{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:08:33Z","timestamp":1761898113975,"version":"3.41.2"},"reference-count":39,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFF1001100","30601985","CRA022052"],"award-info":[{"award-number":["2023YFF1001100","30601985","CRA022052"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.psj.2025.105172","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T18:52:58Z","timestamp":1745347978000},"page":"105172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Epigenomic insights into the immune regulatory mechanism of GBP4L in poultry"],"prefix":"10.1016","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6114-1005","authenticated-orcid":false,"given":"Hao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengbin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruirui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoxi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guirong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruili","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangtao","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2025.105172_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.rvsc.2023.105057","article-title":"Review: the role of heat shock proteins in chicken: insights into stress adaptation and health","volume":"165","author":"Abare","year":"2023","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.psj.2025.105172_bib0002","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1007\/s00484-024-02779-2","article-title":"Probiotic strategies for mitigating heat stress effects on broiler chicken performance","volume":"68","author":"Aydin","year":"2024","journal-title":"Int. J. Biometeorol."},{"key":"10.1016\/j.psj.2025.105172_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5402\/2011\/838606","article-title":"Effects of heat stress on the well-being, fertility, and hatchability of chickens in the Northern Guinea savannah zone of Nigeria: a review","volume":"2011","author":"Ayo","year":"2011","journal-title":"ISRN. Vet. Sci."},{"key":"10.1016\/j.psj.2025.105172_bib0004","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-animal-031412-103644","article-title":"Effects of heat stress on postabsorptive metabolism and energetics","volume":"1","author":"Baumgard","year":"2013","journal-title":"Annu Rev. Anim. Biosci."},{"key":"10.1016\/j.psj.2025.105172_bib0005","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0092-8674(79)90057-6","article-title":"Chicken hematopoietic cells transformed by seven strains of defective avian leukemia viruses display three distinct phenotypes of differentiation","volume":"18","author":"Beug","year":"1979","journal-title":"Cell"},{"key":"10.1016\/j.psj.2025.105172_bib0006","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nmeth.2688","article-title":"Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position","volume":"10","author":"Buenrostro","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.psj.2025.105172_bib0007","article-title":"ATAC-seq assay with low mitochondrial DNA contamination from primary Human CD4+ T lymphocytes","author":"Cheng","year":"2019","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.psj.2025.105172_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.102157","article-title":"Using major genes to mitigate the deleterious effects of heat stress in poultry: an updated review","volume":"101","author":"Fathi","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105172_bib0009","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02038-20","article-title":"Inducible guanylate-binding protein 7 facilitates influenza a virus replication by suppressing innate immunity via NF-\u03bab and JAK-STAT signaling pathways","volume":"95","author":"Feng","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.psj.2025.105172_bib0010","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/imr.12224","article-title":"Tissue macrophage identity and self-renewal","volume":"262","author":"Gentek","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.psj.2025.105172_bib0011","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/imr.12223","article-title":"Macrophage heterogeneity in tissues: phenotypic diversity and functions","volume":"262","author":"Gordon","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.psj.2025.105172_bib0012","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1038\/s41596-022-00692-9","article-title":"Chromatin accessibility profiling by ATAC-seq","volume":"17","author":"Grandi","year":"2022","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.psj.2025.105172_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2021.104353","article-title":"TMT-based quantitative proteomic analysis reveals the spleen regulatory network of dexamethasone-induced immune suppression in chicks","volume":"248","author":"Guo","year":"2021","journal-title":"J. Proteom."},{"key":"10.1016\/j.psj.2025.105172_bib0014","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s12011-021-02634-0","article-title":"Effects of supplemental chromium nanoparticles on IFN-\u03b3 expression of heat stress broilers","volume":"200","author":"Hamidi","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.psj.2025.105172_bib0015","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1359-6101(02)00026-6","article-title":"Regulation of cytokine signaling and inflammation","volume":"13","author":"Hanada","year":"2002","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.psj.2025.105172_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117956","article-title":"Gegen Qinlian decoction ameliorates TNBS-induced ulcerative colitis by regulating Th2\/Th1 and Tregs\/Th17 cells balance, inhibiting NLRP3 inflammasome activation and reshaping gut microbiota","volume":"328","author":"Hu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.psj.2025.105172_bib0017","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ni.3440","article-title":"Interferon-induced guanylate-binding proteins in inflammasome activation and host defense","volume":"17","author":"Kim","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.psj.2025.105172_bib0018","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41576-018-0089-8","article-title":"Chromatin accessibility and the regulatory