{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:16:25Z","timestamp":1792523785485,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre Poland","doi-asserted-by":"publisher","award":["2020\/39\/B\/NZ9\/00765"],"award-info":[{"award-number":["2020\/39\/B\/NZ9\/00765"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.psj.2024.104636","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T11:49:59Z","timestamp":1733312999000},"page":"104636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antibiotics\/coccidiostat exposure induces gut-brain axis remodeling for Akt\/mTOR activation and BDNF-mediated neuroprotection in APEC-infected turkeys"],"prefix":"10.1016","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6194-0042","authenticated-orcid":false,"given":"Przemys\u0142aw","family":"So\u0142ek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2424-8935","authenticated-orcid":false,"given":"Anna","family":"St\u0119pniowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliwia","family":"Kosz\u0142a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Jankowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Ognik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2024.104636_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.101696","article-title":"Alternatives to antibiotics for organic poultry production: types, modes of action and impacts on bird's health and production","volume":"101","author":"Abd El-Hack","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.104636_bib0002","article-title":"mTOR as a potential target for the treatment of microbial infections, inflammatory bowel diseases, and colorectal cancer","volume":"23","author":"Afzal","year":"2022","journal-title":"Int. J. Molecul. Sci."},{"key":"10.1016\/j.psj.2024.104636_bib0003","article-title":"Glutamatergic signaling along the microbiota-gut-brain axis","volume":"20","author":"Baj","year":"2019","journal-title":"Int. J. Molecul. Sci."},{"key":"10.1016\/j.psj.2024.104636_bib0004","first-page":"1164","article-title":"Brain-derived neurotrophic factor and its clinical implications. Archives of medical science","volume":"11","author":"Bathina","year":"2015","journal-title":"AMS"},{"key":"10.1016\/j.psj.2024.104636_bib0005","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s40104-023-00853-0","article-title":"State of the art in research on the gut-liver and gut-brain axis in poultry","volume":"14","author":"Beldowska","year":"2023","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.psj.2024.104636_bib0006","first-page":"13","article-title":"Gut microbiota-derived short-chain fatty acids: novel regulators of intestinal serotonin transporter","author":"Buey","year":"2023","journal-title":"Life (Basel, Switzerl.)"},{"key":"10.1016\/j.psj.2024.104636_bib0007","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.3382\/ps\/pew021","article-title":"The gut-brain axis interactions during heat stress and avian necrotic enteritis","volume":"95","author":"Calefi","year":"2016","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.104636_bib0008","article-title":"Antibiotic-therapy-induced gut dysbiosis affecting gut microbiota-brain axis and cognition: restoration by intake of probiotics and synbiotics","volume":"24","author":"Dahiya","year":"2023","journal-title":"Int. J. Molecul. Sci."},{"key":"10.1016\/j.psj.2024.104636_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2022.173510","article-title":"ERK signaling is required for nicotine-induced conditional place preference by regulating neuroplasticity genes expression in male mice","volume":"222","author":"Fan","year":"2023","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.psj.2024.104636_bib0010","doi-asserted-by":"crossref","DOI":"10.3390\/biom14081017","article-title":"The influence of cecal microbiota transplantation on chicken injurious behavior: perspective in Human neuropsychiatric research","volume":"14","author":"Fu","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.psj.2024.104636_bib0011","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10020436","article-title":"Role of microbiota-gut-brain axis in regulating dopaminergic signaling","volume":"10","author":"Hamamah","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.psj.2024.104636_bib0012","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.psj.2020.10.005","article-title":"The relationship between the mTOR signaling pathway and ovarian aging in peak-phase and late-phase laying hens","volume":"100","author":"Hao","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.104636_bib0013","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2305476","article-title":"Antibiotic-induced gut dysbiosis elicits gut-brain axis relevant multi-omic signatures and behavioral and neuroendocrine changes in a nonhuman primate model","volume":"16","author":"Hayer","year":"2024","journal-title":"Gut Microbe."},{"key":"10.1016\/j.psj.2024.104636_bib0014","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41392-022-00974-4","article-title":"Microbiota in health and diseases","volume":"7","author":"Hou","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.psj.2024.104636_bib0015","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.1035538","article-title":"Connecting gut microbiomes and short chain fatty acids with the serotonergic system and behavior in Gallus gallus and other avian species","volume":"13","author":"Jadhav","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.psj.2024.104636_bib0016","first-page":"12","article-title":"Avian pathogenic Escherichia coli (APEC) in broiler breeders: an overview","author":"Joseph","year":"2023","journal-title":"Pathogen. (Basel, Switzerl.)"},{"key":"10.1016\/j.psj.2024.104636_bib0017","first-page":"10","article-title":"Avian pathogenic Escherichia coli (APEC): an overview of virulence and pathogenesis factors, zoonotic potential, and control strategies","author":"Kathayat","year":"2021","journal-title":"Pathogen. (Basel, Switzerl.)"},{"key":"10.1016\/j.psj.2024.104636_bib0018","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s42523-019-0006-2","article-title":"Impact of coccidiostat and phytase supplementation on gut microbiota composition and phytate degradation in broiler chickens","volume":"1","author":"K\u00fcnzel","year":"2019","journal-title":"Anim. Microbiom."},{"key":"10.1016\/j.psj.2024.104636_bib0019","article-title":"Coccidia-microbiota interactions and their effects on the host","volume":"11","author":"Lu","year":"2021","journal-title":"Front. Cellul. Infect. Microbiol."