{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:33:50Z","timestamp":1787765630315,"version":"build-2784847793"},"reference-count":40,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.psj.2025.105498","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T06:53:51Z","timestamp":1751007231000},"page":"105498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Areca catechu L. extract powder ameliorates Eimeria tenella-induced coccidiosis in chicks through anti-inflammatory effects, growth promotion, hematological restoration, and gut microbiota modulation"],"prefix":"10.1016","volume":"104","author":[{"given":"Danyang","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silu","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyue","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yarong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2025.105498_bib0001","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijfoodmicro.2013.10.014","article-title":"Isolation and molecular characterization of Salmonella enterica, Escherichia coli O157:H7 and Shigella spp. From meat and dairy products in Egypt","author":"Ahmed","year":"2014","journal-title":"Int. J. Food Microbiol."},{"issue":"12","key":"10.1016\/j.psj.2025.105498_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103111","article-title":"Supplementing broiler diets with bacterial selenium nanoparticles enhancing performance, carcass traits, blood indices, antioxidant status, and caecal microbiota of Eimeria tenella-infected broiler chickens","volume":"102","author":"Alsulami","year":"2023","journal-title":"Poult. Sci."},{"issue":"1","key":"10.1016\/j.psj.2025.105498_bib0003","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40104-023-00979-1","article-title":"Layer chicken microbiota: a comprehensive analysis of spatial and temporal dynamics across all major gut sections","volume":"15","author":"Bajagai","year":"2024","journal-title":"J. Anim. Sci. Biotechnol."},{"issue":"6","key":"10.1016\/j.psj.2025.105498_bib0004","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1080\/03079457.2022.2098692","article-title":"The influence of nutrition on intestinal disease with emphasis on coccidiosis","volume":"51","author":"Bedford","year":"2022","journal-title":"Avian Pathol."},{"issue":"5","key":"10.1016\/j.psj.2025.105498_bib0005","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1093\/carcin\/bgt012","article-title":"Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis\u2013a precancer condition","volume":"34","author":"Chang","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.psj.2025.105498_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.134900","article-title":"Polysaccharide from Areca catechu L. inflorescence enhances the intestinal mucosal immunity to maintain immune homeostasis","volume":"278","author":"Chen","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.psj.2025.105498_bib0007","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.biopha.2018.07.114","article-title":"Preventive measures in oral cancer: an overview","volume":"107","author":"D'Souza","year":"2018","journal-title":"Biomed. PharmacOther"},{"issue":"1","key":"10.1016\/j.psj.2025.105498_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101542","article-title":"Phytochemical control of poultry coccidiosis: a review","volume":"101","author":"El-Shall","year":"2022","journal-title":"Poult. Sci."},{"issue":"1","key":"10.1016\/j.psj.2025.105498_bib0009","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s13071-024-06409-z","article-title":"Anticoccidial activity of a botanical natural product based on eucalyptus, apigenin and eugenol against Eimeria tenella in broiler chickens","volume":"17","author":"Geng","year":"2024","journal-title":"Parasit. Vectors."},{"issue":"8","key":"10.1016\/j.psj.2025.105498_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103909","article-title":"Silymarin effectively prevents and treats eimeria tenella infection in chicks","volume":"103","author":"Han","year":"2024","journal-title":"Poult. Sci."},{"issue":"3\u20134","key":"10.1016\/j.psj.2025.105498_bib0011","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.vetpar.2004.03.006","article-title":"World Association for the Advancement of Veterinary Parasitology (WAAVP) guidelines for evaluating the efficacy of anticoccidial drugs in chickens and turkeys","volume":"121","author":"Holdsworth","year":"2004","journal-title":"Vet. Parasitol."