{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:54:18Z","timestamp":1783569258607,"version":"3.55.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Sichuan Province Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009731","name":"Sichuan Provincial Youth Science and Technology Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.psj.2025.105426","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T10:59:06Z","timestamp":1749898746000},"page":"105426","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of immunoprotective effects of PlpE multi-epitope protein incorporated within the aluminum hydroxide-adjuvanted inactivated vaccine against Pasteurella multocida infection in chickens"],"prefix":"10.1016","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3521-7122","authenticated-orcid":false,"given":"Xuelian","family":"Xiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfeng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.psj.2025.105426_bib0001","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.vaccine.2013.11.068","article-title":"Development of immunization trials against Pasteurella multocida","volume":"32","author":"Ahmad","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.psj.2025.105426_bib0002","first-page":"31","article-title":"Pasteurella multocida pneumonia with hemoptysis: a case report","volume":"26","author":"Aida","year":"2019","journal-title":"Respir. Med. Case Rep."},{"issue":"36","key":"10.1016\/j.psj.2025.105426_bib0031","first-page":"313","article-title":"Characterization of Pasteurella multocida isolates of buffalo origin from Gujarat state of India by outer membrane protein profile analysis","volume":"2","author":"Aiswarya","year":"2017","journal-title":"Buffalo Bull"},{"issue":"1","key":"10.1016\/j.psj.2025.105426_bib0003","article-title":"Adjuvants to the S1-subunit of the SARS-CoV-2 spike protein vaccine improve antibody and T cell responses and surrogate neutralization in mice","volume":"14","author":"Becker","year":"2024","journal-title":"Sci. Rep.-Uk"},{"issue":"1","key":"10.1016\/j.psj.2025.105426_bib0004","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12917-023-03743-9","article-title":"Preparation of Escherichia coli ghost of anchoring bovine Pasteurella multocida OmpH and its immunoprotective effect","volume":"19","author":"Chen","year":"2023","journal-title":"BMC. Vet. Res."},{"issue":"11","key":"10.1016\/j.psj.2025.105426_bib0005","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.3390\/vaccines9111244","article-title":"Alum pickering emulsion as effective adjuvant to improve Malaria vaccine efficacy","volume":"9","author":"Chen","year":"2021","journal-title":"Vaccines. (Basel)"},{"key":"10.1016\/j.psj.2025.105426_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2020.125564","article-title":"Morphology and protein adsorption of aluminum phosphate and aluminum hydroxide and their potential catalytic function in the synthesis of polymeric emulsifiers","volume":"608","author":"Cheng","year":"2021","journal-title":"Colloids. Surf. A Physicochem. Eng. Asp."},{"issue":"2","key":"10.1016\/j.psj.2025.105426_bib0008","doi-asserted-by":"crossref","first-page":"70","DOI":"10.15430\/JCP.2020.25.2.70","article-title":"Chemopreventive and chemotherapeutic effect of Propolis and its constituents: a mini-review","volume":"25","author":"Chiu","year":"2020","journal-title":"J. Cancer Prev."},{"issue":"4","key":"10.1016\/j.psj.2025.105426_bib0009","doi-asserted-by":"crossref","first-page":"259","DOI":"10.34172\/bi.2020.33","article-title":"Designing a new generation of expression toolkits for engineering of green microalgae; robust production of human interleukin-2","volume":"10","author":"Dehghani","year":"2020","journal-title":"Bioimpacts."},{"issue":"5","key":"10.1016\/j.psj.2025.105426_bib0010","doi-asserted-by":"crossref","first-page":"946","DOI":"10.14202\/vetworld.2023.946-956","article-title":"Global commercialization and research of veterinary vaccines against Pasteurella multocida: 2015-2022 technological surveillance","volume":"16","author":"Dominguez-Odio","year":"2023","journal-title":"Vet. World"},{"issue":"2","key":"10.1016\/j.psj.2025.105426_bib0011","first-page":"84","article-title":"Evaluation of immunogenicity and protective efficacy of recombinant ptfA of avian Pasteurella multocida","volume":"17","author":"Gong","year":"2016","journal-title":"Iran. J. Vet. Res."},{"issue":"4","key":"10.1016\/j.psj.2025.105426_bib0012","doi-asserted-by":"crossref","first-page":"e5023","DOI":"10.1128\/jvi.00050-23","article-title":"Combining phage display technology with In Silico-designed epitope vaccine to elicit robust antibody responses against emerging pathogen Tilapia Lake Virus","volume":"97","author":"Gong","year":"2023","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.psj.2025.105426_bib0013","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.3390\/vaccines9101155","article-title":"Immune protective efficacy of China's traditional inactivated and attenuated vaccines against the prevalent strains of Pasteurella multocida in mice","volume":"9","author":"Guan","year":"2021","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.psj.2025.105426_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104380","article-title":"Molecular pathogenesis of the hyaluronic acid capsule of Pasteurella multocida","volume":"149","author":"Guan","year":"2020","journal-title":"Microb. Pathog."