{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:08:01Z","timestamp":1793106481732,"version":"4.5.0"},"reference-count":116,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32002211"],"award-info":[{"award-number":["32002211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["KJQN202131"],"award-info":[{"award-number":["KJQN202131"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.psj.2024.103949","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T16:28:55Z","timestamp":1717691335000},"page":"103949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Protective effects of chlorogenic acid on the intestinal barrier of broiler chickens: an immunological stress model study"],"prefix":"10.1016","volume":"103","author":[{"given":"Pingping","family":"Zha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2024.103949_bib0001","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.3390\/ani11123471","article-title":"Phytogenic feed additives in poultry: achievements, prospective and challenges","volume":"11","author":"Abdelli","year":"2021","journal-title":"Animals"},{"key":"10.1016\/j.psj.2024.103949_bib0002","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1053\/j.gastro.2011.02.012","article-title":"Interaction between the host innate immune system and microbes in inflammatory bowel disease","volume":"140","author":"Abraham","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.psj.2024.103949_bib0003","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1053\/j.gastro.2010.07.012","article-title":"Caught in the Akt: regulation of Wnt signaling in the intestine","volume":"139","author":"Anderson","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.psj.2024.103949_bib0004","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.abb.2018.01.004","article-title":"Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function","volume":"640","author":"Aratani","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.psj.2024.103949_bib0005","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.pharmthera.2014.11.016","article-title":"Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases","volume":"148","author":"Beurel","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.psj.2024.103949_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.102199","article-title":"Hepatic transcriptomics and metabolomics indicated pathways associated with immune stress of broilers induced by lipopolysaccharide","volume":"101","author":"Bi","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101612","article-title":"Centennial review: Factors affecting the chicken gastrointestinal microbial composition and their association with gut health and productive performance","volume":"101","author":"Bindari","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0008","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3382\/ps\/pex314","article-title":"Inflammation: friend or foe for animal production?","volume":"97","author":"Broom","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0009","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/JLB.2MR0220-549R","article-title":"ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis","volume":"108","author":"Bui","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.psj.2024.103949_bib0010","doi-asserted-by":"crossref","first-page":"6242","DOI":"10.3390\/ijms22126242","article-title":"Interaction between lipopolysaccharide and gut microbiota in inflammatory bowel diseases","volume":"22","author":"Candelli","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0011","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3390\/microorganisms8010139","article-title":"Dietary factors as triggers of low-grade chronic intestinal inflammation in poultry","volume":"8","author":"Cardoso Dal Pont","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.psj.2024.103949_bib0012","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.anifeedsci.2017.09.012","article-title":"Gastrointestinal functionality in animal nutrition and health: new opportunities for sustainable animal production","volume":"234","author":"Celi","year":"2017","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.psj.2024.103949_bib0013","doi-asserted-by":"crossref","first-page":"e13619","DOI":"10.1111\/asj.13619","article-title":"Effect of chlorogenic acid on intestinal inflammation, antioxidant status, and microbial community of young hens challenged with acute heat stress","volume":"92","author":"Chen","year":"2021","journal-title":"Anim. Sci. J."