{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:41:01Z","timestamp":1782920461134,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T00:00:00Z","timestamp":1679788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016683","name":"Iowa Agriculture and Home Economics Experiment Station, Iowa State University","doi-asserted-by":"publisher","award":["IOW03721"],"award-info":[{"award-number":["IOW03721"]}],"id":[{"id":"10.13039\/100016683","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020184","name":"University of Maryland Eastern Shore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020184","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["2019-67018-29185"],"award-info":[{"award-number":["2019-67018-29185"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.psj.2023.102680","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T12:36:23Z","timestamp":1680698183000},"page":"102680","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["The elastase and melanogenesis inhibitory and anti-inflammatory activities of phosvitin phosphopeptides produced using high-temperature and mild-pressure (HTMP) pretreatment and enzyme hydrolysis combinations"],"prefix":"10.1016","volume":"102","author":[{"given":"Ji-Eun","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong Jeun","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2109-3798","authenticated-orcid":false,"given":"Cheorun","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byungrok","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Dong","family":"Paik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9523-7630","authenticated-orcid":false,"given":"Dong Uk","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2023.102680_bib0001","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.3382\/ps\/pex399","article-title":"Antioxidant, angiotensin-converting enzyme inhibitory activity and other functional properties of egg white proteins and their derived peptides \u2013 a review","volume":"97","author":"Abeyrathne","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2023.102680_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2019.170170","article-title":"Potential role of natural bioactive peptides for the development of cosmeceutical skin products","volume":"122","author":"Aguilar-Toal\u00e1","year":"2019","journal-title":"Peptides"},{"key":"10.1016\/j.psj.2023.102680_bib0003","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1021\/bi00314a003","article-title":"Amino acid sequence of phosvitin derived from the nucleotide sequence of part of the chicken vitellogenin gene","volume":"23","author":"Byrne","year":"1984","journal-title":"Biochemistry"},{"key":"10.1016\/j.psj.2023.102680_bib0004","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1055\/s-2006-962319","article-title":"Results of a large-scale screen of microalgae for the production of protease inhibitors","volume":"54","author":"Cannell","year":"1988","journal-title":"Planta Med."},{"key":"10.1016\/j.psj.2023.102680_bib0005","first-page":"936","article-title":"Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing1","volume":"47","author":"Carmichael","year":"1987","journal-title":"Cancer Res."},{"key":"10.1016\/j.psj.2023.102680_bib0006","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.3390\/nu13124383","article-title":"Natural and synthetic bioactives for skin health, disease, and management","volume":"13","author":"Chamcheu","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.psj.2023.102680_bib0007","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ijbiomac.2019.02.066","article-title":"Effect of chitosan molecular weight on anti-inflammatory activity in the RAW 264.7 macrophage model","volume":"131","author":"Chang","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.psj.2023.102680_bib0008","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.indcrop.2018.06.032","article-title":"Chemical composition, antioxidant, anti-melanogenic, and anti-inflammatory activities of Glechoma hederacea (Lamiaceae) essential oil","volume":"122","author":"Chou","year":"2018","journal-title":"Ind. Crops. Prod."},{"key":"10.1016\/j.psj.2023.102680_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2019.108585","article-title":"Lupine protein hydrolysates decrease the inflammatory response and improve the oxidative status in human peripheral lymphocytes","volume":"126","author":"Cruz-Chamorro","year":"2019","journal-title":"Food Res. Int."},{"key":"10.1016\/j.psj.2023.102680_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.129471","article-title":"Separation, identification, and molecular docking of tyrosinase inhibitory peptides from the hydrolysates of defatted walnut (Juglans regia L.) meal","volume":"353","author":"Feng","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.psj.2023.102680_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2020.104320","article-title":"Anti-inflammatory effects of three selenium-enriched brown rice protein hydrolysates in LPS-induced RAW264.7 macrophages via NF-\u03baB\/MAPKs signaling pathways","volume":"76","author":"Feng","year":"2021","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.psj.2023.102680_bib0012","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3390\/molecules24020242","article-title":"Antioxidant and anti-melanogenic properties of essential oil from the peel of pomelo cv. Guan Xi","volume":"24","author":"He","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.psj.2023.102680_bib0013","first-page":"1474","article-title":"Regulation of melanin synthesis of B16 mouse melanoma cells by 1 alpha, 25-dihydroxyvitamin D3 and retinoic acid","volume":"45","author":"Hosoi","year":"1985","journal-title":"Cancer Res."