},{"issue":"13","key":"10.1016\/j.psj.2025.105426_bib0015","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.2174\/1568026621666210705164319","article-title":"Structure and functions of bacterial outer membrane protein A, A potential therapeutic target for bacterial infection","volume":"21","author":"Guan","year":"2021","journal-title":"Curr. Top. Med. Chem."},{"issue":"4","key":"10.1016\/j.psj.2025.105426_bib0016","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1002\/jmv.26596","article-title":"Vaccine design based on 16 epitopes of SARS-CoV-2 spike protein","volume":"93","author":"He","year":"2021","journal-title":"J. Med. Virol."},{"issue":"9","key":"10.1016\/j.psj.2025.105426_bib0017","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.3390\/ani14091331","article-title":"Analysis of the immunogenicity of African Swine fever F317L protein and screening of T cell epitopes","volume":"14","author":"Huang","year":"2024","journal-title":"Animals (Basel)"},{"issue":"Pt B","key":"10.1016\/j.psj.2025.105426_bib0018","article-title":"Virulence genes and enterobacterial repetitive intergenic consensus region (ERIC) profiling reveals highly diverse genetic population among avian strains of Pasteurella multocida","volume":"161","author":"Karthik","year":"2021","journal-title":"Microb. Pathog."},{"issue":"5","key":"10.1016\/j.psj.2025.105426_bib0019","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3390\/vetsci11050194","article-title":"Antimicrobial susceptibility profiles of Pasteurella multocida isolates from clinical cases of waterfowl in Hungary between 2022 and 2023","volume":"11","author":"Kerek","year":"2024","journal-title":"Vet. Sci."},{"issue":"11","key":"10.1016\/j.psj.2025.105426_bib0020","first-page":"1687","article-title":"Boosting mouse defense against lethal toxoplasma gondii infection with full-length and soluble SAG1 recombinant protein","volume":"11","author":"Li","year":"2023","journal-title":"Vaccines (Basel)"},{"issue":"13","key":"10.1016\/j.psj.2025.105426_bib0021","article-title":"Immunogenicity and protective efficacy of the recombinant Pasteurella multocida lipoproteins VacJ and PlpE, and outer membrane protein H from P. multocida A:1 in ducks","volume":"5","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"issue":"14","key":"10.1016\/j.psj.2025.105426_bib0022","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1016\/j.vaccine.2023.02.070","article-title":"Immunogenicity and protective efficacy of a multi-epitope recombinant toxin antigen of Pasteurella multocida against virulent challenge in mice","volume":"41","author":"Liang","year":"2023","journal-title":"Vaccine"},{"key":"10.1016\/j.psj.2025.105426_bib0023","article-title":"Development of a trivalent construct Omp18\/AhpC\/FlgH multi epitope peptide vaccine against Campylobacter jejuni","volume":"12","author":"Lou","year":"2021","journal-title":"Front. Microbiol."},{"issue":"11","key":"10.1016\/j.psj.2025.105426_bib0025","first-page":"870","article-title":"Pasteurella multocida PlpE protein polytope as a potential subunit vaccine candidate","volume":"21","author":"Mostaan","year":"2021","journal-title":"Vector. Borne Zoonotic. Dis."},{"issue":"3","key":"10.1016\/j.psj.2025.105426_bib0026","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3390\/vaccines10030390","article-title":"Protective efficacy of BCG vaccine against mycobacterium leprae and non-tuberculous mycobacterial infections","volume":"10","author":"Orujyan","year":"2022","journal-title":"Vaccines (Basel)"},{"issue":"4","key":"10.1016\/j.psj.2025.105426_bib0027","first-page":"412","article-title":"Immunization of BALB\/c mice against Shigella sonnei using a Multiepitope protein vaccine through intranasal and subcutaneous administration","volume":"23","author":"Shabnam","year":"2024","journal-title":"Iran. J. Allergy Asthma Immunol."},{"issue":"3","key":"10.1016\/j.psj.2025.105426_bib0028","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4142\/jvs.2010.11.3.227","article-title":"Molecular heterogeneity of plpE gene in Indian isolates of Pasteurella multocida and expression of recombinant PlpE in vaccine strain of P. multocida serotype B: 2","volume":"11","author":"Singh","year":"2010","journal-title":"J. Vet. Sci."},{"issue":"6","key":"10.1016\/j.psj.2025.105426_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2022.152287","article-title":"Bioinformatics-based SARS-CoV-2 epitopes design and the impact of spike protein mutants on epitope humoral immunities","volume":"227","author":"Sun","year":"2022","journal-title":"Immunobiology"},{"issue":"5","key":"10.1016\/j.psj.2025.105426_bib0030","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s11250-017-1304-x","article-title":"Serological evidence of avian encephalomyelitis virus and Pasteurella multocida infections in free-range indigenous chickens in Southern Mozambique","volume":"49","author":"Taunde","year":"2017","journal-title":"Trop. Anim. Health Prod."