{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:03:34Z","timestamp":1765541014514,"version":"3.48.0"},"reference-count":106,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.psj.2025.105708","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:48:23Z","timestamp":1755737303000},"page":"105708","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microbiome and metabolome changes in laying hens induced by dietary epsilon-polylysine"],"prefix":"10.1016","volume":"104","author":[{"given":"Xiaolong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songbai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8789-7858","authenticated-orcid":false,"given":"Ayong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.psj.2025.105708_bib0002","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.4049\/jimmunol.178.7.4641","article-title":"IL-1beta causes an increase in intestinal epithelial tight junction permeability","volume":"178","author":"Al-Sadi","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.psj.2025.105708_bib0003","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3390\/antiox10020174","article-title":"Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy","volume":"10","author":"Arroyave-Ospina","year":"2021","journal-title":"Antioxidants. (Basel)"},{"key":"10.1016\/j.psj.2025.105708_bib0004","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1042\/cs0410023","article-title":"Intestinal absorption of oligopeptides in cystinuria","volume":"41","author":"Asatoor","year":"1971","journal-title":"Clin. Sci."},{"key":"10.1016\/j.psj.2025.105708_bib0005","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/cei.12872","article-title":"Anti-inflammatory effects of infliximab in mice are independent of tumour necrosis factor alpha neutralization","volume":"187","author":"Assas","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.psj.2025.105708_bib0006","first-page":"S148","article-title":"Asymmetric dimethylarginine (ADMA), a marker of endothelial dysfunction levels in metabolic syndrome","volume":"120","author":"Avci","year":"2018","journal-title":"Free Radical Bio Med"},{"key":"10.1016\/j.psj.2025.105708_bib0007","doi-asserted-by":"crossref","first-page":"15718","DOI":"10.1073\/pnas.0407076101","article-title":"The gut microbiota as an environmental factor that regulates fat storage","volume":"101","author":"Backhed","year":"2004","journal-title":"Proc. Natl. Acad. Sci. u S. a"},{"key":"10.1016\/j.psj.2025.105708_bib0008","first-page":"1915","article-title":"Host-bacterial mutualism in the human intestine","volume":"307","author":"Backhed","year":"2005","journal-title":"Science (1979)"},{"key":"10.1016\/j.psj.2025.105708_bib0009","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.lwt.2016.02.049","article-title":"Emulsion stabilized with phytoglycogen octenyl succinate prolongs the antimicrobial efficacy of \u03b5-poly-L-lysine against O157:H7","volume":"70","author":"Bi","year":"2016","journal-title":"Lwt-Food Sci Technol"},{"key":"10.1016\/j.psj.2025.105708_bib0010","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s40168-022-01364-2","article-title":"Mining the microbiota to identify gut commensals modulating neuroinflammation in a mouse model of multiple sclerosis","volume":"10","author":"Bianchimano","year":"2022","journal-title":"Microbiome"},{"key":"10.1016\/j.psj.2025.105708_bib0011","doi-asserted-by":"crossref","first-page":"R202","DOI":"10.1186\/ar4393","article-title":"Evidence that TNF-\u03b2 (lymphotoxin \u03b1) can activate the inflammatory environment in human chondrocytes","volume":"15","author":"Buhrmann","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.psj.2025.105708_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1161067","article-title":"The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions","volume":"14","author":"Carlini","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2025.105708_bib0013","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ijfoodmicro.2010.05.021","article-title":"Control of foodborne pathogens on ready-to-eat roast beef slurry by epsilon-polylysine","volume":"141","author":"Chang","year":"2010","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.psj.2025.105708_bib0017","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.procbio.2018.03.001","article-title":"Preparation, characterization and antimicrobial activity of \u03b5-poly-L-lysine with short chain length produced from glycerol by","volume":"68","author":"Chen","year":"2018","journal-title":"Process. Biochem."},{"key":"10.1016\/j.psj.2025.105708_bib0014","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1039\/C8FO02161A","article-title":"Effects of dietary gamma-aminobutyric acid supplementation on the intestinal functions in weaning piglets","volume":"10","author":"Chen","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.psj.2025.105708_bib0015","doi-asserted-by":"crossref","DOI":"10.1111\/asj.13387","article-title":"Effects of Antimicrobial peptides on egg production, egg quality and caecal microbiota of hens during the late laying period","volume":"91","author":"Chen","year":"2020","journal-title":"Anim. Sci. J."