},{"issue":"1","key":"10.1016\/j.psj.2025.105498_bib0012","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0014-4894(70)90063-9","article-title":"Anticoccidial drugs: lesion scoring techniques in battery and floor-pen experiments with chickens","volume":"28","author":"Johnson","year":"1970","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.psj.2025.105498_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2023.110003","article-title":"In-vivo anticoccidial efficacy of green synthesized iron-oxide nanoparticles using Ficus racemosa Linn leaf extract. (Moraceae) Against Emeria tenella infection in broiler chicks","volume":"321","author":"Khan","year":"2023","journal-title":"Vet. Parasitol."},{"issue":"3","key":"10.1016\/j.psj.2025.105498_bib0014","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jep.2011.03.064","article-title":"Studies on anti-inflammatory and analgesic activities of betel nut in rodents","volume":"135","author":"Khan","year":"2011","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.psj.2025.105498_bib0015","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.14202\/vetworld.2024.1073-1083","article-title":"Modulation of chicken gut microbiota for enhanced productivity and health: a review","volume":"17","author":"Khasanah","year":"2024","journal-title":"Vet. World"},{"issue":"4","key":"10.1016\/j.psj.2025.105498_bib0016","doi-asserted-by":"crossref","first-page":"811","DOI":"10.3382\/ps\/pev441","article-title":"Anticoccidial evaluation of a traditional Chinese medicine\u2013Brucea javanica\u2013in broilers","volume":"95","author":"Lan","year":"2016","journal-title":"Poult. Sci."},{"issue":"31","key":"10.1016\/j.psj.2025.105498_bib0017","doi-asserted-by":"crossref","first-page":"11070","DOI":"10.1073\/pnas.0504978102","article-title":"Obesity alters gut microbial ecology","volume":"102","author":"Ley","year":"2005","journal-title":"Proc. Natl. Acad Sci. U S A"},{"issue":"5","key":"10.1016\/j.psj.2025.105498_bib0018","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1039\/D2BM01543A","article-title":"Nano-encapsulation of halofuginone hydrobromide enhances anticoccidial activity against Eimeria tenella in chickens","volume":"11","author":"Lin","year":"2023","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.psj.2025.105498_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119946","article-title":"Safety evaluation of Areca catechu L. extract powder in rats: acute and 180-day chronic toxicity test","volume":"350","author":"Ma","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.psj.2025.105498_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102975","article-title":"Natural Magnolol ameliorates coccidiosis infected with Eimeria tenella by affecting antioxidant, anti-inflammatory, and gut microbiota of chicks","volume":"102","author":"Mo","year":"2023","journal-title":"Poult. Sci."},{"issue":"2","key":"10.1016\/j.psj.2025.105498_bib0021","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/1574-6968.12608","article-title":"The chicken gastrointestinal microbiome","volume":"360","author":"Oakley","year":"2014","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.psj.2025.105498_bib0022","first-page":"11","article-title":"Spatial and temporal changes in the broiler chicken cecal and fecal microbiomes and correlations of bacterial taxa with","volume":"3","author":"Oakley","year":"2016","journal-title":"Cytokine Gene Expression. Front. Vet. Sci."},{"issue":"1","key":"10.1016\/j.psj.2025.105498_bib0023","doi-asserted-by":"crossref","DOI":"10.1002\/cpmc.81","article-title":"Laboratory growth and genetic manipulation of eimeria tenella","volume":"53","author":"Pastor-Fernandez","year":"2019","journal-title":"Curr. Protoc. Microbiol."},{"key":"10.1016\/j.psj.2025.105498_bib0024","doi-asserted-by":"crossref","DOI":"10.1093\/jas\/skae118","article-title":"Effects of dietary water-soluble extract of rosemary supplementation on growth performance and intestinal health of broilers infected with Eimeria tenella","volume":"102","author":"Peng","year":"2024","journal-title":"J. Anim. Sci."},{"issue":"6","key":"10.1016\/j.psj.2025.105498_bib0025","article-title":"Immunomodulatory effects of natural feed additives for meat chickens","volume":"13","author":"Phillips","year":"2023","journal-title":"Life (Basel)"},{"issue":"5","key":"10.1016\/j.psj.2025.105498_bib0026","doi-asserted-by":"crossref","DOI":"10.3390\/nu16050695","article-title":"Bioactive components of Areca nut: an overview of their positive impacts targeting different organs","volume":"16","author":"Sun","year":"2024","journal-title":"Nutrients"},{"issue":"8","key":"10.1016\/j.psj.2025.105498_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102845","article-title":"Pathogenicity and drug resistance of the Eimeria tenella isolate from Yiwu, Zhejiang province, eastern China","volume":"102","author":"Sun","year":"2023","journal-title":"Poult. Sci."