},{"key":"10.1016\/j.psj.2024.103949_bib0014","doi-asserted-by":"crossref","first-page":"8157","DOI":"10.1007\/s00253-019-10025-8","article-title":"Changes of porcine gut microbiota in response to dietary chlorogenic acid supplementation","volume":"103","author":"Chen","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.psj.2024.103949_bib0015","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jnutbio.2018.06.005","article-title":"Chlorogenic acid improves intestinal barrier functions by suppressing mucosa inflammation and improving antioxidant capacity in weaned pigs","volume":"59","author":"Chen","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.psj.2024.103949_bib0016","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1021\/acsomega.7b01971","article-title":"Chlorogenic acid improves intestinal development via suppressing mucosa inflammation and cell apoptosis in weaned pigs","volume":"3","author":"Chen","year":"2018","journal-title":"ACS Omega"},{"key":"10.1016\/j.psj.2024.103949_bib0017","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1093\/jas\/skx078","article-title":"Dietary chlorogenic acid improves growth performance of weaned pigs through maintaining antioxidant capacity and intestinal digestion and absorption function","volume":"96","author":"Chen","year":"2018","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0018","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1017\/S0007114518000740","article-title":"Dietary l-threonine supplementation attenuates lipopolysaccharide-induced inflammatory responses and intestinal barrier damage of broiler chickens at an early age","volume":"119","author":"Chen","year":"2018","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.psj.2024.103949_bib0019","article-title":"An evaluation of the protective effects of chlorogenic acid on broiler chickens in a dextran sodium sulfate model: a preliminary investigation","volume":"102","author":"Chen","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.anifeedsci.2020.114459","article-title":"Protective effects of dietary supplementation with a silicate clay mineral (palygorskite) in lipopolysaccharide-challenged broiler chickens at an early age","volume":"263","author":"Chen","year":"2020","journal-title":"Anim. Feed Sci Technol."},{"key":"10.1016\/j.psj.2024.103949_bib0021","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00204-010-0585-x","article-title":"Lipopolysaccharide induces apoptotic insults to human alveolar epithelial A549 cells through reactive oxygen species-mediated activation of an intrinsic mitochondrion-dependent pathway","volume":"85","author":"Chuang","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.psj.2024.103949_bib0022","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41580-023-00629-4","article-title":"Mechanisms of BCL-2 family proteins in mitochondrial apoptosis","volume":"24","author":"Czabotar","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.psj.2024.103949_bib0023","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/jpn.13905","article-title":"Bioactive functions of chlorogenic acid and its research progress in pig industry","volume":"108","author":"Dai","year":"2024","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"10.1016\/j.psj.2024.103949_bib0024","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/cbin.11137","article-title":"Cell death: a review of the major forms of apoptosis, necrosis and autophagy","volume":"43","author":"D'Arcy","year":"2019","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.psj.2024.103949_bib0025","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13567-018-0538-6","article-title":"Biomarkers for monitoring intestinal health in poultry: present status and future perspectives","volume":"49","author":"Ducatelle","year":"2018","journal-title":"Vet. Res."},{"key":"10.1016\/j.psj.2024.103949_bib0026","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.aninu.2023.03.005","article-title":"Poultry gut health and beyond","volume":"13","author":"Ducatelle","year":"2023","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.psj.2024.103949_bib0027","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1080\/87559129.2021.1944183","article-title":"Nutritional aspects and health benefits of bioactive plant compounds against infectious diseases: a review","volume":"39","author":"El-Saadony","year":"2023","journal-title":"Food Rev. Int."},{"key":"10.1016\/j.psj.2024.103949_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.101861","article-title":"Effect of red osier dogwood extract on growth performance, blood biochemical parameters, and gut functionality of broiler chickens challenged or unchallenged intraperitoneally with Salmonella Enteritidis lipopolysaccharide","volume":"101","author":"Erinle","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0029","doi-asserted-by":"crossref","first-page":"11221","DOI":"10.1074\/jbc.M611871200","article-title":"Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity","volume":"282","author":"Fang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.psj.2024.103949_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2022.105082","article-title":"Antibiotic residues in chicken meat in China: Occurrence and cumulative health risk assessment","volume":"116","author":"Fei","year":"2023","journal-title":"Food Compos. Anal."},{"key":"10.1016\/j.psj.2024.103949_bib0031","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.3390\/nu10101366","article-title":"Chlorogenic acid targeting of the AKT PH domain activates AKT\/GSK3\u03b2\/FOXO1 signaling and improves glucose metabolism","volume":"10","author":"Gao","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.psj.2024.103949_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.phanu.2019.100145","article-title":"Modulation of GSK-3\u03b2\/\u03b2-catenin cascade by commensal bifidobateria plays an important role for the inhibition of metaflammation-related biomarkers in response to LPS or non-physiological concentrations of fructose: an in vitro study","volume":"8","author":"Ghadimi","year":"2019","journal-title":"PharmaNutrition"},{"key":"10.1016\/j.psj.2024.103949_bib0033","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1071\/AN15725","article-title":"New biomarkers for intestinal permeability induced by lipopolysaccharide in chickens","volume":"56","author":"Gilani","year":"2016","journal-title":"Anim. Prod. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0034","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.aninu.2021.03.001","article-title":"Current experimental models, assessment and dietary modulations of intestinal permeability in broiler chickens","volume":"7","author":"Gilani","year":"2021","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.psj.2024.103949_bib0035","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3109\/08830185.2015.1087518","article-title":"The characteristics and function of bacterial lipopolysaccharides and their endotoxic potential in humans","volume":"35","author":"Gnauck","year":"2016","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.psj.2024.103949_bib0036","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.4049\/jimmunol.1402598","article-title":"Lipopolysaccharide regulation of intestinal tight junction permeability is mediated by TLR4 signal transduction pathway activation of FAK and MyD88","volume":"195","author":"Guo","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.psj.2024.103949_bib0037","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1079\/PNS2001114","article-title":"Nutrient partitioning between reproductive and immune functions in animals","volume":"60","author":"Houdijk","year":"2001","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.psj.2024.103949_bib0038","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1039\/D4FO00059E","article-title":"Unleashing the power of chlorogenic acid: exploring its potential in nutrition delivery and the food industry","volume":"15","author":"Hu","year":"2024","journal-title":"Food Funct"},{"key":"10.1016\/j.psj.2024.103949_bib0039","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1218015","article-title":"Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems","volume":"14","author":"Huang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.psj.2024.103949_bib0040","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/nrm.2016.27","article-title":"Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases","volume":"17","author":"Hydbring","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.psj.2024.103949_bib0041","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3390\/antiox8120575","article-title":"Dietary stevioside supplementation alleviates lipopolysaccharide-induced intestinal mucosal damage through anti-inflammatory and antioxidant effects in broiler chickens","volume":"8","author":"Jiang","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.psj.2024.103949_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.animal.2022.100693","article-title":"Protective effects of protocatechuic acid on growth performance, intestinal barrier and antioxidant capacity in broilers challenged with lipopolysaccharide","volume":"17","author":"Jiang","year":"2023","journal-title":"Animal"},{"key":"10.1016\/j.psj.2024.103949_bib0043","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1071\/AN18281","article-title":"A review of the financial impact of production diseases in poultry production systems","volume":"59","author":"Jones","year":"2019","journal-title":"Anim. Prod. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0044","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.3382\/ps\/pey087","article-title":"Inflammatory phenotypes in the intestine of poultry: not all inflammation is created equal","volume":"97","author":"Kogut","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0045","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1080\/10715762.2019.1621308","article-title":"Chlorogenic acid prevents paraquat-induced apoptosis via Sirt1-mediated regulation of redox and mitochondrial function","volume":"53","author":"Kong","year":"2019","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.psj.2024.103949_bib0046","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1016\/j.bbagen.2012.08.010","article-title":"On the role of Wnt\/\u03b2-catenin signaling in stem cells","volume":"1830","author":"K\u00fchl","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.psj.2024.103949_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114246","article-title":"Role of herbal products in animal production\u2013 An updated review","volume":"278","author":"Kuralkar","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.psj.2024.103949_bib0048","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1023\/B:APPT.0000031453.90821.6a","article-title":"LPS-induced apoptosis is dependent upon mitochondrial dysfunction","volume":"9","author":"Kuwabara","year":"2004","journal-title":"Apoptosis"},{"key":"10.1016\/j.psj.2024.103949_bib0049","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.3382\/ps\/pey407","article-title":"From oxidative stress to inflammation: redox balance and immune system","volume":"98","author":"Lauridsen","year":"2019","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0050","doi-asserted-by":"crossref","first-page":"6464","DOI":"10.1021\/acs.jafc.0c01554","article-title":"Chlorogenic