},{"key":"10.1016\/j.psj.2025.105708_bib0016","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1007\/s12602-022-09923-7","article-title":"Effects of Dietary Supplementation with and on Mucosal Immunity and Intestinal Barrier Are Associated with Its Modulation of Gut Metabolites and Microbiota in Late-Phase Laying Hens","volume":"15","author":"Chen","year":"2023","journal-title":"Probiotics Antimicro"},{"key":"10.1016\/j.psj.2025.105708_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1090338","article-title":"Ferroptosis in non-alcoholic liver disease: Molecular mechanisms and therapeutic implications","volume":"10","author":"Cheng","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.psj.2025.105708_bib0019","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/bip.21438","article-title":"Membrane binding and perturbation studies of the antimicrobial peptides caerin, citropin, and maculatin","volume":"96","author":"Chia","year":"2011","journal-title":"Biopolymers"},{"key":"10.1016\/j.psj.2025.105708_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.840245","article-title":"Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives","volume":"13","author":"Dempsey","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2025.105708_bib0001","article-title":"The relationship among avian influenza, gut microbiota and chicken immunity: an updated overview","volume":"101","author":"El-Hack","year":"2022","journal-title":"Poul Sci"},{"key":"10.1016\/j.psj.2025.105708_bib0022","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.3382\/ps\/pez118","article-title":"Age-related modulation of the isthmic and uterine mucosal innate immune defense system in laying hens","volume":"98","author":"Elhamouly","year":"2019","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105708_bib0021","first-page":"1253","article-title":"SID lysine requirement of immunologically and physically castrated male pigs during the grower, early and late finisher periods","volume":"95","author":"Elsbernd","year":"2017","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.psj.2025.105708_bib0023","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3945\/an.114.007732","article-title":"Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs","volume":"6","author":"Gabbs","year":"2015","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.psj.2025.105708_bib0024","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.3390\/nu15133054","article-title":"Potent Intestinal Mucosal Barrier Enhancement of Nostoc commune Vaucher Polysaccharide Supplementation Ameliorates Acute Ulcerative Colitis in Mice Mediated by Gut Microbiota","volume":"15","author":"Guo","year":"2023","journal-title":"Nutrients."},{"key":"10.1016\/j.psj.2025.105708_bib0025","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1136\/gut.13.12.965","article-title":"Dipeptide absorption in man","volume":"13","author":"Hellier","year":"1972","journal-title":"Gut"},{"key":"10.1016\/j.psj.2025.105708_bib0026","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-52678-5","article-title":"Effects of combined D-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet","volume":"9","author":"Hereu","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2025.105708_bib0027","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0273-2300(03)00029-1","article-title":"Use of ADME studies to confirm the safety of epsilon-polylysine as a preservative in food","volume":"37","author":"Hiraki","year":"2003","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.psj.2025.105708_bib0028","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1939-1676.2011.00867.x","article-title":"Urinary Leukotriene E4 Concentrations as a Potential Marker of Inflammation in Dogs with Inflammatory Bowel Disease","volume":"26","author":"Hof","year":"2012","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.psj.2025.105708_bib0029","doi-asserted-by":"crossref","first-page":"8823","DOI":"10.1007\/s00253-021-11606-2","article-title":"Lactobacillus salivarius and Lactobacillus agilis feeding regulates intestinal stem cells activity by modulating crypt niche in hens","volume":"105","author":"Hong","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.psj.2025.105708_bib0030","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.3390\/molecules22122076","article-title":"The Design and Evaluation of an l-Dopa-Lazabemide Prodrug for the Treatment of Parkinson's Disease","volume":"22","author":"Hoon","year":"2017","journal-title":"Molecules."