{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T17:56:18Z","timestamp":1789322178332,"version":"build-2803163510"},"reference-count":70,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Shaanxi Province Key Research and Development Projects","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007548","name":"Northwest A and F University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007548","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.psj.2025.104893","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T07:50:34Z","timestamp":1738914634000},"page":"104893","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Enhancing oxygen utilization and mitigating oxidative stress in Tibetan chickens for adaptation to high-altitude hypoxia"],"prefix":"10.1016","volume":"104","author":[{"given":"Ruidong","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9163-2676","authenticated-orcid":false,"given":"Xianpei","family":"Ao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunling","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianggui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Cirenluobu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yourong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2532-5218","authenticated-orcid":false,"given":"Zehui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2025.104893_bib0001","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1007\/s13258-021-01137-5","article-title":"Using weighted gene co-expression network analysis (WGCNA) to identify the hub genes related to hypoxic adaptation in yak (Bos grunniens)","volume":"43","author":"Bao","year":"2021","journal-title":"Genes Genomics"},{"key":"10.1016\/j.psj.2025.104893_bib0002","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.leukres.2009.05.016","article-title":"Differential aiolos expression in human hematopoietic subpopulations","volume":"34","author":"Billot","year":"2010","journal-title":"Leuk. Res."},{"key":"10.1016\/j.psj.2025.104893_bib0003","unstructured":"Blighe, K., M. Lewis, A. Lun, and M. K. J. R. o. Blighe. 2019. Package \u2018PCAtools.\u2019."},{"key":"10.1016\/j.psj.2025.104893_bib0004","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102551","article-title":"Multi-tissue omics analyses reveal molecular regulatory networks for puberty in composite beef cattle","volume":"9","author":"C\u00e1novas","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.psj.2025.104893_bib0005","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1182\/blood-2010-04-282350","article-title":"Sox6 enhances erythroid differentiation in human erythroid progenitors","volume":"117","author":"Cant\u00f9","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.psj.2025.104893_bib0006","article-title":"New insights into the inter-organ crosstalk mediated by","volume":"14","author":"Carbinatti","year":"2023","journal-title":"ChREBP. Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.psj.2025.104893_bib0007","doi-asserted-by":"crossref","first-page":"D165","DOI":"10.1093\/nar\/gkab1113","article-title":"JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles","volume":"50","author":"Castro-Mondragon","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.psj.2025.104893_bib0008","doi-asserted-by":"crossref","DOI":"10.3390\/genes11020123","article-title":"Plateau grass and greenhouse flower? Distinct genetic basis of closely related toad tadpoles respectively adapted to high altitude and karst caves","volume":"11","author":"Chang","year":"2020","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.psj.2025.104893_bib0009","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1093\/bioinformatics\/btx364","article-title":"UpSetR: an R package for the visualization of intersecting sets and their properties","volume":"33","author":"Conway","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.psj.2025.104893_bib0010","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1186\/gb-2009-10-5-r55","article-title":"Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease","volume":"10","author":"Dobrin","year":"2009","journal-title":"Genome Biol"},{"key":"10.1016\/j.psj.2025.104893_bib0011","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-3-031-62731-6_11","article-title":"Transcription factor TAL1 in erythropoiesis","volume":"1459","author":"Fechner","year":"2024","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.psj.2025.104893_bib0012","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/1873-3468.12826","article-title":"Esrrb, an estrogen-related receptor involved in early development, pluripotency, and reprogramming","volume":"592","author":"Festuccia","year":"2018","journal-title":"FEBS Lett"},{"key":"10.1016\/j.psj.2025.104893_bib0013","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/stem.160025","article-title":"Role of PU.1 in hematopoiesis","volume":"16","author":"Fisher","year":"1998","journal-title":"Stem Cells"},{"key":"10.1016\/j.psj.2025.104893_bib0014","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00335-007-9043-3","article-title":"Weighted gene coexpression network analysis strategies applied to mouse