{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:03:54Z","timestamp":1789139034122,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H02332"],"award-info":[{"award-number":["18H02332"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H03137"],"award-info":[{"award-number":["20H03137"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K21357"],"award-info":[{"award-number":["20K21357"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20J22235"],"award-info":[{"award-number":["20J22235"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.psj.2023.102532","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T02:52:34Z","timestamp":1674701554000},"page":"102532","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Suppressive modulation of host immune responses by Dermanyssus gallinae infestation"],"prefix":"10.1016","volume":"102","author":[{"given":"Sotaro","family":"Fujisawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2569-899X","authenticated-orcid":false,"given":"Shiro","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Isezaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shwe Yee","family":"Win","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Oishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4708-3176","authenticated-orcid":false,"given":"Akira","family":"Taneno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Maekawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Okagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Konnai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7513-640X","authenticated-orcid":false,"given":"Kazuhiko","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2023.102532_bib0001","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1050-3862(99)00017-0","article-title":"Evidence and mechanisms of immunosuppression in tick infestations","volume":"15","author":"Barriga","year":"1999","journal-title":"Genet. Anal."},{"key":"10.1016\/j.psj.2023.102532_bib0002","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0092-8674(79)90057-6","article-title":"Chicken hematopoietic cells transformed by seven strains of defective avian leukemia viruses display three distinct phenotypes of differentiation","volume":"8","author":"Beug","year":"1979","journal-title":"Cell"},{"key":"10.1016\/j.psj.2023.102532_bib0003","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1136\/vr.140.22.577","article-title":"Resistance of the red poultry mite to pyrethroids in France","volume":"140","author":"Beugnet","year":"1979","journal-title":"Vet. Rec."},{"key":"10.1016\/j.psj.2023.102532_bib0004","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nri1004","article-title":"Innate immune sensing and its roots: the story of endotoxin","volume":"3","author":"Beutler","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.psj.2023.102532_bib0005","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1756-3305-5-38","article-title":"Immunoregulation of bovine macrophages by factors in the salivary glands of Rhipicephalus microplus","volume":"5","author":"Brake","year":"2012","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.psj.2023.102532_bib0006","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/COC.0000000000000239","article-title":"CTLA-4 and PD-1 pathways","volume":"39","author":"Buchbinder","year":"2016","journal-title":"Am. J. Clin. Oncol."},{"key":"10.1016\/j.psj.2023.102532_bib0007","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/1756-3305-5-229","article-title":"Ixodes scapularis saliva mitigates inflammatory cytokine secretion during Anaplasma phagocytophilum stimulation of immune cells","volume":"5","author":"Chen","year":"2012","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.psj.2023.102532_bib0008","doi-asserted-by":"crossref","first-page":"690","DOI":"10.4269\/ajtmh.1994.51.690","article-title":"Differential modulation of murine cellular immune responses by salivary gland extract of Aedes aegypti","volume":"51","author":"Cross","year":"1994","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.psj.2023.102532_bib0009","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.vetmic.2008.12.016","article-title":"Characterization of Erysipelothrix rhusiopathiae isolates from poultry, pigs, emus, the poultry red mite and other animals","volume":"137","author":"Eriksson","year":"2009","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.psj.2023.102532_bib0010","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s13071-015-0768-7","article-title":"Should the poultry red mite Dermanyssus gallinae be of wider concern for veterinary and medical science?","volume":"8","author":"George","year":"2015","journal-title":"Parasit. Vectors."},{"key":"10.1016\/j.psj.2023.102532_bib0011","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3389\/fcimb.2020.00407","article-title":"Aedes mosquito salivary components and their effect on the immune response to arboviruses","volume":"10","author":"Guerrero","year":"2020","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.psj.2023.102532_bib0012","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1007\/s00726-016-2231-2","article-title":"Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection","volume":"48","author":"Hardbower","year":"2016","journal-title":"Amino Acids"},{"key":"10.1016\/j.psj.2023.102532_bib0015","first-page":"72","article-title":"Effect of red mite (Dermanyssus gallinae) infestation on the performance and immune profile in vaccinated broiler breeder flocks","volume":"6","author":"Kaoud","year":"2010","journal-title":"J. Am. Sci."