},{"issue":"8","key":"10.1016\/j.psj.2025.105498_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102845","article-title":"Pathogenicity and drug resistance of the Eimeria tenella isolate from Yiwu, Zhejiang province, eastern China","volume":"102","author":"Sun","year":"2023","journal-title":"Poult. Sci."},{"issue":"6","key":"10.1016\/j.psj.2025.105498_bib0029","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/ame2.12463","article-title":"Histopathologic observations in a coccidiosis model of Eimeria tenella","volume":"7","author":"Sun","year":"2024","journal-title":"Animal. Model. Exp. Med."},{"key":"10.1016\/j.psj.2025.105498_bib0030","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1250080","article-title":"The caecal microbiota promotes the acute inflammatory response and the loss of the intestinal barrier integrity during severe Eimeria tenella infection","volume":"13","author":"Tomal","year":"2023","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.psj.2025.105498_bib0031","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.exppara.2017.11.002","article-title":"Anticoccidial effects of areca nut (Areca catechu L.) extract on broiler chicks experimentally infected with Eimeria tenella","volume":"184","author":"Wang","year":"2018","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.psj.2025.105498_bib0032","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.709046","article-title":"Anticoccidial activity of Qinghao powder against eimeria tenella in broiler chickens","volume":"8","author":"Wang","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.psj.2025.105498_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156005","article-title":"A review of the traditional uses, pharmacology, and toxicology of areca nut","volume":"134","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"issue":"10","key":"10.1016\/j.psj.2025.105498_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.102100","article-title":"Punicalagin: a monomer with anti-eimeria tenella effect from fruit peel of Punica granatum L","volume":"101","author":"Yang","year":"2022","journal-title":"Poult. Sci."},{"issue":"1","key":"10.1016\/j.psj.2025.105498_bib0035","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1080\/13880209.2020.1784234","article-title":"Anticoccidial effect of Fructus meliae toosendan extract against Eimeria tenella","volume":"58","author":"Yong","year":"2020","journal-title":"Pharm. Biol."},{"issue":"09","key":"10.1016\/j.psj.2025.105498_bib0036","first-page":"5696","article-title":"Effects of Rosmarinic Acid on growth performance,lmmuneFunction and inflammatory response of broilers challengedwith eimeria acervulina","volume":"35","author":"You","year":"2023","journal-title":"Chin. J. Anim. Nutr."},{"issue":"4","key":"10.1016\/j.psj.2025.105498_bib0037","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0304-4017(01)00385-5","article-title":"Screening of the anticoccidial effects of herb extracts against Eimeria tenella","volume":"96","author":"Youn","year":"2001","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.psj.2025.105498_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2023.109940","article-title":"Matrine provides a protective effect against Eimeria tenella challenge by alleviating intestinal barrier damage","volume":"319","author":"Yuan","year":"2023","journal-title":"Vet. Parasitol."},{"issue":"3","key":"10.1016\/j.psj.2025.105498_bib0039","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.psj.2019.10.073","article-title":"Effects of Eimeria tenella infection on the barrier damage and microbiota diversity of chicken cecum","volume":"99","author":"Zhou","year":"2020","journal-title":"Poult. Sci."},{"issue":"3","key":"10.1016\/j.psj.2025.105498_bib0040","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.psj.2019.10.073","article-title":"Effects of Eimeria tenella infection on the barrier damage and microbiota diversity of chicken cecum","volume":"99","author":"Zhou","year":"2020","journal-title":"Poult. Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125007412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125007412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T05:56:19Z","timestamp":1759211779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579125007412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0032579125007412"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2025.105498","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Areca catechu L. extract powder ameliorates Eimeria tenella-induced coccidiosis in chicks through anti-inflammatory effects, growth promotion, hematological restoration, and gut microbiota modulation","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2025.105498","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"105498"}}