{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:46:37Z","timestamp":1791650797748,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1800901"],"award-info":[{"award-number":["2023YFD1800901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.psj.2025.105249","type":"journal-article","created":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T10:41:25Z","timestamp":1746355285000},"page":"105249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pharmacokinetic\/pharmacodynamic relationship of a novel pleuromutilin derivative p-furoylamphenmulin against Mycoplasma gallisepticum in vivo in chickens"],"prefix":"10.1016","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2039-5583","authenticated-orcid":false,"given":"Xirui","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4120-9737","authenticated-orcid":false,"given":"Huifang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7783-9864","authenticated-orcid":false,"given":"Xiangyang","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1339-926X","authenticated-orcid":false,"given":"Xuezhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2293-0287","authenticated-orcid":false,"given":"Youzhi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangguang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanzhong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"08","key":"10.1016\/j.psj.2025.105249_bib0001","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3855\/jidc.7850","article-title":"Mutations of domain V in 23S ribosomal RNA of macrolide-resistant Mycoplasma gallisepticum isolates in Egypt","volume":"10","author":"Ammar","year":"2016","journal-title":"J. Infect. Develop. Count."},{"issue":"11","key":"10.1016\/j.psj.2025.105249_bib46","doi-asserted-by":"crossref","first-page":"101437","DOI":"10.1016\/j.psj.2021.101437","article-title":"Pharmacokinetic\/pharmacodynamic profiles of baicalin against Mycoplasma gallisepticum in an in vivo infection model","volume":"100","author":"Bao","year":"2021","journal-title":"Poult. Sci."},{"issue":"8","key":"10.1016\/j.psj.2025.105249_bib0002","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3390\/antibiotics11081021","article-title":"The monitoring of Mycoplasma gallisepticum minimum inhibitory concentrations during the last decade (2010\u20132020) seems to reveal a comeback of susceptibility to macrolides","volume":"11","author":"Bottinelli","year":"2022","journal-title":"Tiamulin, and Lincomycin. Antibiotics"},{"issue":"1","key":"10.1016\/j.psj.2025.105249_bib0003","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0769-2609(84)80062-9","article-title":"Avian mycoplasma infections: prototype of mixed infections with mycoplasmas, bacteria and viruses","volume":"135","author":"Bradbury","year":"1984","journal-title":"Annales de l'Institut Pasteur \/Microbiologie"},{"key":"10.1016\/j.psj.2025.105249_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105859","article-title":"Design, synthesis and biological evaluation of novel pleuromutilin derivatives possessing 4-aminothiophenol linker as promising antibacterial agents","volume":"126","author":"Chai","year":"2022","journal-title":"Bioorg. Chem."},{"issue":"10","key":"10.1016\/j.psj.2025.105249_bib0005","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1515\/CCLM.2002.172","article-title":"Clinical utility of free drug monitoring","volume":"40","author":"Dasgupta","year":"2002","journal-title":"Clin. Chem. Lab. Med."},{"issue":"6","key":"10.1016\/j.psj.2025.105249_bib0006","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1080\/03079450701642016","article-title":"Effects of route of inoculation onMycoplasma gallisepticum infection in captive house finches","volume":"36","author":"Dhondt","year":"2007","journal-title":"Avian. Pathol."},{"key":"10.1016\/j.psj.2025.105249_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2020.603950","article-title":"Tissue residues and pharmacokinetic\/pharmacodynamic modeling of tiamulin against Mycoplasma anatis in ducks","volume":"7","author":"Elazab","year":"2020","journal-title":"Front. Vet. Sci."},{"issue":"1","key":"10.1016\/j.psj.2025.105249_bib0008","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/03079457.2021.1944605","article-title":"Clinical expression, epidemiology, and monitoring ofMycoplasma gallisepticum andMycoplasma synoviae: an update","volume":"51","author":"Feberwee","year":"2022","journal-title":"Avian. Pathol."