weight","volume":"18","author":"Fuller","year":"2007","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.psj.2025.104893_bib0015","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0304-3835(02)00614-6","article-title":"Thyroid hormone receptors\/THR genes in human cancer","volume":"192","author":"Gonz\u00e1lez-Sancho","year":"2003","journal-title":"Cancer Lett"},{"key":"10.1016\/j.psj.2025.104893_bib0016","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/bioinformatics\/btr064","article-title":"FIMO: scanning for occurrences of a given motif","volume":"27","author":"Grant","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.psj.2025.104893_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.980315","article-title":"Integrated co-expression network analysis uncovers novel tissue-specific genes in major depressive disorder and bipolar disorder","volume":"13","author":"Han","year":"2022","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.psj.2025.104893_bib0018","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13046-019-1065-7","article-title":"FUS\/circ_002136\/miR-138-5p\/SOX13 feedback loop regulates angiogenesis in Glioma","volume":"38","author":"He","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.psj.2025.104893_bib0019","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/age.12678","article-title":"Genome-wide association analysis reveals novel loci for hypoxia adaptability in Tibetan chicken","volume":"49","author":"Jiang","year":"2018","journal-title":"Anim. Genet."},{"key":"10.1016\/j.psj.2025.104893_bib0020","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.2147\/IJGM.S351638","article-title":"MYBL2 is a novel independent prognostic biomarker and correlated with immune infiltrates in prostate cancer","volume":"15","author":"Jiao","year":"2022","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/j.psj.2025.104893_bib0021","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12473","article-title":"The regulation and role of carbohydrate response element-binding protein in metabolic homeostasis and disease","volume":"29","author":"Jois","year":"2017","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.psj.2025.104893_bib0022","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1002\/vms3.784","article-title":"Managing broiler production challenges at high altitude","volume":"8","author":"Khajali","year":"2022","journal-title":"Vet. Med. Sci."},{"key":"10.1016\/j.psj.2025.104893_bib0023","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat Methods"},{"key":"10.1016\/j.psj.2025.104893_bib0024","doi-asserted-by":"crossref","first-page":"bar030","DOI":"10.1093\/database\/bar030","article-title":"Ensembl BioMarts: a hub for data retrieval across taxonomic space","volume":"2011","author":"Kinsella","year":"2011","journal-title":"Database (Oxford)"},{"key":"10.1016\/j.psj.2025.104893_bib0025","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1152\/japplphysiol.00110.2017","article-title":"High-altitude champions: birds that live and migrate at altitude","volume":"123","author":"Lagu\u00eb","year":"2017","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.psj.2025.104893_bib0026","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.psj.2025.104893_bib0027","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jcmgh.2023.01.009","article-title":"Osr1 Is a critical regulator of macrophage polarization in NASH progression","volume":"15","author":"Lee","year":"2023","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.psj.2025.104893_bib0028","doi-asserted-by":"crossref","first-page":"12886","DOI":"10.1111\/jcmm.15919","article-title":"Biological roles of Yin Yang 2: its implications in physiological and pathological events","volume":"24","author":"Li","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.psj.2025.104893_bib0029","article-title":"EBF1, PAX5, and MYC: regulation on B cell development and association with hematologic neoplasms","volume":"15","author":"Li","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2025.104893_bib0030","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.psj.2025.104893_bib0031","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1038\/s41375-022-01635-9","article-title":"GFI1B acts as a metabolic regulator in hematopoiesis and acute myeloid leukemia","volume":"36","author":"Liu","year":"2022","journal-title":"Leukemia"},{"key":"10.1016\/j.psj.2025.104893_bib0032","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.jcmgh.2022.12.010","article-title":"Osr1 Regulates macrophage-mediated liver inflammation in nonalcoholic fatty liver disease progression","volume":"15","author":"Liu","year":"2023","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.psj.2025.104893_bib0033","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.psj.2025.104893_bib0034","article-title":"Comparative transcriptome analysis of gayal (Bos frontalis), yak (Bos grunniens), and cattle (Bos taurus) reveal the high-altitude adaptation","volume":"12","author":"Ma","year":"2021","journal-title":"Front Genet"},{"key":"10.1016\/j.psj.2025.104893_bib0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021698","article-title":"Molecular mechanisms of high-altitude