{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:48:39Z","timestamp":1771336119557,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.psj.2023.103226","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T13:54:57Z","timestamp":1698933297000},"page":"103226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["A microbial muramidase improves growth performance and reduces inflammatory cell infiltration in the intestine of broilers chickens under Eimeria and Clostridium perfringens challenge"],"prefix":"10.1016","volume":"103","author":[{"given":"Cristiano","family":"Bortoluzzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3120-8333","authenticated-orcid":false,"given":"Leticia C.","family":"Bittencourt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1007-7250","authenticated-orcid":false,"given":"Estefania","family":"Perez-Calvo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8412-5107","authenticated-orcid":false,"given":"Bruna L.","family":"Belote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Santin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ot\u00e1vio Berti","family":"Sorbara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz F.","family":"Caron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2023.103226_bib0001","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.3390\/ani13081356","article-title":"New insights into the effects of microbial muramidase addition in the diets of broiler chickens","volume":"13","author":"Amer","year":"2023","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.psj.2023.103226_bib0002","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.3382\/ps\/pey064","article-title":"Histological parameters to evaluate intestinal health on broilers challenged with Eimeria and Clostridium perfringens with or without enramycin as growth promoter","volume":"97","author":"Belote","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2023.103226_bib0003","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13567-020-00837-2","article-title":"Re-calculating the cost of coccidiosis in chickens","volume":"51","author":"Blake","year":"2020","journal-title":"Vet. Res."},{"key":"10.1016\/j.psj.2023.103226_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102955","article-title":"Effect of microbial muramidase supplementation in diets formulated with different fiber profile for broiler chickens raised under various coccidiosis management programs","volume":"102","author":"Bortoluzzi","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2023.103226_bib0005","doi-asserted-by":"crossref","first-page":"5559","DOI":"10.1038\/s41598-022-09546-6","article-title":"A multi-omics approach to elucidate the mechanisms of action of a dietary muramidase administered to broiler chickens","volume":"12","author":"Brugaletta","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2023.103226_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2022.104524","article-title":"Novel model for chronic intestinal inflammation in chickens: (2) immunologic mechanism behind the inflammatory response","volume":"138","author":"Cardoso Dal Pont","year":"2023","journal-title":"Dev. Compar. Immunol."},{"key":"10.1016\/j.psj.2023.103226_bib0007","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.vetimm.2007.10.014","article-title":"Coccidia-induced mucogenesis promotes the onset of necrotic enteritis by supporting Clostridium perfringens growth","volume":"122","author":"Collier","year":"2008","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.psj.2023.103226_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.102232","article-title":"Effects of a microbial muramidase on the growth performance, intestinal permeability, nutrient digestibility, and welfare of broiler chickens","volume":"101","author":"Goes","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2023.103226_bib0009","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.3382\/ps\/pey556","article-title":"Evaluation of a microbial muramidase supplementation on growth performance, apparent ileal digestibility, and intestinal histology of broiler chickens","volume":"98","author":"Goodarzi Boroojeni","year":"2019","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2023.103226_bib0010","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cyto.2010.12.009","article-title":"Modulation of chicken macrophage effector function by TH1\/TH2 cytokines","volume":"53","author":"He","year":"2011","journal-title":"Cytokine"},{"key":"10.1016\/j.psj.2023.103226_bib0011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2019.02732","article-title":"Involvement of T cell immunity in avian coccidiosis","volume":"10","author":"Kim","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2023.103226_bib0012","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.3382\/ps\/pey087","article-title":"Inflammatory phenotypes in the intestine of poultry: not all inflammation is created equal","volume":"97","author":"Kogut","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2023.103226_bib0013","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.3382\/ps\/pew397","article-title":"Effect of aflatoxin experimental ingestion and Eimeira vaccine challenges on intestinal histopathology and immune cellular dynamic of broilers: applying an intestinal health