{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:30:20Z","timestamp":1790307020575,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD04068"],"award-info":[{"award-number":["2023ZD04068"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013071","name":"Major Program of National Fund of Philosophy and Social Science of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong Province","doi-asserted-by":"publisher","award":["2023LZGC018"],"award-info":[{"award-number":["2023LZGC018"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772588"],"award-info":[{"award-number":["31772588"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.psj.2025.105592","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T23:36:07Z","timestamp":1753313767000},"page":"105592","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dissection of the gene regulatory network underlying sexual maturity divergence in Jining Bairi chickens through integrated RNA-seq and WGCNA analysis"],"prefix":"10.1016","volume":"104","author":[{"given":"Jiale","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongrui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunliang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2025.105592_bib0001","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ygcen.2009.03.010","article-title":"Gonadotropin-inhibitory hormone receptor signaling and its impact on reproduction in chickens","volume":"163","author":"B\u00e9d\u00e9carrats","year":"2009","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.psj.2025.105592_bib0002","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1046\/j.1471-4159.2000.0752574.x","article-title":"Glutamine synthetase and glutamine synthetase-like protein from human brain: purification and comparative characterization","volume":"75","author":"Boksha","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.psj.2025.105592_bib0003","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/humupd\/dmh012","article-title":"Precocious puberty and statural growth","volume":"10","author":"Carel","year":"2004","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.psj.2025.105592_bib0004","article-title":"Genetic parameter estimation and molecular foundation of chicken egg-laying trait","volume":"103","author":"Chen","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105592_bib0005","first-page":"181","article-title":"Gene expression profiling in ovaries and association analyses reveal as a candidate Gene for","volume":"10","author":"Chen","year":"2020","journal-title":"Sex. Matur. Chick. Anim."},{"key":"10.1016\/j.psj.2025.105592_bib0006","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/s41420-024-02231-9","article-title":"Identification of apelin\/APJ signaling dysregulation in a human iPSC-derived granulosa cell model of Turner syndrome","volume":"10","author":"Chen","year":"2024","journal-title":"Cell Death. Discov."},{"key":"10.1016\/j.psj.2025.105592_bib0007","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.devcel.2013.11.002","article-title":"ELABELA: a hormone essential for heart development signals via the apelin receptor","volume":"27","author":"Chng","year":"2013","journal-title":"Dev. Cell."},{"key":"10.1016\/j.psj.2025.105592_bib0008","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1073\/pnas.052658699","article-title":"The mammalian oocyte orchestrates the rate of ovarian follicular development","volume":"99","author":"Eppig","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.psj.2025.105592_bib0009","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41437-018-0092-z","article-title":"Changes in pituitary gene expression may underlie multiple domesticated traits in chickens","volume":"122","author":"Fallahshahroudi","year":"2018","journal-title":"Heredity"},{"key":"10.1016\/j.psj.2025.105592_bib0010","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1111\/rda.14389","article-title":"An integrated analysis of mRNAs and lncRNAs in goat's hypothalamus to explore the onset of puberty","volume":"58","author":"Gao","year":"2023","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.psj.2025.105592_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.animal.2023.100782","article-title":"Review: gestational and postnatal nutritional effects on the neuroendocrine control of puberty and subsequent reproductive performance in heifers","volume":"17","author":"Garza","year":"2023","journal-title":"Animal"},{"key":"10.1016\/j.psj.2025.105592_bib0012","doi-asserted-by":"crossref","first-page":"6147","DOI":"10.1016\/j.psj.2020.08.001","article-title":"Melatonin regulates chicken granulosa cell proliferation and apoptosis by activating the mTOR signaling pathway via its receptors","volume":"99","author":"Hao","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105592_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103478","article-title":"Molecular mechanisms of hypothalamic-pituitary-ovarian\/thyroid axis regulating age at first egg in geese","volume":"103","author":"He","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105592_bib0014","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ygcen.2010.10.011","article-title":"Characterization of the chicken galanin type I receptor (GalR1) and a novel GalR1-like receptor (GalR1-L)","volume":"170","author":"Ho","year":"2011","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.psj.2025.105592_bib0015","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.cbi.2016.12.012","article-title":"Comparative and evolutionary studies of ALDH18A1 genes and proteins","volume":"276","author":"Holmes","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.psj.2025.105592_bib0016","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.3382\/ps\/pex224","article-title":"Correlated responses to long-term divergent selection for 8-week body weight in female White Plymouth Rock chickens: sexual