acclimatization","volume":"24","author":"Mallet","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.psj.2025.104893_bib0036","doi-asserted-by":"crossref","first-page":"25655","DOI":"10.1073\/pnas.2011795117","article-title":"Deep learning of immune cell differentiation","volume":"117","author":"Maslova","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.psj.2025.104893_bib0037","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.4161\/cc.21569","article-title":"LIN54 harboring a mutation in CHC domain is localized to the cytoplasm and inhibits cell cycle progression","volume":"11","author":"Matsuo","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.psj.2025.104893_bib0038","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1002\/1873-3468.13585","article-title":"Transcriptional control of blood cell emergence","volume":"593","author":"Menegatti","year":"2019","journal-title":"FEBS Lett"},{"key":"10.1016\/j.psj.2025.104893_bib0039","doi-asserted-by":"crossref","first-page":"e206","DOI":"10.1038\/bcj.2014.22","article-title":"The emerging role of Twist proteins in hematopoietic cells and hematological malignancies","volume":"4","author":"Merindol","year":"2014","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.psj.2025.104893_bib0040","doi-asserted-by":"crossref","first-page":"15176","DOI":"10.1038\/s41598-019-51627-6","article-title":"Multi-tissue network analysis for drug prioritization in knee osteoarthritis","volume":"9","author":"Neidlin","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2025.104893_bib0041","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/0955-0674(95)80072-7","article-title":"Hematopoiesis: how does it happen?","volume":"7","author":"Orkin","year":"1995","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.psj.2025.104893_bib0042","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1089\/ham.2019.0032","article-title":"Natural climbers: insights from avian physiology at high altitude","volume":"20","author":"Parr","year":"2019","journal-title":"High. Alt. Med. Biol."},{"key":"10.1016\/j.psj.2025.104893_bib0043","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"Suppl 16","key":"10.1016\/j.psj.2025.104893_bib0044","doi-asserted-by":"crossref","first-page":"S140","DOI":"10.1681\/ASN.V11suppl_2s140","article-title":"Hepatocyte nuclear factor 1, a transcription factor at the crossroads of glucose homeostasis","volume":"11","author":"Pontoglio","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.psj.2025.104893_bib0045","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.3390\/cancers13122953","article-title":"CUT domain proteins in DNA repair and cancer","volume":"13","author":"Ramdzan","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.psj.2025.104893_bib0046","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1128\/MCB.01487-13","article-title":"C\/EBPa-mediated activation of microRNAs 34a and 223 inhibits Lef1 expression to achieve efficient reprogramming into macrophages","volume":"34","author":"Rodriguez-Ubreva","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.psj.2025.104893_bib0047","doi-asserted-by":"crossref","first-page":"eadg5391","DOI":"10.1126\/sciadv.adg5391","article-title":"IRF1 regulates self-renewal and stress-responsiveness to support hematopoietic stem cell maintenance","volume":"9","author":"Rundberg Nilsson","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.psj.2025.104893_bib0048","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.4161\/cc.8.23.10086","article-title":"Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia","volume":"8","author":"Rzymski","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.psj.2025.104893_bib0049","doi-asserted-by":"crossref","first-page":"8155","DOI":"10.1007\/s11033-021-06784-1","article-title":"Nuclear receptor subfamily 5 group A member 2 (NR5A2): role in health and diseases","volume":"48","author":"Sandhu","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.psj.2025.104893_bib0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1010315","article-title":"Combinatorial gli activity directs immune infiltration and tumor growth in pancreatic cancer","volume":"18","author":"Scales","year":"2022","journal-title":"PLoS Genet"},{"key":"10.1016\/j.psj.2025.104893_bib0051","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"10.1016\/j.psj.2025.104893_bib0052","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1089\/scd.2006.15.755","article-title":"Stem cell c-KIT and HOXB4 genes: critical roles and mechanisms in self-renewal, proliferation, and differentiation","volume":"15","author":"Sharma","year":"2006","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.psj.2025.104893_bib0053","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1101\/gad.349879.122","article-title":"Transcription factor networks link B-lymphocyte development and malignant transformation in leukemia","volume":"37","author":"Sigvardsson","year":"2023","journal-title":"Genes Dev"},{"key":"10.1016\/j.psj.2025.104893_bib0054","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/age.12990","article-title":"Comprehensive analysis of lncRNA and mRNA expression changes in Tibetan chicken lung tissue between three developmental stages","volume":"51","author":"Tang","year":"2020","journal-title":"Anim. Genet."