},{"issue":"12","key":"10.1016\/j.psj.2025.105426_bib0032","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1016\/j.vaccine.2024.04.020","article-title":"Dendritic cell targeting peptide plus Salmonella FliCd flagellin fused outer membrane protein H (OmpH) demonstrated increased efficacy against infections caused by different Pasteurella multocida serogroups in mouse models","volume":"42","author":"Wang","year":"2024","journal-title":"Vaccine"},{"issue":"21","key":"10.1016\/j.psj.2025.105426_bib0034","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.1016\/j.vaccine.2007.03.005","article-title":"Protective immunity conferred by recombinant Pasteurella multocida lipoprotein E (PlpE)","volume":"25","author":"Wu","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.psj.2025.105426_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2020.109806","article-title":"Identification of beta-conglycinin alpha' subunit antigenic epitopes destroyed by thermal treatments","volume":"139","author":"Xi","year":"2021","journal-title":"Food Res. Int."},{"key":"10.1016\/j.psj.2025.105426_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2021.105196","article-title":"Characterization of Pasteurella multocida isolated from ducks in China from 2017 to 2019","volume":"160","author":"Xiao","year":"2021","journal-title":"Microb. Pathogenesis"},{"issue":"0","key":"10.1016\/j.psj.2025.105426_bib0037","article-title":"Novel platform for engineering stable and effective vaccines against botulinum neurotoxins A, B and E","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2025.105426_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2023.106212","article-title":"Overexpression of Pasteurella multocida OmpA induces transcriptional changes and its possible implications for the macrophage polarization","volume":"183","author":"Yang","year":"2023","journal-title":"Microb. Pathog."},{"issue":"4","key":"10.1016\/j.psj.2025.105426_bib0039","first-page":"272","article-title":"Immunization with recombinant PlpE of ovine Mannheimia haemolytica isolate provides protection against lethal challenge in mice","volume":"22","author":"Yektaseresht","year":"2021","journal-title":"Iran. J. Vet. Res."},{"key":"10.1016\/j.psj.2025.105426_bib0040","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.668492","article-title":"Design of a novel multi-epitope vaccine against echinococcus granulosus in immunoinformatics","volume":"12","author":"Yu","year":"2021","journal-title":"Front. Immunol."},{"issue":"21","key":"10.1016\/j.psj.2025.105426_bib0041","article-title":"A new multi-epitope DNA vaccine against Helicobacter Pylori infection in a BALB\/c mouse model","volume":"10","author":"Zahra","year":"2024","journal-title":"Heliyon."},{"issue":"3","key":"10.1016\/j.psj.2025.105426_bib0042","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.03362-22","article-title":"Identification of a linear B cell epitope on p54 of African Swine Fever Virus using nanobodies as a novel tool","volume":"11","author":"Zhao","year":"2023","journal-title":"Microbiol. Spectr."},{"issue":"1","key":"10.1016\/j.psj.2025.105426_bib0044","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12917-023-03679-0","article-title":"Recombinant-attenuated Salmonella enterica serovar Choleraesuis vector expressing the PlpE protein of Pasteurella multocida protects mice from lethal challenge","volume":"19","author":"Zhou","year":"2023","journal-title":"BMC. Vet. Res."},{"issue":"3","key":"10.1016\/j.psj.2025.105426_bib0045","doi-asserted-by":"crossref","DOI":"10.1128\/iai.00272-22","article-title":"Combinations but not a single PlpE epitope induces host protective immunity against Pasteurella multocida","volume":"91","author":"Zhu","year":"2023","journal-title":"Infect. Immun."},{"key":"10.1016\/j.psj.2025.105426_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2020.108649","article-title":"Characterization of Pasteurella multocida isolates from rabbits in China","volume":"244","author":"Zhu","year":"2020","journal-title":"Vet. Microbiol."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125006704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125006704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T03:17:27Z","timestamp":1756437447000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579125006704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0032579125006704"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2025.105426","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of immunoprotective effects of PlpE multi-epitope protein incorporated within the aluminum hydroxide-adjuvanted inactivated vaccine against Pasteurella multocida infection in chickens","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2025.105426","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"105426"}}