acids in cardiovascular disease: A review of dietary consumption, pharmacology, and pharmacokinetics","volume":"68","author":"Li","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.psj.2024.103949_bib0051","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11101-019-09655-7","article-title":"Lonicerae japonicae flos and Lonicerae flos: A systematic review of ethnopharmacology, phytochemistry and pharmacology","volume":"19","author":"Li","year":"2020","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.psj.2024.103949_bib0052","article-title":"Effects of dietary chlorogenic acid on ileal intestinal morphology, barrier function, immune factors and gut microbiota of broilers under high stocking density stress","volume":"14","author":"Li","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.psj.2024.103949_bib0053","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3390\/nu8010016","article-title":"Role of chlorogenic acids in controlling oxidative and inflammatory stress conditions","volume":"8","author":"Liang","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.psj.2024.103949_bib0054","article-title":"Chlorogenic acid ameliorates intestinal inflammation by inhibiting NF-\u03baB and endoplasmic reticulum stress in lipopolysaccharide-challenged broilers","volume":"103","author":"Liu","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0055","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3390\/ani12080963","article-title":"Effects of chlorogenic acid on performance, anticoccidial indicators, immunity, antioxidant status, and intestinal barrier function in coccidia-infected broilers","volume":"12","author":"Liu","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.psj.2024.103949_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.102036","article-title":"Chlorogenic acid improves growth performance and intestinal health through autophagy-mediated nuclear factor erythroid 2-related factor 2 pathway in oxidatively stressed broilers induced by dexamethasone","volume":"101","author":"Liu","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0058","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","article-title":"Wnt\/\u03b2-catenin signalling: function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.psj.2024.103949_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2021.106039","article-title":"Chlorogenic acid alleviates thioacetamide-induced toxicity and promotes liver development in zebrafish (Danio rerio) through the Wnt signaling pathway","volume":"242","author":"Liu","year":"2022","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.psj.2024.103949_bib0056","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.aninu.2023.05.009","article-title":"Integrated multi-omics reveals the beneficial role of chlorogenic acid in improving the growth performance and immune function of immunologically stressed broilers","volume":"14","author":"Liu","year":"2023","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.psj.2024.103949_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.anifeedsci.2023.115570","article-title":"Effects of different levels of dietary chlorogenic acid supplementation on growth performance, intestinal integrity, and antioxidant status of broiler chickens at an early age","volume":"297","author":"Liu","year":"2023","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.psj.2024.103949_bib0061","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.psj.2024.103949_bib0062","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1111\/1541-4337.12620","article-title":"Chlorogenic acid: A comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions","volume":"19","author":"Lu","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.psj.2024.103949_bib0063","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","article-title":"LPS\/TLR4 signal transduction pathway","volume":"42","author":"Lu","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.psj.2024.103949_bib0064","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103274","article-title":"Chlorogenic acid protects against intestinal inflammation and injury by inactivating the mtDNA-cGAS-STING signaling pathway in broilers under necrotic enteritis challenge","volume":"103","author":"Lv","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0065","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.3390\/antiox10091461","article-title":"Plant feed additives as natural alternatives to the use of synthetic antioxidant vitamins on livestock mammals' performances, health, and oxidative status: a review of the literature in the last 20 years","volume":"10","author":"Manuelian","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.psj.2024.103949_bib0066","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/jas\/sky401","article-title":"Immune system stimulation induced by Escherichia coli lipopolysaccharide alters plasma free amino acid flux and dietary nitrogen utilization in growing pigs","volume":"97","author":"McGilvray","year":"2019","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0067","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nrmicro1068","article-title":"LPS, TLR4 and infectious disease