},{"key":"10.1016\/j.psj.2024.104636_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103393","article-title":"Cold stress initiates catecholaminergic and serotonergic responses in the chicken gut that are associated with functional shifts in the microbiome","volume":"103","author":"Lyte","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.104636_bib0021","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2141\/jpsa.0180074","article-title":"Ethical poultry and the bioethics of poultry production","volume":"56","author":"Macer","year":"2019","journal-title":"J. Poult. Sci."},{"key":"10.1016\/j.psj.2024.104636_bib0022","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1197759","article-title":"Short chain fatty acids: the messengers from down below","volume":"17","author":"Mansuy-Aubert","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.psj.2024.104636_bib0023","first-page":"23","article-title":"Antibiotic use in agriculture and its consequential resistance in environmental sources: potential public health implications","author":"Manyi-Loh","year":"2018","journal-title":"Molecul. (Basel, Switzerl.)"},{"key":"10.1016\/j.psj.2024.104636_bib0024","doi-asserted-by":"crossref","unstructured":"Martins, R.R., L.J.G. Silva, A. Pereira, A. Esteves, S.C. Duarte, and A. Pena. 2022. Coccidiostats and poultry: a comprehensive review and current legislation. Food. (Basel, Switzerl.) 11. doi 10.3390\/foods11182738.","DOI":"10.3390\/foods11182738"},{"key":"10.1016\/j.psj.2024.104636_bib0025","unstructured":"Mazur-Gonkowska, B., A. Koncicki, and A.J.B.o.T.V.I.i.P. Krasnod\u0119bska-Depta. 2004. Assessment of acute phase response in turkeys experimentally infected with Escherichia coli or haemorrhagic enteritis virus. 48."},{"key":"10.1016\/j.psj.2024.104636_bib0026","article-title":"Role of microbiota-derived short-chain fatty acids in nervous system disorders","volume":"139","author":"Mirzaei","year":"2021","journal-title":"Biomed. Pharmacother. Biomed. Pharmacother."},{"key":"10.1016\/j.psj.2024.104636_bib0027","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.biopsych.2012.09.006","article-title":"The role of eukaryotic elongation factor 2 kinase in rapid antidepressant action of ketamine","volume":"73","author":"Monteggia","year":"2013","journal-title":"Biolog. Psychiatry"},{"key":"10.1016\/j.psj.2024.104636_bib0028","article-title":"Antibiotics as major disruptors of gut microbiota","volume":"10","author":"Ramirez","year":"2020","journal-title":"Front. Cellul. Infect. Microbiol."},{"key":"10.1016\/j.psj.2024.104636_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102876","article-title":"The effect of early administration of antibiotics or feeding a diet containing a coccidiostat on inflammatory responses and the morphological structure of selected organs of the immune system in young meat-type turkeys","volume":"102","author":"Smagie\u0142","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.104636_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.animal.2024.101321","article-title":"The effect of early administration of antibiotics or feeding a diet containing coccidiostats on the level of their accumulation in liver and the redox status of turkeys","volume":"18","author":"Smagie\u0142","year":"2024","journal-title":"Anim.: Int. J. Anim. Biosci."},{"key":"10.1016\/j.psj.2024.104636_bib0031","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2023.1149618","article-title":"Emerging role of gut microbiota dysbiosis in neuroinflammation and neurodegeneration","volume":"14","author":"Solanki","year":"2023","journal-title":"Front. Neurol."},{"key":"10.1016\/j.psj.2024.104636_bib0032","article-title":"Toxic effect of antidepressants on male reproductive system cells: evaluation of possible fertility reduction mechanism","volume":"72","author":"Solek","year":"2021","journal-title":"J. Physiol. Pharmacol.: Off. J. Pol. Physiolog. Soc."},{"key":"10.1016\/j.psj.2024.104636_bib0033","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10020289","article-title":"Implication of intestinal barrier dysfunction in gut dysbiosis and diseases","volume":"10","author":"Stolfi","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.psj.2024.104636_bib0034","unstructured":"Turkeys., H. 2020. Commercial management guide and nutrient guidelines for hybrid turkeys. http:\/\/www.hybridturkeys.com Accessed July 2021."},{"key":"10.1016\/j.psj.2024.104636_bib0035","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1113\/JP276431","article-title":"Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain-gut axis alterations","volume":"596","author":"van de Wouw","year":"2018","journal-title":"J. Physiol."},{"key":"10.1016\/j.psj.2024.104636_bib0036","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.3382\/ps\/pex148","article-title":"Microbial endocrinology: why the intersection of microbiology and neurobiology matters to poultry health","volume":"96","author":"Villageliu","year":"2017","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2024.104636_bib0037","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fncel.2020.00082","article-title":"The role of BDNF on neural plasticity in depression","volume":"14","author":"Yang","year":"2020","journal-title":"Front. Cellul. Neurosci."},{"key":"10.1016\/j.psj.2024.104636_bib0038","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s40104-022-00720-4","article-title":"Constant light in early life induces fear-related behavior in chickens with suppressed melatonin secretion and disrupted hippocampal expression of clock- and BDNF-associated genes","volume":"13","author":"Yang","year":"2022","journal-title":"J. Anim. Sci. Biotechnol."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579124012148?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579124012148?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T06:45:16Z","timestamp":1776667516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579124012148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S0032579124012148"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2024.104636","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibiotics\/coccidiostat exposure induces gut-brain axis remodeling for Akt\/mTOR activation and BDNF-mediated neuroprotection in APEC-infected turkeys","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2024.104636","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"104636"}}