},{"issue":"2","key":"10.1016\/j.psj.2025.105249_bib0009","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1637\/11991-110818-Reg.1","article-title":"Efficacy of tylosin and tilmicosin against experimental Mycoplasma gallisepticum infection in chickens","volume":"63","author":"Garmyn","year":"2019","journal-title":"Avian. Dis."},{"issue":"9","key":"10.1016\/j.psj.2025.105249_bib0010","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.3382\/ps\/pex105","article-title":"Efficacy of tiamulin alone or in combination with chlortetracycline against experimental Mycoplasma gallisepticum infection in chickens","volume":"96","author":"Garmyn","year":"2017","journal-title":"Poult. Sci."},{"issue":"4","key":"10.1016\/j.psj.2025.105249_bib0011","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.ARBA-0030-2018","article-title":"Antimicrobial resistance in Mycoplasma spp","volume":"6","author":"Gautier-Bouchardon","year":"2018","journal-title":"Microbiol. Spectr."},{"issue":"1","key":"10.1016\/j.psj.2025.105249_bib0012","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0378-1135(02)00087-1","article-title":"In vitro development of resistance to enrofloxacin, erythromycin, tylosin, tiamulin and oxytetracycline in Mycoplasma gallisepticum, Mycoplasma iowae and Mycoplasma synoviae","volume":"88","author":"Gautier-Bouchardon","year":"2002","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.psj.2025.105249_bib0013","article-title":"Prudent use of Tylosin for treatment of Mycoplasma gallisepticum based on its clinical breakpoint and lung microbiota shift","volume":"12","author":"Huang","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.psj.2025.105249_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104255","article-title":"Pharmacokinetic-pharmacodynamic integration and resistance of tiamulin against Mycoplasma hyopneumoniae in an in vitro dynamic model","volume":"147","author":"Huang","year":"2020","journal-title":"Microb. Pathog."},{"issue":"9","key":"10.1016\/j.psj.2025.105249_bib0015","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1073\/pnas.37.9.570","article-title":"Antibiotic substances from basidiomycetes","volume":"37","author":"Kavanagh","year":"1951","journal-title":"Proc. Natl Acad. Sci."},{"issue":"3","key":"10.1016\/j.psj.2025.105249_bib0016","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1637\/8323-041808-Review.1","article-title":"Control of avian Mycoplasma infections in commercial poultry","volume":"52","author":"Kleven","year":"2008","journal-title":"Avian. Dis."},{"issue":"4","key":"10.1016\/j.psj.2025.105249_bib0017","doi-asserted-by":"crossref","first-page":"915","DOI":"10.2307\/1588772","article-title":"Airsacculitis in broilers from Mycoplasma synoviae: effect on air-sac lesions of vaccinating with infectious bronchitis and Newcastle virus","volume":"16","author":"Kleven","year":"1972","journal-title":"Avian. Dis."},{"issue":"2","key":"10.1016\/j.psj.2025.105249_bib0018","first-page":"144","article-title":"Mutations in 23S rRNA gene associated with decreased susceptibility to tiamulin and valnemulin in Mycoplasma gallisepticum","volume":"308","author":"Li","year":"2010","journal-title":"FEMS Microbiol. Lett."},{"issue":"12","key":"10.1016\/j.psj.2025.105249_bib0019","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.2174\/1871520620666200424130204","article-title":"Synthesis, In vitro antitumor activity and molecular mechanism of novel furan derivatives and their precursors","volume":"20","author":"Lu","year":"2020","journal-title":"Anticancer Agents Med. Chem."},{"issue":"1","key":"10.1016\/j.psj.2025.105249_bib0020","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/jps.1167","article-title":"Pharmacokinetic\/pharmacodynamic studies in drug product development","volume":"91","author":"Meibohm","year":"2002","journal-title":"J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.psj.2025.105249_bib0021","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1749-6632.2011.06219.x","article-title":"Are pleuromutilin antibiotics finally fit for human use?","volume":"1241","author":"Novak","year":"2011","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.psj.2025.105249_bib0022","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.2147\/IJN.S319708","article-title":"Evaluation of the effects of silver nanoparticles against experimentally induced necrotic enteritis in broiler chickens","volume":"16","author":"Salem","year":"2021","journal-title":"Int. J. Nanomedicine"},{"issue":"7","key":"10.1016\/j.psj.2025.105249_bib0023","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.addr.2007.05.010","article-title":"Salt formation to improve drug solubility","volume":"59","author":"Serajuddin","year":"2007","journal-title":"Adv. Drug. Deliv. Rev."