},{"key":"10.1016\/j.psj.2023.102532_bib0017","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jprot.2015.07.005","article-title":"Modulation of host immunity by tick saliva","volume":"128","author":"Kot\u00e1l","year":"2015","journal-title":"J Proteomics"},{"key":"10.1016\/j.psj.2023.102532_bib0018","doi-asserted-by":"crossref","first-page":"26298","DOI":"10.1074\/jbc.M513010200","article-title":"Antiinflammatory and immunosuppressive activity of sialostatin L, a salivary cystatin from the tick Ixodes scapularis","volume":"281","author":"Kotsyfakis","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.psj.2023.102532_bib0019","first-page":"231","article-title":"Influence of Dermanyssus gallinae (poultry red mite) invasion on the plasma levels of corticosterone, catecholamines and proteins in layer hens","volume":"12","author":"Kowalski","year":"2009","journal-title":"Pol. J. Vet. Sci."},{"key":"10.1016\/j.psj.2023.102532_bib0020","doi-asserted-by":"crossref","first-page":"987","DOI":"10.3390\/ani10060987","article-title":"Changes in the percentages of B- and T-lymphocytes and antibody titres in laying hens infested with Dermanyssus gallinae-A preliminary study","volume":"10","author":"Koziatek-Sad\u0142owska","year":"2020","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.psj.2023.102532_bib0021","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/ni.1990","article-title":"IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses","volume":"12","author":"Krausgruber","year":"2011","journal-title":"Nat. Immunol"},{"key":"10.1016\/j.psj.2023.102532_bib0022","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1128\/IAI.69.1.575-578.2001","article-title":"Tick salivary gland extract inhibits killing of Borrelia afzelii spirochetes by mouse macrophages","volume":"69","author":"Kuthejlov\u00e1","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.psj.2023.102532_bib0023","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/jmedent\/43.6.1208","article-title":"Effect of tick saliva on mechanisms of innate immune response against Borrelia afzelii","volume":"43","author":"K\u00fdckov\u00e1","year":"2006","journal-title":"J. Med. Entomol."},{"key":"10.1016\/j.psj.2023.102532_bib0024","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0092-8674(95)90490-5","article-title":"Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock","volume":"80","author":"Li","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.psj.2023.102532_bib0026","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10493-008-9224-0","article-title":"Evaluation of the poultry red mite, Dermanyssus gallinae (Acari: Dermanyssidae) susceptibility to some acaricides in field populations from Italy","volume":"48","author":"Marangi","year":"2009","journal-title":"Exp. Appl. Acarol."},{"key":"10.1016\/j.psj.2023.102532_bib0028","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s00436-001-0515-1","article-title":"Immunosuppressive effects of Ixodes ricinus tick saliva or salivary gland extracts on innate and acquired immune response of BALB\/c mice","volume":"88","author":"Mejri","year":"2002","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.psj.2023.102532_bib0029","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1017\/S0043933909000403","article-title":"Control methods for Dermanyssus gallinae in systems for laying hens: results of an international seminar","volume":"65","author":"Mul","year":"2009","journal-title":"Worlds Poult. Sci. J."},{"key":"10.1016\/j.psj.2023.102532_bib0030","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.12688\/f1000research.26398.1","article-title":"The evaluation of feeding, mortality and oviposition of poultry red mite (Dermanyssus gallinae) on aging hens using a high welfare on-hen feeding device","volume":"9","author":"Nunn","year":"2020","journal-title":"F1000Res"},{"key":"10.1016\/j.psj.2023.102532_bib0031","doi-asserted-by":"crossref","unstructured":"Nuttall P.A., Tick saliva and its role in pathogen transmission, Wien. Klin. Wochenschr, 2019, online ahead of print.","DOI":"10.1007\/s00508-019-1500-y"},{"key":"10.1016\/j.psj.2023.102532_bib0032","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/1756-3305-6-261","article-title":"Prostaglandin E(2) in tick saliva regulates macrophage cell migration and cytokine profile","volume":"6","author":"Poole","year":"2013","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.psj.2023.102532_bib0033","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/mve.12333","article-title":"Circulation dynamics of Salmonella enterica subsp. Enterica ser. Gallinarum biovar Gallinarum in a poultry farm infested by Dermanyssus gallinae","volume":"33","author":"Pugliese","year":"2019","journal-title":"Med. Vet. Entomol"},{"key":"10.1016\/j.psj.2023.102532_bib0034","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.4049\/jimmunol.179.3.1913","article-title":"Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages","volume":"179","author":"Qu","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.psj.2023.102532_bib0035","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1093\/jmedent\/29.5.818","article-title":"Modulation of host-immune responses by ticks (Acari: Ixodidae): effect of salivary gland extracts on host macrophages and lymphocyte cytokine production","volume":"29","author":"Ramachandra","year":"1992","journal-title":"J. Med. Entomol."