{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:18:29Z","timestamp":1792977509881,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.psj.2025.105224","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T20:27:59Z","timestamp":1745958479000},"page":"105224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Xylanase and stimbiotic supplementation improve broilers performance and nutrient digestibility across both wheat-barley and corn-based diets"],"prefix":"10.1016","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5065-1739","authenticated-orcid":false,"given":"Mehdi","family":"Toghyani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8884-6593","authenticated-orcid":false,"given":"Eunjoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6771-3804","authenticated-orcid":false,"given":"Shemil P.","family":"Macelline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Gonz\u00e1lez-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7184-0881","authenticated-orcid":false,"given":"Reza","family":"Barekatain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4519-4905","authenticated-orcid":false,"given":"Sonia Y.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2025.105224_bib0001","series-title":"Official Methods of Analysis","article-title":"Official Method 930.15. Loss on drying (moisture) at 95\u2013100\u00b0C for feeds","year":"2012"},{"key":"10.1016\/j.psj.2025.105224_bib0002","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3382\/ps\/pew297","article-title":"Effect of exogenous xylanase, amylase, and protease as single or combined activities on nutrient digestibility and growth performance of broilers fed corn\/soy diets","volume":"96","author":"Amerah","year":"2017","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105224_bib0003","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1021\/jf00007a011","article-title":"Relationship between the levels of soluble nonstarch polysaccharides and the apparent metabolizable energy of wheats assayed in broiler chickens","volume":"39","author":"Annison","year":"1991","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.psj.2025.105224_bib0004","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.anifeedsci.2016.05.004","article-title":"Interaction between chicken intestinal microbiota and protein digestion","volume":"221","author":"Apajalahti","year":"2016","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.psj.2025.105224_bib0005","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.3382\/ps.2014-03902","article-title":"Fiber and nonstarch polysaccharide content and variation in common crops used in broiler diets","volume":"93","author":"Bach Knudsen","year":"2014","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105224_bib0006","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.3382\/ps\/pey563","article-title":"Reduced protein diet and amino acid concentration alter intestinal barrier function and performance of broiler chickens with or without synthetic glucocorticoid","volume":"98","author":"Barekatain","year":"2019","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105224_bib0007","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.aninu.2020.11.015","article-title":"Feed endoxylanase type and dose affect arabinoxylan hydrolysis and fermentation in ageing broilers","volume":"7","author":"Bautil","year":"2021","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.psj.2025.105224_bib0008","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1016\/j.psj.2019.12.041","article-title":"Arabinoxylan-oligosaccharides kick-start arabinoxylan digestion in the aging broiler","volume":"99","author":"Bautil","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105224_bib0009","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3389\/fgene.2019.00480","article-title":"Evaluation of intestinal permeability and liver bacterial translocation in two modern broilers and their jungle fowl ancestor","volume":"10","author":"Baxter","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.psj.2025.105224_bib0010","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1016\/j.carres.2004.08.012","article-title":"Impact and efficiency of GH10 and GH11 thermostable endoxylanases on wheat bran and alkali-extractable arabinoxylans","volume":"339","author":"Beaugrand","year":"2004","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.psj.2025.105224_bib0011","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.anifeedsci.2011.12.018","article-title":"Exogenous enzymes and their effects on intestinal microbiology","volume":"173","author":"Bedford","year":"2012","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.psj.2025.105224_bib0012","doi-asserted-by":"crossref","unstructured":"Bedford, M.R., C.L. Walk, and M. Hruby. 2022. Evolving enzyme Applications. Pages 286-290 in Enzymes in farm animal nutrition. Ed. M.R. Bedford, G.G. Partridge, M. Hruby and C. L. Walk, Oxfordshire, UK.","DOI":"10.1079\/9781789241563.0017"},{"key":"10.1016\/j.psj.2025.105224_bib0013","doi-asserted-by":"crossref","first-page":"5324","DOI":"10.1016\/j.psj.2020.07.027","article-title":"Sodium bisulfate feed additive aids broilers in growth and intestinal health during a coccidiosis challenge","volume":"99","author":"Chadwick","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105224_bib0014","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3390\/biology12030441","article-title":"Stimbiotics supplementation promotes growth performance by improving plasma immunoglobulin and IGF-1 levels and regulating gut microbiota composition in weaned piglets","volume":"12","author":"Chen","year":"2023","journal-title":"Biology"},{"key":"10.1016\/j.psj.2025.105224_bib0015","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1071\/AN15276","article-title":"Feed non-starch polysaccharides for monogastric animals: classification and function","volume":"55","author":"Choct","year":"2015","journal-title":"Anim. Prod. Sci."