_bib0030","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11274-018-2413-z","article-title":"Antifungal mechanism of sodium dehydroacetate against Geotrichum citri-aurantii","volume":"34","author":"Tang","year":"2018","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.psj.2023.102482_bib0031","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/cod.12307","article-title":"Contact sensitization to modern dressings: a multicentre study on 354 patients with chronic leg ulcers","volume":"72","author":"Valois","year":"2015","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.psj.2023.102482_bib0032","doi-asserted-by":"crossref","first-page":"15085","DOI":"10.1074\/jbc.M110.210971","article-title":"Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function","volume":"286","author":"Westhofen","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.psj.2023.102482_bib0033","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0300-483X(03)00133-1","article-title":"Species comparison of vitamin K1 2,3-epoxide reductase activity in vitro: kinetics and warfarin inhibition","volume":"189","author":"Wilson","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.psj.2023.102482_bib0034","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1002\/fsn3.2366","article-title":"Effects of thermal and nonthermal processing technology on the quality of red sour soup after storage","volume":"9","author":"Yangbo","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.psj.2023.102482_bib0035","doi-asserted-by":"crossref","first-page":"46210","DOI":"10.1038\/srep46210","article-title":"Serum pharmacokinetics and coagulation aberration induced by sodium dehydroacetate in male and female Wistar rats","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2023.102482_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.111974","article-title":"The antithrombotic activity of the active fractions from the fruits of Celastrus orbiculatus Thunb through the anti-coagulation, anti-platelet activation and anti-fibrinolysis pathways","volume":"241","author":"Zhou","year":"2019","journal-title":"J. Ethnopharmacol."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579123000081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579123000081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T22:50:15Z","timestamp":1758495015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579123000081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0032579123000081"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2023.102482","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sodium dehydroacetate-induced disorder of coagulation function in broiler chickens and the protective effect afforded by vitamin K","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2023.102482","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"102482"}}