},{"key":"10.1016\/j.psj.2025.105708_bib0031","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3389\/fmicb.2018.00897","article-title":"Lactobacillus frumenti Facilitates Intestinal Epithelial Barrier Function Maintenance in Early-Weaned Piglets","volume":"9","author":"Hu","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.psj.2025.105708_bib0032","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.chom.2018.11.006","article-title":"A Microbiota-Derived Bacteriocin Targets the Host to Confer Diarrhea Resistance in Early-Weaned Piglets","volume":"24","author":"Hu","year":"2018","journal-title":"Cell Host. Microbe"},{"key":"10.1016\/j.psj.2025.105708_bib0033","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1021\/acs.jproteome.8b00946","article-title":"Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline","volume":"18","author":"Hubbard","year":"2019","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.psj.2025.105708_bib0034","doi-asserted-by":"crossref","first-page":"7758","DOI":"10.1128\/AEM.02204-14","article-title":"The antimicrobial mechanism of action of epsilon-poly-l-lysine","volume":"80","author":"Hyldgaard","year":"2014","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.psj.2025.105708_bib0035","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.677008","article-title":"Elevated Interleukin-10 Levels in COVID-19: Potentiation of Pro-Inflammatory Responses or Impaired Anti-Inflammatory Action?","volume":"12","author":"Islam","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2025.105708_bib0036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0352-x","article-title":"A protective mechanism of probiotic Lactobacillus against hepatic steatosis via reducing host intestinal fatty acid absorption","volume":"51","author":"Jang","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.psj.2025.105708_bib0037","first-page":"174","article-title":"The Gut Microbiome and Ferroptosis in MAFLD","volume":"11","author":"Ji","year":"2023","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.psj.2025.105708_bib0038","first-page":"1099","article-title":"The clinical efficacy and safety study of Esculin and Digitalis glycosides Eye Drops in treating ametropic asthenopia","volume":"46","author":"Jiang","year":"2010","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"10.1016\/j.psj.2025.105708_bib0039","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/ps\/82.4.640","article-title":"Alternatives to antibiotics: bacteriocins, antimicrobial peptides and bacteriophages","volume":"82","author":"Joerger","year":"2003","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105708_bib0040","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.767456","article-title":"IL-1beta and the Intestinal Epithelial Tight Junction Barrier","volume":"12","author":"Kaminsky","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2025.105708_bib0041","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1124\/dmd.122.001059","article-title":"Identification of 5-Hydroxycotinine in the Plasma of Nicotine-Treated Mice: Implications for Cotinine Metabolism and Disposition in Vivo","volume":"50","author":"Kanamori","year":"2022","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.psj.2025.105708_bib0042","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14368-y","article-title":"4-Hydroxybenzaldehyde accelerates acute wound healing through activation of focal adhesion signalling in keratinocytes","volume":"7","author":"Kang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2025.105708_bib0043","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.cyto.2014.03.007","article-title":"How is inflammation initiated? Individual influences of IL-1, IL-18 and HMGB1","volume":"69","author":"Keyel","year":"2014","journal-title":"Cytokine"},{"key":"10.1016\/j.psj.2025.105708_bib0045","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1128\/JCM.01576-09","article-title":"Characterization of Slackia exigua isolated from human wound infections, including abscesses of intestinal origin","volume":"48","author":"Kim","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.psj.2025.105708_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101676","article-title":"Research Note: Improvement of eggshell strength and intensity of brown eggshell color by dietary magnesium and delta-aminolevulinic acid supplementation in laying hens","volume":"101","author":"Kim","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105708_bib0046","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s11160-012-9266-6","article-title":"The effect of dietary dipeptide lysine-glycine on growth, muscle proteins, and intestine gene expression in juvenile yellow perch","volume":"22","author":"Kwasek","year":"2012","journal-title":"Rev Fish Bio Fish"},{"key":"10.1016\/j.psj.2025.105708_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2020.11.052","article-title":"Effects of alpha-glyceryl monolaurate on growth, immune function, volatile