diversity","volume":"3","author":"Miller","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.psj.2024.103949_bib0068","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.diff.2019.01.002","article-title":"Wnt signaling in intestinal inflammation","volume":"108","author":"Moparthi","year":"2019","journal-title":"Differentiation"},{"key":"10.1016\/j.psj.2024.103949_bib0069","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.3390\/molecules28052381","article-title":"The chemopreventive effects of chlorogenic acids, phenolic compounds in coffee, against inflammation, cancer, and neurological diseases","volume":"28","author":"Murai","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.psj.2024.103949_bib0070","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.immuni.2010.03.001","article-title":"Interferon-\u03b3 regulates intestinal epithelial homeostasis through converging \u03b2-catenin signaling pathways","volume":"32","author":"Nava","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.psj.2024.103949_bib0071","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1016\/j.ajpath.2017.08.005","article-title":"Lipopolysaccharide-Induced increase in intestinal epithelial tight permeability is mediated by toll-like receptor 4\/myeloid differentiation primary response 88 (MyD88) activation of myosin light chain kinase expression","volume":"187","author":"Nighot","year":"2017","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.psj.2024.103949_bib0072","doi-asserted-by":"crossref","first-page":"909","DOI":"10.3390\/ani12070909","article-title":"Effect of immune stress on growth performance and immune functions of livestock: mechanisms and prevention","volume":"12","author":"Niu","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.psj.2024.103949_bib0073","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.anifeedsci.2019.01.009","article-title":"Holistic view of intestinal health in poultry","volume":"250","author":"Oviedo-Rond\u00f3n","year":"2019","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.psj.2024.103949_bib0074","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1038\/emm.2013.97","article-title":"Recognition of lipopolysaccharide pattern by TLR4 complexes","volume":"45","author":"Park","year":"2013","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.psj.2024.103949_bib0075","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.4049\/jimmunol.1402101","article-title":"IRAK4 as a molecular target in the amelioration of innate immunity-related endotoxic shock and acute liver injury by chlorogenic acid","volume":"194","author":"Park","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.psj.2024.103949_bib0076","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nri3608","article-title":"Intestinal epithelial cells: regulators of barrier function and immune homeostasis","volume":"14","author":"Peterson","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.psj.2024.103949_bib0077","first-page":"26","article-title":"Atorvastatin inhibits GSK-3beta phosphorylation by cardiac hypertrophic stimuli","volume":"1781","author":"Planavila","year":"2008","journal-title":"Biochim. Biophys. Acta 2008"},{"key":"10.1016\/j.psj.2024.103949_bib0078","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/10495398.2020.1798973","article-title":"Beneficial and adverse effects of medicinal plants as feed supplements in poultry nutrition: a review","volume":"33","author":"Pliego","year":"2022","journal-title":"Anim. Biotechnol."},{"key":"10.1016\/j.psj.2024.103949_bib0079","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/00439339.2022.2151395","article-title":"Application of herbs and their derivatives in broiler chickens: a review","volume":"79","author":"Rafeeq","year":"2023","journal-title":"World's Poult. Sci. J."},{"key":"10.1016\/j.psj.2024.103949_bib0080","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3389\/fgene.2012.00267","article-title":"Immune response from a resource allocation perspective","volume":"3","author":"Rauw","year":"2012","journal-title":"Front. Genet."},{"key":"10.1016\/j.psj.2024.103949_bib0081","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.jff.2016.08.038","article-title":"Chlorogenic acid enhances intestinal barrier by decreasing MLCK expression and promoting dynamic distribution of tight junction proteins in colitic rats","volume":"26","author":"Ruan","year":"2016","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.psj.2024.103949_bib0082","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.149205","article-title":"A systematic review on antibiotics misuse in livestock and aquaculture and regulation implications in China","volume":"798","author":"Shao","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.psj.2024.103949_bib0083","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3390\/nu9020165","article-title":"Catechol groups enable reactive oxygen species scavenging-mediated suppression of PKD-NFkappaB-IL-8 signaling pathway by chlorogenic and caffeic acids in human intestinal cells","volume":"9","author":"Shin","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.psj.2024.103949_bib0084","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1053\/j.gastro.2009.09.045","article-title":"Toll-like receptor-4 inhibits enterocyte proliferation via impaired \u03b2-catenin signaling in necrotizing