{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T13:08:09Z","timestamp":1776517689276,"version":"3.51.2"},"reference-count":33,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972545"],"award-info":[{"award-number":["31972545"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2021YFD1300100"],"award-info":[{"award-number":["2021YFD1300100"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.psj.2024.104501","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T13:08:50Z","timestamp":1730552930000},"page":"104501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Characterization of a novel IGFBP-2 transcript in the ovarian granulosa cells of chicken follicles: mRNA expression, function and effect of reproductive hormones and IGF1"],"prefix":"10.1016","volume":"103","author":[{"given":"Longxiao","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingqing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunliang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2024.104501_bib0001","doi-asserted-by":"crossref","first-page":"bqac112","DOI":"10.1210\/endocr\/bqac112","article-title":"Leptin promotes primordial follicle activation by regulating ovarian insulin-like growth factor system in chicken","volume":"163","author":"Ahmadi","year":"2022","journal-title":"Endocrinology"},{"key":"10.1016\/j.psj.2024.104501_bib0002","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1095\/biolreprod64.3.839","article-title":"Alterations in intrafollicular regulatory factors and apoptosis during selection of follicles in the first follicular wave of the bovine estrous Cycle1","volume":"64","author":"Austin","year":"2001","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.psj.2024.104501_bib0003","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1210\/endrev\/bnad008","article-title":"Signaling pathways of the insulin-like growth factor binding proteins","volume":"44","author":"Baxter","year":"2023","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.psj.2024.104501_bib0004","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1186\/s12864-020-06855-w","article-title":"Transcriptomic and proteomic analyses of ovarian follicles reveal the role of VLDLR in chicken follicle selection","volume":"21","author":"Chen","year":"2020","journal-title":"BMC. Genomics."},{"key":"10.1016\/j.psj.2024.104501_bib0005","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1095\/biolreprod66.6.1640","article-title":"Effect of follicle size on in vitro production of steroids and insulin-like growth factor (IGF)-I, IGF-II, and the IGF-binding proteins by equine ovarian granulosa cells1","volume":"66","author":"Davidson","year":"2002","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.psj.2024.104501_bib0006","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1095\/biolreprod51.5.971","article-title":"Relationships among concentrations of steroids, insulin-like growth factor-I, and insulin-like growth factor binding proteins in ovarian follicular fluid of beef cattle1","volume":"51","author":"Echternkamp","year":"1994","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.psj.2024.104501_bib0007","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1210\/er.2001-0033","article-title":"Cellular actions of the insulin-like growth factor binding proteins","volume":"23","author":"Firth","year":"2002","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.psj.2024.104501_bib0008","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/biolre\/ioad082","article-title":"Effect of IGF1 and FSH on the function of granulosa cells from prehierarchal follicles in chickens","volume":"109","author":"Francoeur","year":"2023","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.psj.2024.104501_bib0009","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fendo.2014.00043","article-title":"Control of IGFBP-2 expression by steroids and peptide hormones in vertebrates","volume":"5","author":"Hoeflich","year":"2014","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.psj.2024.104501_bib0010","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3382\/ps\/peu008","article-title":"Ovarian follicle selection and granulosa cell differentiation","volume":"94","author":"Johnson","year":"2015","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.104501_bib0011","doi-asserted-by":"crossref","first-page":"31616","DOI":"10.1210\/endo.142.7.8240","article-title":"Regulation of steroidogenic acute regulatory protein and luteinizing hormone receptor messenger ribonucleic acid in hen granulosa cells","volume":"142","author":"Johnson","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.psj.2024.104501_bib0012","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ygcen.2008.11.012","article-title":"Dynamics of avian ovarian follicle development: Cellular mechanisms of granulosa cell differentiation","volume":"163","author":"Johnson","year":"2009","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.psj.2024.104501_bib0013","first-page":"3","article-title":"Insulin-like growth factors and their binding proteins: biological actions","volume":"16","author":"Jones","year":"1995","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.psj.2024.104501_bib0014","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/jn\/132.2.145","article-title":"Insulin-like growth factor binding protein-2 gene expression can be regulated by diet manipulation in several tissues of young chickens","volume":"132","author":"Kita","year":"2002","journal-title":"J. Nutr."