fatty acids, and gut microbiota in broiler chickens","volume":"100","author":"Lan","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105708_bib0048","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3390\/ani13030345","article-title":"Comparison of the Microbiome-Metabolome Response to Copper Sulfate and Copper Glycinate in Growing Pigs","volume":"13","author":"Lei","year":"2023","journal-title":"Animals"},{"key":"10.1016\/j.psj.2025.105708_bib0049","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1053\/j.gastro.2022.07.004","article-title":"Altered Gut Microbiome Composition and Function Are Associated With Gut Barrier Dysfunction in Healthy Relatives of Patients With Crohn's Disease","volume":"163","author":"Leibovitzh","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.psj.2025.105708_bib0052","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.foodcont.2014.02.023","article-title":"Antibacterial characteristics and mechanisms of \u03b5-poly-lysine against and","volume":"43","author":"Li","year":"2014","journal-title":"Food Control"},{"key":"10.1016\/j.psj.2025.105708_bib0050","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3390\/ani14010138","article-title":"Effects of Curcumin on the Egg Quality and Hepatic Lipid Metabolism of Laying Hens","volume":"14","author":"Li","year":"2023","journal-title":"Animals"},{"key":"10.1016\/j.psj.2025.105708_bib0051","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/nutrit\/nuac070","article-title":"Arginine metabolism regulates the pathogenesis of inflammatory bowel disease","volume":"81","author":"Li","year":"2023","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.psj.2025.105708_bib0053","article-title":"The effects of rhein on D-GalN\/LPS-induced acute liver injury in mice: Results from gut microbiome-metabolomics and host transcriptome analysis","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.psj.2025.105708_bib0054","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11250-020-02546-6","article-title":"Effects of supplementation of dietary humate, probiotic, and their combination on performance, egg quality, and yolk fatty acid composition of laying hens","volume":"53","author":"Macit","year":"2021","journal-title":"Trop. Anim. Health Prod."},{"key":"10.1016\/j.psj.2025.105708_bib0055","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1110536","article-title":"Gut microbiota modulation in patients with non-alcoholic fatty liver disease: Effects of current treatments and future strategies","volume":"10","author":"Maestri","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.psj.2025.105708_bib0056","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ijpharm.2018.03.021","article-title":"epsilon-Poly-l-Lysine\/plasmid DNA nanoplexes for efficient gene delivery in vivo","volume":"542","author":"Mandal","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.psj.2025.105708_bib0057","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.3390\/nu11112642","article-title":"The Role of Probiotics in Nonalcoholic Fatty Liver Disease: a New Insight into Therapeutic Strategies","volume":"11","author":"Meroni","year":"2019","journal-title":"Nutrients."},{"key":"10.1016\/j.psj.2025.105708_bib0058","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1016\/j.psj.2019.11.046","article-title":"Effects of dietary probiotic (Pediococcus acidilactici) supplementation on productive performance, egg quality, and body composition in laying hens fed diets varying in energy density","volume":"99","author":"Mikulski","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105708_bib0059","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.875270","article-title":"Natural Products of Plants and Animal Origin Improve Albumen Quality of Chicken Eggs","volume":"9","author":"Obianwuna","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.psj.2025.105708_bib0060","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.987241","article-title":"Enhancing egg production and quality by the supplementation of probiotic strains (Clostridium and Brevibacillus) via improved amino acid digestibility, intestinal health, immune response, and antioxidant activity","volume":"13","author":"Obianwuna","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.psj.2025.105708_bib0061","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1600-079X.2006.00346.x","article-title":"Melatonin ameliorates nonalcoholic fatty liver induced by high-fat diet in rats","volume":"41","author":"Pan","year":"2006","journal-title":"J. Pineal. Res."