},{"issue":"7","key":"10.1016\/j.psj.2025.105249_bib0024","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/chromsci\/bmy033","article-title":"Determination of a new pleuromutilin derivative in broiler chicken plasma by RP-HPLC-UV and its application to a pharmacokinetic study","volume":"56","author":"Shang","year":"2018","journal-title":"J. Chromatogr. Sci."},{"issue":"3","key":"10.1016\/j.psj.2025.105249_bib0025","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1139\/cjm-2015-0763","article-title":"In vitro antimicrobial susceptibility ofMycoplasma bovis clinical isolates recovered from bison (Bison bison)","volume":"62","author":"Suleman","year":"2016","journal-title":"Can. J. Microbiol."},{"issue":"11","key":"10.1016\/j.psj.2025.105249_bib0026","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1007\/s40262-019-00791-z","article-title":"What antibiotic exposures are required to suppress the emergence of resistance for gram-negative bacteria?","volume":"58","author":"Sumi","year":"2019","journal-title":"A Systemat. Review. Clin Pharmacokinet"},{"issue":"1","key":"10.1016\/j.psj.2025.105249_bib0027","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2174\/138955712798868968","article-title":"Pleuromutilin and its derivatives-the lead compounds for novel antibiotics","volume":"12","author":"Tang","year":"2012","journal-title":"Mini Rev. Med. Chem."},{"issue":"6","key":"10.1016\/j.psj.2025.105249_bib0028","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/jac\/dkm360","article-title":"AUC\/MIC: a PK\/PD index for antibiotics with a time dimension or simply a dimensionless scoring factor?","volume":"60","author":"Toutain","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"issue":"11","key":"10.1016\/j.psj.2025.105249_bib0029","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1128\/JCM.01439-12","article-title":"Standardized methods and quality control limits for Agar and broth microdilution susceptibility testing of Mycoplasma pneumoniae, Mycoplasma hominis, and ureaplasma urealyticum","volume":"50","author":"Waites","year":"2012","journal-title":"J. Clin. Microbiol."},{"issue":"3","key":"10.1016\/j.psj.2025.105249_bib0030","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3390\/antibiotics11030403","article-title":"Rational use of Danofloxacin for treatment of Mycoplasma gallisepticum in chickens based on the clinical breakpoint and lung microbiota shift","volume":"11","author":"Wang","year":"2022","journal-title":"Antibiotics"},{"issue":"2","key":"10.1016\/j.psj.2025.105249_bib0031","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.03675-23","article-title":"Pharmacokinetic\/pharmacodynamic integration of amphenmulin: a novel pleuromutilin derivative against Mycoplasma gallisepticum","volume":"12","author":"Wang","year":"2024","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.psj.2025.105249_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114341","article-title":"Semisynthetic pleuromutilin antimicrobials with therapeutic potential against methicillin-resistant Staphylococcus aureus by targeting 50S ribosomal subunit","volume":"237","author":"Wang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"Supplement_3","key":"10.1016\/j.psj.2025.105249_bib0033","doi-asserted-by":"crossref","first-page":"iii5","DOI":"10.1093\/jac\/dkz085","article-title":"In vivo pharmacodynamics of lefamulin, the first systemic pleuromutilin for human use, in a neutropenic murine thigh infection model","volume":"74","author":"Wicha","year":"2019","journal-title":"J. Antimicrob. Chemother."},{"issue":"5","key":"10.1016\/j.psj.2025.105249_bib0034","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1080\/03079457.2017.1311990","article-title":"Immune responses to vaccination and infection withMycoplasma gallisepticumin turkeys","volume":"46","author":"Wijesurendra","year":"2017","journal-title":"Avian. Pathol."