enterocolitis","volume":"138","author":"Sodhi","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.psj.2024.103949_bib0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103649","article-title":"Comparison of the effects of chlorogenic acid isomers and their compounds on alleviating oxidative stress injury in broilers","volume":"103","author":"Song","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0086","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.1039\/D1FO02662C","article-title":"Chlorogenic acid improves the intestinal barrier by relieving endoplasmic reticulum stress and inhibiting ROCK\/MLCK signaling pathways","volume":"13","author":"Song","year":"2022","journal-title":"Food Funct"},{"key":"10.1016\/j.psj.2024.103949_bib0087","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.2527\/1997.7571773x","article-title":"Regulation of metabolism and growth during immune challenge: an overview of cytokine function","volume":"75","author":"Spurlock","year":"1997","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0088","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellimm.2017.05.002","article-title":"Myeloperoxidase: a new player in autoimmunity","volume":"317","author":"Strzepa","year":"2017","journal-title":"Cell Immunol"},{"key":"10.1016\/j.psj.2024.103949_bib0089","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/ncb0311-184","article-title":"Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress","volume":"13","author":"Tabas","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.psj.2024.103949_bib0090","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1007\/s00394-017-1379-1","article-title":"The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature","volume":"56","author":"Tajik","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.psj.2024.103949_bib0091","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102623","article-title":"Effects of dietary chlorogenic acid on intestinal barrier function and the inflammatory response in broilers during lipopolysaccharide-induced immune stress","volume":"102","author":"Tan","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0092","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1126\/science.1156037","article-title":"Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation","volume":"320","author":"Thornton","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.psj.2024.103949_bib0093","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3390\/antibiotics10050539","article-title":"Pollution by antibiotics and antimicrobial resistance in livestock and poultry manure in china, and countermeasures","volume":"10","author":"Tian","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.psj.2024.103949_bib0094","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.102397","article-title":"Trans-anethole exerts protective effects on lipopolysaccharide-induced acute jejunal inflammation of broilers via repressing NF-\u03baB signaling pathway","volume":"102","author":"Tong","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104808","article-title":"Chlorogenic acid supplementation alleviates dextran sulfate sodium (DSS)-induced colitis via inhibiting inflammatory responses and oxidative stress, improving gut barrier integrity and Nrf-2\/HO-1 pathway","volume":"87","author":"Wan","year":"2021","journal-title":"J. Funct. Foods."},{"key":"10.1016\/j.psj.2024.103949_bib0096","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1142\/S0192415X19500137","article-title":"Ethnobotany, phytochemistry and pharmacological properties of Eucommia ulmoides: A review","volume":"47","author":"Wang","year":"2019","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.psj.2024.103949_bib0097","article-title":"The biological activity mechanism of chlorogenic acid and its applications in food industry: a review","volume":"9","author":"Wang","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.psj.2024.103949_bib0098","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.tips.2014.02.004","article-title":"PCNA: a silent housekeeper or a potential therapeutic target?","volume":"35","author":"Wang","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0099","doi-asserted-by":"crossref","first-page":"skad234","DOI":"10.1093\/jas\/skad234","article-title":"Effect of 3-caffeoylquinic acid on growth performance, nutrient digestibility, and intestinal functions in weaned pigs","volume":"101","author":"Wei","year":"2023","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0100","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1053\/j.gastro.2011.12.001","article-title":"Dysregulation of Wnt\/\u03b2-catenin signaling in gastrointestinal cancers","volume":"142","author":"White","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.psj.2024.103949_bib0101","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3390\/vaccines10020172","article-title":"Role of physiology, immunity, microbiota, and infectious diseases in the gut health of poultry","volume":"10","author":"Wickramasuriya","year":"2022","journal-title":"Vaccines"},{"key":"10.1016\/j.psj.2024.103949_bib0102","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102785","article-title":"Modulation of the immune system of chickens a key factor in maintaining poultry production-a