},{"key":"10.1016\/j.psj.2023.102532_bib0036","doi-asserted-by":"crossref","first-page":"305","DOI":"10.14411\/fp.2003.050","article-title":"Modulation of human lymphocyte proliferation by salivary gland extracts of ixodid ticks (Acari: Ixodidae): effect of feeding stage and sex","volume":"50","author":"Roln\u00edkov\u00e1","year":"2003","journal-title":"Folia Parasitol. (Praha)"},{"key":"10.1016\/j.psj.2023.102532_bib0039","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/s41598-020-80251-y","article-title":"Tick saliva-induced programmed death-1 and PD-ligand 1 and its related host immunosuppression","volume":"11","author":"Sajiki","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2023.102532_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ttbdis.2019.101332","article-title":"Immunosuppressive effects of sialostatin L1 and L2 isolated from the taiga tick Ixodes persulcatus Schulze","volume":"11","author":"Sajiki","year":"2020","journal-title":"Ticks Tick Borne Dis"},{"key":"10.1016\/j.psj.2023.102532_bib0041","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/ni.1920","article-title":"The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection","volume":"11","author":"Satoh","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.psj.2023.102532_bib0042","doi-asserted-by":"crossref","first-page":"eabc8433","DOI":"10.1126\/science.abc8433","article-title":"Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10","volume":"371","author":"Saxton","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.psj.2023.102532_bib0043","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13071-021-05142-1","article-title":"Dermanyssus gallinae: the long journey of the poultry red mite to become a vector","volume":"15","author":"Schiavone","year":"2022","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.psj.2023.102532_bib0044","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.trstmh.2008.01.024","article-title":"The enhancement of arbovirus transmission and disease by mosquito saliva is associated with modulation of the host immune response","volume":"102","author":"Schneider","year":"2008","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.psj.2023.102532_bib0045","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1089\/vim.2004.17.565","article-title":"Aedes aegypti salivary gland extracts modulate anti-viral and TH1\/TH2 cytokine responses to Sindbis virus infection","volume":"17","author":"Schneider","year":"2004","journal-title":"Viral Immunol"},{"key":"10.1016\/j.psj.2023.102532_bib0046","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.4049\/jimmunol.1002040","article-title":"Regulatory T cell properties of chicken CD4+CD25+ cells","volume":"186","author":"Shanmugasundaram","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.psj.2023.102532_bib0047","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3389\/fcimb.2017.00281","article-title":"The essential role of tick salivary glands and saliva in tick feeding and pathogen transmission","volume":"7","author":"\u0160imo","year":"2017","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.psj.2023.102532_bib0048","doi-asserted-by":"crossref","first-page":"26","DOI":"10.15653\/TPG-150413","article-title":"Role of the poultry red mite (Dermanyssus gallinae) in the transmission of avian influenza A virus","volume":"44","author":"Sommer","year":"2016","journal-title":"Tierarztl Prax. Ausg. G Grosstiere Nutztiere"},{"key":"10.1016\/j.psj.2023.102532_bib0049","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10493-008-9233-z","article-title":"Prevalence and key figures for the poultry red mite Dermanyssus gallinae infections in poultry farm systems","volume":"48","author":"Sparagano","year":"2009","journal-title":"Exp. Appl. Acarol."},{"key":"10.1016\/j.psj.2023.102532_bib0050","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1146\/annurev-ento-011613-162101","article-title":"Significance and control of the poultry red mite, dermanyssus gallinae","volume":"59","author":"Sparagano","year":"2014","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.psj.2023.102532_bib0051","doi-asserted-by":"crossref","first-page":"W71","DOI":"10.1093\/nar\/gkm306","article-title":"Primer3Plus, an enhanced web interface to Primer3","volume":"35","author":"Untergasser","year":"2007","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.psj.2023.102532_bib0052","first-page":"26","article-title":"Wage war against the red mite!","volume":"44","author":"van Emous","year":"2005","journal-title":"Poult. Int."},{"key":"10.1016\/j.psj.2023.102532_bib0053","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nri2343","article-title":"How regulatory T cells work","volume":"8","author":"Vignali","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.psj.2023.102532_bib0054","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nri3862","article-title":"Molecular and cellular insight into T cell exhaustion","volume":"15","author":"Wherry","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.psj.2023.102532_bib0055","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1080\/00034983.1982.11687593","article-title":"Influence of Dermacentor andersoni infestation on lymphocyte responsiveness to mitogens","volume":"76","author":"Wikel","year":"1982","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.psj.2023.102532_bib0056","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF01262196","article-title":"The susceptibility of the poultry red mite, Dermanyssus gallinae (De Geer, 1778), to some acaricides under laboratory conditions","volume":"1","author":"Zeman","year":"1985","journal-title":"Exp. Appl. Acarol."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579123000561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579123000561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:00:15Z","timestamp":1777395615000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579123000561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S0032579123000561"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2023.102532","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suppressive modulation of host immune responses by Dermanyssus gallinae infestation","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2023.102532","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"102532"}}