epigenome","volume":"20","author":"Klemm","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.psj.2025.105172_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtherbio.2021.102867","article-title":"Climate change and heat stress: impact on production, reproduction and growth performance of poultry and its mitigation using genetic strategies","volume":"97","author":"Kumar","year":"2021","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.psj.2025.105172_bib0020","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aau6085","article-title":"Structure and function of the immune system in the spleen","volume":"4","author":"Lewis","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.psj.2025.105172_bib0021","doi-asserted-by":"crossref","first-page":"6205","DOI":"10.1016\/j.psj.2020.08.019","article-title":"Heat stress impacts on broiler performance: a systematic review and meta-analysis","volume":"99","author":"Liu","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105172_bib0022","first-page":"31","article-title":"Cytoprotective effects of proteasome beta5 subunit overexpression in lens epithelial cells","volume":"13","author":"Liu","year":"2007","journal-title":"Mol. Vis."},{"key":"10.1016\/j.psj.2025.105172_bib0023","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.3233\/JAD-220321","article-title":"Regulation of the Human IL-10RB gene expression by Sp8 and Sp9","volume":"88","author":"Luo","year":"2022","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.psj.2025.105172_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2022.155828","article-title":"Interleukin-8: an evolving chemokine","volume":"153","author":"Matsushima","year":"2022","journal-title":"Cytokine"},{"key":"10.1016\/j.psj.2025.105172_bib0025","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/eat.20432","article-title":"Cholinesterase and other serum liver enzymes in underweight outpatients with eating disorders","volume":"40","author":"Montagnese","year":"2007","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.psj.2025.105172_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104003","article-title":"Oxidative stress in poultry production","volume":"103","author":"Oke","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105172_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103141","article-title":"Heat stress and poultry production: a comprehensive review","volume":"102","author":"Oluwagbenga","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105172_bib0028","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1378\/chest.117.4.1162","article-title":"Anti-inflammatory cytokines","volume":"117","author":"Opal","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.psj.2025.105172_bib0029","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ygcen.2018.01.027","article-title":"Behavioral phenotype relates to physiological differences in immunological and stress responsiveness in reactive and proactive birds","volume":"261","author":"Pusch","year":"2018","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.psj.2025.105172_bib0030","first-page":"1","article-title":"Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic pain","volume":"2013","author":"Ramesh","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.psj.2025.105172_bib0031","doi-asserted-by":"crossref","DOI":"10.3390\/v14092015","article-title":"The importance of the bursa of Fabricius, B cells and T cells for the pathogenesis of Marek\u2019s disease: A review","volume":"14","author":"Schat","year":"2022","journal-title":"Viruses."},{"key":"10.1016\/j.psj.2025.105172_bib0032","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.1007\/s11033-020-05485-5","article-title":"Transcriptome analysis of heat stress response genes in potato leaves","volume":"47","author":"Tang","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.psj.2025.105172_bib0033","article-title":"The importance of propolis in alleviating the negative physiological effects of heat stress in quail chicks","volume":"12","author":"Te Pas","year":"2017","journal-title":"PLoS. One"},{"key":"10.1016\/j.psj.2025.105172_bib0034","first-page":"2103","article-title":"PSMB5 plays a dual role in cancer development and immunosuppression","volume":"7","author":"Wang","year":"2017","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.psj.2025.105172_bib0035","article-title":"Effect of heat stress on blood biochemistry and energy metabolite of the Dazu black goats","volume":"11","author":"Wang","year":"2024","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.psj.2025.105172_bib0036","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1078\/0171-2985-00091","article-title":"Molecular mechanisms involved in macrophage survival, proliferation, activation or apoptosis","volume":"204","author":"Xaus","year":"2001","journal-title":"Immunobiology"},{"key":"10.1016\/j.psj.2025.105172_bib0037","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1101\/gr.276554.122","article-title":"Cell cycle arrest explains the observed bulk 3D genomic alterations in response to long-term heat shock in K562 cells","volume":"32","author":"Xu","year":"2022","journal-title":"Genome Res."},{"key":"10.1016\/j.psj.2025.105172_bib0038","article-title":"Clinical characteristics and CD4+ T cell subsets in IgG4-related disease","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2025.105172_bib0039","doi-asserted-by":"crossref","first-page":"53","DOI":"10.24272\/j.issn.2095-8137.2022.228","article-title":"Chicken chromatin accessibility atlas accelerates epigenetic annotation of birds and gene fine-mapping associated with growth traits","volume":"44","author":"Zhu","year":"2023","journal-title":"Zool. Res."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125004146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125004146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T14:32:36Z","timestamp":1754058756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579125004146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0032579125004146"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2025.105172","relation":{},"ISSN":["0032-5791"],"issn-type":[{"type":"print","value":"0032-5791"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenomic insights into the immune regulatory mechanism of GBP4L in poultry","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2025.105172","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"105172"}}