review","volume":"102","author":"Wla\u017alak","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0103","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2023.109284","article-title":"Artemisia ordosica polysaccharide ameliorated LPS-induced growth inhibition and intestinal injury in broilers through enhancing immune-regulation and antioxidant capacity","volume":"115","author":"Xing","year":"2023","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.psj.2024.103949_bib0104","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112566","article-title":"Artemisia ordosica polysaccharide alleviated lipopolysaccharide-induced oxidative stress of broilers via Nrf2\/Keap1 and TLR4\/NF-\u03baB pathway","volume":"223","author":"Xing","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.psj.2024.103949_bib0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154961","article-title":"Chlorogenic acids: A pharmacological systematic review on their hepatoprotective effects","volume":"118","author":"Xue","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.psj.2024.103949_bib0106","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.3382\/ps.2008-00091","article-title":"Factors affecting intestinal health in poultry","volume":"87","author":"Yegani","year":"2008","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0107","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108872","article-title":"Trans-anethole ameliorates LPS-induced inflammation via suppression of TLR4\/NF-\u03baB pathway in IEC-6 cells","volume":"108","author":"Yu","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.psj.2024.103949_bib0108","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104640","article-title":"Chlorogenic acid improves intestinal barrier function by downregulating CD14 to inhibit the NF-\u03baB signaling pathway","volume":"85","author":"Yu","year":"2021","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.psj.2024.103949_bib0109","article-title":"Effects of dietary supplementation with chlorogenic acid on growth performance, antioxidant capacity, and hepatic inflammation in broiler chickens subjected to diquat-induced oxidative stress","volume":"102","author":"Zha","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0110","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s40104-020-00460-3","article-title":"Comparison of the protective effects of resveratrol and pterostilbene against intestinal damage and redox imbalance in weanling piglets","volume":"11","author":"Zhang","year":"2020","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.psj.2024.103949_bib0111","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102968","article-title":"Dietary resveratrol supplementation on growth performance, immune function and intestinal barrier function in broilers challenged with lipopolysaccharide","volume":"102","author":"Zhang","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0112","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114721","article-title":"Ethylbenzene induces hearing loss by triggering mitochondrial impairments and excess apoptosis in cochlear progenitor cells via suppressing the Wnt\/\u03b2-catenin signaling","volume":"254","author":"Zhang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.psj.2024.103949_bib0113","doi-asserted-by":"crossref","first-page":"6606","DOI":"10.1016\/j.psj.2020.09.082","article-title":"Evaluation of the efficacy of chlorogenic acid in reducing small intestine injury, oxidative stress, and inflammation in chickens challenged with Clostridium perfringens type A","volume":"99","author":"Zhang","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0114","doi-asserted-by":"crossref","first-page":"4968","DOI":"10.1039\/C8FO01126E","article-title":"Dietary chlorogenic acid supplementation affects gut morphology, antioxidant capacity and intestinal selected bacterial populations in weaned piglets","volume":"9","author":"Zhang","year":"2018","journal-title":"Food Funct"},{"key":"10.1016\/j.psj.2024.103949_bib0115","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.3382\/ps\/pew161","article-title":"Effects of Oridonin on growth performance and oxidative stress in broilers challenged with lipopolysaccharide","volume":"95","author":"Zheng","year":"2016","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.103949_bib0116","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.692839","article-title":"Progress on gut health maintenance and antibiotic alternatives in broiler chicken production","volume":"8","author":"Zhu","year":"2021","journal-title":"Front. Nutr."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579124005285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579124005285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:41:56Z","timestamp":1723164116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579124005285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":116,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S0032579124005285"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2024.103949","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of chlorogenic acid on the intestinal barrier of broiler chickens: an immunological stress model study","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2024.103949","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"103949"}}