{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:15:23Z","timestamp":1791724523816,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.psj.2024.103598","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T11:25:53Z","timestamp":1709119553000},"page":"103598","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Deoxynivalenol and fumonisin predispose broilers to bacterial chondronecrosis with osteomyelitis lameness"],"prefix":"10.1016","volume":"103","author":[{"given":"Khawla","family":"Alharbi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4522-0758","authenticated-orcid":false,"given":"Nnamdi","family":"Ekesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amer","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andi","family":"Asnayanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jundi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1285-2126","authenticated-orcid":false,"given":"Raj","family":"Murugesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Rochell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Kidd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5122-9150","authenticated-orcid":false,"given":"Adnan","family":"Alrubaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2024.103598_bib0001","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.diagmicrobio.2012.11.008","article-title":"High-resolution melt analysis for species identification of coagulase-negative staphylococci derived from bovine milk","volume":"75","author":"Ajitkumar","year":"2013","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.psj.2024.103598_bib0002","article-title":"Genome analysis of Staphylococcus agnetis, an agent of lameness in broiler chickens","volume":"10","author":"Alrubaye","year":"2015","journal-title":"PLoS. One"},{"key":"10.1016\/j.psj.2024.103598_bib0003","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3382\/ps\/pew299","article-title":"Chondronecrosis with osteomyelitis in broilers: Further defining a bacterial challenge model using the wire flooring model","volume":"96","author":"Alrubaye","year":"2017","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103598_bib0004","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.1016\/j.psj.2020.08.027","article-title":"Chondronecrosis with osteomyelitis in broilers: Further defining lameness-inducing models with wire or litter flooring to evaluate protection with organic trace minerals","volume":"99","author":"Alrubaye","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103598_bib0005","doi-asserted-by":"crossref","first-page":"6474","DOI":"10.1016\/j.psj.2020.08.067","article-title":"Chondronecrosis with osteomyelitis in broilers: further defining a bacterial challenge model using standard litter flooring and protection with probiotics","volume":"99","author":"Alrubaye","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103598_bib0006","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.3382\/ps.2011-01470","article-title":"Meta-analytical study of productive and nutritional interactions of mycotoxins in broilers","volume":"90","author":"Andretta","year":"2011","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103598_bib0007","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fvets.2017.00056","article-title":"Optimizing fluorescein isothiocyanate dextran measurement as a biomarker in a 24-h feed restriction model to induce gut permeability in broiler chickens","volume":"4","author":"Baxter","year":"2017","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.psj.2024.103598_bib0008","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.fct.2006.05.018","article-title":"Mycotoxin fumonisin B1 selectively down-regulates the basal IL-8 expression in pig intestine: in vivo and in vitro studies","volume":"44","author":"Bouhet","year":"2006","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.psj.2024.103598_bib0009","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1080\/00071660902942783","article-title":"Clinical and morphological investigations on the prevalence of lameness associated with femoral head necrosis in broilers","volume":"50","author":"Dinev","year":"2009","journal-title":"Br. Poult. Sci."},{"key":"10.1016\/j.psj.2024.103598_bib0010","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1017\/S0043933912000293","article-title":"Rickets: prevalence of its forms and association with other pathological conditions in broiler chickens","volume":"68","author":"Dinev","year":"2012","journal-title":"Worlds. Poult. Sci. J."},{"key":"10.1016\/j.psj.2024.103598_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101148","article-title":"Analysis of genomes of bacterial isolates from lameness outbreaks in broilers","volume":"100","author":"Ekesi","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103598_bib0015","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.3390\/ani11072129","article-title":"Effect of nanosilica and bentonite as mycotoxins adsorbent agent in broiler chickens\u2019 diet on growth performance and hepatic histopathology","volume":"11","author":"Ghazalah","year":"2021","journal-title":"Animals"},{"key":"10.1016\/j.psj.2024.103598_bib0016","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.3382\/ps.2013-03781","article-title":"Evaluating portable wire-flooring models for inducing bacterial chondronecrosis with osteomyelitis in broilers","volume":"93","author":"Gilley","year":"2014","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103598_bib0017","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3920\/WMJ2008.1015","article-title":"Impact of feed-borne mycotoxins on avian cell-mediated and humoral immune responses","volume":"1","author":"Girish","year":"2008","journal-title":"World Mycotoxin. J."},{"key":"10.1016\/j.psj.2024.103598_bib0018","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3390\/toxins11070375","article-title":"Global mycotoxin occurrence in feed: a ten-year survey","volume":"11","author":"Gruber-Dorninger","year":"2019","journal-title":"Toxins. (Basel)"},{"key":"10.1016\/j.psj.2024.103598_bib0012","article-title":"Molecular survey of bacterial communities associated with bacterial chondronecrosis with osteomyelitis (bco) in broilers","volume":"10","author":"Jiang","year":"2015","journal-title":"PLoS. One"},{"key":"10.1016\/j.psj.2024.103598_bib0013","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3109\/08923979509019758","article-title":"Trichothecene mycotoxins depress the mononuclear-phagocytic system of young turkeys","volume":"17","author":"Kidd","year":"1995","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.psj.2024.103598_bib0014","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1515\/aoas-2016-0098","article-title":"Infectious and non-infectious factors associated with leg disorders in poultry\u2013a review","volume":"17","author":"Kiero\u0144czyk","year":"2017","journal-title":"Annals of animal science"},{"key":"10.1016\/j.psj.2024.103598_bib0019","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3382\/ps\/pez484","article-title":"The