},{"key":"10.1016\/j.psj.2025.105708_bib0062","doi-asserted-by":"crossref","first-page":"8848","DOI":"10.1038\/s41598-020-65051-8","article-title":"Gut metabolites and inflammation factors in non-alcoholic fatty liver disease: a systematic review and meta-analysis","volume":"10","author":"Pan","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2025.105708_bib0063","first-page":"1","article-title":"Novel alternatives to antibiotics: bacteriophages, bacterial cell wall hydrolases, and antimicrobial peptides","volume":"104","author":"Parisien","year":"2008","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.psj.2025.105708_bib0064","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3390\/jcm10020272","article-title":"Alterations in Small Intestine and Liver Morphology, Immunolocalization of Leptin, Ghrelin and Nesfatin-1 as Well as Immunoexpression of Tight Junction Proteins in Intestinal Mucosa after Gastrectomy in Rat Model","volume":"10","author":"Puzio","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.psj.2025.105708_bib0065","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-90553-4","article-title":"Identification of mucin degraders of the human gut microbiota","volume":"11","author":"Raimondi","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.psj.2025.105708_bib0066","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/oby.20640","article-title":"Effect of (D)-fagomine on excreted Enterobacteria and weight gain in rats fed a high-fat high-sucrose diet","volume":"22","author":"Ramos-Romero","year":"2014","journal-title":"Obesity. (Silver. Spring)"},{"key":"10.1016\/j.psj.2025.105708_bib0067","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.3390\/nu14214656","article-title":"Fiber-like Action of d-Fagomine on the Gut Microbiota and Body Weight of Healthy Rats","volume":"14","author":"Ramos-Romero","year":"2022","journal-title":"Nutrients."},{"key":"10.1016\/j.psj.2025.105708_bib0068","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101266","article-title":"Dietary effect of licorice (Glycyrrhiza glabra) on quail performance, carcass, blood metabolites and intestinal microbiota","volume":"100","author":"Reda","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105708_bib0069","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nature25973","article-title":"Environment dominates over host genetics in shaping human gut microbiota","volume":"555","author":"Rothschild","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.psj.2025.105708_bib0073","first-page":"326","article-title":"Effect of Dietary Supplementation of Antimicrobial Peptide on Production Performance, Egg Quality and Serum Biochemical Parameters of Laying Hens","volume":"44","author":"Shastri","year":"2025","journal-title":"Asian J. Dairy Food Res"},{"key":"10.1016\/j.psj.2025.105708_bib0070","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.biortech.2004.08.012","article-title":"Microbial synthesis of poly(epsilon-lysine) and its various applications","volume":"97","author":"Shih","year":"2006","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.psj.2025.105708_bib0071","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.1111\/1750-3841.15971","article-title":"Lactobacillus alleviated obesity induced by high-fat diet in mice","volume":"86","author":"Song","year":"2021","journal-title":"J. Food Sci."},{"key":"10.1016\/j.psj.2025.105708_bib0072","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.cmet.2014.07.003","article-title":"Starving our microbial self: the deleterious consequences of a diet deficient in microbiota-accessible carbohydrates","volume":"20","author":"Sonnenburg","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.psj.2025.105708_bib0074","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2022.184054","article-title":"Clostridium perfringens alpha-toxin up-regulates plasma membrane CD11b expression on murine neutrophils by changing intracellular localization","volume":"1864","author":"Takehara","year":"2022","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.psj.2025.105708_bib0075","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.fshw.2022.04.034","article-title":"Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice","volume":"11","author":"Tang","year":"2022","journal-title":"Food Sci Hum Wellness"},{"key":"10.1016\/j.psj.2025.105708_bib0076","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1177\/0300985813503569","article-title":"Fatty liver hemorrhagic syndrome in the backyard chicken: a retrospective histopathologic case series","volume":"51","author":"Trott","year":"2014","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.psj.2025.105708_bib0078","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41577-022-00792-3","article-title":"Death by TNF: a road to inflammation","volume":"23","author":"van Loo","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.psj.2025.105708_bib0077","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3390\/ani8070114","article-title":"A Description of Laying Hen Husbandry and Management Practices in Canada","volume":"8","author":"van Staaveren","year":"2018","journal-title":"Animals"},{"key":"10.1016\/j.psj.2025.105708_bib0079","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.3390\/ani10091718","article-title":"as