maturity","volume":"96","author":"Jambui","year":"2017","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105592_bib0017","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ygcen.2016.02.010","article-title":"A domestication related mutation in the thyroid stimulating hormone receptor gene (TSHR) modulates photoperiodic response and reproduction in chickens","volume":"228","author":"Karlsson","year":"2016","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.psj.2025.105592_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2021.167378","article-title":"Apoptosis, pyroptosis, and necroptosis-oh my! the many ways a cell can die","volume":"434","author":"Ketelut-Carneiro","year":"2022","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.psj.2025.105592_bib0019","doi-asserted-by":"crossref","first-page":"303","DOI":"10.5194\/aab-63-303-2020","article-title":"Comparative transcriptome and histomorphology analysis of testis tissues from mulard and Pekin ducks","volume":"63","author":"Li","year":"2020","journal-title":"Arch. Anim. Breed."},{"key":"10.1016\/j.psj.2025.105592_bib0020","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.3390\/ani14152253","article-title":"Transcriptome analysis of hypothalamic-pituitary-ovarian axis reveals circRNAs related to egg production of Bian Chicken","volume":"14","author":"Li","year":"2024","journal-title":"Animals"},{"key":"10.1016\/j.psj.2025.105592_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygeno.2022.110396","article-title":"Comparative transcriptomics in the hypothalamic-pituitary-gonad axis of mammals and poultry","volume":"114","author":"Li","year":"2022","journal-title":"Genomics"},{"key":"10.1016\/j.psj.2025.105592_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104325","article-title":"Genetic structure, selective characterization and specific molecular identity cards of high-yielding Houdan chickens based on genome-wide SNP","volume":"103","author":"Liu","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105592_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118310","article-title":"Apelin\/Apelin receptor: a new therapeutic target in Polycystic Ovary Syndrome","volume":"260","author":"Liu","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.psj.2025.105592_bib0024","doi-asserted-by":"crossref","DOI":"10.1590\/fst.07222","article-title":"The influence of sexual maturity on the meat quality of free-range chickens","volume":"42","author":"Mar\u00c7al","year":"2022","journal-title":"Food Sci. Technol."},{"key":"10.1016\/j.psj.2025.105592_bib0025","doi-asserted-by":"crossref","first-page":"5976","DOI":"10.1038\/s41598-020-62886-z","article-title":"Transcriptome analysis reveals differentially expressed genes associated with high rates of egg production in chicken hypothalamic-pituitary-ovarian axis","volume":"10","author":"Mishra","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2025.105592_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124654","article-title":"p regulates chicken granulosa cell function via 14-3-3\u03b2\/FoxO and PPAR-\u03b3\/LPL signaling pathways","volume":"241","author":"Ning","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.psj.2025.105592_bib0027","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0378-1119(93)90495-O","article-title":"A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11","volume":"136","author":"O'dowd","year":"1993","journal-title":"Gene"},{"key":"10.1016\/j.psj.2025.105592_bib0028","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1089\/dna.2018.4467","article-title":"Genes involved in the processes of cell proliferation, migration, adhesion, and tissue development as new potential markers of Porcine Granulosa cellular processes: a microarray approach","volume":"38","author":"Ozegowska","year":"2019","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.psj.2025.105592_bib0029","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.2527\/jas.2008-1756","article-title":"The effect of gilt age at first estrus and breeding on third estrus on sow body weight changes and long-term reproductive performance1","volume":"88","author":"Patterson","year":"2010","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.psj.2025.105592_bib0030","doi-asserted-by":"crossref","DOI":"10.1126\/science.1248636","article-title":"Toddler: an embryonic signal that promotes cell movement via apelin receptors","volume":"343","author":"Pauli","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.psj.2025.105592_bib0031","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1093\/gbe\/evu125","article-title":"Evolutionary origin and methylation status of Human intronic CpG islands that are not present in mouse","volume":"6","author":"Rademacher","year":"2014","journal-title":"Genome Biol. Evol."},{"key":"10.1016\/j.psj.2025.105592_bib0032","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.seizure.2021.10.013","article-title":"GABRA1 and GABRA6 gene mutations in idiopathic generalized epilepsy patients","volume":"93","author":"Riaz","year":"2021","journal-title":"Seizure"},{"key":"10.1016\/j.psj.2025.105592_bib0033","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1095\/biolreprod.116.141754","article-title":"Apelin (APLN) and Apelin receptor (APLNR) in Human ovary: expression, signaling, and regulation of steroidogenesis in primary Human luteinized granulosa cells","volume":"95,","author":"Roche","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.psj.2025.105592_bib0034","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1530\/REP-16-0677","article-title":"Apelin (APLN) regulates progesterone secretion and oocyte maturation in bovine ovarian cells","volume":"153","author":"Roche","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.psj.2025.105592_bib0035","doi-asserted-by":"crossref","first-page":"344","DOI":"10.7150\/ijbs.5.344","article-title":"The expression of apelin and its receptor apj during different physiological stages in the bovine ovary","volume":"5","author":"Schilffarth","year":"2009","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.psj.2025.105592_bib0036","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.theriogenology.2023.08.030","article-title":"microRNA transcriptome analysis of granulosa cells predicts that the Notch and insulin pathways affect follicular development in chickens","volume":"212","author":"Shen","year":"2023","journal-title":"Theriogenology"},{"key":"10.1016\/j.psj.2025.105592_bib0037","article-title":"Apelin and Apelin receptor in follicular granulosa cells of Buffalo ovaries","volume":"13","author":"Shokrollahi","year":"2022","journal-title":"Expr. Regul. Steroidogenes. Front. Endocrinol."