impact of deoxynivalenol, Fumonisins, and their combination on performance, nutrient, and energy digestibility in broiler chickens","volume":"99","author":"Liu","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103598_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101202","article-title":"Assay considerations for fluorescein isothiocyanate-dextran (FITC-d): an indicator of intestinal permeability in broiler chickens","volume":"100","author":"Liu","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103598_bib0021","first-page":"5134","article-title":"Dietary deoxynivalenol and oral lipopolysaccharide challenge differently affect intestinal innate immune response and barrier function in broiler chickens","volume":"96","author":"Lucke","year":"2018","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.psj.2024.103598_bib0022","doi-asserted-by":"crossref","DOI":"10.1038\/srep25882","article-title":"An investigation into blood microbiota and its potential association with bacterial chondronecrosis with osteomyelitis (BCO) in broilers","volume":"6","author":"Mandal","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2024.103598_bib0023","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s11914-015-0292-x","article-title":"Prebiotic and probiotic regulation of bone health: role of the intestine and its microbiome","volume":"13","author":"McCabe","year":"2015","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.psj.2024.103598_bib0024","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1080\/030794500750047243","article-title":"Bacterial chondronecrosis with osteomyelitis ('femoral head necrosis') of broiler chickens: a review","volume":"29","author":"McNamee","year":"2000","journal-title":"Avian Pathology"},{"key":"10.1016\/j.psj.2024.103598_bib0025","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3382\/ps\/pev075","article-title":"Prevalence and effects of mycotoxins on poultry health and performance, and recent development in mycotoxin counteracting strategies","volume":"94","author":"Murugesan","year":"2015","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103598_bib0026","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.anifeedsci.2018.01.017","article-title":"Strategies to prevent and reduce mycotoxins for compound feed manufacturing","volume":"237","author":"Peng","year":"2018","journal-title":"Anim. Feed. Sci. Technol."},{"key":"10.1016\/j.psj.2024.103598_bib0030","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.aninu.2016.03.001","article-title":"Impact of mycotoxin on immune response and consequences for pig health","volume":"2","author":"Pierron","year":"2016","journal-title":"Animal Nutrition"},{"key":"10.1016\/j.psj.2024.103598_bib0031","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.taap.2009.03.003","article-title":"The food contaminant deoxynivalenol decreases intestinal barrier permeability and reduces claudin expression","volume":"237","author":"Pinton","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.psj.2024.103598_bib0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/009841096161447","article-title":"Invited review: toxicology of deoxynivalenol (vomitoxin)","volume":"48","author":"Rotter","year":"1996","journal-title":"J. Toxicol. Environ. Health a"},{"key":"10.1016\/j.psj.2024.103598_bib0027","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3390\/toxins11050290","article-title":"Prevalent mycotoxins in animal feed: Occurrence and analytical methods","volume":"11","author":"Santos Pereira","year":"2019","journal-title":"Toxins. (Basel)"},{"key":"10.1016\/j.psj.2024.103598_bib0028","doi-asserted-by":"crossref","first-page":"e00484","DOI":"10.1128\/AEM.00484-20","article-title":"Whole-genome comparisons of Staphylococcus agnetis isolates from cattle and chickens","volume":"86","author":"Shwani","year":"2020","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.psj.2024.103598_bib0033","doi-asserted-by":"crossref","first-page":"104247","DOI":"10.1016\/j.micpath.2020.104247","article-title":"Pathogenetic effects of feed intake containing of fumonisin (Fusarium verticillioides) in early broiler chicks and consequences on weight gain","volume":"147","author":"Sousa","year":"2020","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.psj.2024.103598_bib0029","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1177\/104063871002200426","article-title":"Arthritis and osteomyelitis associated with Enterococcus cecorum infection in broiler and broiler breeder chickens in Ontario, Canada","volume":"22","author":"Stalker","year":"2010","journal-title":"Journal of veterinary diagnostic investigation"},{"key":"10.1016\/j.psj.2024.103598_bib0034","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.toxlet.2013.05.003","article-title":"Individual and combined effects of Fusarium toxins on the mRNA expression of pro-inflammatory cytokines in swine jejunal epithelial cells","volume":"220","author":"Wan","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.psj.2024.103598_bib0035","doi-asserted-by":"crossref","first-page":"870","DOI":"10.3382\/ps.2011-01907","article-title":"A wire-flooring model for inducing lameness in broilers: evaluation of probiotics as a prophylactic treatment","volume":"91","author":"Wideman","year":"2012","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103598_bib0036","first-page":"183","article-title":"Bone circulatory disturbances in the development of spontaneous bacterial chondronecrosis with osteomyelitis: A translational model for the pathogenesis of femoral head necrosis","volume":"3","author":"Wideman","year":"2013","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.psj.2024.103598_bib0037","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.3382\/ps.2014-03912","article-title":"Bacterial chondronecrosis with osteomyelitis in broilers: Influence of sires and straight-run versus sex-separate rearing","volume":"93","author":"Wideman","year":"2014","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103598_bib0038","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3382\/ps\/pev320","article-title":"Bacterial chondronecrosis with osteomyelitis and lameness in broilers: a review","volume":"95","author":"Wideman","year":"2016","journal-title":"Poult. Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579124001779?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579124001779?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T23:01:06Z","timestamp":1758495666000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579124001779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S0032579124001779"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2024.103598","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deoxynivalenol and fumonisin predispose broilers to bacterial chondronecrosis with osteomyelitis lameness","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2024.103598","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"103598"}}