},{"key":"10.1016\/j.psj.2024.104501_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0739-7240(97)00057-X","article-title":"Two steroidogenic pathways present in the chicken ovary: theca layer prefers delta 5 pathway and granulosa layer prefers delta 4 pathway","volume":"15","author":"Lee","year":"1998","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.psj.2024.104501_bib0016","doi-asserted-by":"crossref","first-page":"938","DOI":"10.3382\/ps.2008-00453","article-title":"A polymorphism in the 3\u2019-flanking region of insulin-like growth factor binding protein 2 gene associated with abdominal fat in chickens","volume":"88","author":"Leng","year":"2009","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.104501_bib0017","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.2527\/jas.2006-144","article-title":"Identification of a single nucleotide polymorphism of the insulin-like growth factor binding protein 2 gene and its association with growth and body composition traits in the chicken","volume":"84","author":"Li","year":"2006","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.psj.2024.104501_bib0018","article-title":"Identification of genes involved in chicken follicle selection by ONT sequencing on granulosa cells","volume":"13","author":"Li","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.psj.2024.104501_bib0019","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1530\/rep.0.1230291","article-title":"Modulatory effects of gonadotrophins and insulin-like growth factor on the secretion of inhibin A and progesterone by granulosa cells from chicken preovulatory (F1-F3) follicles","volume":"123","author":"Lovell","year":"2002","journal-title":"Reproduction."},{"key":"10.1016\/j.psj.2024.104501_bib0020","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1530\/jrf.0.1040259","article-title":"Effects of insulin-like growth factor I and interactions with transforming growth factor alpha and LH on proliferation of chicken granulosa cells and production of progesterone in culture","volume":"104","author":"Onagbesan","year":"1995","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.psj.2024.104501_bib0021","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0739-7240(99)00046-6","article-title":"Insulin-like growth factors in the regulation of avian ovarian functions","volume":"17","author":"Onagbesan","year":"1999","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.psj.2024.104501_bib0022","first-page":"801","article-title":"Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions","volume":"18","author":"Rajaram","year":"1997","journal-title":"Endocr Rev."},{"key":"10.1016\/j.psj.2024.104501_bib0023","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1017\/S0967199413000166","article-title":"Expression levels of mRNA for insulin-like growth factors 1 and 2, IGF receptors and IGF binding proteins in in vivo and in vitro grown bovine follicles","volume":"22","author":"Rebou\u00e7as","year":"2014","journal-title":"Zygote"},{"key":"10.1016\/j.psj.2024.104501_bib0024","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cytogfr.2014.12.001","article-title":"IGFBP-2: the dark horse in metabolism and cancer","volume":"26","author":"Russo","year":"2015","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.psj.2024.104501_bib0025","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1677\/jme.0.0150049","article-title":"Cloning and characterization of a chick embryo cDNA and gene for IGF-binding protein-2","volume":"15","author":"Schoen","year":"1995","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.psj.2024.104501_bib0026","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1210\/endo-127-5-2166","article-title":"Hormonal regulation of insulin-like growth factor gene expression in pig uterus*","volume":"127","author":"Simmen","year":"1990","journal-title":"Endocrinology"},{"key":"10.1016\/j.psj.2024.104501_bib0027","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fendo.2018.00119","article-title":"Potential functions of IGFBP-2 for ovarian folliculogenesis and steroidogenesis","volume":"9","author":"Spitschak","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.psj.2024.104501_bib0028","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1095\/biolreprod44.2.305","article-title":"Stage of ovarian follicular development associated with the initiation of steroidogenic competence in avian granulosa cells","volume":"44","author":"Tilly","year":"1991","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.psj.2024.104501_bib0029","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.domaniend.2007.03.001","article-title":"IGF-1 receptor signaling pathways and effects of AMPK activation on IGF-1-induced progesterone secretion in hen granulosa cells","volume":"34","author":"Tosca","year":"2008","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.psj.2024.104501_bib0030","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1095\/biolreprod.104.033902","article-title":"Regulation of follicle-stimulating hormone-receptor messenger RNA in hen granulosa cells relative to follicle selection1","volume":"72","author":"Woods","year":"2005","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.psj.2024.104501_bib0031","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s43032-022-00932-z","article-title":"Synthesis, regulatory factors, and signaling pathways of estrogen in the ovary","volume":"30","author":"Xiao","year":"2023","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.psj.2024.104501_bib0032","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1210\/me.2012-1307","article-title":"IGF-I signaling is essential for FSH stimulation of AKT and steroidogenic genes in granulosa cells","volume":"27","author":"Zhou","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.psj.2024.104501_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.anireprosci.2022.107091","article-title":"Insulin-like growth factor-1 regulates follicle selection of hens by promoting proliferation and inhibiting apoptosis of granulosa cells in prehierarchical follicles in vitro","volume":"247","author":"Zhu","year":"2022","journal-title":"Anim. Reprod. Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579124010794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579124010794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T20:38:59Z","timestamp":1776458339000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579124010794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S0032579124010794"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2024.104501","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of a novel IGFBP-2 transcript in the ovarian granulosa cells of chicken follicles: mRNA expression, function and effect of reproductive hormones and IGF1","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2024.104501","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"104501"}}