},{"key":"10.1016\/j.psj.2025.105224_bib0016","doi-asserted-by":"crossref","first-page":"G1151","DOI":"10.1152\/ajpgi.90649.2008","article-title":"A guide to Ussing chamber studies of mouse intestine","volume":"296","author":"Clarke","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.psj.2025.105224_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1301727","article-title":"Stimbiotic supplementation and xylose-rich carbohydrates modulate broiler\u2019s capacity to ferment fibre","volume":"14","author":"Davies","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.psj.2025.105224_bib0018","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.aninu.2021.03.001","article-title":"Current experimental models, assessment and dietary modulations of intestinal permeability in broiler chickens","volume":"7","author":"Gilani","year":"2021","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.psj.2025.105224_bib0020","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.3382\/ps\/pex092","article-title":"Response of broiler chickens fed wheat-based diets to xylanase supplementation","volume":"96","author":"Gonzalez-Ortiz","year":"2017","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105224_bib0021","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Ortiz, G., Bedford, M.R., Bach Knudsen, K.E., Courtin, C.M., and Classen, H.L. (eds.). 2019. The value of fibre: Engaging the second brain for animal nutrition. Wageningen Academic Publishers, Wageningen, the Netherlands.","DOI":"10.3920\/978-90-8686-893-3"},{"key":"10.1016\/j.psj.2025.105224_bib0022","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1113\/jphysiol.2011.224568","article-title":"Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics","volume":"590","author":"Hering","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.psj.2025.105224_bib0023","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3844\/ajisp.2017.45.49","article-title":"Glucans and the poultry immune system","volume":"13","author":"Jacob","year":"2017","journal-title":"Am. J. Immunol."},{"key":"10.1016\/j.psj.2025.105224_bib0024","doi-asserted-by":"crossref","first-page":"487","DOI":"10.22358\/jafs\/67618\/2004","article-title":"The effect of dietary fiberfractions from different cereals and microbial enzyme supplementation on performance, ileal viscosity and short-chain fatty acid concentrations in the caeca of broiler chickens","volume":"13","author":"J\u00f3zefiak","year":"2004","journal-title":"J. Anim. Feed Sci."},{"key":"10.1016\/j.psj.2025.105224_bib0025","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.3382\/ps.2013-03715","article-title":"Growth performance, nutrient utilization, and digesta characteristics in broiler chickens fed corn or wheat diets without or with supplemental xylanase","volume":"93","author":"Kiarie","year":"2014","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105224_bib0026","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.aninu.2022.03.005","article-title":"Ileal profile of non-starch polysaccharides and oligosaccharides in response to exogenous enzymes in broiler chickens offered wheat-or maize-based diets under subclinical necrotic enteritis challenge","volume":"10","author":"Kim","year":"2022","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.psj.2025.105224_bib0027","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s40104-022-00753-9","article-title":"Stimbiotic supplementation modulated intestinal inflammatory response and improved broilers performance in an experimentally-induced necrotic enteritis infection model","volume":"13","author":"Lee","year":"2022","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.psj.2025.105224_bib0028","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/ps\/84.1.37","article-title":"Degradation of cell wall polysaccharides by combinations of carbohydrase enzymes and their effect on nutrient utilization and broiler chicken performance","volume":"84","author":"Meng","year":"2005","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105224_bib0029","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3920\/JAAN2022.0003","article-title":"Comparing a single dose of xylanase to a double dose or cocktail of non-starch polysaccharide-degrading enzymes in broiler chicken diets","volume":"10","author":"Morgan","year":"2022","journal-title":"J. Appl. Anim. Nutr."},{"key":"10.1016\/j.psj.2025.105224_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115645","article-title":"In vitro versus in situ evaluation of xylan hydrolysis into xylo-oligosaccharides in broiler chicken gastrointestinal tract","volume":"230","author":"Morgan","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.psj.2025.105224_bib0031","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1007\/s00253-016-7555-z","article-title":"Insights into the mechanism of enzymatic hydrolysis of xylan","volume":"100","author":"Moreira","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.psj.2025.105224_bib0032","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1111\/asj.13011","article-title":"Effect of humic acids on intestinal viscosity, leaky gut, and ammonia excretion in a 24-hour feed restriction model to induce intestinal permeability in broiler chickens","volume":"89","author":"Maguey-Gonzalez","year":"2018","journal-title":"Anim. Sci. J."