},{"key":"10.1016\/j.psj.2025.105592_bib0038","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s11259-023-10107-z","article-title":"The effects of apelin on IGF1\/FSH-induced steroidogenesis, proliferation, Bax expression, and total antioxidant capacity in granulosa cells of buffalo ovarian follicles","volume":"47","author":"Shokrollahi","year":"2023","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.psj.2025.105592_bib0039","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.euroneuro.2014.02.009","article-title":"Transitions in the transcriptome of the serotonergic and dopaminergic systems in the human brain during adolescence","volume":"24","author":"Shoval","year":"2014","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.psj.2025.105592_bib0040","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s10571-020-00968-2","article-title":"Apelin receptor signaling protects GT1-7 GnRH neurons against oxidative stress in vitro","volume":"42","author":"\u015ei\u015fli","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.psj.2025.105592_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101325","article-title":"Effect of age at first egg on reproduction performance and characterization of the hypothalamo\u2013pituitary\u2013gonadal axis in chickens","volume":"100","author":"Tan","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105592_bib0042","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/age.12028","article-title":"Genome-wide prediction of age at puberty and reproductive longevity in sows","volume":"44","author":"Tart","year":"2013","journal-title":"Anim. Genet."},{"key":"10.1016\/j.psj.2025.105592_bib0043","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1017\/S1751731115000075","article-title":"Evaluation of productivity of sexually precocious Nelore heifers","volume":"9","author":"Terakado","year":"2015","journal-title":"Animal"},{"key":"10.1016\/j.psj.2025.105592_bib0044","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3389\/fncel.2016.00230","article-title":"Altered expression of genes encoding neurotransmitter receptors in GnRH neurons of proestrous mice","volume":"10","author":"Vastagh","year":"2016","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.psj.2025.105592_bib0045","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3389\/fgene.2018.00491","article-title":"Dynamic changes in the global MicroRNAome and transcriptome identify key nodes associated with ovarian development in chickens","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Genet."},{"key":"10.1016\/j.psj.2025.105592_bib0046","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.gene.2018.03.079","article-title":"Microarray analysis of obese women with polycystic ovary syndrome for key gene screening, key pathway identification and drug prediction","volume":"661","author":"Wei","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.psj.2025.105592_bib0047","article-title":"Dynamic changes in the follicular transcriptome and promoter DNA methylation pattern of steroidogenic genes in chicken follicles throughout the ovulation cycle","volume":"10","author":"Wolfe","year":"2015","journal-title":"PLoS. One"},{"key":"10.1016\/j.psj.2025.105592_bib0048","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s40104-024-01107-3","article-title":"The assembly and activation of the PANoptosome promote porcine granulosa cell programmed cell death during follicular atresia","volume":"15","author":"Wu","year":"2024","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.psj.2025.105592_bib0049","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s12264-023-01128-4","article-title":"Inflammatory factor IL1\u03b1 induces aberrant astrocyte proliferation in spinal cord injury through the Grin2c\/Ca2+\/CaMK2b pathway","volume":"40","author":"Xia","year":"2023","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.psj.2025.105592_bib0050","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1038\/s41598-024-52716-x","article-title":"miRNA profiling of chicken follicles during follicular development","volume":"14","author":"Xu","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2025.105592_bib0051","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s11658-022-00409-6","article-title":"Three-dimensional genome landscape comprehensively reveals patterns of spatial gene regulation in papillary and anaplastic thyroid cancers: a study using representative cell lines for each cancer type","volume":"28","author":"Zhang","year":"2023","journal-title":"Cell Mol. Biol. Lett."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125008338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125008338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:03:11Z","timestamp":1778652191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579125008338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0032579125008338"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2025.105592","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dissection of the gene regulatory network underlying sexual maturity divergence in Jining Bairi chickens through integrated RNA-seq and WGCNA analysis","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2025.105592","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"105592"}}