index","volume":"96","author":"Kraieski","year":"2017","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2023.103226_bib0014","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.cyto.2007.02.007","article-title":"Neutrophil CD64 expression and serum IL-8: sensitive early markers of severity and outcome in sepsis","volume":"36","author":"Livaditi","year":"2006","journal-title":"Cytokine"},{"key":"10.1016\/j.psj.2023.103226_bib0015","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nri2097","article-title":"TH1 cells control themselves by producing interleukin-10","volume":"7","author":"O'Garra","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.psj.2023.103226_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102619","article-title":"Dietary muramidase increases ileal amino acid digestibility of wheat and corn-based broiler diets without affecting endogenous amino acid losses","volume":"102","author":"P\u00e9rez-Calvo","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2023.103226_bib0017","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/00071668.2020.1817330","article-title":"Dietary microbial muramidase improves feed efficiency, energy and nutrient availability and welfare of broilers fed commercial type diets containing exogenous enzymes","volume":"62","author":"Pirgozliev","year":"2021","journal-title":"Br. Poult. Sci."},{"key":"10.1016\/j.psj.2023.103226_bib0018","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1080\/03079457.2016.1139688","article-title":"The pathogenesis of necrotic enteritis in chickens: what we know and what we need to know: a review","volume":"45","author":"Prescott","year":"2016","journal-title":"Avian Pathol."},{"key":"10.1016\/j.psj.2023.103226_bib0019","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1093\/ps\/77.7.978","article-title":"Role of macrophages in avian health and disease","volume":"77","author":"Qureshi","year":"1998","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2023.103226_bib0020","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.3382\/ps\/pew035","article-title":"Effects of Eimeria acervulina infection severity on growth performance, apparent ileal amino acid digestibility, and plasma concentrations of amino acids, carotenoids, and \u03b11-acid glycoprotein in broilers","volume":"95","author":"Rochell","year":"2016","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2023.103226_bib0021","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3382\/ps\/pez466","article-title":"Evaluation of dietary supplementation of a novel microbial muramidase on gastrointestinal functionality and growth performance in broiler chickens","volume":"99","author":"Sais","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2023.103226_bib0022","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.plaphy.2015.07.004","article-title":"Lysozyme- and chitinase activity in latex bearing plants of genus Euphorbia\u2014a contribution to plant defense mechanism","volume":"95","author":"Sytwala","year":"2015","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.psj.2023.103226_bib0023","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1017\/S0007114514001846","article-title":"Supplemental dietary l-arginine attenuates intestinal mucosal disruption during a coccidial vaccine challenge in broiler chickens","volume":"112","author":"Tan","year":"2014","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.psj.2023.103226_bib0024","first-page":"69","article-title":"Invited review: MDP and other muropeptides \u2014 direct and synergistic effects on the immune system","volume":"12","author":"Traub","year":"2006","journal-title":"J. Endotoxin Res."},{"key":"10.1016\/j.psj.2023.103226_bib0025","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3382\/ps.0741117","article-title":"Eimeria acervulina infection: evidence for the involvement of CD8+ T lymphocytes in sporozoite transport and host protection","volume":"74","author":"Trout","year":"1995","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2023.103226_bib0026","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1021\/jf048692o","article-title":"Development of an ELISA for quantifying lysozyme in hen egg white","volume":"53","author":"Vidal","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.psj.2023.103226_bib0027","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1017\/S0007114520004493","article-title":"Dietary muramidase degrades bacterial peptidoglycan to NOD-activating muramyl dipeptides and reduces duodenal inflammation in broiler chickens","volume":"126","author":"Wang","year":"2021","journal-title":"Br. J. Nutr."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579123007459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579123007459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T23:01:07Z","timestamp":1758495667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579123007459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S0032579123007459"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2023.103226","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A microbial muramidase improves growth performance and reduces inflammatory cell infiltration in the intestine of broilers chickens under Eimeria and Clostridium perfringens challenge","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2023.103226","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"103226"}}