},{"key":"10.1016\/j.psj.2025.105224_bib0033","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ijbiomac.2017.01.015","article-title":"Inhibitory effects of soybean oligosaccharides and water-soluble soybean fiberon formation of putrefactive compounds from soy protein by gut microbiota","volume":"97","author":"Nakata","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.psj.2025.105224_bib0034","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3390\/ani12050547","article-title":"Dietary soluble non-starch polysaccharide level influences performance, nutrient utilization, and disappearance of non-starch polysaccharides in broiler chickens","volume":"12","author":"Nguyen","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.psj.2025.105224_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101183","article-title":"Soluble non-starch polysaccharide modulates broiler gastrointestinal tract environment","volume":"100","author":"Nguyen","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105224_bib0036","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.foodchem.2017.03.149","article-title":"Prebiotic effect of xylooligosaccharides produced from birchwood xylan by a novel fungal GH11 xylanase","volume":"232","author":"Nieto-Dom\u00ednguez","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.psj.2025.105224_bib0037","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.3382\/japr\/pfz095","article-title":"Effects of glutamine supplementation on broiler performance and intestinal immune parameters during an experimental coccidiosis infection","volume":"28","author":"Oxford","year":"2019","journal-title":"J. Appl. Poult. Res."},{"key":"10.1016\/j.psj.2025.105224_bib0038","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1017\/S0043933915000124","article-title":"Dietary factors affecting hindgut protein fermentation in broilers: a review","volume":"71","author":"Qaisrani","year":"2015","journal-title":"World. Poult. Sci. J."},{"key":"10.1016\/j.psj.2025.105224_bib0039","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.3382\/ps\/pey336","article-title":"Xylo-oligosaccharides display a prebiotic activity when used to supplement wheat or corn-based diets for broilers","volume":"97","author":"Ribeiro","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105224_bib0040","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3390\/ani8100162","article-title":"Betaine and antioxidants improve growth performance, breast muscle development, and ameliorate thermoregulatory responses to cyclic heat exposure in broiler chickens","volume":"8","author":"Shakeri","year":"2018","journal-title":"Animals"},{"key":"10.1016\/j.psj.2025.105224_bib0041","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0377-8401(95)00916-7","article-title":"Determination of titanium dioxide added as an inert marker in chicken digestibility studies","volume":"59","author":"Short","year":"1996","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.psj.2025.105224_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103000","article-title":"Broiler chicken response to xylanase and fermentable xylooligosaccharide supplementation","volume":"102","author":"\u0160imi\u0107","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105224_bib0043","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40104-021-00617-8","article-title":"Effects of supplemental xylanase and xylooligosaccharides on production performance and gut health variables of broiler chickens","volume":"12","author":"Singh","year":"2021","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.psj.2025.105224_bib0044","doi-asserted-by":"crossref","first-page":"753","DOI":"10.4161\/cbt.8.9.8232","article-title":"Mucositis and non-invasive markers of small intestinal function","volume":"8","author":"Tooley","year":"2009","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.psj.2025.105224_bib0045","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1007\/s10620-012-2259-4","article-title":"Butyrate enhances intestinal epithelial barrier function via up-regulation of tight junction protein Claudin-1 transcription","volume":"57","author":"Wang","year":"2012","journal-title":"Dig. Dis. Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125004663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125004663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:57:35Z","timestamp":1762217855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579125004663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0032579125004663"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2025.105224","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xylanase and stimbiotic supplementation improve broilers performance and nutrient digestibility across both wheat-barley and corn-based diets","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2025.105224","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"105224"}}