},{"issue":"22","key":"10.1016\/j.psj.2025.105249_bib0035","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1080\/14786419.2017.1374269","article-title":"Two new alkylated furan derivatives with antifungal and antibacterial activities from the plant endophytic fungusEmericella sp. XL029","volume":"32","author":"Wu","year":"2018","journal-title":"Nat. Prod. Res."},{"issue":"7","key":"10.1016\/j.psj.2025.105249_bib0036","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1128\/AAC.00200-15","article-title":"Vivo pharmacokinetic\/pharmacodynamic profiles of Valnemulin in an experimental intratracheal Mycoplasma gallisepticum infection model","volume":"59","author":"Xiao","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.psj.2025.105249_bib0037","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2016.00075","article-title":"Pharmacokinetic\/pharmacodynamic profiles of tiamulin in an experimental intratracheal infection model of Mycoplasma gallisepticum","volume":"3","author":"Xiao","year":"2016","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.psj.2025.105249_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.117061","article-title":"Design, synthesis, and biological evaluation of novel pleuromutilin derivatives with methicillin-resistant Staphylococcus aureus -targeting phenol linker groups","volume":"282","author":"Yi","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.psj.2025.105249_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106353","article-title":"Antibiotic resistance and drug modification: synthesis, characterization and bioactivity of newly modified potent pleuromutilin derivatives with a substituted piperazine moiety","volume":"132","author":"Yi","year":"2023","journal-title":"Bioorg. Chem."},{"issue":"4","key":"10.1016\/j.psj.2025.105249_bib0040","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1093\/jac\/dkv442","article-title":"Simultaneous assessment of the pharmacokinetics of a pleuromutilin, lefamulin, in plasma, soft tissues and pulmonary epithelial lining fluid","volume":"71","author":"Zeitlinger","year":"2016","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.psj.2025.105249_bib0041","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.952599","article-title":"Pharmacokinetic and pharmacodynamic integration of tilmicosin against Mycoplasma gallisepticum in the target infection site in chickens","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.psj.2025.105249_bib0042","article-title":"The PK\u2013PD relationship and resistance development of Danofloxacin against Mycoplasma gallisepticum in an In vivo infection model","volume":"8","author":"Zhang","year":"2017","journal-title":"Front. Microbiol."},{"issue":"3","key":"10.1016\/j.psj.2025.105249_bib0043","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1111\/cbdd.13328","article-title":"Synthesis and antibacterial activities of novel pleuromutilin derivatives bearing an aminothiophenol moiety","volume":"92","author":"Zhang","year":"2018","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.psj.2025.105249_bib0044","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.anaerobe.2016.04.005","article-title":"Ex vivo pharmacokinetic\/pharmacodynamic relationship of valnemulin against Clostridium perfringens in plasma, the small intestinal and caecal contents of rabbits","volume":"39","author":"Zhou","year":"2016","journal-title":"Anaerobe"},{"issue":"4","key":"10.1016\/j.psj.2025.105249_bib0045","doi-asserted-by":"crossref","first-page":"878","DOI":"10.3390\/molecules25040878","article-title":"Antibacterial activity and pharmacokinetic profile of a promising Antibacterial agent: 22-(2-Amino-phenylsulfanyl)-22-deoxypleuromutilin","volume":"25","author":"Zuo","year":"2020","journal-title":"Molecules"}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125004912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125004912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:37:57Z","timestamp":1756305477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579125004912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0032579125004912"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2025.105249","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacokinetic\/pharmacodynamic relationship of a novel pleuromutilin derivative p-furoylamphenmulin against Mycoplasma gallisepticum in vivo in chickens","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2025.105249","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"105249"}}