Foodborne Pathogen in Broiler Production: Pathophysiology and Potential Strategies for Controlling Necrotic Enteritis","volume":"10","author":"Villagr\u00e1n-de la Mora","year":"2020","journal-title":"Animals"},{"key":"10.1016\/j.psj.2025.105708_bib0080","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.641734","article-title":"Role of Interleukin-6 in Vascular Health and Disease","volume":"8","author":"Villar-Fincheira","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.psj.2025.105708_bib0081","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1099\/0022-1317-79-4-731","article-title":"Antimicrobial peptides melittin and cecropin inhibit replication of human immunodeficiency virus 1 by suppressing viral gene expression","volume":"79","author":"Wachinger","year":"1998","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.psj.2025.105708_bib0082","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1016\/j.cell.2023.08.017","article-title":"Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle","volume":"186","author":"Wang","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.psj.2025.105708_bib0083","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.802805","article-title":"Applications of Medium-Chain Triglycerides in Foods","volume":"9","author":"Watanabe","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.psj.2025.105708_bib0085","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.3382\/ps\/pex122","article-title":"Effects of dietary energy and lysine levels on growth performance and carcass yields of Pekin ducks from hatch to 21 days of age","volume":"96","author":"Wen","year":"2017","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105708_bib0084","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s40168-021-01040-x","article-title":"Joint contributions of the gut microbiota and host genetics to feed efficiency in chickens","volume":"9","author":"Wen","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.psj.2025.105708_bib0086","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.3382\/ps\/pex349","article-title":"Comparison of two methods for determination of intestinal villus to crypt ratios and documentation of early age-associated ratio changes in broiler chickens","volume":"97","author":"Wilson","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.psj.2025.105708_bib0087","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41420-021-00660-4","article-title":"Ferroptosis in liver disease: new insights into disease mechanisms","volume":"7","author":"Wu","year":"2021","journal-title":"Cell Death. Discov."},{"key":"10.1016\/j.psj.2025.105708_bib0088","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/cbin.11960","article-title":"Protective effect of rutin on ferroptosis-induced oxidative stress in aging laying hens through Nrf2\/HO-1 signaling","volume":"47","author":"Wu","year":"2023","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.psj.2025.105708_bib0089","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3390\/molecules22040653","article-title":"Gamma-Aminobutyric Acid Increases the Production of Short-Chain Fatty Acids and Decreases pH Values in Mouse Colon","volume":"22","author":"Xie","year":"2017","journal-title":"Molecules."},{"key":"10.1016\/j.psj.2025.105708_bib0090","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41419-021-03559-1","article-title":"The emerging role of ferroptosis in intestinal disease","volume":"12","author":"Xu","year":"2021","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.psj.2025.105708_bib0093","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3389\/fphys.2017.00220","article-title":"Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated with Suppressed Inflammatory Transcriptional Networks in the Mouse Colon","volume":"8","author":"Yang","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.psj.2025.105708_bib0092","doi-asserted-by":"crossref","first-page":"S642","DOI":"10.1016\/S0016-5085(18)32292-3","article-title":"Intestinal Epithelial Cells Promote Growth and Function of Lactobacillus Rhamnosus Gg (Lgg) in Vitro and in Mice","volume":"154","author":"Yang","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.psj.2025.105708_bib0091","doi-asserted-by":"crossref","first-page":"9793","DOI":"10.1039\/D1FO01468D","article-title":"Gut microbiota-dependent catabolites of tryptophan play a predominant role in the protective effects of turmeric polysaccharides against DSS-induced ulcerative colitis","volume":"12","author":"Yang","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.psj.2025.105708_bib0094","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1194089","article-title":"The mechanisms crosstalk and therapeutic opportunities between ferroptosis and ovary