{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:25:53Z","timestamp":1787315153509,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007860","name":"Ilam University","doi-asserted-by":"publisher","award":["981511070 2"],"award-info":[{"award-number":["981511070 2"]}],"id":[{"id":"10.13039\/501100007860","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.psj.2025.105684","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T15:53:16Z","timestamp":1755100396000},"page":"105684","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Optimal dietary arginine improves productive performance, gut morphology, and expression of growth-related and stress-response genes in Japanese quails"],"prefix":"10.1016","volume":"104","author":[{"given":"Ali Reza","family":"Ghiasvand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0524-5392","authenticated-orcid":false,"given":"Hassan","family":"Shirzadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein Ali","family":"Ghasemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6830-7904","authenticated-orcid":false,"given":"Kamran","family":"Taherpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shokoufeh","family":"Hasanvand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9214-8146","authenticated-orcid":false,"given":"Ali","family":"Khatibjoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2025.105684_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.105601","article-title":"Effect of arginine supplementation on liver and pectoral muscle: tissue-specific lipid metabolism in broilers","author":"Ali","year":"2025","journal-title":"Poult. Sci. In Press."},{"key":"10.1016\/j.psj.2025.105684_bib0002","series-title":"Official Methods of Analysis","year":"2007"},{"key":"10.1016\/j.psj.2025.105684_bib0003","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40104-023-00839-y","article-title":"Feeding broiler chickens with arginine above recommended levels: effects on growth performance, metabolism, and intestinal microbiota","volume":"14","author":"Brugaletta","year":"2023","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.psj.2025.105684_bib0004","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.3382\/ps\/pey504","article-title":"L-arginine supplementation enhances growth performance, lean muscle, and bone density but not fat in broiler chickens","volume":"98","author":"Castro","year":"2019","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0005","doi-asserted-by":"crossref","first-page":"5844","DOI":"10.1016\/j.psj.2020.08.017","article-title":"The effects of L-Arginine supplementation on growth performance and intestinal health of broiler chickens challenged with Eimeria spp","volume":"99","author":"Castro","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0006","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.3390\/ani10112106","article-title":"Secondary functions of arginine and sulfur amino acids in poultry health: review","volume":"10","author":"De Souza Castro","year":"2020","journal-title":"Animals"},{"key":"10.1016\/j.psj.2025.105684_bib0007","series-title":"Applied Regression Analysis","author":"Draper","year":"1981"},{"key":"10.1016\/j.psj.2025.105684_bib0008","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/00071668.2013.864381","article-title":"The effect of feeding excess arginine on lipogenic gene expression and growth performance in broilers","volume":"55","author":"Ebrahimi","year":"2014","journal-title":"Br. Poult. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0009","article-title":"Effect of arginine supplementation on the growth performance, intestinal health, and immune responses of broilers during necrotic enteritis challenge","volume":"103","author":"Fathima","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1326809","article-title":"Beyond protein synthesis: the emerging role of arginine in poultry nutrition and host-microbe interactions","volume":"14","author":"Fathima","year":"2024","journal-title":"Front. Physiol."},{"key":"10.1016\/j.psj.2025.105684_bib0011","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.3382\/ps.2008-00214","article-title":"Effect of arginine on the development of the pectoralis muscle and the diameter and the protein:deoxyribonucleic acid rate of its skeletal myofibers in broilers","volume":"88","author":"Fernandes","year":"2009","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.animal.2020.100120","article-title":"Supplemental L-arginine improves feed conversion and modulates lipid metabolism in male and female broilers from 29 to 42 days of age","volume":"15","author":"Filho","year":"2021","journal-title":"Animal"},{"key":"10.1016\/j.psj.2025.105684_bib0013","doi-asserted-by":"crossref","first-page":"750","DOI":"10.3390\/ani11030750","article-title":"Phytogenic water additives improve broiler growth performance via modulation of intermediary metabolism-related signaling pathways","volume":"11","author":"Flees","year":"2021","journal-title":"Animals"},{"key":"10.1016\/j.psj.2025.105684_bib0014","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/00439339.2021.1925198","article-title":"Physiological role of arginine in growth performance, gut health, and immune response in broilers: A review","volume":"77","author":"Hassan","year":"2021","journal-title":"World\u2019s Poult. Sci. J."},{"key":"10.1016\/j.psj.2025.105684_bib0015","first-page":"35","article-title":"Effect of arginine supplementation on productive performance, carcass traits, hematology and economic efficiency of broilers under heat stress conditions","volume":"21","author":"Hassan","year":"2022","journal-title":"J. Agric. Environ. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0016","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1016\/S2095-3119(16)61404-1","article-title":"Regulatory effects of dietary L-arg supplementation on the innate immunity and antioxidant ability in broiler chickens","volume":"15","author":"Hu","year":"2016","journal-title":"J. Integr. Agric."},{"key":"10.1016\/j.psj.2025.105684_bib0017","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/1828051X.2021.2013136","article-title":"Arginine supplementation improves reproductive performance, antioxidant status, immunity and maternal antibody transmission in breeder Japanese quail under heat stress conditions","volume":"21","author":"Kalvandi","year":"2022","journal-title":"Ital. J. Anim. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0018","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1017\/S0043933910000711","article-title":"Dietary arginine: metabolic, environmental, immunological and physiological interrelationships","volume":"66","author":"Khajali","year":"2010","journal-title":"World\u2019s Poult. Sci. J."},{"key":"10.1016\/j.psj.2025.105684_bib0019","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s00484-013-0710-7","article-title":"An L-arginine supplement improves broiler hypertensive response and gut function in broiler chickens reared at high altitude","volume":"58","author":"Khajali","year":"2014","journal-title":"Int. J. Biometeorol."},{"key":"10.1016\/j.psj.2025.105684_bib0020","first-page":"1","article-title":"Growth performance, intestinal morphology, serum biochemical and hematological parameters in Japanese quail (Coturnix japonica) fed supplemental L-Arginine","volume":"22","author":"Kheiri","year":"2019","journal-title":"Braz. J. Poult. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0022","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1080\/00071660903110851","article-title":"Expression of heat shock protein 90 (Hsp90) and transcription of its corresponding mRNA in broilers exposed to high temperature","volume":"50","author":"Lei","year":"2009","journal-title":"Br. Poult. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0023","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.14202\/vetworld.2022.1365-1372","article-title":"Effect of L-arginine and L-lysine HCl ratio on growth performance and ileum morphology of native chickens aged 2\u201314 weeks","volume":"15","author":"Lisnahan","year":"2022","journal-title":"Vet. World"},{"key":"10.1016\/j.psj.2025.105684_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102773","article-title":"The effects of arginine and branched-chain amino acid supplementation to reduced-protein diet on intestinal health, cecal short-chain fatty acid profiles, and immune response in broiler chickens challenged with Eimeria spp","volume":"102","author":"Liu","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0025","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1111\/jpn.13110","article-title":"Dietary l-arginine supplementation influences growth performance and B-cell secretion of immunoglobulin in broiler chickens","volume":"103","author":"Liu","year":"2019","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"10.1016\/j.psj.2025.105684_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103790","article-title":"High-energy and high-amino acid diet enhances production performance and antioxidant capacity in yellow-feathered broilers under heat stress","volume":"103","author":"Mao","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0027","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.3382\/ps\/pew471","article-title":"Effects of dietary L-arginine levels on small intestine protein turnover and the expression of genes related to protein synthesis and proteolysis of layers","volume":"96","author":"Miao","year":"2017","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101548","article-title":"Effects of low eggshell temperatures during incubation, in ovo feeding of L-arginine, and post-hatch dietary guanidinoacetic acid on hatching traits, performance, and physiological responses of broilers reared at low ambient temperature","volume":"101","author":"Miri","year":"2022","journal-title":"Poultry Sci"},{"key":"10.1016\/j.psj.2025.105684_bib0029","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1590\/1516-635x160263-72","article-title":"The effect of arginine dietary supplementation in broiler breeder hens on offspring humoral and cell-mediated immune responses","volume":"16","author":"Murakami","year":"2012","journal-title":"Braz. J. Poult. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0030","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00360-024-01542-8","article-title":"Embryonic methionine triggers post-natal developmental programming in Japanese quail","volume":"194","author":"Ndunguru","year":"2024","journal-title":"J. Comp. Physiol. B"},{"key":"10.1016\/j.psj.2025.105684_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.102148","article-title":"The effects of arginine supplementation through different ratios of arginine:lysine on performance, skin quality and creatine levels of broiler chickens fed diets reduced in protein content","volume":"101","author":"Oliveira","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0033","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1590\/1806-9061-2017-0620","article-title":"Effect of feeding arginine on the growth performance, carcass traits, relative expression of lipogenic genes, and blood parameters of Arian broilers","volume":"20","author":"Pirsaraei","year":"2018","journal-title":"Braz. J. Poult. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0034","doi-asserted-by":"crossref","first-page":"8314","DOI":"10.1038\/s41598-024-58487-9","article-title":"Dietary restriction reveals sex-specific expression of the mTOR pathway genes in Japanese quails","volume":"14","author":"Reda","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2025.105684_bib0035","doi-asserted-by":"crossref","first-page":"E155","DOI":"10.2527\/2006.8413_supplE155x","article-title":"Estimation of nutrient requirements using broken-line regression analysis1","volume":"84","author":"Robbins","year":"2006","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0036","doi-asserted-by":"crossref","first-page":"6935","DOI":"10.1016\/j.psj.2020.09.042","article-title":"Dietary L-arginine supplementation enhances growth performance, intestinal antioxidative capacity, immunity and modulates gut microbiota in yellow-feathered chickens","volume":"99","author":"Ruan","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0038","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40104-022-00817-w","article-title":"Effects of arginine replacement with L-citrulline on the arginine\/nitric oxide metabolism in chickens: an animal model without urea cycle","volume":"14","author":"Uyanga","year":"2023","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.psj.2025.105684_bib0039","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.671691","article-title":"L-citrulline influences the body temperature, heat shock response, and nitric oxide regeneration of broilers under thermoneutral and heat stress conditions","volume":"12","author":"Uyanga","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.psj.2025.105684_bib0040","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.aninu.2022.04.010","article-title":"L-arginine\/nitric oxide regulates skeletal muscle development via muscle fibre-specific nitric oxide\/mTOR pathway in chickens","volume":"10","author":"Wang","year":"2022","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.psj.2025.105684_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.livsci.2024.105624","article-title":"Effect of different arginine-to-lysine ratios and guanidinoacetic acid supplementation on growth performance, carcass characteristics, and breast myopathies in broiler chickens","volume":"291","author":"Westreicher-Kristen","year":"2025","journal-title":"Livest. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0043","doi-asserted-by":"crossref","first-page":"6435","DOI":"10.1007\/s11033-019-05090-1","article-title":"L-arginine alleviates heat stress-induced intestinal epithelial barrier damage by promoting expression of tight junction proteins via the AMPK pathway","volume":"46","author":"Xia","year":"2019","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.psj.2025.105684_bib0044","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.livsci.2018.01.001","article-title":"Dietary arginine supplementation enhances the growth performance and immune status of broiler chickens","volume":"209","author":"Xu","year":"2018","journal-title":"Livest. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0045","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1007\/s11033-019-04720-y","article-title":"Association analysis between feed efficiency and expression of key genes of the avTOR signaling pathway in meat-type ducks","volume":"46","author":"Yang","year":"2019","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.psj.2025.105684_bib0046","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1080\/1828051X.2018.1434692","article-title":"Effects of arginine on the growth performance, hormones, digestive organ development and intestinal morphology in the early growth stage of layer chickens","volume":"17","author":"Yu","year":"2018","journal-title":"Ital. J. Anim. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0047","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.3382\/ps\/pev051","article-title":"L-arginine upregulates the gene expression of target of rapamycin signaling pathway and stimulates protein synthesis in chicken intestinal epithelial cells","volume":"94","author":"Yuan","year":"2015","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105684_bib0048","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s40104-018-0294-5","article-title":"Effect of dietary arginine to lysine ratios on productive performance, meat quality, plasma and muscle metabolomics profile in fast-growing broiler chickens","volume":"9","author":"Zampiga","year":"2018","journal-title":"J. Anim. Sci. Biotechnol."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125009265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125009265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:00:40Z","timestamp":1777395640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579125009265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0032579125009265"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2025.105684","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimal dietary arginine improves productive performance, gut morphology, and expression of growth-related and stress-response genes in Japanese quails","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2025.105684","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"105684"}}