},{"key":"10.1016\/j.psj.2025.104893_bib0055","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1089\/ham.2005.6.301","article-title":"Acclimatization to oxidative stress at high altitude","volume":"6","author":"Vij","year":"2005","journal-title":"High. Alt. Med. Biol."},{"key":"10.1016\/j.psj.2025.104893_bib0056","article-title":"A crucial angiogenesis-associated gene MEOX2 could Be a promising biomarker candidate for breast cancer","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.psj.2025.104893_bib0057","article-title":"KLF4, a key regulator of a transitive triplet, acts on the TGF-\u03b2 signaling pathway and contributes to high-altitude adaptation of Tibetan pigs","volume":"12","author":"Wang","year":"2021","journal-title":"Front Genet"},{"key":"10.1016\/j.psj.2025.104893_bib0058","article-title":"Integration analysis identifies MYBL1 as a novel immunotherapy biomarker affecting the immune microenvironment in clear cell renal cell carcinoma: evidence based on machine learning and experiments","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2025.104893_bib0059","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/ps\/86.5.904","article-title":"Blood gas, hemoglobin, and growth of Tibetan chicken embryos incubated at high altitude","volume":"86","author":"Wei","year":"2007","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.104893_bib0060","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.tem.2017.07.003","article-title":"Surviving stress: modulation of ATF4-mediated stress responses in normal and malignant cells","volume":"28","author":"Wortel","year":"2017","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.psj.2025.104893_bib0061","series-title":"Physiology and genetics of adaptability to highland hypoxia in Tibetan chicken","author":"Wu","year":"2012"},{"key":"10.1016\/j.psj.2025.104893_bib0062","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/bioinformatics\/bti042","article-title":"Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification","volume":"21","author":"Yanai","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.psj.2025.104893_bib0063","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.psj.2025.104893_bib0064","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1186\/s12885-023-11069-w","article-title":"Glioma angiogenesis is boosted by ELK3 activating the HIF-1[Formula: see text]\/VEGF-A signaling axis","volume":"23","author":"Yueyang","year":"2023","journal-title":"BMC Cancer"},{"key":"10.1016\/j.psj.2025.104893_bib0065","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/gbe\/evw032","article-title":"Genome resequencing identifies unique adaptations of Tibetan chickens to hypoxia and high-dose ultraviolet radiation in high-altitude environments","volume":"8","author":"Zhang","year":"2016","journal-title":"Genome Biol. Evol."},{"key":"10.1016\/j.psj.2025.104893_bib0066","doi-asserted-by":"crossref","first-page":"e3891","DOI":"10.7717\/peerj.3891","article-title":"Genome methylation and regulatory functions for hypoxic adaptation in Tibetan chicken embryos","volume":"5","author":"Zhang","year":"2017","journal-title":"PeerJ"},{"key":"10.1016\/j.psj.2025.104893_bib0067","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s40104-021-00582-2","article-title":"Comprehensive analysis of coding and non-coding RNA transcriptomes related to hypoxic adaptation in Tibetan chickens","volume":"12","author":"Zhang","year":"2021","journal-title":"J Anim Sci Biotechnol"},{"key":"10.1016\/j.psj.2025.104893_bib0068","doi-asserted-by":"crossref","first-page":"11213","DOI":"10.1038\/s41598-020-68178-w","article-title":"Comparative transcriptomic and proteomic analyses provide insights into functional genes for hypoxic adaptation in embryos of Tibetan chickens","volume":"10","author":"Zhang","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2025.104893_bib0069","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1111\/eva.13503","article-title":"Microevolutionary mechanism of high-altitude adaptation in Tibetan chicken populations from an elevation gradient","volume":"15","author":"Zhong","year":"2022","journal-title":"Evol. Appl."},{"key":"10.1016\/j.psj.2025.104893_bib0070","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.235127","article-title":"Molecular regulation of Snai2 in development and disease","volume":"132","author":"Zhou","year":"2019","journal-title":"J. Cell Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125001300?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125001300?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T06:26:57Z","timestamp":1748500017000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579125001300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":70,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0032579125001300"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2025.104893","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhancing oxygen utilization and mitigating oxidative stress in Tibetan chickens for adaptation to high-altitude hypoxia","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2025.104893","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"104893"}}