diseases","volume":"14","author":"Yao","year":"2023","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.psj.2025.105708_bib0095","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1159\/000487027","article-title":"Micro Integral Membrane Protein (MIMP), a Newly Discovered Anti-Inflammatory Protein of Lactobacillus Plantarum, Enhances the Gut Barrier and Modulates Microbiota and Inflammatory Cytokines","volume":"45","author":"Yin","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.psj.2025.105708_bib0096","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.5713\/ajas.2012.12555","article-title":"Effects of dietary lysine levels on apparent nutrient digestibility and serum amino Acid absorption mode in growing pigs","volume":"26","author":"Zeng","year":"2013","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"10.1016\/j.psj.2025.105708_bib0097","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/ismej.2014.165","article-title":"Host adaptive immunity alters gut microbiota","volume":"9","author":"Zhang","year":"2015","journal-title":"ISMe J."},{"key":"10.1016\/j.psj.2025.105708_bib0099","article-title":"The Effect of the Antimicrobial Peptide Plectasin on the Growth Performance, Intestinal Health, and Immune Function of Yellow-Feathered Chickens","volume":"8","author":"Zhang","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.psj.2025.105708_bib0098","doi-asserted-by":"crossref","DOI":"10.12659\/AJCR.936329","article-title":"Clostridium perfringens and Escherichia coli Bacteremia in a Patient with Acute Obstructive Suppurative Cholangitis: a Case Report and Review of the Literature","volume":"23","author":"Zhang","year":"2022","journal-title":"Am. J. Case Rep."},{"key":"10.1016\/j.psj.2025.105708_bib0100","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/1751-7915.13841","article-title":"Caecal microbiota could effectively increase chicken growth performance by regulating fat metabolism","volume":"15","author":"Zhang","year":"2022","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.psj.2025.105708_bib0101","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2020.104057","article-title":"Effects of polysaccharides from bee collected pollen of Chinese wolfberry on immune response and gut microbiota composition in cyclophosphamide-treated mice","volume":"72","author":"Zhao","year":"2020","journal-title":"J. Funct. Foods."},{"key":"10.1016\/j.psj.2025.105708_bib0103","article-title":"Lactobacillus salivarius Promotion of Intestinal Stem","volume":"7","author":"Zhou","year":"2022","journal-title":"Cell Activity in Hens Is Associated with Succinate-Induced Mitochondrial Energy Metabolism. Msystems"},{"key":"10.1016\/j.psj.2025.105708_bib0102","first-page":"820","article-title":"The Induction Mechanism of Ferroptosis, Necroptosis, and Pyroptosis in Inflammatory Bowel Disease","volume":"13","author":"Zhou","year":"2023","journal-title":"Colorectal Cancer, and Intestinal Injury. Biomolecules"},{"key":"10.1016\/j.psj.2025.105708_bib0104","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1007\/s00213-020-05569-x","article-title":"Abnormalities in gut microbiota and serum metabolites in hemodialysis patients with mild cognitive decline: a single-center observational study","volume":"237","author":"Zhu","year":"2020","journal-title":"Psychopharmacology. (Berl)"},{"key":"10.1016\/j.psj.2025.105708_bib0106","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.665406","article-title":"Prediction of Gut Microbial Community Structure and Function in Polycystic Ovary Syndrome With High Low-Density Lipoprotein Cholesterol","volume":"11","author":"Zhu","year":"2021","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.psj.2025.105708_bib0105","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.3390\/ani12243462","article-title":"Effects of the Antimicrobial Peptide Mastoparan X on the Performance, Permeability and Microbiota Populations of Broiler Chickens","volume":"12","author":"Zhu","year":"2022","journal-title":"Animals"}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125009502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579125009502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:59:23Z","timestamp":1765540763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579125009502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":106,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0032579125009502"],"URL":"https:\/\/doi.org\/10.1016\/j.psj.2025.105708","relation":{},"ISSN":["0032-5791"],"issn-type":[{"type":"print","value":"0032-5791"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microbiome and metabolome changes in laying hens induced by dietary epsilon-polylysine","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.psj.2025.105708","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc. on behalf of Poultry Science Association Inc.","name":"copyright","label":"Copyright"}],"article-number":"105708"}}