{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:25:29Z","timestamp":1788481529647,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:00:00Z","timestamp":1740873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31802248"],"award-info":[{"award-number":["31802248"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.psj.2025.104978","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T02:32:44Z","timestamp":1740969164000},"page":"104978","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hexavalent chromium induces ferroptosis in small intestinal tissue of broilers through GPX4\/HMGB1\/p38-MAPK pathway"],"prefix":"10.1016","volume":"104","author":[{"given":"Juezhang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingtong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zibo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2275-6493","authenticated-orcid":false,"given":"Ci","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2025.104978_bib0001","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0300-483X(02)00378-5","article-title":"Cytotoxicity and oxidative mechanisms of different forms of chromium","volume":"180","author":"Bagchi","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.psj.2025.104978_bib0002","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.toxrep.2018.03.007","article-title":"A comprehensive review on chromium induced alterations in fresh water fishes","volume":"5","author":"Bakshi","year":"2018","journal-title":"Toxicol Rep"},{"key":"10.1016\/j.psj.2025.104978_bib0003","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s12276-022-00736-w","article-title":"The mechanism of HMGB1 secretion and release","volume":"54","author":"Chen","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.psj.2025.104978_bib0004","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.840245","article-title":"Lactobacillus spp. For Gastrointestinal Health: current and Future perspectives","volume":"13","author":"Dempsey","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2025.104978_bib0005","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.psj.2025.104978_bib0006","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1017\/S1751731119002593","article-title":"Effects of ochratoxin A on membrane phospholipids of the intestine of broiler chickens, practical consequences","volume":"14","author":"El Cafsi","year":"2020","journal-title":"Animal"},{"key":"10.1016\/j.psj.2025.104978_bib0007","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1083\/jcb.141.7.1539","article-title":"Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occluding","volume":"141","author":"Furuse","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.psj.2025.104978_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133747","article-title":"Field-scale assessment of soil, water, plant, and soil microbiome in and around Rania-Khan Chandpur Chromium contaminated site, India","volume":"467","author":"Gupta","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.psj.2025.104978_bib0009","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/cod.13508","article-title":"Release of hexavalent chromium from cement collected in Honduras and Sweden","volume":"83","author":"Hedberg","year":"2020","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.psj.2025.104978_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157819","article-title":"Cadmium induces ferroptosis mediated inflammation by activating Gpx4\/ager\/p65 axis in pancreatic \u03b2-cells","volume":"849","author":"Hong","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.psj.2025.104978_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.163483","article-title":"A review of chromium (Cr) epigenetic toxicity and health hazards","volume":"882","author":"Iyer","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.psj.2025.104978_bib0012","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.psj.2025.104978_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.140844","article-title":"Cadmium exacerbates dextran sulfate sodium-induced chronic colitis and impairs intestinal barrier","volume":"744","author":"Jiang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.psj.2025.104978_bib0014","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tox.2011.03.001","article-title":"Advances in metal-induced oxidative stress and human disease","volume":"283","author":"Jomova","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.psj.2025.104978_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115293","article-title":"Long-term exposure of high concentration heavy metals induced toxicity, fatality, and gut microbial dysbiosis in common carp, Cyprinus carpio","volume":"266","author":"Kakade","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.psj.2025.104978_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164395","article-title":"Ecotoxicology of hexavalent chromium in fish: an updated review","volume":"890","author":"Kamila","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.psj.2025.104978_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.623739","article-title":"Probiotics Bacillus licheniformis improves intestinal health of subclinical necrotic enteritis-challenged broilers","volume":"12","author":"Kan","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.psj.2025.104978_bib0018","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.scitotenv.2017.03.128","article-title":"Origin of hexavalent chromium in groundwater: the example of Sarigkiol Basin, Northern Greece","volume":"593-594","author":"Kazakis","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.psj.2025.104978_bib0019","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"key":"10.1016\/j.psj.2025.104978_bib0020","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.scitotenv.2018.12.122","article-title":"Increased prevalence of Sjogren's syndrome in where soils contain high levels of chromium","volume":"657","author":"Lee","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.psj.2025.104978_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112871","article-title":"Environmental hexavalent chromium exposure induces gut microbial dysbiosis in chickens","volume":"227","author":"Li","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.psj.2025.104978_bib0022","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell. Death. Dis."