},{"key":"10.1016\/j.psj.2023.102680_bib0014","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3390\/foods11030391","article-title":"Effect of grass carp scale collagen peptide FTGML on cAMP-PI3K\/Akt and MAPK signaling pathways in B16F10 melanoma cells and correlation between anti-melanin and antioxidant properties","volume":"11","author":"Hu","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.psj.2023.102680_bib0015","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/1750-3841.14430","article-title":"How can the value and use of egg yolk be increased?","volume":"84","author":"Huang","year":"2019","journal-title":"J. Food Sci."},{"key":"10.1016\/j.psj.2023.102680_bib0016","doi-asserted-by":"crossref","first-page":"14086","DOI":"10.1021\/acs.jafc.9b05973","article-title":"Effective preparation method of phosphopeptides from phosvitin and the analysis of peptide profiles using tandem mass spectrometry","volume":"67","author":"Huang","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.psj.2023.102680_bib0017","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jff.2018.03.043","article-title":"Inhibitory effect of carvacrol on melanin synthesis via suppression of tyrosinase expression","volume":"45","author":"Jeon","year":"2018","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.psj.2023.102680_bib0018","doi-asserted-by":"crossref","first-page":"688","DOI":"10.3390\/md17120688","article-title":"Potential use of seaweed bioactive compounds in skincare - a review","volume":"17","author":"Jesumani","year":"2019","journal-title":"Marine Drugs"},{"key":"10.1016\/j.psj.2023.102680_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2020.100636","article-title":"Antioxidant and anti-inflammatory activity of peptides from foxtail millet (Setaria italica) prolamins in HaCaT cells and RAW264.7 murine macrophages","volume":"36","author":"Ji","year":"2020","journal-title":"Food Biosci."},{"key":"10.1016\/j.psj.2023.102680_bib0020","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.foodchem.2012.05.113","article-title":"The functional property of egg yolk phosvitin as a melanogenesis inhibitor","volume":"135","author":"Jung","year":"2012","journal-title":"Food Chem."},{"key":"10.1016\/j.psj.2023.102680_bib0021","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.3390\/antiox11071396","article-title":"Enzymatic biosynthesis of simple phenolic glycosides as potential anti-melanogenic antioxidants","volume":"11","author":"Jung","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.psj.2023.102680_bib0022","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.3382\/ps.2014-04093","article-title":"Sequential separation of immunoglobulin Y and phosvitin from chicken egg yolk","volume":"93","author":"Lee","year":"2014","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2023.102680_bib0023","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.3390\/molecules27092613","article-title":"Mechanistic insights into the ameliorating effect of melanogenesis of psoralen derivatives in B16F10 melanoma cells","volume":"27","author":"Lee","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.psj.2023.102680_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2022.105264","article-title":"Immunostimulatory effect of egg yolk phosvitin phosphopeptides produced by high-temperature and mild-pressure pretreatment and enzyme combinations in RAW 264.7 cells via TLR2\/MAPK signaling pathway","volume":"98","author":"Lee","year":"2022","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.psj.2023.102680_bib0025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/00071668.2019.1686124","article-title":"Anti-elastase and anti-hyaluronidase activity of phosvitin isolated from hen egg yolk","volume":"61","author":"Lee","year":"2020","journal-title":"Br. Poult. Sci."},{"key":"10.1016\/j.psj.2023.102680_bib0026","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jff.2017.08.025","article-title":"Non-starch polysaccharide from Chinese yam activated RAW 264.7 macrophages through the Toll-like receptor 4 (TLR4)-NF-\u03baB signaling pathway","volume":"37","author":"Li","year":"2017","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.psj.2023.102680_bib0027","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1080\/10408398.2017.1329704","article-title":"Bioactive peptides derived from egg proteins: a review","volume":"58","author":"Liu","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.psj.2023.102680_bib0028","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.3390\/ijms20051043","article-title":"Anti-wrinkling and anti-melanogenic effect of Pradosia mutisii methanol extract","volume":"20","author":"Lorz","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.psj.2023.102680_bib0029","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.foodres.2017.07.032","article-title":"Anti-inflammatory effects of egg yolk livetins (\u03b1, \u03b2, and \u03b3-livetin) fraction and its enzymatic hydrolysates in lipopolysaccharide-induced RAW 264.7 macrophages","volume":"100","author":"Meram","year":"2017","journal-title":"Food Res. Int."