},{"key":"10.1016\/j.psj.2025.104978_bib0023","doi-asserted-by":"crossref","first-page":"gaad020","DOI":"10.1093\/molehr\/gaad020","article-title":"Systematic assessment of hexavalent chromium-induced damage to male fertility and the preventive role of melatonin: a longitudinal study from the translational point of view","volume":"29","author":"Li","year":"2023","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.psj.2025.104978_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.172781","article-title":"Intestinal toxicity of Pb: structural and functional damages, effects on distal organs and preventive strategies","volume":"931","author":"Liu","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.psj.2025.104978_bib0025","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature13148","article-title":"Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy","volume":"509","author":"Mancias","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.psj.2025.104978_bib0026","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41577-022-00760-x","article-title":"Mitochondrial control of inflammation","volume":"23","author":"Marchi","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.psj.2025.104978_bib0027","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1083\/jcb.142.1.117","article-title":"Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration","volume":"142","author":"Mart\u00ecn-Padura","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.psj.2025.104978_bib0028","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.1100988","article-title":"Seaweed polysaccharide relieves hexavalent chromium-induced gut microbial homeostasis","volume":"13","author":"Mu","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.psj.2025.104978_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121947","article-title":"Co-exposure to environmentally relevant concentrations of cadmium and polystyrene nanoplastics induced oxidative stress, ferroptosis and excessive mitophagy in mice kidney","volume":"333","author":"Qiu","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.psj.2025.104978_bib0030","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1053\/gast.2002.35391","article-title":"HMGB1 B box increases the permeability of caco-2 enterocytic monolayers and impairs intestinal barrier function in mice","volume":"123","author":"Sappington","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.psj.2025.104978_bib0031","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.3390\/antiox11122375","article-title":"Hexavalent-chromium-induced oxidative stress and the protective role of antioxidants against cellular toxicity","volume":"11","author":"Singh","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.psj.2025.104978_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153396","article-title":"Gut as the target tissue of mercury and the extraintestinal effects","volume":"484","author":"Tian","year":"2023","journal-title":"Toxicology"},{"key":"10.1016\/j.psj.2025.104978_bib0033","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00204-023-03476-6","article-title":"ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis","volume":"97","author":"Wang","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.psj.2025.104978_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123958","article-title":"Cadmium exposure induced neuronal ferroptosis and cognitive deficits via the mtROS-ferritinophagy pathway","volume":"349","author":"Wang","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.psj.2025.104978_bib0035","first-page":"634","article-title":"Baicalin ameliorates the gut barrier function and intestinal microbiota of broiler chickens","volume":"56","author":"Wan","year":"2024","journal-title":"Acta. Biochim. Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.psj.2025.104978_bib0036","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12964-023-01170-9","article-title":"The emerging roles of MAPK-AMPK in ferroptosis regulatory network","volume":"21","author":"Wang","year":"2023","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.psj.2025.104978_bib0037","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.bbrc.2019.01.090","article-title":"The release and activity of HMGB1 in ferroptosis","volume":"510","author":"Wen","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.psj.2025.104978_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122262","article-title":"Cadmium ingestion exacerbates Salmonella infection, with a loss of goblet cells through activation of Notch signaling pathways by ROS in the intestine","volume":"391","author":"Xie","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.psj.2025.104978_bib0039","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.952639","article-title":"Hexavalent chromium exposure induces intestinal barrier damage via activation of the NF-\u03bab signaling pathway and NLRP3 inflammasome in ducks","volume":"13","author":"Xing","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2025.104978_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.137982","article-title":"Exploring the mechanism of probiotics in enhancing the utilization of chemical components (or polyphenols) of grape seed extract","volume":"438","author":"Xu","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.psj.2025.104978_bib0041","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1080\/15548627.2023.2165323","article-title":"Copper-dependent autophagic degradation of GPX4 drives ferroptosis","volume":"19","author":"Xue","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.psj.2025.104978_bib0042","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3389\/fimmu.2020.00484","article-title":"Targeting inflammation driven by HMGB1","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2025.104978_bib0043","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.chemosphere.2018.10.147","article-title":"Effects of hexavalent chromium on intestinal histology and microbiota in Bufo gargarizans tadpoles","volume":"216","author":"Yao","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.psj.2025.104978_bib0044","article-title":"The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents","volume":"2","author":"Yu","year":"2015","journal-title":"Mol. Cell. Oncol"},{"key":"10.1016\/j.psj.2025.104978_bib0045","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/bdd.2200","article-title":"Biopharmaceutics classification and intestinal absorption of chikusetsusaponin IVa","volume":"40","author":"Zhang","year":"2019","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.psj.2025.104978_bib0046","first-page":"530","volume":"50","author":"Zhao","year":"2021"},{"key":"10.1016\/j.psj.2025.104978_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.147780","article-title":"Arsenic exposure induces intestinal barrier damage and consequent activation of gut-liver axis leading to inflammation and pyroptosis of liver in ducks","volume":"788","author":"Zhong","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.psj.2025.104978_bib0048","doi-asserted-by":"crossref","first-page":"31568","DOI":"10.1039\/C8RA06534A","article-title":"Adsorption and reduction of hexavalent chromium on magnetic greigite (Fe3S4)-CTAB: leading role of Fe(ii) and S(-ii)","volume":"8","author":"Zhou","year":"2018","journal-title":"RSC Adv."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125002172?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125002172?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:54:13Z","timestamp":1762217653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579125002172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0032579125002172"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2025.104978","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hexavalent chromium induces ferroptosis in small intestinal tissue of broilers through GPX4\/HMGB1\/p38-MAPK pathway","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2025.104978","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"104978"}}