},{"key":"10.1016\/j.psj.2023.102680_bib0030","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jdermsci.2021.08.008","article-title":"Multiple roles of macrophage in skin","volume":"104","author":"Nakai","year":"2021","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.psj.2023.102680_bib0031","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3390\/cosmetics7030060","article-title":"Tyrosinase and melanogenesis inhibition by indigenous African plants: a review","volume":"7","author":"Opperman","year":"2020","journal-title":"Cosmetics"},{"key":"10.1016\/j.psj.2023.102680_bib0032","doi-asserted-by":"crossref","first-page":"R143","DOI":"10.1111\/j.1750-3841.2011.02291.x","article-title":"Egg yolk phosvitin and functional phosphopeptides - review","volume":"76","author":"Samaraweera","year":"2011","journal-title":"J. Food Sci."},{"key":"10.1016\/j.psj.2023.102680_bib0033","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.3390\/pharmaceutics13081185","article-title":"Anti-Melanogenic mechanism of tetrahydrocurcumin and enhancing its topical delivery efficacy using a lecithin-based nanoemulsion","volume":"13","author":"Tang","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.psj.2023.102680_bib0034","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.sajb.2019.06.031","article-title":"Cosmeceutical efficiency by some plant extracts used traditionally for skin care in inhibiting tyrosinase activity in a human epidermal melanocyte (HEM) cell line","volume":"126","author":"Thibane","year":"2019","journal-title":"S. Afr. J. Bot."},{"key":"10.1016\/j.psj.2023.102680_bib0035","doi-asserted-by":"crossref","first-page":"16723","DOI":"10.3390\/molecules200916723","article-title":"Antioxidant, anti-aging, and anti-melanogenic properties of the essential oils from two varieties of Alpinia zerumbet","volume":"20","author":"Tu","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.psj.2023.102680_bib0036","first-page":"517","article-title":"The effect of tyrosinase inhibition for aloe","volume":"3981","author":"Yagi","year":"1986","journal-title":"Planta Med."},{"key":"10.1016\/j.psj.2023.102680_bib0037","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00424-017-1953-7","article-title":"The role of macrophages in skin homeostasis","volume":"469","author":"Yanez","year":"2017","journal-title":"Pflug. Arch. Eur. J. Physiol."},{"key":"10.1016\/j.psj.2023.102680_bib0038","doi-asserted-by":"crossref","first-page":"918","DOI":"10.3390\/plants11070918","article-title":"GC\/MS profiling, anti-collagenase, anti-elastase, anti-tyrosinase and anti-hyaluronidase activities of a Stenocarpus sinuatus leaves extract","volume":"11","author":"Younis","year":"2022","journal-title":"Plants"},{"key":"10.1016\/j.psj.2023.102680_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2020.104634","article-title":"Anti-melanogenic effects of epigallocatechin-3-gallate (EGCG), epicatechin-3-gallate (ECG) and gallocatechin-3-gallate (GCG) via down-regulation of cAMP\/CREB\/MITF signaling pathway in B16F10 melanoma cells","volume":"145","author":"Zhang","year":"2020","journal-title":"Fitoterapia"},{"key":"10.1016\/j.psj.2023.102680_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.127539","article-title":"Enhanced antioxidant, anti-inflammatory and \u03b1-glucosidase inhibitory activities of citrus hesperidin by acid-catalyzed hydrolysis","volume":"336","author":"Zheng","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.psj.2023.102680_bib0041","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/app13010184","article-title":"Anti-melanogenesis effect of Rosa rugosa on \u03b1-MSH-induced B16F10 cells via PKA\/CREB pathway activation","volume":"13","author":"Zhou","year":"2023","journal-title":"Appl. Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579123002031?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579123002031?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T22:49:52Z","timestamp":1758494992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579123002031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S0032579123002031"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2023.102680","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The elastase and melanogenesis inhibitory and anti-inflammatory activities of phosvitin phosphopeptides produced using high-temperature and mild-pressure (HTMP) pretreatment and enzyme hydrolysis combinations","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2023.102680","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"102680"}}